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Penicillin and cephalosporin biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
S-adenosyl-L-methionine + 7a-Hydroxy-O-carbamoyl-deacetylcephalosporin_C <=> H+ + cephamycin_C + S-adenosyl-L-homocysteine not assigned

isopenicillin_N + acyl-CoA + H2O <=> penicillin + CoA + L-2-aminoadipate 2.3.1.164 isopenicillin-N N-acyltransferase

cephalosporin_C + H2O + O2 <=> 7-(5-oxoadipoamido)cephalosporanic_acid + NH3 + H2O2 1.4.3.3 D-amino-acid oxidase

7-(5-oxoadipoamido)cephalosporanic_acid + D-glutamate <=> cephalosporin_C + 2-oxoglutarate 2.6.1.74 cephalosporin-C transaminase

7beta-(5-D-Aminoadipamido)-3-carbamoyloxymethylceph-3-em-4-carboxylic_acid + 2-oxoglutarate + O2 <=> 7a-Hydroxy-O-carbamoyl-deacetylcephalosporin_C + succinate + CO2 not assigned

a_penicillin + H2O <=> a_(2R,4S)-2-[(R)-(acylamino)(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic_acid 3.5.2.6 beta-lactamase

penicillin + H2O <=> 6-aminopenicillanic_acid + a_carboxylate 3.5.1.11 penicillin amidase

L-2-aminoadipate + L-cysteine + L-valine + ATP + H2O <=> H+ + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + AMP + diphosphate 6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

deacetoxycephalosporin_C + 2-oxoglutarate + O2 <=> deacetylcephalosporin_C + succinate + CO2 1.14.11.26 deacetoxycephalosporin-C hydroxylase
1.14.20.1 deacetoxycephalosporin-C synthase


O2 + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine <=> H2O + isopenicillin_N 1.21.3.1 isopenicillin-N synthase

deacetylcephalosporin_C + Carbamoyl_phosphate <=> 7beta-(5-D-Aminoadipamido)-3-carbamoyloxymethylceph-3-em-4-carboxylic_acid + phosphate 2.1.3.7 3-hydroxymethylcephem carbamoyltransferase

acetyl-CoA + deacetylcephalosporin_C <=> CoA + cephalosporin_C 2.3.1.175 deacetylcephalosporin-C acetyltransferase

H2O + cephalosporin_C <=> H+ + acetate + deacetylcephalosporin_C 3.1.1.41 cephalosporin-C deacetylase
3.5.2.6 beta-lactamase


7-(5-oxoadipoamido)cephalosporanic_acid + H2O2 <=> (7R)-7-(4-carboxybutanamido)cephalosporanate + CO2 + H2O not assigned

Penicillin_N + 2-oxoglutarate + O2 <=> deacetoxycephalosporin_C + succinate + CO2 + H2O 1.14.20.1 deacetoxycephalosporin-C synthase

isopenicillin_N <=> Penicillin_N 5.1.1.17 isopenicillin-N epimerase

(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O <=> 7-aminocephalosporanic_acid + Glutarate 3.5.1.11 penicillin amidase
3.5.1.93 glutaryl-7-aminocephalosporanic-acid acylase


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