|
|
S-adenosyl-L-methionine + 7a-Hydroxy-O-carbamoyl-deacetylcephalosporin_C <=> H+ + cephamycin_C + S-adenosyl-L-homocysteine
|
not assigned
|
–
|
| |
KEGG:
R05303
MetaCyc:
RXN-8812
|
|
|
|
isopenicillin_N + acyl-CoA + H2O <=> penicillin + CoA + L-2-aminoadipate
|
2.3.1.164
isopenicillin-N N-acyltransferase
|
–
|
| |
KEGG:
R06361
|
|
|
|
cephalosporin_C + H2O + O2 <=> 7-(5-oxoadipoamido)cephalosporanic_acid + NH3 + H2O2
|
1.4.3.3
D-amino-acid oxidase
|
–
|
| |
BRENDA:
BS259063
KEGG:
R07400
SABIO-RK:
9046
|
|
|
|
7-(5-oxoadipoamido)cephalosporanic_acid + D-glutamate <=> cephalosporin_C + 2-oxoglutarate
|
2.6.1.74
cephalosporin-C transaminase
|
–
|
| |
BRENDA:
BR47708
KEGG:
R03063
MetaCyc:
CEPHALOSPORIN-C-TRANSAMINASE-RXN
|
|
|
|
7beta-(5-D-Aminoadipamido)-3-carbamoyloxymethylceph-3-em-4-carboxylic_acid + 2-oxoglutarate + O2 <=> 7a-Hydroxy-O-carbamoyl-deacetylcephalosporin_C + succinate + CO2
|
not assigned
|
–
|
| |
KEGG:
R05302
|
|
|
|
a_penicillin + H2O <=> a_(2R,4S)-2-[(R)-(acylamino)(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic_acid
|
3.5.2.6
beta-lactamase
|
–
|
| |
BRENDA:
BS36785
KEGG:
R06363
|
|
|
|
penicillin + H2O <=> 6-aminopenicillanic_acid + a_carboxylate
|
3.5.1.11
penicillin amidase
|
–
|
| |
BRENDA:
BR19233
KEGG:
R02170
MetaCyc:
PENICILLIN-AMIDASE-RXN
|
|
|
|
L-2-aminoadipate + L-cysteine + L-valine + ATP + H2O <=> H+ + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + AMP + diphosphate
|
6.3.2.26
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
|
–
|
| |
BRENDA:
BR40508
KEGG:
R04870
MetaCyc:
6.3.2.26-RXN
|
|
|
|
deacetoxycephalosporin_C + 2-oxoglutarate + O2 <=> deacetylcephalosporin_C + succinate + CO2
|
1.14.11.26
deacetoxycephalosporin-C hydroxylase
1.14.20.1
deacetoxycephalosporin-C synthase
|
–
–
|
| |
BRENDA:
BR48571
KEGG:
R05229
MetaCyc:
1.14.11.26-RXN
|
|
|
|
O2 + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine <=> H2O + isopenicillin_N
|
1.21.3.1
isopenicillin-N synthase
|
–
|
| |
BRENDA:
BR40531;
BS394923
KEGG:
R04872
MetaCyc:
1.21.3.1-RXN
SABIO-RK:
4514
|
|
|
|
deacetylcephalosporin_C + Carbamoyl_phosphate <=> 7beta-(5-D-Aminoadipamido)-3-carbamoyloxymethylceph-3-em-4-carboxylic_acid + phosphate
|
2.1.3.7
3-hydroxymethylcephem carbamoyltransferase
|
–
|
| |
BRENDA:
BS320114
KEGG:
R05230
MetaCyc:
RXN-8810
|
|
|
|
acetyl-CoA + deacetylcephalosporin_C <=> CoA + cephalosporin_C
|
2.3.1.175
deacetylcephalosporin-C acetyltransferase
|
–
|
| |
BRENDA:
BR48556
KEGG:
R03064
MetaCyc:
2.3.1.175-RXN
|
|
|
|
H2O + cephalosporin_C <=> H+ + acetate + deacetylcephalosporin_C
|
3.1.1.41
cephalosporin-C deacetylase
3.5.2.6
beta-lactamase
|
–
–
|
| |
BRENDA:
BR19191
KEGG:
R03062
MetaCyc:
CEPHALOSPORIN-C-DEACETYLASE-RXN
SABIO-RK:
2905
|
|
|
|
7-(5-oxoadipoamido)cephalosporanic_acid + H2O2 <=> (7R)-7-(4-carboxybutanamido)cephalosporanate + CO2 + H2O
|
not assigned
|
–
|
| |
KEGG:
R07401
|
|
|
|
Penicillin_N + 2-oxoglutarate + O2 <=> deacetoxycephalosporin_C + succinate + CO2 + H2O
|
1.14.20.1
deacetoxycephalosporin-C synthase
|
–
|
| |
BRENDA:
BR40542
KEGG:
R05301
MetaCyc:
1.14.20.1-RXN
SABIO-RK:
4910
|
|
|
|
isopenicillin_N <=> Penicillin_N
|
5.1.1.17
isopenicillin-N epimerase
|
–
|
| |
BRENDA:
BR44345;
BS323502
KEGG:
R04147
MetaCyc:
5.1.1.17-RXN
|
|
|
|
(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O <=> 7-aminocephalosporanic_acid + Glutarate
|
3.5.1.11
penicillin amidase
3.5.1.93
glutaryl-7-aminocephalosporanic-acid acylase
|
–
–
|
| |
BRENDA:
BR48552;
BS379804
KEGG:
R07402
MetaCyc:
3.5.1.93-RXN
SABIO-RK:
9513
|
|
