Copied!

Pathway Search


Pantothenate and CoA biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
H+ + pyruvate <=> (S)-2-Hydroxy-2-methyl-3-oxobutanoate + CO2 2.2.1.6 acetolactate synthase
4.1.1.1 pyruvate decarboxylase
–
–
(R)-4''-phosphopantothenate + L-cysteine + CTP <=> H+ + (R)-4''-phosphopantothenoyl-L-cysteine + diphosphate + CMP 6.3.2.5 phosphopantothenate---cysteine ligase (CTP)
–
ATP + N-[(R)-pantothenoyl]-L-cysteine <=> ADP + (R)-4''-Phosphopantothenoyl-L-cysteine 2.7.1.33 pantothenate kinase
–
GTP + 3'-dephospho-CoA <=> GDP + CoA 2.7.1
–
CoA-[4''-phosphopantetheine] + apo-acyl-carrier_protein <=> adenosine_3'',5''-bisphosphate + [acyl-carrier_protein] 2.7.8
2.7.8.7 holo-[acyl-carrier-protein] synthase
–
–
H+ + (R)-4''-phosphopantothenoyl-L-cysteine <=> 4''-phosphopantetheine + CO2 4.1.1.36 phosphopantothenoylcysteine decarboxylase
–
(R)-pantoate + NADP+ <=> H+ + ketopantoate + NADPH 1.1.1.169 2-dehydropantoate 2-reductase
1.1.1.86 ketol-acid reductoisomerase (NADP+)
–
–
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ <=> (S)-2-Hydroxy-2-methyl-3-oxobutanoate + NADPH + H+ 1.1.1.383 ketol-acid reductoisomerase [NAD(P)+]
1.1.1.86 ketol-acid reductoisomerase (NADP+)
–
–
H2O + 5,6-dihydrouracil <=> H+ + N-Carbamoyl-beta-alanine 3.5.2.16 maleimide hydrolase
3.5.2.2 dihydropyrimidinase
–
–
(R)-pantoate + NAD+ <=> (R)-4-dehydropantoate + NADH + H+ 1.1.1.106 pantoate 4-dehydrogenase
–
pantetheine + ATP <=> 4''-phosphopantetheine + ADP + H+ 2.7.1.33 pantothenate kinase
2.7.1.34 pantetheine kinase
–
–
H+ + L-aspartate <=> beta-Alanine + CO2 4.1.1.11 aspartate 1-decarboxylase
4.1.1.15 glutamate decarboxylase
4.1.1.25 tyrosine decarboxylase
4.1.1.29 sulfinoalanine decarboxylase
–
–
–
–
3''-dephospho-CoA + ATP <=> H+ + CoA + ADP 2.7.1.24 dephospho-CoA kinase
–
(R)-4-phosphopantoate + beta-Alanine + ATP <=> (R)-4''-phosphopantothenate + AMP + diphosphate + H+ 6.3.2.36 4-phosphopantoate---beta-alanine ligase
–
beta-Alanine + (R)-pantoate + ATP <=> H+ + pantothenate + diphosphate + AMP 6.3.2.1 pantoate---beta-alanine ligase (AMP-forming)
–
L-valine + 2-oxoglutarate <=> L-glutamate + 2-oxoisovalerate 2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.66 valine---pyruvate transaminase
–
–
–
–
pantothenate + H2O <=> beta-Alanine + (R)-pantoate 3.5.1.22 pantothenase
–
(R)-2,3-dihydroxy-3-methylbutanoate <=> 2-oxoisovalerate + H2O 4.2.1.9 dihydroxy-acid dehydratase
–
[acyl-carrier_protein] + H2O <=> 4''-phosphopantetheine + apo-acyl-carrier_protein 3.1.4.14 [acyl-carrier-protein] phosphodiesterase
–
(R)-4''-phosphopantothenate + L-cysteine + ATP <=> H+ + (R)-4''-phosphopantothenoyl-L-cysteine + diphosphate + AMP 6.3.2.51 phosphopantothenate---cysteine ligase (ATP)
–
N-Carbamoyl-beta-alanine + H2O + H+ <=> beta-Alanine + NH3 + CO2 3.5.1.6 beta-ureidopropionase
–
ATP + (R)-pantoate <=> H+ + ADP + (R)-4-phosphopantoate 2.7.1.169 pantoate kinase
–
(R)-4-dehydropantoate + H2O + NAD+ <=> (R)-3,3-dimethylmalate + NADH + H+ 1.2.1.33 (R)-dehydropantoate dehydrogenase
–
H+ + 4''-phosphopantetheine + ATP <=> 3''-dephospho-CoA + diphosphate 2.7.7.3 pantetheine-phosphate adenylyltransferase
–
pantothenate + ATP <=> H+ + (R)-4''-phosphopantothenate + ADP 2.7.1.169 pantoate kinase
2.7.1.33 pantothenate kinase
–
–
3'-dephospho-CoA + H2O <=> Pantetheine_4''-phosphate + AMP 3.6.1.9 nucleotide diphosphatase
–
pantothenate + 2 reduced_acceptor <=> pantothenol + 2 acceptor + H2O not assigned
 –
H+ + N-[(R)-pantothenoyl]-L-cysteine <=> pantetheine + CO2 4.1.1.30 pantothenoylcysteine decarboxylase
–
5,6-dihydrouracil + NAD+ <=> Uracil + NADH + H+ 1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)
1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)
–
–
3-aminopropionaldehyde + NAD+ + H2O <=> H+ + beta-Alanine + NADH 1.2.1
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase
–
–
–
–
–
–
5,6-dihydrouracil + NADP+ <=> Uracil + NADPH + H+ 1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)
1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)
–
–
5,10-methylenetetrahydrofolate + 2-oxoisovalerate + H2O <=> ketopantoate + tetrahydrofolate 2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase
–
spermine + O2 + H2O <=> spermidine + 3-aminopropionaldehyde + H2O2 1.5.3.16 spermine oxidase
1.5.3.17 non-specific polyamine oxidase
–
–
pantetheine + H2O <=> pantothenate + cysteamine 3.5.1.92 pantetheine hydrolase
–
NAD+ + (R)-3,3-dimethylmalate <=> NADH + CO2 + 2-oxoisovalerate 1.1.1.84 dimethylmalate dehydrogenase
–

Visualization of the pathway