|
|
5-formimidoyltetrahydrofolate + glycine <=> Formiminoglycine + tetrahydrofolate
|
2.1.2.4
glycine formimidoyltransferase
|
–
|
| |
BRENDA:
BR43943
KEGG:
R02729
MetaCyc:
GLYCINE-FORMIMINOTRANSFERASE-RXN
|
|
|
|
5-methyltetrahydrofolate + oxidized_ferredoxin <=> 5,10-methylenetetrahydrofolate + reduced_ferredoxin_[iron-sulfur]_cluster + H+
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
–
|
| |
BRENDA:
BR48613
KEGG:
R01217
MetaCyc:
RXN-5061
|
|
|
|
S-aminomethyldihydrolipoylprotein + tetrahydrofolate <=> dihydrolipoylprotein + 5,10-methylenetetrahydrofolate + NH3
|
2.1.2.10
aminomethyltransferase
|
–
|
| |
BRENDA:
BS320028
KEGG:
R04125
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP <=> dTMP + 7,8-dihydrofolate
|
2.1.1.45
thymidylate synthase
|
–
|
| |
BRENDA:
BR43900;
BS319728
KEGG:
R02101
MetaCyc:
THYMIDYLATESYN-RXN
SABIO-RK:
88
|
|
|
|
10-formyltetrahydrofolate + H2O <=> tetrahydrofolate + formate + H+
|
3.5.1.10
formyltetrahydrofolate deformylase
|
–
|
| |
BRENDA:
BR22680
KEGG:
R00944
MetaCyc:
FORMYLTHFDEFORMYL-RXN
SABIO-RK:
1259
|
|
|
|
tetrahydrofolate + ATP + formate <=> 10-formyltetrahydrofolate + ADP + phosphate
|
6.3.4.3
formate---tetrahydrofolate ligase
|
–
|
| |
BRENDA:
BR140;
BS443140
KEGG:
R00943
MetaCyc:
FORMATETHFLIG-RXN
SABIO-RK:
51
|
|
|
|
7,8-dihydrofolate + NAD+ <=> folate + NADH + H+
|
1.5.1.3
dihydrofolate reductase
|
–
|
| |
KEGG:
R02235
|
|
|
|
5''-Phosphoribosylglycinamide + 5,10-methenyltetrahydrofolate + H2O <=> 5''-Phosphoribosyl-N-formylglycinamide + tetrahydrofolate
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
| |
KEGG:
R04326
|
|
|
|
5-formimidoyltetrahydrofolate + L-glutamate <=> N-formimino-L-glutamate + tetrahydrofolate
|
2.1.2.5
glutamate formimidoyltransferase
|
–
|
| |
BRENDA:
BR43944;
BS451911
KEGG:
R02287
MetaCyc:
GLUTAMATE-FORMIMINOTRANSFERASE-RXN
SABIO-RK:
2252
|
|
|
|
L-homocysteine + 5-methyltetrahydrofolate <=> L-methionine + tetrahydrofolate
|
2.1.1.13
methionine synthase
2.1.1.14
5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
|
–
–
|
| |
BRENDA:
BR40552
KEGG:
R00946
MetaCyc:
HOMOCYSMETB12-RXN
SABIO-RK:
1260
|
|
|
|
10-formyltetrahydrofolate + H2O + NADP+ <=> tetrahydrofolate + CO2 + NADPH + H+
|
1.5.1.6
formyltetrahydrofolate dehydrogenase
|
–
|
| |
BRENDA:
BR36903
KEGG:
R00941
MetaCyc:
FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN
SABIO-RK:
1257
|
|
|
|
5-methyltetrahydrofolate + NADP+ <=> 5,10-methylenetetrahydrofolate + NADPH + H+
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
| |
BRENDA:
BR36896
KEGG:
R01224
SABIO-RK:
1453
|
|
|
|
5,10-methylenetetrahydrofolate + NAD+ <=> 5,10-methenyltetrahydrofolate + NADH
|
1.5.1.15
methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5
methylenetetrahydrofolate dehydrogenase (NADP+)
|
–
–
|
| |
BRENDA:
BR36891
KEGG:
R01218
MetaCyc:
1.5.1.15-RXN
SABIO-RK:
1450
|
|
|
|
L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O
|
2.1.2.1
glycine hydroxymethyltransferase
|
–
|
| |
BRENDA:
BR40573
KEGG:
R00945
MetaCyc:
GLYOHMETRANS-RXN
SABIO-RK:
95
|
|
|
|
5,10-methenyltetrahydrofolate + H2O <=> 10-formyltetrahydrofolate + H+
|
3.5.4.9
methenyltetrahydrofolate cyclohydrolase
|
–
|
| |
BRENDA:
BR22746
KEGG:
R01655
MetaCyc:
METHENYLTHFCYCLOHYDRO-RXN
SABIO-RK:
74
|
|
|
|
5-methyltetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + H+ + NADH
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
| |
BRENDA:
BR36896-a
KEGG:
R07168
MetaCyc:
1.5.1.20-RXN
SABIO-RK:
9210
|
|
|
|
5,10-methenyltetrahydrofolate + H2O <=> 5-formyltetrahydrofolate + H+
|
2.1.2.10
aminomethyltransferase
3.5.4.9
methenyltetrahydrofolate cyclohydrolase
|
–
–
|
| |
BRENDA:
BS372118
KEGG:
R02300
MetaCyc:
RXN-6321
SABIO-RK:
2262
|
|
|
|
5,10-methylenetetrahydrofolate + NADP+ <=> 5,10-methenyltetrahydrofolate + NADPH
|
1.5.1.15
methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5
methylenetetrahydrofolate dehydrogenase (NADP+)
|
–
–
|
| |
BRENDA:
BR36902;
BS454753
KEGG:
R01220
MetaCyc:
METHYLENETHFDEHYDROG-NADP-RXN
SABIO-RK:
73
|
|
|
|
folate + NADPH <=> tetrahydrofolate + NADP+
|
1.5.1.3
dihydrofolate reductase
1.5.1.33
pteridine reductase
1.5.1.34
6,7-dihydropteridine reductase
|
–
–
–
|
| |
BRENDA:
BS259283
KEGG:
R00940
SABIO-RK:
1256
|
|
|
|
5-formyltetrahydrofolate + ATP <=> 5,10-methenyltetrahydrofolate + ADP + phosphate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
| |
BRENDA:
BR127;
BS453763
KEGG:
R02301
MetaCyc:
5-FORMYL-THF-CYCLO-LIGASE-RXN
SABIO-RK:
2263
|
|
|
|
dCMP + H2O + 5,10-methylenetetrahydrofolate <=> 2''-deoxy-5-hydroxymethylcytidine_5''-phosphate + tetrahydrofolate
|
2.1.2.8
deoxycytidylate 5-hydroxymethyltransferase
2.1.2.B2
|
–
–
|
| |
BRENDA:
BR43946
KEGG:
R01669
MetaCyc:
2.1.2.8-RXN
|
|
|
|
5-formimidoyltetrahydrofolate + H+ <=> NH3 + 5,10-methenyltetrahydrofolate
|
4.3.1.4
formimidoyltetrahydrofolate cyclodeaminase
|
–
|
| |
BRENDA:
BR3426
KEGG:
R02302
MetaCyc:
4.3.1.4-RXN
SABIO-RK:
2264
|
|
|
|
5,10-methylenetetrahydrofolate + D-alanine + H2O <=> 2-methyl-DL-serine + tetrahydrofolate
|
2.1.2.1
glycine hydroxymethyltransferase
2.1.2.7
D-alanine 2-hydroxymethyltransferase
|
–
–
|
| |
BRENDA:
BR43945
KEGG:
R01225
MetaCyc:
D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN
|
|
|
|
tetrahydrofolate + Trimethylsulfonium <=> H+ + Dimethylsulfide + 5-methyltetrahydrofolate
|
2.1.1.19
trimethylsulfonium---tetrahydrofolate N-methyltransferase
|
–
|
| |
BRENDA:
BR43885
KEGG:
R02573
MetaCyc:
2.1.1.19-RXN
|
|
|
|
5-formyltetrahydrofolate + L-glutamate <=> N-formyl-L-glutamate + tetrahydrofolate + H+
|
2.1.2.5
glutamate formimidoyltransferase
|
–
|
| |
BRENDA:
BS320077
KEGG:
R03189
MetaCyc:
RXN-20716
|
|
|
|
7,8-dihydrofolate + NADH + H+ <=> tetrahydrofolate + NAD+
|
1.5.1.3
dihydrofolate reductase
|
–
|
| |
BRENDA:
BS424618
KEGG:
R00936
SABIO-RK:
1254
|
|
|
|
dUMP + 5,10-methylenetetrahydrofolate + NADPH + H+ <=> dTMP + tetrahydrofolate + NADP+
|
1.5.1.3
dihydrofolate reductase
2.1.1.148
thymidylate synthase (FAD)
|
–
–
|
| |
BRENDA:
BR47450
KEGG:
R06613
MetaCyc:
RXN-8850
SABIO-RK:
7840
|
|
|
|
Met-tRNA + 10-formyltetrahydrofolate <=> tetrahydrofolate + N-formylmethionyl-tRNA
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
| |
KEGG:
R03940
|
|
|
|
tetrahydrofolate + NADP+ <=> 7,8-dihydrofolate + NADPH + H+
|
1.5.1.3
dihydrofolate reductase
1.5.1.33
pteridine reductase
1.5.1.34
6,7-dihydropteridine reductase
1.5.1.50
dihydromonapterin reductase
|
–
–
–
–
|
| |
BRENDA:
BR36900
KEGG:
R00939
MetaCyc:
DIHYDROFOLATEREDUCT-RXN;
RXN-19329
|
|
|
|
10-formyltetrahydrofolate + beta-glycinamide_ribonucleotide <=> tetrahydrofolate + formylglycinamide_ribonucleotide + H+
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
| |
BRENDA:
BR43941
KEGG:
R04325
MetaCyc:
GART-RXN
|
|
|
|
10-formyltetrahydrofolate + 5-aminoimidazole-4-carboxamide_ribonucleotide <=> tetrahydrofolate + 5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
| |
BRENDA:
BR43942
KEGG:
R04560
MetaCyc:
AICARTRANSFORM-RXN
SABIO-RK:
122
|
|
|
|
7,8-dihydrofolate + NADP+ <=> folate + NADPH + H+
|
1.5.1.3
dihydrofolate reductase
1.5.1.33
pteridine reductase
|
–
–
|
| |
KEGG:
R02236
MetaCyc:
RXN-18357
SABIO-RK:
2207
|
|
|
|
folate + NADH <=> tetrahydrofolate + NAD+
|
1.5.1.3
dihydrofolate reductase
1.5.1.34
6,7-dihydropteridine reductase
|
–
–
|
| |
BRENDA:
BS319536-a
KEGG:
R00937
|
|
