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One carbon pool by folate

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
5-formimidoyltetrahydrofolate + glycine <=> Formiminoglycine + tetrahydrofolate 2.1.2.4 glycine formimidoyltransferase

5-methyltetrahydrofolate + oxidized_ferredoxin <=> 5,10-methylenetetrahydrofolate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]
1.5.7.1 methylenetetrahydrofolate reductase (ferredoxin)


S-aminomethyldihydrolipoylprotein + tetrahydrofolate <=> dihydrolipoylprotein + 5,10-methylenetetrahydrofolate + NH3 2.1.2.10 aminomethyltransferase

5,10-methylenetetrahydrofolate + dUMP <=> dTMP + 7,8-dihydrofolate 2.1.1.45 thymidylate synthase

10-formyltetrahydrofolate + H2O <=> tetrahydrofolate + formate + H+ 3.5.1.10 formyltetrahydrofolate deformylase

tetrahydrofolate + ATP + formate <=> 10-formyltetrahydrofolate + ADP + phosphate 6.3.4.3 formate---tetrahydrofolate ligase

7,8-dihydrofolate + NAD+ <=> folate + NADH + H+ 1.5.1.3 dihydrofolate reductase

5''-Phosphoribosylglycinamide + 5,10-methenyltetrahydrofolate + H2O <=> 5''-Phosphoribosyl-N-formylglycinamide + tetrahydrofolate 2.1.2.2 phosphoribosylglycinamide formyltransferase

5-formimidoyltetrahydrofolate + L-glutamate <=> N-formimino-L-glutamate + tetrahydrofolate 2.1.2.5 glutamate formimidoyltransferase

L-homocysteine + 5-methyltetrahydrofolate <=> L-methionine + tetrahydrofolate 2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase


10-formyltetrahydrofolate + H2O + NADP+ <=> tetrahydrofolate + CO2 + NADPH + H+ 1.5.1.6 formyltetrahydrofolate dehydrogenase

5-methyltetrahydrofolate + NADP+ <=> 5,10-methylenetetrahydrofolate + NADPH + H+ 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]

5,10-methylenetetrahydrofolate + NAD+ <=> 5,10-methenyltetrahydrofolate + NADH 1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)


L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O 2.1.2.1 glycine hydroxymethyltransferase

5,10-methenyltetrahydrofolate + H2O <=> 10-formyltetrahydrofolate + H+ 3.5.4.9 methenyltetrahydrofolate cyclohydrolase

5-methyltetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + H+ + NADH 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]

5,10-methenyltetrahydrofolate + H2O <=> 5-formyltetrahydrofolate + H+ 2.1.2.10 aminomethyltransferase
3.5.4.9 methenyltetrahydrofolate cyclohydrolase


5,10-methylenetetrahydrofolate + NADP+ <=> 5,10-methenyltetrahydrofolate + NADPH 1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)


folate + NADPH <=> tetrahydrofolate + NADP+ 1.5.1.3 dihydrofolate reductase
1.5.1.33 pteridine reductase
1.5.1.34 6,7-dihydropteridine reductase



5-formyltetrahydrofolate + ATP <=> 5,10-methenyltetrahydrofolate + ADP + phosphate 6.3.3.2 5-formyltetrahydrofolate cyclo-ligase

dCMP + H2O + 5,10-methylenetetrahydrofolate <=> 2''-deoxy-5-hydroxymethylcytidine_5''-phosphate + tetrahydrofolate 2.1.2.8 deoxycytidylate 5-hydroxymethyltransferase
2.1.2.B2


5-formimidoyltetrahydrofolate + H+ <=> NH3 + 5,10-methenyltetrahydrofolate 4.3.1.4 formimidoyltetrahydrofolate cyclodeaminase

5,10-methylenetetrahydrofolate + D-alanine + H2O <=> 2-methyl-DL-serine + tetrahydrofolate 2.1.2.1 glycine hydroxymethyltransferase
2.1.2.7 D-alanine 2-hydroxymethyltransferase


tetrahydrofolate + Trimethylsulfonium <=> H+ + Dimethylsulfide + 5-methyltetrahydrofolate 2.1.1.19 trimethylsulfonium---tetrahydrofolate N-methyltransferase

5-formyltetrahydrofolate + L-glutamate <=> N-formyl-L-glutamate + tetrahydrofolate + H+ 2.1.2.5 glutamate formimidoyltransferase

7,8-dihydrofolate + NADH + H+ <=> tetrahydrofolate + NAD+ 1.5.1.3 dihydrofolate reductase

dUMP + 5,10-methylenetetrahydrofolate + NADPH + H+ <=> dTMP + tetrahydrofolate + NADP+ 1.5.1.3 dihydrofolate reductase
2.1.1.148 thymidylate synthase (FAD)


Met-tRNA + 10-formyltetrahydrofolate <=> tetrahydrofolate + N-formylmethionyl-tRNA 2.1.2.9 methionyl-tRNA formyltransferase

tetrahydrofolate + NADP+ <=> 7,8-dihydrofolate + NADPH + H+ 1.5.1.3 dihydrofolate reductase
1.5.1.33 pteridine reductase
1.5.1.34 6,7-dihydropteridine reductase
1.5.1.50 dihydromonapterin reductase




10-formyltetrahydrofolate + beta-glycinamide_ribonucleotide <=> tetrahydrofolate + formylglycinamide_ribonucleotide + H+ 2.1.2.2 phosphoribosylglycinamide formyltransferase

10-formyltetrahydrofolate + 5-aminoimidazole-4-carboxamide_ribonucleotide <=> tetrahydrofolate + 5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide 2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase

7,8-dihydrofolate + NADP+ <=> folate + NADPH + H+ 1.5.1.3 dihydrofolate reductase
1.5.1.33 pteridine reductase


folate + NADH <=> tetrahydrofolate + NAD+ 1.5.1.3 dihydrofolate reductase
1.5.1.34 6,7-dihydropteridine reductase


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