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O-Antigen nucleotide sugar biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
UDP-N-acetyl-D-glucosamine <=> UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + H2O 4.2.1.135 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)
–
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-idosamine + acetyl-CoA <=> UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-idose + CoA + H+ 2.3.1
–
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine + 2-oxoglutarate <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate 2.6.1.92 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase
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UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + acetyl-CoA <=> UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate + CoA + H+ 2.3.1.201 UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase
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UDP-glucuronate <=> UDP-L-iduronate 5.1.3
5.1.3.12 UDP-glucuronate 5'-epimerase
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UDP-glucose + H2O + NAD+ <=> UDP-glucuronate + NADH + H+ 1.1.1.22 UDP-glucose 6-dehydrogenase
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5-N-Acetyl-7-N-(D-alanyl)-legionaminic_acid + CTP <=> CMP-5-N-acetyl-7-N-(D-alanyl)-legionaminic_acid + diphosphate 2.7.7
–
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine + D-alanine <=> UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-glucose + H2O not assigned
 –
CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NAD+ + H2O <=> CDP-4-dehydro-6-deoxy-D-glucose + NADH + H+ 1.17.1.1 CDP-4-dehydro-6-deoxyglucose reductase
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UDP-N-acetylmannosamine + NAD+ + H2O <=> UDP-N-acetyl-alpha-D-mannosaminuronate + NADH + H+ 1.1.1.336 UDP-N-acetyl-D-mannosamine dehydrogenase
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GDP-mannose <=> GDP-4-dehydro-6-deoxy-D-mannose + H2O 4.2.1.47 GDP-mannose 4,6-dehydratase
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UDP-2-acetamido-2,6-dideoxy-beta-L-talose <=> UDP-N-acetyl-beta-L-fucosamine 5.1.3.28 UDP-N-acetyl-L-fucosamine synthase
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UDP-glucuronate <=> UDP-D-galacturonate 5.1.3.6 UDP-glucuronate 4-epimerase
–
dTDP-4-amino-4,6-dideoxy-D-galactose + acetyl-CoA <=> H+ + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + CoA 2.3.1.210 dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase
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alpha-D-mannose_1-phosphate <=> D-mannose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.8 phosphomannomutase
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–
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UDP-glucose <=> UDP-galactose 5.1.3.16 UDP-glucosamine 4-epimerase
5.1.3.2 UDP-glucose 4-epimerase
5.1.3.7 UDP-N-acetylglucosamine 4-epimerase
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–
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2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose <=> L-glutamate + dTDP-4-dehydro-6-deoxy-D-glucose 2.6.1.33 dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
2.6.1.B6
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GDP-4-dehydro-6-deoxy-D-mannose + L-glutamate <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + 2-oxoglutarate + NH3 4.2.1.168 GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase
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CDP-4-dehydro-3,6-dideoxy-D-glucose_epimer + NADH + H+ <=> CDP-ascarylose + NAD+ 1.1.1
1.1.1.M47
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dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate <=> dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate 2.6.1.33 dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
2.6.1.59 dTDP-4-amino-4,6-dideoxygalactose transaminase
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dTDP-6-deoxy-beta-L-talose + NADP+ <=> dTDP-4-dehydro-beta-L-rhamnose + NADPH + H+ 1.1.1.134 dTDP-6-deoxy-L-talose 4-dehydrogenase (NADP+)
1.1.1.344 dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]
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UDP-N-acetyl-D-glucosamine + H2O <=> N-acetyl-D-mannosamine + UDP 3.2.1.183 UDP-N-acetylglucosamine 2-epimerase (hydrolysing)
5.1.3.14 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)
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GDP-beta-L-colitose + NADP+ <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NADPH + H+ 1.1.1.356 GDP-L-colitose synthase
–
UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose 1.1.1
1.1.1.367 UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase
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phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O <=> phosphate + N-acetylneuraminate 2.5.1.56 N-acetylneuraminate synthase
–
dTDP-glucose <=> H2O + dTDP-4-dehydro-6-deoxy-D-glucose 4.2.1.46 dTDP-glucose 4,6-dehydratase
4.2.1.76 UDP-glucose 4,6-dehydratase
–
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UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose 5.1.3
–
CDP-3,6-dideoxy-D-glucose <=> CDP-3,6-dideoxy-D-mannose 5.1.3.10 CDP-paratose 2-epimerase
–
UDP-2-acetamido-2,6-dideoxy-beta-L-mannose + NADP+ <=> UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose + NADPH + H+ 1.1.1
–
H+ + alpha-D-glucose_1-phosphate + CTP <=> CDP-glucose + diphosphate 2.7.7.24 glucose-1-phosphate thymidylyltransferase
2.7.7.33 glucose-1-phosphate cytidylyltransferase
2.7.7.9 UTP---glucose-1-phosphate uridylyltransferase
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–
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UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + 2-oxoglutarate <=> UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-glutamate 2.6.1.98 UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase
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UDP-2-acetamido-2-deoxy-alpha-D-glucuronate <=> UDP-N-acetyl-D-galactosaminuronate 5.1.3
–
GDP-beta-L-colitose + NAD+ <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NADH + H+ 1.1.1.356 GDP-L-colitose synthase
–
CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose <=> CDP-4-dehydro-3,6-dideoxy-D-glucose_epimer 5.1.3
5.1.3.M5
–
–
UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NADP+ <=> UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose + NADPH + H+ 1.1.1.367 UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase
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dTDP-alpha-D-fucopyranose <=> dTDP-alpha-D-fucofuranose 5.4.99.59 dTDP-fucopyranose mutase
–
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate 5.1.3.23 UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase
–
UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + H2O <=> H+ + 2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + UDP 3.6.1.57 UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase
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CDP-3,6-dideoxy-D-glucose + NADP+ <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADPH + H+ 1.1.1.342 CDP-paratose synthase
–
acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H+ 2.3.1.209 dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase
–
GDP-6-deoxy-D-talose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+ 1.1.1.135 GDP-6-deoxy-D-talose 4-dehydrogenase
1.1.1.187 GDP-4-dehydro-D-rhamnose reductase
–
–
UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-idose <=> UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-gulose 5.1.3
–
UDP-N-acetyl-D-glucosamine <=> UDP-N-acetyl-D-galactosamine 5.1.3.2 UDP-glucose 4-epimerase
5.1.3.7 UDP-N-acetylglucosamine 4-epimerase
–
–
UDP-N-acetyl-D-glucosamine <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O 4.2.1.115 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)
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UDP-N-acetyl-D-galactosamine + NAD+ + H2O <=> UDP-N-acetyl-D-galactosaminuronate + NADH + H+ 1.1.1
1.1.1.136 UDP-N-acetylglucosamine 6-dehydrogenase
–
–
dTDP-6-deoxy-beta-L-talose + NAD+ <=> dTDP-4-dehydro-beta-L-rhamnose + NADH + H+ 1.1.1.339 dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
1.1.1.344 dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]
–
–
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-idosamine + 2-oxoglutarate <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate 2.6.1
2.6.1.34 UDP-N-acetylbacillosamine transaminase
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–
2,4-Diacetamido-2,4,6-trideoxy-beta-L-gulose + phosphoenolpyruvate + H2O <=> 5,7-Diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonate + phosphate 2.5.1
–
CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADP+ + H2O <=> CDP-4-dehydro-6-deoxy-D-glucose + NADPH + H+ 1.17.1.1 CDP-4-dehydro-6-deoxyglucose reductase
–
CDP-glucose <=> H2O + CDP-4-dehydro-6-deoxy-D-glucose 4.2.1.45 CDP-glucose 4,6-dehydratase
–
UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-mannopyranose + H2O <=> 2-Acetamido-4-(D-alanylamino)-2,4,6-trideoxy-D-mannopyranose + UDP 3.6.1
–
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine + 2-oxoglutarate <=> UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + L-glutamate 2.6.1.34 UDP-N-acetylbacillosamine transaminase
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dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate 2.6.1.89 dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase
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dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2-oxoglutarate <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose + L-glutamate 2.6.1.90 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
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dTDP-L-rhamnose + NADP+ <=> dTDP-4-dehydro-beta-L-rhamnose + NADPH + H+ 1.1.1.133 dTDP-4-dehydrorhamnose reductase
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UDP-galactose <=> UDP-alpha-D-galactofuranose 5.4.99.9 UDP-galactopyranose mutase
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UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine + acetyl-CoA <=> H+ + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + CoA 2.3.1.202 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase
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GDP-L-fucose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+ 1.1.1.271 GDP-L-fucose synthase
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acetyl-CoA + GDP-4-amino-4,6-dideoxy-alpha-D-mannose <=> CoA + GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose + H+ 2.3.1.227 GDP-perosamine N-acetyltransferase
–
CDP-abequose + NADP+ <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADPH + H+ 1.1.1.341 CDP-abequose synthase
4.2.1
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–
GDP-6-deoxy-D-mannose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+ 1.1.1.187 GDP-4-dehydro-D-rhamnose reductase
1.1.1.281 GDP-4-dehydro-6-deoxy-D-mannose reductase
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2-Acetamido-4-(D-alanylamino)-2,4,6-trideoxy-D-mannopyranose + phosphoenolpyruvate + H2O <=> 5-N-Acetyl-7-N-(D-alanyl)-legionaminic_acid + phosphate 2.5.1
–
5,7-Diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonate + CTP <=> 5,7-Diacetamido-3,5,7,9-tetradeoxy-L-glycero-D-galacto-non-2-ulosonate + diphosphate 2.7.7
–
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose <=> UDP-N-acetyl-6-deoxy-alpha-D-galactosamine not assigned
 –
GDP-6-deoxy-D-talose + NAD+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+ 1.1.1.135 GDP-6-deoxy-D-talose 4-dehydrogenase
1.1.1.187 GDP-4-dehydro-D-rhamnose reductase
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–
CDP-4-dehydro-3,6-dideoxy-D-glucose_epimer + NADPH + H+ <=> CDP-ascarylose + NADP+ 1.1.1
1.1.1.M47
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N-acetylneuraminate + CTP <=> CMP-N-acetylneuraminate + diphosphate 2.7.7.43 N-acylneuraminate cytidylyltransferase
2.7.7.92 3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase
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–
UDP-N-acetyl-beta-L-fucosamine <=> UDP-2,6-dideoxy-2-acetamidino-beta-L-galactose not assigned
 –
UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-gulose + H2O <=> 2,4-Diacetamido-2,4,6-trideoxy-beta-L-gulose + UDP + H+ 3.6.1
–
GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate <=> GDP-4-dehydro-6-deoxy-D-mannose + L-glutamate 2.6.1.102 GDP-perosamine synthase
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UDP-N-acetyl-D-glucosamine + NAD+ + H2O <=> UDP-2-acetamido-2-deoxy-alpha-D-glucuronate + NADH + H+ 1.1.1.136 UDP-N-acetylglucosamine 6-dehydrogenase
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H+ + alpha-D-mannose_1-phosphate + GTP <=> GDP-mannose + diphosphate 2.7.7.13 mannose-1-phosphate guanylyltransferase
2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
2.7.7.30 fucose-1-phosphate guanylyltransferase
2.7.7.34 glucose-1-phosphate guanylyltransferase
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–
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GDP-6-deoxy-D-mannose + NAD+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+ 1.1.1.187 GDP-4-dehydro-D-rhamnose reductase
1.1.1.281 GDP-4-dehydro-6-deoxy-D-mannose reductase
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5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic_acid + CTP <=> CMP-5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic_acid + diphosphate 2.7.7.81 pseudaminic acid cytidylyltransferase
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dTTP + alpha-D-glucose_1-phosphate + H+ <=> dTDP-glucose + diphosphate 2.7.7.24 glucose-1-phosphate thymidylyltransferase
2.7.7.64 UTP-monosaccharide-1-phosphate uridylyltransferase
2.7.7.9 UTP---glucose-1-phosphate uridylyltransferase
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–
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acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H+ 2.3.1.197 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase
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alpha-D-glucose_1-phosphate + UTP + H+ <=> UDP-glucose + diphosphate 2.7.7.23 UDP-N-acetylglucosamine diphosphorylase
2.7.7.24 glucose-1-phosphate thymidylyltransferase
2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
2.7.7.33 glucose-1-phosphate cytidylyltransferase
2.7.7.64 UTP-monosaccharide-1-phosphate uridylyltransferase
2.7.7.9 UTP---glucose-1-phosphate uridylyltransferase
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–
–
–
–
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phosphoenolpyruvate + 2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + H2O <=> 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic_acid + phosphate 2.5.1.97 pseudaminic acid synthase
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dTDP-alpha-D-fucopyranose + NADP+ <=> dTDP-4-dehydro-6-deoxy-D-glucose + NADPH + H+ 1.1.1.266 dTDP-4-dehydro-6-deoxyglucose reductase
1.1.1.B28
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UDP-2-acetamido-2-deoxy-alpha-D-glucuronate + NAD+ <=> UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + NADH + H+ 1.1.1.335 UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase
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UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-glucose <=> UDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-mannopyranose 5.1.3
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dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose 5.3.2.4 TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming)
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UDP-2-acetamido-2,6-dideoxy-beta-L-mannose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-glucose 5.1.3
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UDP-N-acetyl-D-galactosaminuronic_acid + ATP + L-glutamine + H2O <=> UDP-2-acetamido-2-deoxy-alpha-D-galacturonamide + AMP + L-glutamate + diphosphate 6.3.5
–
UDP-N-acetyl-6-deoxy-alpha-D-glucosamine + NADP+ <=> UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + NADPH + H+ 1.1.1
–
dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-4-dehydro-beta-L-rhamnose 5.1.3.13 dTDP-4-dehydrorhamnose 3,5-epimerase
–
UTP + N-acetyl-D-glucosamine_1-phosphate + H+ <=> UDP-N-acetyl-D-glucosamine + diphosphate 2.3.1.157 glucosamine-1-phosphate N-acetyltransferase
2.7.7.23 UDP-N-acetylglucosamine diphosphorylase
2.7.7.64 UTP-monosaccharide-1-phosphate uridylyltransferase
2.7.7.83 UDP-N-acetylgalactosamine diphosphorylase
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–
–
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dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose 5.3.2.3 TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)
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dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + acetyl-CoA <=> dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose + CoA + H+ 2.3.1
–
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate <=> UDP-2,3-dideoxy-2-acetamido-3-acetamidino-alpha-D-mannuronic_acid not assigned
 –
UDP-N-acetyl-D-glucosamine <=> UDP-N-acetylmannosamine 5.1.3.14 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)
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D-mannose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.8 mannose-6-phosphate isomerase
5.3.1.9 glucose-6-phosphate isomerase
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Visualization of the pathway