Copied!

Pathway Search



Metabolism of xenobiotics by cytochrome P450

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
7,12-dimethylbenz[a]anthracene + O2 + NADPH + H+ <=> 1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene + H2O + NADP+ 1.14.14.1 unspecific monooxygenase

7,12-dimethylbenz[a]anthracene + O2 + NADPH + H+ <=> 7-hydroxymethyl-12-methylbenz[a]anthracene + H2O + NADP+ 1.14.13

2,2-Dichloroacetaldehyde + glutathione <=> S-(2,2-Dichloro-1-hydroxy)ethyl_glutathione 2.5.1.18 glutathione transferase

4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone <=> 4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone + formaldehyde not assigned

4-bromocatechol <=> 4-Bromo-3,5-cyclohexadiene-1,2-dione not assigned

1,1-dichloroethylene + NADPH + O2 + H+ <=> Chloroacetyl_chloride + NADP+ + H2O 1.14.13

Trichloroethylene + glutathione <=> S-(1,2-Dichlorovinyl)glutathione + Hydrochloric_acid 2.5.1.18 glutathione transferase

1-Nitronaphthalene <=> 1-Nitrosonaphthalene not assigned

(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene <=> (1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene not assigned

(1S,2R)-Naphthalene_1,2-oxide + glutathione <=> (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene 2.5.1.18 glutathione transferase

2,2,2-trichloroethanol + 2 NADPH + 2 O2 + 2 H+ <=> trichloroacetate + 2 NADP+ + 3 H2O 1.14.13

(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene <=> (1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene not assigned

alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde <=> 6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione not assigned

4-methylnitrosamino-1-(3-pyridyl)-1-butanol + UDP-glucuronate <=> NNAL-N-glucuronide + UDP 2.4.1.17 glucuronosyltransferase

1-Nitronaphthalene-7,8-oxide + glutathione <=> 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene 2.5.1.18 glutathione transferase

N-hydroxy-1-naphthylamine <=> naphthylamine not assigned

Chloral_hydrate + NADH + H+ <=> 2,2,2-trichloroethanol + NAD+ + H2O 1.1.1.1 alcohol dehydrogenase

S-(Formylmethyl)glutathione <=> Thiodiacetic_acid not assigned

Aflatoxin_B1_diol <=> Aflatoxin_B1_dialdehyde not assigned

Bromobenzene-3,4-oxide + glutathione <=> 3,4-Dihydro-3-hydroxy-4-S-glutathionyl_bromobenzene 2.5.1.18 glutathione transferase

1,4-naphthoquinol <=> 1,4-Naphthoquinone not assigned

(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene <=> (1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic_acid not assigned

(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene <=> (1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene not assigned

4-methylnitrosamino-1-(3-pyridyl)-1-butanol + O2 + NADPH + H+ <=> alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol + H2O + NADP+ 1.14.13
1.14.14.1 unspecific monooxygenase


4-Bromophenol + NADPH + O2 + H+ <=> 4-Bromophenol-2,3-epoxide + NADP+ + H2O 1.14.13

Naphthalene + NADPH + O2 + H+ <=> (1R,2S)-Naphthalene_1,2-oxide + NADP+ + H2O 1.14.13
1.14.14.1 unspecific monooxygenase


4-methylnitrosamino-1-(3-pyridyl)-1-butanol + UDP-glucuronate <=> 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol_glucuronide + UDP 2.4.1.17 glucuronosyltransferase

Bromobenzene-3,4-dihydrodiol <=> 4-bromocatechol not assigned

4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP+ <=> 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+ 1.2.1.83 3-succinoylsemialdehyde-pyridine dehydrogenase

2-(S-Glutathionyl)acetyl_chloride + H2O <=> 2-S-Glutathionyl_acetate not assigned

Chloroacetyl_chloride + glutathione <=> S-(2-Chloroacetyl)glutathione + Hydrochloric_acid 2.5.1.18 glutathione transferase

bromoacetaldehyde + glutathione <=> S-(Formylmethyl)glutathione + Hydrobromic_acid 2.5.1.18 glutathione transferase

Bromobenzene-2,3-oxide <=> 2-bromophenol not assigned

(1R,2S)-Naphthalene_1,2-oxide <=> 1-naphthol not assigned

(1S,2R)-Naphthalene_1,2-oxide + H2O <=> Naphthalene_dihydrodiol 3.3.2.9 microsomal epoxide hydrolase

Naphthalene_dihydrodiol + NADP+ <=> 1,2-dihydroxynaphthalene + NADPH 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase



Aflatoxin_M1 + O2 + NADPH + H+ <=> Aflatoxin-M1-8,9-epoxide + H2O + NADP+ 1.14.14.1 unspecific monooxygenase

4-methylnitrosamino-1-(3-pyridyl)-1-butanol <=> 4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol not assigned

7,12-Dimethylbenz[a]anthracene_5,6-oxide + H2O <=> trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene 3.3.2.9 microsomal epoxide hydrolase

Trichloroethylene + NADPH + O2 + H+ <=> chloral + NADP+ + H2O 1.14.13
1.14.14.1 unspecific monooxygenase


alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol + H2O <=> 1-(3-Pyridinyl)-1,4-butanediol + N2 + H2O not assigned

bromobenzene + NADPH + O2 + H+ <=> Bromobenzene-2,3-oxide + NADP+ + H2O 1.14.13

1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene + H2O <=> trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene 3.3.2.9 microsomal epoxide hydrolase

1-Nitronaphthalene-5,6-oxide + glutathione <=> 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene 2.5.1.18 glutathione transferase

Aflatoxin_B1_dialdehyde <=> 1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal not assigned

4-methylnitrosamino-1-(3-pyridyl)-1-butanone + O2 + NADPH + H+ <=> 4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone + H2O + NADP+ 1.14.13
1.14.14.1 unspecific monooxygenase


(1R,2S)-Naphthalene_1,2-oxide <=> 2-naphthol not assigned

alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol <=> alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol + formaldehyde not assigned

(1R,2S)-Naphthalene_1,2-oxide + H2O <=> Naphthalene_dihydrodiol 3.3.2.9 microsomal epoxide hydrolase

4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH + H+ <=> 4-methylnitrosamino-1-(3-pyridyl)-1-butanol + NADP+ 1.1.1.146 11beta-hydroxysteroid dehydrogenase
1.1.1.184 carbonyl reductase (NADPH)
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase



9-hydroxybenzo(a)pyrene + NADPH + O2 + H+ <=> 9-Hydroxybenzo[a]pyrene-4,5-oxide + NADP+ + H2O 1.14.13
1.14.14
1.14.14.1 unspecific monooxygenase



4-Bromophenol-2,3-epoxide <=> 4-bromocatechol not assigned

aflatoxin_B1 + O2 + NADPH + H+ <=> Aflatoxin_M1 + H2O + NADP+ 1.14.14.1 unspecific monooxygenase

Bromobenzene-3,4-oxide + H2O <=> Bromobenzene-3,4-dihydrodiol 3.3.2.9 microsomal epoxide hydrolase

(1S,2R)-Naphthalene_1,2-oxide + glutathione <=> (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene 2.5.1.18 glutathione transferase

Bromobenzene-2,3-oxide + H2O <=> Bromobenzene-2,3-dihydrodiol 3.3.2.9 microsomal epoxide hydrolase

1,2-dihydroxynaphthalene <=> 1,2-naphthoquinone not assigned

2,2-Dichloroacetaldehyde + H2O <=> 2,2-Dichloro-1,1-ethanediol not assigned

benzo(a)pyrene-7,8-diol + glutathione <=> 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + H2O 2.5.1.18 glutathione transferase

trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene + O2 + NADPH + H+ <=> (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol + H2O + NADP+ 1.14.14.1 unspecific monooxygenase

(1S,2R)-Naphthalene_1,2-oxide <=> 2-naphthol not assigned

4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone <=> 4-oxo-4-(pyridin-3-yl)butanal + N-Nitrosomethanamine not assigned

Bromobenzene-2,3-oxide + glutathione <=> 2,3-Dihydro-2-S-glutathionyl-3-hydroxy_bromobenzene 2.5.1.18 glutathione transferase

1-Nitronaphthalene + NADPH + O2 + H+ <=> 1-Nitronaphthalene-5,6-oxide + NADP+ + H2O 1.14.13
1.14.14.1 unspecific monooxygenase


1-(3-Pyridinyl)-1,4-butanediol <=> gamma-Hydroxy-3-pyridinebutanoate not assigned

3''-phosphoadenylylsulfate + 7-hydroxymethyl-12-methylbenz[a]anthracene <=> adenosine_3'',5''-bisphosphate + 7-hydroxymethyl-12-methylbenz[a]anthracene_sulfate 2.8.2.1 aryl sulfotransferase
2.8.2.14 bile-salt sulfotransferase
2.8.2.2 alcohol sulfotransferase



1-Nitronaphthalene-5,6-oxide + H2O <=> 1-Nitro-5,6-dihydroxy-dihydronaphthalene 3.3.2.9 microsomal epoxide hydrolase

bromobenzene + NADPH + O2 + H+ <=> Bromobenzene-3,4-oxide + NADP+ + H2O 1.14.13

S-(Formylmethyl)glutathione <=> 2-(glutathion-S-yl)-ethan-1-ol not assigned

1-naphthol <=> 1,4-naphthoquinol not assigned

benzo(a)pyrene-7,8-diol + NADPH + O2 + H+ <=> Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide + NADP+ + H2O 1.14.13
1.14.14
1.14.14.1 unspecific monooxygenase



S-(Formylmethyl)glutathione <=> Thiodiacetic_acid_sulfoxide not assigned

4-Hydroxy-1-(3-pyridinyl)-1-butanone <=> 4-oxo-4-(pyridin-3-yl)butanoate not assigned

Chloroacetyl_chloride + H2O <=> Chloroacetate not assigned

1,1-dichloroethylene + NADPH + O2 + H+ <=> 2,2-Dichloroacetaldehyde + NADP+ + H2O 1.14.13

aflatoxin_B1 + O2 + NADPH + H+ <=> Aflatoxin_Q1 + H2O + NADP+ 1.14.13
1.14.14.1 unspecific monooxygenase


(1S,2R)-Naphthalene_1,2-oxide <=> 1-naphthol not assigned

1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal <=> 6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione not assigned

Aflatoxin_B1_dialdehyde <=> alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde not assigned

Benzo[a]pyrene-9,10-oxide <=> 9-hydroxybenzo(a)pyrene not assigned

1,2-Dibromoethane + NADPH + O2 + H+ <=> bromoacetaldehyde + NADP+ + H2O + Hydrobromic_acid 1.14.13

2-(glutathion-S-yl)-ethan-1-ol <=> S-(2-Hydroxyethyl)-N-acetyl-L-cysteine not assigned

Naphthalene + NADPH + O2 + H+ <=> (1S,2R)-Naphthalene_1,2-oxide + NADP+ + H2O 1.14.13
1.14.14.1 unspecific monooxygenase


Glutathione_episulfonium_ion <=> S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine not assigned

1-Nitrosonaphthalene <=> N-hydroxy-1-naphthylamine not assigned

2,2,2-trichloroethanol + UDP-glucuronate <=> Trichloroethanol_glucuronide + UDP 2.4.1.17 glucuronosyltransferase

benzo[a]pyrene + NADPH + O2 + H+ <=> benzopyrene_4,5-oxide + NADP+ + H2O 1.14.13
1.14.14
1.14.14.1 unspecific monooxygenase



2,2,3-trichlorooxirane <=> Dichloroacetyl_chloride not assigned

aflatoxin_B1 + O2 + NADPH + H+ <=> Aflatoxin_B1-exo-8,9-epoxide + H2O + NADP+ 1.14.13
1.14.14.1 unspecific monooxygenase


benzo[a]pyrene + NADPH + O2 + H+ <=> Benzo[a]pyrene-9,10-oxide + NADP+ + H2O 1.14.13
1.14.14
1.14.14.1 unspecific monooxygenase



benzo[a]pyrene + NADPH + O2 + H+ <=> benzo[a]pyrene-7,8-epoxide + NADP+ + H2O 1.14.13
1.14.14
1.14.14.1 unspecific monooxygenase



chloral + H2O <=> Chloral_hydrate not assigned

Naphthalene_dihydrodiol + NADPH + O2 + H+ <=> 1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene + NADP+ + H2O not assigned

2-naphthol + NADPH + O2 + H+ <=> 1,2-dihydroxynaphthalene + NADP+ + H2O not assigned

Dichloroacetyl_chloride <=> Dichloroacetate not assigned

Chloral_hydrate + NAD+ <=> trichloroacetate + NADH + H+ 1.1.1.184 carbonyl reductase (NADPH)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]


1,1-Dichloroethylene_epoxide + glutathione <=> 2-(S-Glutathionyl)acetyl_chloride + Hydrochloric_acid 2.5.1.18 glutathione transferase

Aflatoxin_B1-exo-8,9-epoxide + glutathione <=> Aflatoxin_B1exo-8,9-epoxide-GSH 2.5.1.18 glutathione transferase

4-methylnitrosamino-1-(3-pyridyl)-1-butanol + O2 + NADPH + H+ <=> 1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol + H2O + NADP+ 1.14.13
1.14.14.1 unspecific monooxygenase


1-Nitronaphthalene + NADPH + O2 + H+ <=> 1-Nitronaphthalene-7,8-oxide + NADP+ + H2O 1.14.13
1.14.14.1 unspecific monooxygenase


1-Nitronaphthalene-7,8-oxide + glutathione <=> 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene 2.5.1.18 glutathione transferase

1-Nitronaphthalene-5,6-oxide + glutathione <=> 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene 2.5.1.18 glutathione transferase

1,1-dichloroethylene + NADPH + O2 + H+ <=> 1,1-Dichloroethylene_epoxide + NADP+ + H2O 1.14.13

1,2-Dibromoethane + glutathione + H+ <=> Glutathione_episulfonium_ion + 2 Hydrobromic_acid 2.5.1.18 glutathione transferase

Trichloroethylene + NADPH + O2 + H+ <=> 2,2,3-trichlorooxirane + NADP+ + H2O 1.14.13
1.14.13.25 methane monooxygenase (soluble)
1.14.14.1 unspecific monooxygenase



Glutathione_episulfonium_ion + H2O <=> 2-(glutathion-S-yl)-ethan-1-ol not assigned

1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol <=> 5-(3-Pyridyl)-2-hydroxytetrahydrofuran + N-Nitrosomethanamine not assigned

Aflatoxin_B1-exo-8,9-epoxide + H2O <=> Aflatoxin_B1_diol 3.3.2.9 microsomal epoxide hydrolase

benzo[a]pyrene-7,8-epoxide + H2O <=> benzo(a)pyrene-7,8-diol 3.3.2.9 microsomal epoxide hydrolase

2-(S-Glutathionyl)acetyl_chloride + glutathione <=> 2-(S-Glutathionyl)acetyl_glutathione + Hydrochloric_acid 2.5.1.18 glutathione transferase

7,12-dimethylbenz[a]anthracene + O2 + NADPH + H+ <=> 7,12-Dimethylbenz[a]anthracene_5,6-oxide + H2O + NADP+ 1.14.14.1 unspecific monooxygenase

aflatoxin_B1 + O2 + NADPH + H+ <=> Aflatoxin_B1-endo-8,9-epoxide + H2O + NADP+ 1.14.14.1 unspecific monooxygenase

(1R,2S)-Naphthalene_1,2-oxide + glutathione <=> (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene 2.5.1.18 glutathione transferase

benzopyrene_4,5-oxide + glutathione <=> 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene 2.5.1.18 glutathione transferase

4-methylnitrosamino-1-(3-pyridyl)-1-butanone + O2 + NADPH + H+ <=> 4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone + H2O + NADP+ 1.14.13
1.14.14.1 unspecific monooxygenase


4-methylnitrosamino-1-(3-pyridyl)-1-butanone <=> 4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone not assigned

Bromobenzene-3,4-oxide <=> 4-Bromophenol not assigned

2-(S-Glutathionyl)acetyl_glutathione + H2O <=> 2-S-Glutathionyl_acetate + glutathione not assigned

5-(3-Pyridyl)-2-hydroxytetrahydrofuran <=> gamma-Hydroxy-3-pyridinebutanoate not assigned

trichloroacetate <=> Dichloroacetate not assigned

4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone + H2O <=> 4-Hydroxy-1-(3-pyridinyl)-1-butanone + N2 + H2O not assigned

Visualization of the pathway