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Pathway Search


Metabolic pathways

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
Hydroxyspheroidene + 2 O2 + 4 reduced_ferredoxin + 4 H+ <=> Hydroxyspheroidenone + 3 H2O + 4 oxidized_ferredoxin 1.14.15.9 spheroidene monooxygenase
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5-hydroxyisourate + H2O <=> 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate 3.5.2.17 hydroxyisourate hydrolase
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acetyl-CoA + malonyl-CoA + NADPH + H+ <=> 6-Methylsalicylate + CoA + CO2 + NADP+ + H2O 2.3.1.165 6-methylsalicylic-acid synthase
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phosphoenolpyruvate + dihydroxyacetone <=> pyruvate + dihydroxyacetone_phosphate 2.7.1.121 phosphoenolpyruvate---glycerone phosphotransferase
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ATP + lipoic_acid + glycine_cleavage_system_H <=> Lipoyl-protein + AMP + diphosphate 6.3.1.20 lipoate---protein ligase
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H+ + pyruvate + phosphate + O2 <=> acetyl_phosphate + CO2 + H2O2 1.2.3.3 pyruvate oxidase
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n (3R)-hydroxybutyryl-CoA <=> poly(3-hydroxybutanoate)n + n CoA 2.3.1
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N-acetylmuramate_6-phosphate + H2O <=> N-acetylmuramic_acid + phosphate 3.1.3.105 N-acetyl-D-muramate 6-phosphate phosphatase
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S-adenosyl-L-methionine + 5-hydroxyferulic_acid <=> H+ + Sinapic_acid + S-adenosyl-L-homocysteine 2.1.1.104 caffeoyl-CoA O-methyltransferase
2.1.1.42 flavone 3'-O-methyltransferase
2.1.1.68 caffeate O-methyltransferase
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–
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N,N''-diacetylchitobiose + phosphate <=> N-acetyl-D-glucosamine_1-phosphate + N-acetyl-D-glucosamine 2.4.1.280 N,N'-diacetylchitobiose phosphorylase
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3-Hydroxy-6,7,8-trimethoxy-2-naphthoate <=> 3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoate not assigned
 –
UDP-MurNAc-Ala-D-Glu-Lys + D-Ala-D-Ala + ATP <=> H+ + UDP-MurNAc-pentapeptide + phosphate + ADP 6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
6.3.2.4 D-alanine---D-alanine ligase
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salicylate + NADPH + H+ + O2 <=> 2,5-Dihydroxybenzoate + NADP+ + H2O 1.14.13.172 salicylate 5-hydroxylase
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arachidonic_acid + O2 <=> 15-hydroperoxyeicosatetraenoic_acid 1.13.11.12 linoleate 13S-lipoxygenase
1.13.11.33 arachidonate 15-lipoxygenase
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dUTP + H2O <=> H+ + dUMP + diphosphate 3.6.1
3.6.1.23 dUTP diphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
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–
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3-methylthiopropionyl-CoA + FAD <=> 3-(methylthio)acryloyl-CoA + FADH2 1.3.8
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P1,P4-bis(5''-guanosyl)_tetraphosphate + H2O <=> H+ + GTP + GMP 3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
3.6.1.29 bis(5'-adenosyl)-triphosphatase
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NO + H2O + ferricytochrome_c <=> nitrite + ferricytochrome_c + 2 H+ 1.7.2.1 nitrite reductase (NO-forming)
1.7.2.6 hydroxylamine dehydrogenase
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3-(2,3-dihydroxyphenyl)propanoate + O2 <=> H+ + (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate 1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
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S-adenosyl-L-methionine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> elloramycin + S-adenosyl-L-homocysteine + H+ 2.1.1
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CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NAD+ + H2O <=> CDP-4-dehydro-6-deoxy-D-glucose + NADH + H+ 1.17.1.1 CDP-4-dehydro-6-deoxyglucose reductase
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(S)-allantoin + H2O <=> H+ + Allantoate 3.5.2.5 allantoinase
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7-Oxoheptanoic_acid <=> 7-Mercaptoheptanoic_acid not assigned
 –
Guanidinoacetate + ATP <=> H+ + phosphoguanidinoacetate + ADP 2.7.3.1 guanidinoacetate kinase
2.7.3.2 creatine kinase
2.7.3.4 taurocyamine kinase
2.7.3.6 hypotaurocyamine kinase
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–
–
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6,8a-Seco-6,8a-deoxy-5-oxoavermectin_''''1a''''_aglycone + NADPH + O2 <=> 5-Oxoavermectin_''''1a''''_aglycone + NADP+ + H2O 1.14
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alpha-D-ribose_1,5-bisphosphate + ATP <=> 5-phospho-alpha-D-ribose_1-diphosphate + ADP 2.7.4.23 ribose 1,5-bisphosphate phosphokinase
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S-adenosyl-L-methionine + aklanonate <=> S-adenosyl-L-homocysteine + methyl_aklanonate 2.1.1.288 aklanonic acid methyltransferase
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Sinapic_acid + CoA + ATP <=> sinapoyl-CoA + AMP + diphosphate 6.2.1.12 4-coumarate---CoA ligase
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H2O + 4-Fumarylacetoacetate <=> H+ + fumarate + acetoacetate 3.7.1.2 fumarylacetoacetase
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beta-Hydroxy-L-tyrosyl-[pcp] <=> beta-Keto-L-tyrosyl-[pcp] not assigned
 –
(S)-beta-Tyrosyl-[pcp] + FADH2 + Cl- + O2 + H+ <=> (S)-3-Chloro-beta-tyrosyl-[pcp] + FAD + 2 H2O 1.14.19
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glycine + 2-oxoglutarate <=> glyoxylate + L-glutamate 2.6.1.2 alanine transaminase
2.6.1.4 glycine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.48 5-aminovalerate transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
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D-erythrose_4-phosphate + D-xylulose_5-phosphate <=> beta-D-fructose_6-phosphate + D-glyceraldehyde_3-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase
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CMP-N-acetylneuraminate + paragloboside <=> CMP + 3''-isoLM1 2.4.99.6 N-acetyllactosaminide alpha-2,3-sialyltransferase
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spermidine + S-adenosylmethioninamine <=> H+ + spermine + S-methyl-5''-thioadenosine 2.5.1.104 N1-aminopropylagmatine synthase
2.5.1.16 spermidine synthase
2.5.1.22 spermine synthase
2.5.1.23 sym-norspermidine synthase
2.5.1.79 thermospermine synthase
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Premithramycin_A3 + dTDP-D-boivinose <=> 3A-Deolivosylpremithramycin_B + dTDP + H+ 2.4.1
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cellooligomers + H2O <=> cellobiose + H2O 3.2.1.176 cellulose 1,4-beta-cellobiosidase (reducing end)
3.2.1.4 cellulase
3.2.1.91 cellulose 1,4-beta-cellobiosidase (non-reducing end)
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UDP-glucose + alpha-D-glucose_6-phosphate <=> UDP + alpha,alpha''-Trehalose_6-phosphate 2.4.1.15 alpha,alpha-trehalose-phosphate synthase (UDP-forming)
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L-tryptophan + FADH2 + Cl- + O2 <=> 7-chloro-L-tryptophan + FAD + H2O 1.14.19.9 tryptophan 7-halogenase
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4-coumaroyl-CoA + NADPH + H+ <=> 4-coumaraldehyde + CoA + NADP+ 1.2.1.44 cinnamoyl-CoA reductase
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OPC6-CoA + FAD <=> trans-2-Enoyl-OPC6-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
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NAD+ + ATP <=> H+ + NADP+ + ADP 2.7.1.23 NAD+ kinase
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IMP + diphosphate <=> hypoxanthine + 5-phospho-alpha-D-ribose_1-diphosphate 2.4.2.22 xanthine phosphoribosyltransferase
2.4.2.7 adenine phosphoribosyltransferase
2.4.2.8 hypoxanthine phosphoribosyltransferase
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–
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delta-tocotrienol <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol 5.5.1.24 tocopherol cyclase
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seleno-L-methionine + H2O <=> methylselenol + NH3 + 2-oxobutyrate 4.4.1.1 cystathionine gamma-lyase
4.4.1.11 methionine gamma-lyase
4.4.1.13 cysteine-S-conjugate beta-lyase
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–
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UDP-N-acetyl-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)]-[beta-D-GlcNAc-(1->4)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn 2.4.1.144 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
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L-cystine + glutathione <=> GSSG + L-cysteine 1.8.1.6 cystine reductase
1.8.4.4 glutathione---cystine transhydrogenase
1.8.4.9 adenylyl-sulfate reductase (glutathione)
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dopamine + O2 + ascorbate + H+ <=> norepinephrine + ascorbate + H2O 1.14.17.1 dopamine beta-monooxygenase
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UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate + D-Ala-D-Ala + ATP <=> H+ + UDP-N-acetylmuramoyl-pentapeptide + phosphate + ADP 6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
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H+ + o-Cresol + NADH + O2 <=> 3-methylcatechol + NAD+ + H2O 1.14.13.236 toluene 4-monooxygenase
1.14.13.243 toluene 2-monooxygenase
1.14.13.44 2-hydroxybiphenyl 3-monooxygenase
1.14.13.7 phenol 2-monooxygenase (NADPH)
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1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ <=> 3-methylcatechol + CO2 + NADH + H+ 1.3.1
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L-serine <=> D-serine 4.3.1.17 L-serine ammonia-lyase
5.1.1.1 alanine racemase
5.1.1.10 amino-acid racemase
5.1.1.18 serine racemase
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9-cis-violaxanthin <=> 9''-cis-Neoxanthin 5.3.99.9 neoxanthin synthase
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CTP + phosphocholine + H+ <=> CDP-choline + diphosphate 2.7.7.15 choline-phosphate cytidylyltransferase
2.7.7.57 N-methylphosphoethanolamine cytidylyltransferase
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oxaloacetate + ITP <=> CO2 + phosphoenolpyruvate + IDP 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)
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(3S)-3-carboxy-3-hydroxypropanoyl-CoA <=> glyoxylate + acetyl-CoA 4.1.3.24 malyl-CoA lyase
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H2O + hippuric_acid <=> glycine + benzoate 3.4.17.B1
3.5.1.32 hippurate hydrolase
3.5.1.71 N-feruloylglycine deacylase
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Prostaglandin_B2 <=> Prostaglandin_C2 not assigned
 –
O2 + arachidonic_acid <=> (5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyeicosa-5,9,11,14-tetraenoate 1.13.11
1.13.11.40 arachidonate 8-lipoxygenase
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dUMP + 5,10-methylenetetrahydrofolate + NADPH + H+ <=> dTMP + tetrahydrofolate + NADP+ 1.5.1.3 dihydrofolate reductase
2.1.1.148 thymidylate synthase (FAD)
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UDP-galactose + GD2-ganglioside <=> UDP + GD1b 2.4.1.62 ganglioside galactosyltransferase
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glutathione + glutathionylspermidine + ATP <=> H+ + trypanothione + ADP + phosphate 6.3.1.9 trypanothione synthase
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paraxanthine <=> 1-Methylxanthine 1.14.14.1 unspecific monooxygenase
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CoA + heptanedioate + ATP <=> pimeloyl-CoA + diphosphate + AMP 6.2.1.14 6-carboxyhexanoate---CoA ligase
6.2.1.23 dicarboxylate---CoA ligase
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dTDP-4-oxo-2,6-dideoxy-D-allose <=> dTDP-4-oxo-2,6-dideoxy-L-mannose 5.1.3
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ATP + L-rhamnulose <=> ADP + L-rhamnulose_1-phosphate 2.7.1.5 rhamnulokinase
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L-phenylalanine + tetrahydrobiopterin + O2 <=> L-tyrosine + 4a-hydroxytetrahydrobiopterin 1.14.16.1 phenylalanine 4-monooxygenase
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2-epi-5-epi-valiolone <=> 5-epi-valiolone 5.1.3.33 2-epi-5-epi-valiolone epimerase
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cholesterol + NADP+ <=> desmosterol + NADPH + H+ 1.3.1.72 Delta24-sterol reductase
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S-hydroxymethylglutathione + NAD+ <=> S-formylglutathione + NADH + H+ 1.1.1
1.1.1.1 alcohol dehydrogenase
1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase
1.2.1.46 formaldehyde dehydrogenase
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UDP-galactose + GT2 <=> UDP + GT1c 2.4.1.62 ganglioside galactosyltransferase
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2-hydro-1,2-dihydroxybenzoate + NAD+ <=> catechol + CO2 + NADH 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
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L-3-hydroxydodecanoyl-CoA + NAD+ <=> 3-oxododecanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
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D-ribose_5-phosphate <=> D-ribulose_5-phosphate 5.3.1.6 ribose-5-phosphate isomerase
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ATP + D-mannoheptulose <=> ADP + sedoheptulose_7-phosphate + H+ 2.7.1.14 sedoheptulokinase
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S-adenosyl-L-methionine + 3,4-dihydroxyphenylglycol <=> S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxyphenylglycol 2.1.1.6 catechol O-methyltransferase
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bilirubin + coenzyme_F420-1 <=> Biliverdin + Reduced_coenzyme_F420-(gamma-Glu)n 1.3.98
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Sulfide + NADP+ + H2O <=> sulfite + NADPH + H+ 1.8.1.2 assimilatory sulfite reductase (NADPH)
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H+ + 6,7-dimethyl-8-(1'-D-ribityl)lumazine <=> 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + riboflavin 2.5.1.9 riboflavin synthase
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cholesterol + reduced_flavodoxin + O2 <=> 7alpha-hydroxycholesterol + flavin + H2O 1.14.14.23 cholesterol 7alpha-monooxygenase
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NAD+ + (1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol <=> H+ + NADH + 3-methylcatechol 1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
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dehydroascorbate + H2O <=> (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate 0.0.0.0
3.1.1.17 gluconolactonase
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9-fluorenone + NADH + H+ + O2 <=> 1,1a-dihydroxy-1-hydrofluoren-9-one + NAD+ 1.14.12
1.14.12.22 carbazole 1,9a-dioxygenase
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L-2-methyl-3-oxopropionate + CoA + NAD+ <=> propionyl-CoA + CO2 + NADH + H+ 1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
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campesterol <=> Campest-4-en-3beta-ol 5.3.3.1 steroid Delta-isomerase
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ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate <=> H+ + ADP + phosphate + 5''-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole 6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase
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formate + GTP + H+ <=> dGTP + CO2 + H2O 1.1.98.6 ribonucleoside-triphosphate reductase (formate)
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sedoheptulose_1,7-diphosphate <=> dihydroxyacetone_phosphate + D-erythrose_4-phosphate 4.1.2.13 fructose-bisphosphate aldolase
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CDP-diacylglycerol + sn-glycerol_3-phosphate <=> CMP + 1-(3-sn-phosphatidyl)-sn-glycerol_3-phosphate + H+ 2.7.8.5 CDP-diacylglycerol---glycerol-3-phosphate 1-phosphatidyltransferase
2.7.8.8 CDP-diacylglycerol---serine O-phosphatidyltransferase
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mesaconate + CoA <=> 2-methylfumaryl-CoA + H2O not assigned
 –
xylene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 3-methylbenzyl_alcohol + oxidized_ferredoxin + H2O 1.14.15.26 toluene methyl-monooxygenase
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10-deoxymethymycin + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> methymycin + oxidized_ferredoxin + H2O 1.14.15.33 pikromycin synthase
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adenosine_3''-monophosphate + H2O <=> adenosine + phosphate 3.1.21.1 deoxyribonuclease I
3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.31 nucleotidase
3.1.3.5 5'-nucleotidase
3.1.3.6 3'-nucleotidase
3.1.30.1 Aspergillus nuclease S1
3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
3.6.1.1 inorganic diphosphatase
3.6.1.11 exopolyphosphatase
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7,8-dihydroneopterin_2,3''-cyclic_phosphate + H2O <=> H+ + 7,8-dihydroneopterin_2''-phosphate 3.1.4.56 7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase
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ent-kaur-16-en-19-oate + reduced_flavodoxin + O2 <=> ent-7alpha-hydroxykaur-16-en-19-oate + flavin + H2O 1.14.14.107 ent-kaurenoic acid monooxygenase
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4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2 <=> 2 dichlorochromopyrrolate + 2 NH3 + 2 H2O 1.21.98.2 dichlorochromopyrrolate synthase
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heme + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> Biliverdin + Fe2+ + CO + oxidized_ferredoxin + H2O 1.14.15.20 heme oxygenase (biliverdin-producing, ferredoxin)
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ergothioneine <=> Thiourocanic_acid + trimethylamine not assigned
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sitosterol + NADPH + H+ + O2 <=> stigmasterol + NADP+ + H2O 1.14.19.41 sterol 22-desaturase
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Sulfide + oxidized_ferredoxin + H2O <=> sulfite + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.8.7.1 assimilatory sulfite reductase (ferredoxin)
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L-glutamate + L-cysteine + ATP <=> gamma-Glu-L-Cys + ADP + phosphate + H+ 6.3.2.2 glutamate---cysteine ligase
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UDP-D-xylose + protein <=> D-xylosylprotein + UDP + H+ 2.4.2.26 protein xylosyltransferase
2.4.2.63 EGF-domain serine xylosyltransferase
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Nomega-hydroxy-L-arginine + NADPH + O2 <=> L-citrulline + NO + NADP+ + H2O + H+ 1.14.13.39 nitric-oxide synthase (NADPH)
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malonyl-CoA + [acyl-carrier_protein] <=> CoA + malonyl-[acyl-carrier_protein] 2.3.1
2.3.1.39 [acyl-carrier-protein] S-malonyltransferase
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
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S-adenosyl-L-methionine + (8S)-8-amino-7-oxononanoate <=> S-adenosyl-4-methylthio-2-oxobutanoate + (7R,8S)-diaminononanoate 2.3.1.47 8-amino-7-oxononanoate synthase
2.6.1.62 adenosylmethionine---8-amino-7-oxononanoate transaminase
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H+ + alpha-D-glucose_1-phosphate + GTP <=> GDP-glucose + diphosphate 2.7.7.13 mannose-1-phosphate guanylyltransferase
2.7.7.24 glucose-1-phosphate thymidylyltransferase
2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
2.7.7.30 fucose-1-phosphate guanylyltransferase
2.7.7.34 glucose-1-phosphate guanylyltransferase
2.7.7.9 UTP---glucose-1-phosphate uridylyltransferase
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beta-D-glucose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.9 glucose-6-phosphate isomerase
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GDP-mannose + 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol <=> 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol + GDP + H+ 2.4.1.346 phosphatidyl-myo-inositol dimannoside synthase
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crocetin_dialdehyde <=> crocetin not assigned
 –
Fumiquinazoline_F + 3 reduced_flavodoxin + 2 O2 <=> Fumiquinazoline_F-indoline-2'',3''-diol + 3 flavin + 2 H2O 1.14.14
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2-tetradecenoyl-CoA + NADPH <=> myristoyl-CoA + NADP+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)
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NH3 + NADP+ + H2O <=> nitrite + NADPH + H+ 1.7.1.4 nitrite reductase [NAD(P)H]
1.7.7.1 ferredoxin---nitrite reductase
1.8.1.2 assimilatory sulfite reductase (NADPH)
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ATP + D-Fructose_1-phosphate <=> H+ + ADP + D-fructose_1,6-bisphosphate 2.7.1.11 6-phosphofructokinase
2.7.1.56 1-phosphofructokinase
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5-Aminopentanamide + H2O <=> 5-Aminopentanoate + NH3 3.5.1.30 5-aminopentanamidase
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UDP-glucose + beta-D-fructose_6-phosphate <=> sucrose_6F-phosphate + UDP + H+ 2.4.1.13 sucrose synthase
2.4.1.14 sucrose-phosphate synthase
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L-threo-3-methylaspartate <=> NH3 + mesaconate 4.3.1.2 methylaspartate ammonia-lyase
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L-4-hydroxyglutamate_semialdehyde + NAD+ + H2O <=> L-erythro-4-hydroxyglutamate + NADH + H+ 1.2.1
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
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cocaine + H2O <=> H+ + methyl_ecgonine + benzoate 3.1.1.1 carboxylesterase
3.1.1.8 cholinesterase
3.1.1.84 cocaine esterase
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succinate_semialdehyde + NADP+ + CoA <=> succinyl-CoA + NADPH + H+ 1.2.1.75 malonyl-CoA reductase (malonate semialdehyde-forming)
1.2.1.76 succinate-semialdehyde dehydrogenase (acylating)
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3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic_acid + ATP + CoA <=> trihydroxycoprostanoyl-CoA + AMP + diphosphate 6.2.1.7 cholate---CoA ligase
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1-phosphatidyl-1D-myo-inositol_5-phosphate + ATP <=> phosphatidylinositol_4,5-bisphosphate + ADP + H+ 2.7.1.149 1-phosphatidylinositol-5-phosphate 4-kinase
2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase
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tetrachlorohydroquinone + NAD+ + H+ <=> tetrafluoro-1,4-benzoquinone + NADH 1.1.1.404 tetrachlorobenzoquinone reductase
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eriodictyol <=> 2',3,4,4',6'-pentahydroxychalcone 5.5.1.6 chalcone isomerase
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scyllo-inosose <=> H2O + 3D-3,5/4-trihydroxycyclohexa-1,2-dione 4.2.1.44 myo-inosose-2 dehydratase
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cellotriose + H2O <=> cellobiose + D-glucose 3.2.1.151 xyloglucan-specific endo-beta-1,4-glucanase
3.2.1.176 cellulose 1,4-beta-cellobiosidase (reducing end)
3.2.1.21 beta-glucosidase
3.2.1.25 beta-mannosidase
3.2.1.39 glucan endo-1,3-beta-D-glucosidase
3.2.1.4 cellulase
3.2.1.73 licheninase
3.2.1.74 glucan 1,4-beta-glucosidase
3.2.1.91 cellulose 1,4-beta-cellobiosidase (non-reducing end)
–
–
–
–
–
–
–
–
–
myo-inositol + O2 <=> D-glucuronate + H2O 1.13.99.1 inositol oxygenase
–
H+ + sulfate + ATP <=> adenosine_5''-phosphosulfate + diphosphate 2.7.7.4 sulfate adenylyltransferase
–
dATP + thioredoxin_disulfide + H2O <=> ATP + thioredoxin 1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)
–
D-glucosamine + D-Glucosaminide <=> D-Glucosaminide + H2O 3.2.1.165 exo-1,4-beta-D-glucosaminidase
–
ATP + NH3 + CO2 + H2O <=> ADP + phosphate + Carbamoyl_phosphate 6.3.4.16 carbamoyl-phosphate synthase (ammonia)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
–
–
H+ + 5-guanidino-2-oxopentanoate <=> CO2 + 4-guanidinobutyraldehyde 4.1.1.75 5-guanidino-2-oxopentanoate decarboxylase
–
S-adenosyl-L-methionine + 24(28)-methylene_lophenol <=> H+ + 24-ethylidenelophenol + S-adenosyl-L-homocysteine 2.1.1.142 cycloartenol 24-C-methyltransferase
2.1.1.143 24-methylenesterol C-methyltransferase
2.1.1.41 sterol 24-C-methyltransferase
–
–
–
dihydrolipoylprotein + Lipoyl-carrier_protein_E2 <=> glycine_cleavage_system_H + enzyme_N6-(dihydrolipoyl)lysine not assigned
 –
8-O-methyldihydrosterigmatocystin <=> Aflatoxin_G2 not assigned
 –
octanoyl-[acyl-carrier_protein] + NADP+ <=> 2-octenoyl-[acyl-carrier_protein] + NADPH + H+ 1.3.1
1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
–
–
–
–
–
–
24(28)-methylene_lophenol <=> 4alpha-methyl-5alpha-ergosta-8,24-dien-3beta-ol 5.3.3.5 cholestenol Delta-isomerase
–
4a-hydroxytetrahydrobiopterin <=> dihydrobiopterin + H2O 4.2.1.96 4a-hydroxytetrahydrobiopterin dehydratase
–
[protein]-L-asparagine + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> dolichyl_diphosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn 2.4.99.18 dolichyl-diphosphooligosaccharide---protein glycotransferase
–
H+ + 2-aminoacrylate + H2O <=> malonate_semialdehyde + NH3 3.5.1
–
D-glucuronolactone + H2O <=> D-glucuronate + H+ 3.1.1
3.1.1.19 uronolactonase
–
–
L-arogenate + oxaloacetate <=> prephenate + L-aspartate 2.6.1.1 aspartate transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase
–
–
–
–
D-xylose + NADP+ <=> D-xylono-1,5-lactone + NADPH + H+ 1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)
1.1.1.359 aldose 1-dehydrogenase [NAD(P)+]
1.1.1.376 L-arabinose 1-dehydrogenase [NAD(P)+]
1.1.1.424 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
1.1.1.B35
–
–
–
–
–
–
ATP + (S)-beta-tyrosine + pC3'p <=> AMP + diphosphate + (S)-beta-Tyrosyl-[pcp] 6.2.1
–
3-Hydroxyanthranilate + O2 <=> alpha-amino-beta-carboxymuconate-epsilon-semialdehyde 1.13.11.6 3-hydroxyanthranilate 3,4-dioxygenase
–
7-hydroxychlorophyllide_a + NADP+ <=> chlorophyllide_b + NADPH + H+ 1.1.1.294 chlorophyll(ide) b reductase
–
H+ + H2O + 1-pyrroline-4-hydroxy-2-carboxylate <=> NH3 + 2,5-dioxopentanoate 3.5.4.22 1-pyrroline-4-hydroxy-2-carboxylate deaminase
–
cyclo-L-Trp-L-Phe + S-adenosyl-L-methionine <=> N-Methyl-cyclo(L-Trp-L-Phe) + S-adenosyl-L-homocysteine 2.1.1
–
1,4-dihydroxy-2-naphthoyl-CoA + H2O <=> H+ + 1,4-dihydroxy-2-naphthoate + CoA 3.1.2.28 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
–
ATP + D-tagatose <=> ADP + D-tagatose_6-phosphate 2.7.1.101 tagatose kinase
–
RX + glutathione <=> acceptor + R-S-glutathione 2.5.1.18 glutathione transferase
2.5.1.75 tRNA dimethylallyltransferase
–
–
N-acetyl-L-citrulline + H2O <=> L-citrulline + acetate 3.5.1.16 acetylornithine deacetylase
3.5.1.B4
–
–
cannabigerolate + O2 <=> DELTA9-tetrahydrocannabinolate + H2O2 1.21.3.7 tetrahydrocannabinolic acid synthase
–
3-dehydro-6-deoxoteasterone <=> 6-deoxotyphasterol not assigned
 –
L-lactate + O2 <=> acetate + CO2 + H2O 1.13.12.4 lactate 2-monooxygenase
–
thiamine + ATP <=> H+ + thiamine_diphosphate + AMP 2.7.6.2 thiamine diphosphokinase
–
6-carboxyhex-2-enoyl-CoA + H2O <=> 3-hydroxypimeloyl-CoA 4.2.1
–
sucrose_6F-phosphate + H2O <=> sucrose + phosphate 3.1.3.24 sucrose-phosphate phosphatase
–
1,1a-dihydroxy-1-hydrofluoren-9-one + H2O <=> 2,3-Dihydroxy-2''-carboxybiphenyl + 2 H+ 1.3
–
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate 6.2.1.41 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate---CoA ligase
–
gamma-L-glutamylputrescine + H2O + O2 <=> gamma-glutamyl-gamma-aminobutyraldehyde + H2O2 + NH3 1.4.3
1.4.3.B1
1.4.3.M3
–
–
–
ATP + NAD+ <=> H+ + 3''-dehydro-ATP + NADH 1
–
3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp] <=> 7,12-Decaketide_intermediate_1 + H2O 4.2.1
–
XMP + H2O <=> Xanthosine + phosphate 3.1.3.5 5'-nucleotidase
–
Premithramycin_A1 + dTDP-D-oliose <=> Premithramycin_A2' + dTDP + H+ 2.4.1
–
globotriosylceramide + H2O <=> lactosylceramide + D-galactose 3.2.1.22 alpha-galactosidase
3.2.1.47 galactosylgalactosylglucosylceramidase
–
–
naringenin_chalcone <=> naringenin 5.5.1.6 chalcone isomerase
–
D-fructose_1,6-bisphosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde_3-phosphate 4.1.2.13 fructose-bisphosphate aldolase
4.1.2.40 tagatose-bisphosphate aldolase
–
–
S-adenosyl-L-methionine + 3,4-dihydroxymandelate <=> vanillylmandelic_acid + S-adenosyl-L-homocysteine + H+ 2.1.1.6 catechol O-methyltransferase
–
2,4,5-trichloro-2,5-cyclohexadiene-1-ol + H2O <=> 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + Hydrochloric_acid 3.8.1.5 haloalkane dehalogenase
–
NAD+ + L-gulonate <=> H+ + NADH + 3-dehydro-L-gulonate 1.1.1.45 L-gulonate 3-dehydrogenase
–
L-tryptophan + L-proline + 2 ATP <=> brevianamide_F + 2 AMP + 2 diphosphate not assigned
 –
D-xylonate <=> H2O + 2-dehydro-3-deoxy-D-xylonate 4.2.1.82 xylonate dehydratase
–
D-fructose_1,6-bisphosphate + H2O <=> beta-D-fructose_6-phosphate + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase
–
–
–
–
trans-cinnamate <=> 3-hydroxycinnamic_acid not assigned
 –
3-oxo-2-(cis-2''-pentenyl)-cyclopentane-1-butanoyl-CoA + acetyl-CoA <=> 3-oxo-2-(cis-2''-pentenyl)-cyclopentane-1-(3-oxohexanoyl)-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
–
L-aspartate + ATP <=> L-4-aspartyl_phosphate + ADP 2.7.2.4 aspartate kinase
–
butyryl-CoA + phosphate <=> butyryl_phosphate + CoA 2.3.1.19 phosphate butyryltransferase
2.3.1.222 phosphate propanoyltransferase
2.3.1.8 phosphate acetyltransferase
–
–
–
L-ribulose_5-phosphate <=> D-xylulose_5-phosphate 5.1.3.4 L-ribulose-5-phosphate 4-epimerase
–
anthranilate + O2 + NADPH + H+ <=> catechol + CO2 + NH3 + NADP+ 1.14.12.1 anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
–
UDP-glucose <=> H2O + UDP-4-dehydro-6-deoxy-D-glucose 4.2.1.46 dTDP-glucose 4,6-dehydratase
4.2.1.76 UDP-glucose 4,6-dehydratase
–
–
myo-inositol + ATP <=> H+ + D-myo-Inositol_1-phosphate + ADP 2.7.1.64 inositol 3-kinase
–
ADP + ATP <=> ATP + ADP 2.4.2.12 nicotinamide phosphoribosyltransferase
2.7.1.20 adenosine kinase
2.7.4.6 nucleoside-diphosphate kinase
3.6.4.10 non-chaperonin molecular chaperone ATPase
–
–
–
–
GDP-6-deoxy-D-talose + NAD+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+ 1.1.1.135 GDP-6-deoxy-D-talose 4-dehydrogenase
1.1.1.187 GDP-4-dehydro-D-rhamnose reductase
–
–
beta-L-galactose_1-phosphate + H2O <=> L-galactopyranose + phosphate 3.1.3.93 L-galactose 1-phosphate phosphatase
3.1.3.B9
–
–
6-hydroxyprotopine <=> Dihydrosanguinarine + H2O not assigned
 –
2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 4-Aminobenzoic_acid <=> 7,8-dihydropteroate + H2O 2.5.1
2.5.1.15 dihydropteroate synthase
–
–
D-mannitol + 2 ferricytochrome_c <=> D-fructose + 2 ferricytochrome_c + 2 H+ 1.1.2.2 mannitol dehydrogenase (cytochrome)
–
L-lactaldehyde + NAD+ <=> methylglyoxal + NADH + H+ 1.1.1.6 glycerol dehydrogenase
–
UDP-galactose + myo-inositol <=> H+ + 1-alpha-D-galactosyl-myo-inositol + UDP 2.4.1.123 inositol 3-alpha-galactosyltransferase
–
2-Benzylmalate <=> 3-Benzylmalate 4.2.1
–
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O <=> H+ + 5-formyl-5,6,7,8-tetrahydromethanopterin 3.5.4.27 methenyltetrahydromethanopterin cyclohydrolase
–
3beta-hydroxyergosta-7,24(241)-dien-4alpha-carboxylate + NAD+ <=> Episterone + NADH + CO2 1.1.1.418 plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
–
trans-4-hydroxy-L-proline + NAD+ <=> NADH + L-1-pyrroline-3-hydroxy-5-carboxylate + H+ 1.5.1.2 pyrroline-5-carboxylate reductase
–
gibberellin_a15 + 2-oxoglutarate + O2 <=> Gibberellin_A24 + succinate + CO2 + H2O 1.14.11.12 gibberellin-44 dioxygenase
1.14.20
–
–
L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + dihydrobiopterin + H2O 1.14.16.2 tyrosine 3-monooxygenase
–
L-arginine + NADPH + H+ + O2 <=> L-citrulline + NO + NADP+ + H2O 1.14.13.39 nitric-oxide synthase (NADPH)
1.14.14.47 nitric-oxide synthase (flavodoxin)
–
–
all-trans-retinal + H2O + O2 <=> retinoic_acid + H2O2 + H+ 1.2.3.1 aldehyde oxidase
–
N-hydroxy-L-phenylalanine + reduced_flavodoxin + O2 <=> N,N-dihydroxy-L-phenylalanine + flavin + H2O 1.14.14.40 phenylalanine N-monooxygenase
–
3-Hydroxy-OPC4-CoA + NAD+ <=> 3-Oxo-OPC4-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
2-Amino-4-chloro-4-pentenoic_acid <=> DL-propargylglycine + Cl- + H+ 4.5.1
–
GDP-6-deoxy-D-mannose + NAD+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+ 1.1.1.187 GDP-4-dehydro-D-rhamnose reductase
1.1.1.281 GDP-4-dehydro-6-deoxy-D-mannose reductase
–
–
propionyl-CoA + enzyme_N6-(dihydrolipoyl)lysine <=> CoA + Enzyme_N6-(S-propyldihydrolipoyl)lysine 2.3.1.168 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
–
2-propanol + NADP+ <=> acetone + NADPH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.156 glycerol 2-dehydrogenase (NADP+)
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.4 (R,R)-butanediol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.80 isopropanol dehydrogenase (NADP+)
1.1.1.B4
–
–
–
–
–
–
–
–
p-coumaric_acid + CoA + ATP <=> 4-coumaroyl-CoA + AMP + diphosphate 6.2.1.12 4-coumarate---CoA ligase
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.30 phenylacetate---CoA ligase
–
–
–
H2O + N-formimino-L-aspartate <=> NH3 + N-formyl-L-aspartate 3.5.3.13 formimidoylglutamate deiminase
3.5.3.5 formimidoylaspartate deiminase
–
–
D-xylose + NADP+ <=> D-xylono-1,4-lactone + NADPH + H+ 1.1.1.424 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
–
tetradecanoyl-[acyl-carrier_protein] + dodecanoyl-Kdo2-lipid_IVA <=> Kdo2-lipid_A + [acyl-carrier_protein] 2.3.1.243 lauroyl-Kdo2-lipid IVA myristoyltransferase
–
7,9,12-Decaketide_intermediate_6 <=> 12-Deoxyaklanonic_acid not assigned
 –
H2O + Chlorophyll <=> chlorophyllide_a + phytol 3.1.1.14 chlorophyllase
–
H+ + L-Dopa <=> dopamine + CO2 4.1.1.22 histidine decarboxylase
4.1.1.25 tyrosine decarboxylase
4.1.1.28 aromatic-L-amino-acid decarboxylase
4.1.1.53 phenylalanine decarboxylase
–
–
–
–
gamma-Glu-L-Cys <=> 5-oxoproline + L-cysteine 4.3.2.9 gamma-glutamylcyclotransferase
–
(R)-citramalate + CO2 <=> 4-hydroxy-4-methyl-2-oxoglutarate + H2O not assigned
 –
5-(aminomethyl)-3-furanmethanol_phosphate + ATP <=> [5-(aminomethyl)furan-3-yl]methyl_diphosphate + ADP 2.7.4.31 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase
–
D-glucose_6-phosphate + NAD+ <=> 3-dehydro-D-glucose_6-phosphate + NADH + H+ 1.1.1.361 glucose-6-phosphate 3-dehydrogenase
–
D-glyceraldehyde + H2O + NADP+ <=> D-glycerate + NADPH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase
1.2.1.89 D-glyceraldehyde dehydrogenase (NADP+)
–
–
–
–
–
–
L-proline + 2-oxoglutarate + O2 <=> trans-4-hydroxy-L-proline + succinate + CO2 1.14.11.2 procollagen-proline 4-dioxygenase
1.14.11.57 L-proline trans-4-hydroxylase
–
–
acyl-CoA + sphingosine <=> ceramide + CoA + H+ 2.3.1.24 sphingosine N-acyltransferase
2.3.1.291 sphingoid base N-palmitoyltransferase
–
–
S-adenosyl-L-methionine + uroporphyrinogen_III <=> S-adenosyl-L-homocysteine + precorrin-2 + H+ 2.1.1.107 uroporphyrinogen-III C-methyltransferase
–
(2E,6E)-farnesyl_diphosphate <=> longifolene + diphosphate 4.2.3.58 longifolene synthase
–
phosphatidylinositol_4,5-bisphosphate + H2O <=> diacylglycerol + 1D-myo-inositol_1,4,5-trisphosphate + H+ 3.1.4.11 phosphoinositide phospholipase C
3.1.4.3 phospholipase C
–
–
5-aminoimidazole-4-carboxamide_ribonucleotide + formate + ATP <=> 5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide + ADP + phosphate 6.3.4.23 formate---phosphoribosylaminoimidazolecarboxamide ligase
–
2-((1R,3S),-1,9''-dihydroxy-1''-methyl-10''-oxo-3,4,5,10''-tetrahydro-1H-benzo[g]isochromen-3''-yl)acetate <=> (S)-DNPA + H2O 4.2.1
–
4-hydroxy-4-methyl-2-oxoglutarate <=> pyruvate 4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
–
2-hydroxy-2H-chromene-2-carboxylate <=> (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate 2.5.1.18 glutathione transferase
5.99.1.4 2-hydroxychromene-2-carboxylate isomerase
–
–
amylose <=> alpha-cyclodextrin 2.4.1.19 cyclomaltodextrin glucanotransferase
3.2.1.54 cyclomaltodextrinase
–
–
2,4,5-Trichlorophenol + O2 + FADH2 <=> 2,5-dichlorohydroquinone + Cl- + H2O + FAD + H+ 1.14.14
–
amidinoproclavaminate + H2O <=> proclavaminate + Urea 3.5.3.22 proclavaminate amidinohydrolase
–
1-hydroxylycopene <=> lycopene + H2O 4.2.1.131 carotenoid 1,2-hydratase
–
3-Hydroxy-OPC6-CoA <=> trans-2-Enoyl-OPC6-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase
–
–
amylose <=> glycogen 2.4.1.18 1,4-alpha-glucan branching enzyme
2.4.1.25 4-alpha-glucanotransferase
3.2.1.1 alpha-amylase
3.2.1.116 glucan 1,4-alpha-maltotriohydrolase
3.2.1.133 glucan 1,4-alpha-maltohydrolase
3.2.1.135 neopullulanase
3.2.1.41 pullulanase
3.2.1.54 cyclomaltodextrinase
3.2.1.68 isoamylase
–
–
–
–
–
–
–
–
–
CMP-N-acetylneuraminate + GD1a <=> CMP + GT1a 2.4.99
–
4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD+ <=> avenastenone + NADH + CO2 1.1.1.418 plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
–
(+)-7-Isojasmonate_CoA + acetyl-CoA <=> 3-oxo-2-(cis-2''-pentenyl)-cyclopentane-1-(3-oxobutanoyl)-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
–
phenylacetyl-CoA + H2O <=> phenylacetate + CoA + H+ 3.1.2
3.1.2.20 acyl-CoA hydrolase
3.1.2.23 4-hydroxybenzoyl-CoA thioesterase
3.1.2.25 phenylacetyl-CoA hydrolase
3.1.2.B5
–
–
–
–
–
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + acetyl-CoA <=> dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose + CoA + H+ 2.3.1
–
2-oxosuccinamic_acid + H2O <=> oxaloacetate + NH3 3.5.1.3 omega-amidase
–
5,10-methylenetetrahydrofolate + 2-oxoisovalerate + H2O <=> ketopantoate + tetrahydrofolate 2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase
–
aurachin_B + NAD+ + H2O <=> 4-hydroxy-2-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]quinolin-3(4H)-one_1-oxide + NADH + H+ 1.1.1.394 aurachin B dehydrogenase
–
cyanuric_acid + H2O <=> carboxybiuret + H+ 3.5.2.15 cyanuric acid amidohydrolase
–
phosphatidylethanolamine + H2O <=> ethanolamine + phosphatidic_acid 3.1.4.4 phospholipase D
–
dTDP-3-O-methyl-beta-L-rhamnose + Calicheamicin_alpha1(I) <=> dTDP + Calicheamicin_gamma(1)I 2.4.1
–
ent-copalyl_diphosphate <=> diphosphate + ent-kaurene 4.2.3.19 ent-kaurene synthase
5.5.1.13 ent-copalyl diphosphate synthase
–
–
UDP-N-acetyl-D-glucosamine + trans,octacis-decaprenyl_phosphate <=> N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol + UMP 2.7.8.35 UDP-N-acetylglucosamine---decaprenyl-phosphate N-acetylglucosaminephosphotransferase
–
dGTP + thioredoxin_disulfide + H2O <=> GTP + thioredoxin 1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)
–
S-adenosyl-L-methionine + carnosine <=> H+ + S-adenosyl-L-homocysteine + anserine 2.1.1.22 carnosine N-methyltransferase
–
D-Lysine + H+ <=> cadaverine + CO2 4.1.1.116 D-ornithine/D-lysine decarboxylase
6707
–
–
L-N-acetyl-2-amino-6-oxopimelate + L-glutamate <=> N-acetyl-L,L-2,6-diaminopimelate + 2-oxoglutarate 2.6.1
–
taurine + 2-oxoglutarate <=> L-glutamate + 2-sulfoacetaldehyde 2.6.1.55 taurine---2-oxoglutarate transaminase
–
S-adenosyl-L-methionine + Demethylmacrocin <=> H+ + S-adenosyl-L-homocysteine + macrocin 2.1.1.102 demethylmacrocin O-methyltransferase
–
(3S)-3-hydroxytetradecanoyl-CoA <=> 2-tetradecenoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase
–
–
L-lysine + acetyl-CoA <=> H+ + N6-acetyl-L-lysine + CoA 2.3.1
2.3.1.32 lysine N-acetyltransferase
–
–
5-hydroxy-L-tryptophan + O2 <=> 5-hydroxy-N-formylkynurenine 1.13.11.26 peptide-tryptophan 2,3-dioxygenase
1.13.11.52 indoleamine 2,3-dioxygenase
–
–
(2E,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> 4-hydroxy-2-oxohexanoate 4.2.1.132 2-hydroxyhexa-2,4-dienoate hydratase
–
CMP-N-acetylneuraminate + ganglioside_GD3 <=> CMP + GT3 2.4.99.8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase
–
2-dehydro-3-deoxy-D-galactonate + ATP <=> H+ + 2-dehydro-3-deoxy-D-galactonate_6-phosphate + ADP 2.7.1.178 2-dehydro-3-deoxyglucono/galactono-kinase
2.7.1.58 2-dehydro-3-deoxygalactonokinase
–
–
Caffeine + NADPH + O2 + H+ <=> Theobromine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
–
–
Nonaketamide_tricyclic_intermediate <=> Pretetramid not assigned
 –
geranyl_diphosphate <=> (-)-camphene + diphosphate 4.2.3
4.2.3.116 (+)-camphene synthase
4.2.3.117 (-)-camphene synthase
–
–
–
geranyl_diphosphate + H2O <=> (-)-alpha-terpineol + diphosphate 4.2.3.108 1,8-cineole synthase
4.2.3.111 (-)-alpha-terpineol synthase
4.2.3.112 (+)-alpha-terpineol synthase
–
–
–
dADP + thioredoxin_disulfide + H2O <=> ADP + thioredoxin 1.17.4.1 ribonucleoside-diphosphate reductase
1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)
–
–
decanoyl-CoA + acetyl-CoA <=> 3-oxododecanoyl-CoA + CoA 2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
–
–
D-glycero-beta-D-manno-heptose_1,7-bisphosphate + H2O <=> D-glycero-beta-D-manno-heptose_1-phosphate + phosphate 3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase
–
heme_O <=> heme_a not assigned
 –
1-hydroxyneurosporene <=> all-trans-neurosporene + H2O 4.2.1.131 carotenoid 1,2-hydratase
–
NTP + pyruvate <=> NDP + phosphoenolpyruvate 2.7.1.40 pyruvate kinase
–
ITP + cytidine <=> IDP + CMP 2.7.1.48 uridine/cytidine kinase
2.7.1.B20
–
–
2-Fluorobenzoate + NADH + H+ + O2 <=> 2-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
–
arachidonic_acid + O2 <=> prostaglandin_G2 1.14.99.1 prostaglandin-endoperoxide synthase
–
spheroidene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> spheroiden-2-one + H2O + oxidized_ferredoxin 1.14.15.9 spheroidene monooxygenase
–
S-adenosyl-L-methionine + Xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine 2.1.1.158 7-methylxanthosine synthase
–
ATP + D-ribulose <=> H+ + ADP + D-ribulose_5-phosphate 2.7.1.16 ribulokinase
2.7.1.47 D-ribulokinase
–
–
D-glucose + NAD+ <=> D-glucono-1,5-lactone + NADH + H+ 1.1.1.118 glucose 1-dehydrogenase (NAD+)
1.1.1.119 glucose 1-dehydrogenase (NADP+)
1.1.1.121 aldose 1-dehydrogenase (NAD+)
1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
–
–
–
–
–
divinyl_protochlorophyllide_a + 2 H+ <=> protochlorophyllide not assigned
 –
alpha-amino-beta-carboxymuconate-epsilon-semialdehyde <=> quinolinic_acid + H2O + H+ not assigned
 –
dTDP-3-dehydro-2,6-dideoxy-alpha-D-glucose <=> TDP-3-amino-2,3,6-trideoxy-alpha-D-glucose not assigned
 –
D-lactate + H+ <=> methylglyoxal + H2O 3.5.1.124 protein deglycase
4.2.1.130 D-lactate dehydratase
–
–
S-adenosyl-L-methionine + 3,4-Dihydroxyphenylacetate <=> H+ + homovanillic_acid + S-adenosyl-L-homocysteine 2.1.1.6 catechol O-methyltransferase
–
(R)-2-hydroxyglutarate + pyruvate <=> 2-oxoglutarate + D-lactate 1.1.99.40 (R)-2-hydroxyglutarate---pyruvate transhydrogenase
–
NH3 + H2O + oxidized_ferredoxin <=> nitrite + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.7.7.1 ferredoxin---nitrite reductase
1.8.7.1 assimilatory sulfite reductase (ferredoxin)
–
–
ent-7alpha-hydroxykaur-16-en-19-oate + reduced_flavodoxin + O2 <=> gibberellin_A12_aldehyde + flavin + 2 H2O 1.14.14.107 ent-kaurenoic acid monooxygenase
–
D-mannose <=> D-fructose 5.3.1.15 D-lyxose ketol-isomerase
5.3.1.5 xylose isomerase
5.3.1.7 mannose isomerase
5.3.1.B3
–
–
–
–
UDP-N,N''-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + UDP + H+ 3.2.1.184 UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing)
–
D-chiro-Inositol + NAD+ <=> 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+ 1.1.1.18 inositol 2-dehydrogenase
1.1.1.369 D-chiro-inositol 1-dehydrogenase
–
–
TDP-3-amino-2,3,6-trideoxy-alpha-D-glucose <=> dTDP-D-angolosamine not assigned
 –
H+ + L-phenylalanine <=> 2-Phenylethylamine + CO2 4.1.1.14 valine decarboxylase
4.1.1.19 arginine decarboxylase
4.1.1.25 tyrosine decarboxylase
4.1.1.28 aromatic-L-amino-acid decarboxylase
4.1.1.53 phenylalanine decarboxylase
–
–
–
–
–
trypanothione + H2O <=> glutathione + glutathionylspermidine 3.5.1
3.5.1.78 glutathionylspermidine amidase
–
–
succinate + GTP + CoA <=> succinyl-CoA + GDP + phosphate 6.2.1.4 succinate---CoA ligase (GDP-forming)
–
UDP-N-acetyl-D-galactosamine + beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-1-Ser <=> UDP + beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-1-Ser 2.4.1.175 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
–
L-ribulose + ATP <=> H+ + L-ribulose_5-phosphate + ADP 2.7.1.16 ribulokinase
2.7.1.17 xylulokinase
–
–
(3R)-3-hydroxybutanoyl-[acyl-carrier_protein] + NADP+ <=> acetoacetyl-[acyl-carrier_protein] + NADPH + H+ 1.1.1
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
–
–
–
–
–
2-oxobutyrate + thiamine_diphosphate <=> 2-(alpha-Hydroxypropyl)thiamine_diphosphate + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
–
2-deoxy-D-ribose_5-phosphate <=> D-glyceraldehyde_3-phosphate + acetaldehyde 4.1.2.4 deoxyribose-phosphate aldolase
–
avenasterol + ferricytochrome_b5 + O2 + H+ <=> DELTA5,7-avenasterol + ferricytochrome_b5 + H2O 1.14.19.20 Delta7-sterol 5(6)-desaturase
–
acetoacetate <=> 3-Butynoate + H2O 4.2.1.27 acetylenecarboxylate hydratase
–
H+ + (2S)-2-isopropyl-3-oxosuccinate <=> 4-methyl-2-oxopentanoate + CO2 0.0.0.0
1.1.1.85 3-isopropylmalate dehydrogenase
–
–
(S)-3-hydroxydecanoyl-CoA + NAD+ <=> 3-oxodecanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
(2S)-2-phospholactate + GTP + H+ <=> L-lactyl-2-diphospho-5''-guanosine + diphosphate 2.7.7.68 2-phospho-L-lactate guanylyltransferase
–
p-hydroxyphenylacetaldoxime + reduced_flavodoxin + O2 <=> (S)-4-hydroxymandelonitrile + flavin + 2 H2O 1.14.14.37 4-hydroxyphenylacetaldehyde oxime monooxygenase
–
(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate <=> o-succinylbenzoate + H2O 4.2.1.113 o-succinylbenzoate synthase
–
5,6-dihydrouracil + NAD+ <=> Uracil + NADH + H+ 1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)
1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)
–
–
nocardicin_G <=> nocardicin_E not assigned
 –
ATP + acetate <=> diphosphate + acetyl_adenylate 6.2.1.1 acetate---CoA ligase
–
fecosterol <=> episterol not assigned
 –
N-acetyl-D-mannosamine_6-phosphate + phosphoenolpyruvate + H2O <=> N-acetylneuraminate_9-phosphate + phosphate 2.5.1.56 N-acetylneuraminate synthase
2.5.1.57 N-acylneuraminate-9-phosphate synthase
–
–
R-S-glutathione + H2O <=> an_(L-cysteinylglycine)-S-conjugate + L-glutamate 2.3.2.2 gamma-glutamyltransferase
3.4.19.13 glutathione gamma-glutamate hydrolase
–
–
4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid + H2O <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+ 3.7.1.17 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
–
dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose <=> dTDP-3-dehydro-2,6-dideoxy-alpha-D-glucose not assigned
 –
L-1-pyrroline-3-hydroxy-5-carboxylate + NAD+ + H2O <=> H+ + L-erythro-4-hydroxyglutamate + NADH 1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
1.5.1
–
–
alpha-D-mannose_1-phosphate <=> D-mannose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.8 phosphomannomutase
–
–
–
4-(hydroxymethyl)-2-furancarboxaldehyde_phosphate + L-alanine <=> 5-(aminomethyl)-3-furanmethanol_phosphate + pyruvate 2.6.1.108 (5-formylfuran-3-yl)methyl phosphate transaminase
–
Avermectin_B1b_aglycone + dTDP-L-oleandrose <=> Avermectin_B1b_monosaccharide + dTDP 2.4.1
–
hydrogenobyrinic_acid_a,c-diamide + Co2+ + ATP + H2O <=> H+ + cob(II)yrinic_acid_a,c-diamide + ADP + phosphate 6.6.1.2 cobaltochelatase
–
acyl-CoA + sphinganine <=> dihydroceramide + CoA + H+ 2.3.1.24 sphingosine N-acyltransferase
2.3.1.291 sphingoid base N-palmitoyltransferase
2.3.1.297 very-long-chain ceramide synthase
–
–
–
demethylphylloquinone + NADPH + H+ <=> demethylphylloquinol + NADP+ 1.6.5.12 demethylphylloquinone reductase
–
(R)-(indol-3-yl)lactate + NAD+ <=> 3-Indole-2-oxopropanoate + NADH + H+ 1.1.1.110 aromatic 2-oxoacid reductase
–
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> succinate + pyruvate 4.1.3.1 isocitrate lyase
4.1.3.30 methylisocitrate lyase
–
–
S-adenosyl-L-methionine + tryptamine <=> S-adenosyl-L-homocysteine + N-methyltryptamine + H+ 2.1.1.49 amine N-methyltransferase
–
4-(phosphonooxy)-L-threonine + NAD+ <=> 2-amino-3-oxo-4-phosphonooxybutyrate + NADH 1.1.1.262 4-hydroxythreonine-4-phosphate dehydrogenase
–
Butyraldehyde + CoA + NADP+ <=> butyryl-CoA + NADPH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.57 butanal dehydrogenase
1.2.1.76 succinate-semialdehyde dehydrogenase (acylating)
–
–
–
UDP-N-acetyl-D-glucosamine + nLc6Cer <=> UDP + beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-1-Cer 2.4.1.150 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase
–
ATP + 4-methoxy-2,2''-bipyrrole-5-carbaldehyde + 2-Methyl-3-n-amyl-pyrrole <=> ADP + phosphate + prodigiosin + H+ 6.4.1
–
sulfate + H+ + ADP <=> adenosine_5''-phosphosulfate + phosphate 2.7.7.5 sulfate adenylyltransferase (ADP)
–
palmitoyl-CoA + H2O <=> H+ + palmitate + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
3.1.1.1 carboxylesterase
3.1.1.23 acylglycerol lipase
3.1.1.5 lysophospholipase
3.1.2
3.1.2.1 acetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.22 palmitoyl[protein] hydrolase
3.1.2.25 phenylacetyl-CoA hydrolase
–
–
–
–
–
–
–
–
–
–
H+ + S-methyl-5''-thioadenosine + H2O <=> S-methyl-5''-thioinosine + NH3 3.5.4.31 S-methyl-5'-thioadenosine deaminase
3.5.4.4 adenosine deaminase
–
–
D-galactose + O2 + H2O <=> D-galactonate + H2O2 1.1.3.9 galactose oxidase
–
UDP-N-acetyl-D-glucosamine + H2O <=> N-acetyl-D-mannosamine + UDP 3.2.1.183 UDP-N-acetylglucosamine 2-epimerase (hydrolysing)
5.1.3.14 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)
–
–
Toluene + O2 + NADH + H+ <=> p-Cresol + H2O + NAD+ 1.14.13.236 toluene 4-monooxygenase
–
tyramine + O2 + H2O <=> 4-hydroxyphenylacetaldehyde + NH3 + H2O2 1.4.3.10 putrescine oxidase
1.4.3.21 primary-amine oxidase
1.4.3.22 diamine oxidase
1.4.3.4 monoamine oxidase
1.4.9.2 aralkylamine dehydrogenase (azurin)
–
–
–
–
–
adenosine + H2O + H+ <=> Inosine + NH3 3.5.4.4 adenosine deaminase
–
methanethiol + coenzyme_M <=> methyl-CoM + Sulfide + H+ 2.1.1.251 methylated-thiol---coenzyme M methyltransferase
–
NADP+ + CoA + (R)-mevalonate <=> H+ + NADPH + (S)-3-hydroxy-3-methylglutaryl-CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
1.1.1.88 hydroxymethylglutaryl-CoA reductase
1.1.1.B38
–
–
–
(S)-2-Hydroxy-2-methyl-3-oxobutanoate <=> 3-hydroxy-3-methyl-2-oxobutanoic_acid 1.1.1.86 ketol-acid reductoisomerase (NADP+)
5.4.99.3 2-acetolactate mutase
–
–
DELTA1-piperideine + acetoacetyl-CoA + H2O <=> Pelletierine + CoA + CO2 not assigned
 –
S-adenosyl-L-methionine + 1-hydroxyneurosporene <=> 1-methoxyneurosporene + S-adenosyl-L-homocysteine + H+ 2.1.1
2.1.1.210 demethylspheroidene O-methyltransferase
–
–
Caffeine + O2 + NADPH + H+ <=> theophylline + formaldehyde + NADP+ + H2O 1.13.12
1.14.13.128 7-methylxanthine demethylase
–
–
(S)-3-hydroxybutyryl-CoA <=> (3R)-hydroxybutyryl-CoA 5.1.2.3 3-hydroxybutyryl-CoA epimerase
–
thiosulfate + 5 H2O + 8 ferricytochrome_c <=> 2 sulfate + 8 ferricytochrome_c + 10 H+ not assigned
 –
L-cysteine + NAD+ <=> H+ + L-cystine + NADH 1.8.1.6 cystine reductase
–
L-xylo-hex-3-ulonolactone <=> H+ + ascorbate 1.1.3.8 L-gulonolactone oxidase
–
4''-Dephosphorylated_1-PEtN-KDO-lipid_A + H2O <=> H._pylori_KDO-lipid_A + (R)-3-(Tetradecanoyloxy)hexadecanoic_acid 3.1.1
–
biphenyl + O2 + NADH + H+ <=> cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+ 1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
–
–
N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine + H2O <=> 4-amino-5-aminomethyl-2-methylpyrimidine + formate 3.5.1
–
S-adenosyl-L-methionine + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol <=> plastoquinol + S-adenosyl-L-homocysteine + H+ 2.1.1.295 2-methyl-6-phytyl-1,4-hydroquinone methyltransferase
–
n UDP-D-galacturonate <=> n UDP + Pectin 2.4.1.43 polygalacturonate 4-alpha-galacturonosyltransferase
–
adenosine + phosphate <=> adenine + alpha-D-ribose_1-phosphate 2.4.2.1 purine-nucleoside phosphorylase
2.4.2.28 S-methyl-5'-thioadenosine phosphorylase
2.4.2.44 S-methyl-5'-thioinosine phosphorylase
–
–
–
Inosine + H2O <=> D-ribose + hypoxanthine 3.2.2.1 purine nucleosidase
3.2.2.2 inosine nucleosidase
3.2.2.7 adenosine nucleosidase
3.2.2.8 ribosylpyrimidine nucleosidase
–
–
–
–
beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-[alpha-L-Fuc-(1->3)]-D-GlcNAc + H2O <=> alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-1-Asn + N-acetyl-D-glucosamine 3.2.1.52 beta-N-acetylhexosaminidase
–
tryparedoxin + ROOH <=> Tryparedoxin_disulfide + H2O + rhodopsin 1.11.1
–
retinoic_acid + NADPH + H+ + O2 <=> all-trans-4-Hydroxyretinoic_acid + NADP+ + H2O 1.14.13
1.14.14
1.14.14.1 unspecific monooxygenase
–
–
–
(S)-malate + NADP+ <=> H+ + NADPH + oxaloacetate 1.1.1.299 malate dehydrogenase [NAD(P)+]
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.81 hydroxypyruvate reductase
1.1.1.82 malate dehydrogenase (NADP+)
–
–
–
–
–
–
(8S)-3,8-cyclo-7,8-dihydroguanosine_5''-triphosphate <=> cyclic_pyranopterin_phosphate + diphosphate 4.6.1.17 cyclic pyranopterin monophosphate synthase
–
UDP-N-acetylmuramate + NAD+ <=> UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADH + H+ 1.3.1.98 UDP-N-acetylmuramate dehydrogenase
–
AMP + diphosphate <=> adenine + 5-phospho-alpha-D-ribose_1-diphosphate 2.4.2.22 xanthine phosphoribosyltransferase
2.4.2.7 adenine phosphoribosyltransferase
2.4.2.8 hypoxanthine phosphoribosyltransferase
–
–
–
UDP-glucose + D-fructose <=> sucrose + UDP + H+ 2.4.1.13 sucrose synthase
2.4.1.14 sucrose-phosphate synthase
–
–
alpha-D-ribose_1-methylphosphonate_5-triphosphate + H2O <=> alpha-D-ribose_1-methylphosphonate_5-phosphate + diphosphate + H+ 3.6.1.63 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase
–
S-adenosyl-L-methionine + 8-demethylnovobiocic_acid <=> S-adenosyl-L-homocysteine + novobiocic_acid + H+ 2.1.1.284 8-demethylnovobiocic acid C8-methyltransferase
–
2-hydroxyhepta-2,4-dienedioate + H2O <=> 2,4-Dihydroxyhept-2-enedioate 4.2.1
–
L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + 4a-hydroxytetrahydrobiopterin 1.14.16.2 tyrosine 3-monooxygenase
–
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol 5.4.99.17 squalene---hopene cyclase
5.4.99.7 lanosterol synthase
–
–
UDP-2-acetamido-2-deoxy-alpha-D-glucuronate <=> UDP-N-acetyl-D-galactosaminuronate 5.1.3
–
folate + NADPH <=> tetrahydrofolate + NADP+ 1.5.1.3 dihydrofolate reductase
1.5.1.33 pteridine reductase
1.5.1.34 6,7-dihydropteridine reductase
–
–
–
N2 + H2O + 2 ferricytochrome_c <=> N2O + 2 ferricytochrome_c + 2 H+ 1.7.2.4 nitrous-oxide reductase
–
H2O + anserine <=> 1-methylhistidine + beta-Alanine 3.4.13.20 beta-Ala-His dipeptidase
3.4.13.5 Xaa-methyl-His dipeptidase
–
–
4-hydroxybutyrate + NAD+ <=> succinate_semialdehyde + NADH + H+ 1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.61 4-hydroxybutyrate dehydrogenase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.B47
–
–
–
–
–
D-glucose_6-phosphate <=> beta-D-fructose_6-phosphate 2.6.1.16 glutamine---fructose-6-phosphate transaminase (isomerizing)
5.3.1.8 mannose-6-phosphate isomerase
5.3.1.9 glucose-6-phosphate isomerase
–
–
–
fumiquinazoline_F-indoline-2,3''-diol + L-alanine + ATP <=> Fumiquinazoline_A + AMP + diphosphate + H2O + H+ 6.3.2
–
S-adenosyl-L-methionine + 3''-O-demethyl-staurosporine <=> staurosporine + S-adenosyl-L-homocysteine + H+ 2.1.1.139 3'-demethylstaurosporine O-methyltransferase
–
Caffeine + NADH + O2 + H+ <=> paraxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
–
–
a_D-amino_acid + pyruvate <=> a_2-oxo_carboxylate + D-alanine 2.6.1.21 D-amino-acid transaminase
–
2-hydroxy-2,4-hexadienedioate <=> 4-oxalocrotonate 5.3.2.6 2-hydroxymuconate tautomerase
5.3.2.M1
–
–
S-adenosyl-L-methionine + dihydrosterigmatocystin <=> H+ + 8-O-methyldihydrosterigmatocystin + S-adenosyl-L-homocysteine 2.1.1.110 sterigmatocystin 8-O-methyltransferase
–
CoA + acetate + ATP <=> acetyl-CoA + diphosphate + AMP 6.2.1.1 acetate---CoA ligase
6.2.1.17 propionate---CoA ligase
6.2.1.36 3-hydroxypropionyl-CoA synthase
–
–
–
D-arabitol + NADP+ <=> D-xylulose + NADPH + H+ 1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.287 D-arabinitol dehydrogenase (NADP+)
–
–
(Z)-pent-1-ene-1,2,5-tricarboxylate + H2O <=> (-)-threo-iso(homo)2citrate 4.2.1.114 methanogen homoaconitase
–
sarcosine + H2O + flavin <=> glycine + formaldehyde + reduced_flavodoxin 1.5.8.3 sarcosine dehydrogenase
–
UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + H2O <=> H+ + 2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + UDP 3.6.1.57 UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase
–
alpha-D-GlcNAc-(1->4)-beta-D-GlcA2S-(1->4)-alpha-D-GlcNAc6S-(1->4)-D-GlcA + H2O <=> beta-D-GlcA2S-(1->4)-alpha-D-GlcNAc6S-(1->4)-D-GlcA + N-acetyl-D-glucosamine 3.2.1.50 alpha-N-acetylglucosaminidase
–
6-keto-prostaglandin_F1alpha + acceptor <=> 6-ketoprostaglandin_E1 + reduced_acceptor not assigned
 –
5,6-dihydrouracil + NADP+ <=> Uracil + NADPH + H+ 1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)
1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)
–
–
5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ <=> 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADPH + H+ 1.1.1.213 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
–
–
D-glucose <=> D-glucose 5.1.3.21 maltose epimerase
5.1.3.3 aldose 1-epimerase
–
–
CMP-N-acetylneuraminate + Galactosylgloboside <=> monosialylgalactosylgloboside + CMP + H+ 2.4.99.4 beta-galactoside alpha-2,3-sialyltransferase
–
H+ + precorrin-8X <=> Hydrogenobyrinate 5.4.99.61 precorrin-8X methylmutase
–
D-xylose + NAD+ <=> D-xylono-1,5-lactone + NADH + H+ 1.1.1.121 aldose 1-dehydrogenase (NAD+)
1.1.1.122 D-threo-aldose 1-dehydrogenase
1.1.1.175 D-xylose 1-dehydrogenase
1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)
1.1.1.18 inositol 2-dehydrogenase
1.1.1.359 aldose 1-dehydrogenase [NAD(P)+]
1.1.1.376 L-arabinose 1-dehydrogenase [NAD(P)+]
1.1.1.424 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
–
–
–
–
–
–
–
–
–
H2O + 2-Phosphoglycolate <=> glycolate + phosphate 3.1.3.18 phosphoglycolate phosphatase
3.1.3.2 acid phosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.71 2-phosphosulfolactate phosphatase
5.4.2.4 bisphosphoglycerate mutase
–
–
–
–
–
phosphate + thymidine <=> 2-deoxy-alpha-D-ribose_1-phosphate + thymine 2.4.2.2 pyrimidine-nucleoside phosphorylase
2.4.2.3 uridine phosphorylase
2.4.2.4 thymidine phosphorylase
–
–
–
2,4-Diaminopentanoate + H2O + NADP+ <=> (2R)-2-amino-4-oxopentanoate + NH3 + NADPH + H+ 1.4.1.12 2,4-diaminopentanoate dehydrogenase
–
TDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 3-alpha-mycarosylerythronolide_B <=> erythromycin_D + dTDP + H+ 2.4.1.278 3-alpha-mycarosylerythronolide B desosaminyl transferase
–
H+ + Phosphonopyruvate <=> phosphonoacetaldehyde + CO2 4.1.1.82 phosphonopyruvate decarboxylase
–
L-arogenate + 2-oxoglutarate <=> prephenate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase
–
–
–
–
(3R,6Z,9Z,12Z,15Z,18Z)-3-Hydroxytetracosapentaenoyl-CoA + NAD+ <=> (6Z,9Z,12Z,15Z,18Z)-3-Oxotetracosapentaenoyl-CoA + NADH + H+ 1.1.1
–
UDP-N-acetyl-D-glucosamine <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O 4.2.1.115 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)
–
phenylacetonitrile + reduced_flavodoxin + O2 <=> (R)-mandelonitrile + flavin + H2O 1.14.14.44 phenylacetaldehyde oxime monooxygenase
1.14.14.77 phenylacetonitrile alpha-monooxygenase
–
–
ATP + L-glutamine + HCO3- + H2O <=> L-glutamate + Carbamoyl_phosphate + ADP + phosphate + H+ 6.3.4.16 carbamoyl-phosphate synthase (ammonia)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
–
–
Carbamate + ATP <=> Carbamoyl_phosphate + ADP 2.7.2.2 carbamate kinase
6.3.4.14 biotin carboxylase
6.3.4.16 carbamoyl-phosphate synthase (ammonia)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
–
–
–
–
ATP + maltose <=> H+ + ADP + alpha-maltose_1-phosphate 2.7.1.175 maltokinase
–
L-arabitol + NAD+ <=> L-xylulose + NADH + H+ 1.1.1.12 L-arabinitol 4-dehydrogenase
1.1.1.16 galactitol 2-dehydrogenase
1.1.1.56 ribitol 2-dehydrogenase
1.1.1.9 D-xylulose reductase
–
–
–
–
L-pipecolic_acid + FAD <=> FADH2 + (S)-2,3,4,5-tetrahydropyridine-2-carboxylate 1.5.99.3 L-pipecolate dehydrogenase
–
8-Methyl-6-nonenoic_acid <=> (6E)-8-methylnon-6-enoyl-CoA not assigned
 –
N-acetyl-D-mannosamine <=> N-acetyl-D-glucosamine 5.1.3.8 N-acylglucosamine 2-epimerase
–
3-Fluorobenzoate + NADH + H+ + O2 <=> 5-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
–
L-tyrosine + pyruvate <=> 4-hydroxyphenylpyruvate + L-alanine 2.6.1.12 alanine---oxo-acid transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.5 tyrosine transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.58 phenylalanine(histidine) transaminase
–
–
–
–
–
dopamine + 4-hydroxyphenylacetaldehyde <=> H2O + (S)-norcoclaurine 4.2.1.78 (S)-norcoclaurine synthase
–
ATP + GMP <=> ADP + GDP 2.7.4.8 guanylate kinase
–
prostaglandin_H2 <=> prostaglandin_I2 5.3.99.4 prostaglandin-I synthase
–
salutaridinol + acetyl-CoA <=> 7-O-acetylsalutaridinol + CoA 2.3.1.150 salutaridinol 7-O-acetyltransferase
–
uric_acid_ribonucleoside + phosphate <=> alpha-D-ribose_1-phosphate + Urate 2.4.2.16 urate-ribonucleoside phosphorylase
–
5-Aminopentanoate + 2-oxoglutarate <=> L-glutamate + 5-Oxopentanoate 2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.48 5-aminovalerate transaminase
–
–
–
S-adenosyl-L-methionine + L-adrenaline <=> metanephrine + S-adenosyl-L-homocysteine + H+ 2.1.1.6 catechol O-methyltransferase
–
L-glutamine + H2O <=> L-glutamate + NH3 1.4.1.13 glutamate synthase (NADPH)
1.4.1.14 glutamate synthase (NADH)
1.4.7.1 glutamate synthase (ferredoxin)
2.3.2.2 gamma-glutamyltransferase
2.4.2
2.4.2.14 amidophosphoribosyltransferase
3.4.11.17 tryptophanyl aminopeptidase
3.5.1.1 asparaginase
3.5.1.2 glutaminase
3.5.1.38 glutamin-(asparagin-)ase
3.5.1.43 peptidyl-glutaminase
3.5.1.44 protein-glutamine glutaminase
4.3.1.B2
4.3.2.10 imidazole glycerol-phosphate synthase
4.3.3.6 pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
6.3.4.2 CTP synthase (glutamine hydrolysing)
6.3.5.13 lipid II isoglutaminyl synthase (glutamine-hydrolysing)
6.3.5.2 GMP synthase (glutamine-hydrolysing)
6.3.5.4 asparagine synthase (glutamine-hydrolysing)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
6.3.5.6 asparaginyl-tRNA synthase (glutamine-hydrolysing)
6.3.5.7 glutaminyl-tRNA synthase (glutamine-hydrolysing)
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
D-malate <=> H2O + Maleate 4.2.1.31 maleate hydratase
4.2.1.36 homoaconitate hydratase
–
–
all-trans-zeta-carotene + reduced_acceptor + O2 <=> all-trans-neurosporene + A + H2O 1.3.5.6 9,9'-dicis-zeta-carotene desaturase
1.3.99.26 all-trans-zeta-carotene desaturase
1.3.99.28 phytoene desaturase (neurosporene-forming)
1.3.99.30 phytoene desaturase (3,4-didehydrolycopene-forming)
1.3.99.31 phytoene desaturase (lycopene-forming)
–
–
–
–
–
isopenicillin_N + acyl-CoA + H2O <=> penicillin + CoA + L-2-aminoadipate 2.3.1.164 isopenicillin-N N-acyltransferase
–
phosphatidylcholine + H2O <=> lysophosphatidylcholine + linolenic_acid 3.1.1.4 phospholipase A2
–
L-proline + pC3'p + ATP <=> (L-prolyl)-[peptidyl-carrier_protein] + AMP + diphosphate 6.2.1.53 L-proline---[L-prolyl-carrier protein] ligase
–
H2O + Phosphonoacetate <=> H+ + phosphate + acetate 3.11.1.2 phosphonoacetate hydrolase
–
N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine + H2O <=> ganglioside_GM3 + N-acetyl-D-galactosamine 3.2.1.52 beta-N-acetylhexosaminidase
–
campesterol + O2 + reduced_acceptor <=> 6alpha-Hydroxycampestanol + H2O + acceptor 1.14.99
–
Inosine + phosphate <=> hypoxanthine + alpha-D-ribose_1-phosphate 2.4.2.1 purine-nucleoside phosphorylase
2.4.2.15 guanosine phosphorylase
2.4.2.28 S-methyl-5'-thioadenosine phosphorylase
2.4.2.3 uridine phosphorylase
2.4.2.44 S-methyl-5'-thioinosine phosphorylase
–
–
–
–
–
O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + ferricytochrome_b5 + O2 + H+ <=> ethanolamine_plasmalogen + ferricytochrome_b5 + H2O 1.14.19.77 plasmanylethanolamine desaturase
–
D-glucose_6-phosphate + acetyl-CoA <=> N-acetyl-D-glucosamine_6-phosphate + H+ + CoA 2.3.1.4 glucosamine-phosphate N-acetyltransferase
–
S-adenosyl-L-methionine + N-acetyl-O-demethylpuromycin <=> H+ + N-acetylpuromycin + S-adenosyl-L-homocysteine 2.1.1.38 O-demethylpuromycin O-methyltransferase
–
(3R,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-CoA <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosaheptaenoyl-CoA + H2O 4.2.1.119 enoyl-CoA hydratase 2
–
tetrahydrobiopterin + NADP+ <=> (6R)-L-erythro-6,7-dihydrobiopterin + NADPH + H+ 1.5.1.3 dihydrofolate reductase
1.5.1.33 pteridine reductase
1.5.1.34 6,7-dihydropteridine reductase
–
–
–
H+ + alpha-D-glucuronic_acid_1-phosphate + UTP <=> UDP-glucuronate + diphosphate 2.7.7.44 glucuronate-1-phosphate uridylyltransferase
2.7.7.64 UTP-monosaccharide-1-phosphate uridylyltransferase
–
–
prostaglandin_F2alpha + NADP+ <=> prostaglandin_H2 + NADPH + H+ 1.1.1
1.1.1.188 prostaglandin-F synthase
1.1.1.189 prostaglandin-E2 9-reductase
1.6.99.1 NADPH dehydrogenase
–
–
–
–
ubiquinone + D-glucose <=> ubiquinol + D-glucono-1,5-lactone 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone)
1.1.5.9 glucose 1-dehydrogenase (FAD, quinone)
–
–
UDP-N-acetyl-D-glucosamine + glycoprotein_N-acetyl-D-galactosamine <=> N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-alpha-D-galactosaminyl-R + H+ + UDP 2.4.1.147 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
–
chlorophyllide_a + O2 + NADPH + H+ <=> 7-hydroxychlorophyllide_a + H2O + NADP+ 1.14.13.122 chlorophyllide-a oxygenase
–
UDP-glucose + beta-D-gentiobiosyl_beta-D-glucosyl_crocetin <=> crocin + UDP + H+ 2.4.1.330 beta-D-glucosyl crocetin beta-1,6-glucosyltransferase
–
L-homoserine + acetyl-CoA <=> O-acetyl-L-homoserine + CoA 2.3.1.31 homoserine O-acetyltransferase
–
propionyl-CoA + H2O + glyoxylate <=> 2-hydroxyglutarate + H+ + CoA 2.3.3.11 2-hydroxyglutarate synthase
–
ATP + Urea + HCO3- + H+ <=> ADP + phosphate + allophanate 6.3.4.6 urea carboxylase
–
behenoyl-CoA + NADP+ <=> trans-docos-2-enoyl-CoA + NADPH + H+ 1.3.1.93 very-long-chain enoyl-CoA reductase
–
N,N''-diacetylchitobiose + H2O <=> N-acetyl-D-glucosamine 3.2.1.14 chitinase
3.2.1.169 protein O-GlcNAcase
3.2.1.21 beta-glucosidase
3.2.1.52 beta-N-acetylhexosaminidase
3.5.1.41 chitin deacetylase
–
–
–
–
–
S-adenosyl-L-methionine + 1-hydroxy-3,4-didehydrolycopene <=> 1-methoxy-3,4-didehydrolycopene + S-adenosyl-L-homocysteine + H+ 2.1.1
2.1.1.210 demethylspheroidene O-methyltransferase
–
–
D-glycerate + ATP <=> H+ + 3-phospho-D-glycerate + ADP 2.7.1.165 glycerate 2-kinase
2.7.1.31 glycerate 3-kinase
–
–
chondroitin_D-glucuronate <=> dermatan_L-iduronate 5.1.3.19 chondroitin-glucuronate 5-epimerase
–
campesterol + NADPH + H+ + O2 <=> (22S)-22-hydroxycampesterol + NADP+ + H2O 1.14.13
1.14.99.B1
–
–
acetyl-CoA + GDP-4-amino-4,6-dideoxy-alpha-D-mannose <=> CoA + GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose + H+ 2.3.1.227 GDP-perosamine N-acetyltransferase
–
2,5-dichloromaleylacetate + NADH <=> 2-chloro-3-oxohexanedioic_acid + NAD+ + Cl- 1.3.1.32 maleylacetate reductase
–
3''-Keto-3''-deoxy-ATP <=> 3''-Keto-3''-deoxy-AMP + diphosphate 3
–
O-succinyl-L-homoserine + Sulfide <=> H+ + L-homocysteine + succinate 2.5.1
2.5.1.48 cystathionine gamma-synthase
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
–
–
–
L-alanine + H2O + NAD+ <=> pyruvate + NH3 + NADH + H+ 1.4.1.1 alanine dehydrogenase
1.4.1.23 valine dehydrogenase (NAD+)
1.4.1.3 glutamate dehydrogenase [NAD(P)+]
1.4.1.8 valine dehydrogenase (NADP+)
1.4.1.9 leucine dehydrogenase
–
–
–
–
–
UDP-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine <=> UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine 2.4.1.135 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
–
(22R)-22-hydroxycholesterol + O2 + reduced_adrenodoxin + H+ <=> (20R,22R)-20,22-dihydroxy-cholesterol + H2O + oxidized_ferredoxin 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving)
–
zeaxanthin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ + O2 <=> antheraxanthin + oxidized_ferredoxin + H2O 1.14.15.21 zeaxanthin epoxidase
–
17alpha-hydroxyprogesterone + reduced_flavodoxin + O2 <=> 11-deoxycortisol + flavin + H2O 1.14.14.16 steroid 21-monooxygenase
–
choline + NAD+ <=> Betaine_aldehyde + NADH + H+ 1.1.1
1.1.1.1 alcohol dehydrogenase
–
–
dAMP + H2O <=> 2''-deoxyadenosine + phosphate 3.1.3.2 acid phosphatase
3.1.3.31 nucleotidase
3.1.3.5 5'-nucleotidase
3.1.3.89 5'-deoxynucleotidase
–
–
–
–
pyruvate + trans-2-octenal + H+ <=> (S)-3-acetyloctanal + CO2 2.2.1.12 3-acetyloctanal synthase
–
(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 + H+ <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + H2O2 + CO2 not assigned
 –
N6-acetyl-L-lysine + H2O <=> L-lysine + acetate 3.5.1.17 acyl-lysine deacylase
–
cholesterol + O2 + 2 H+ + 2 reduced_ferredoxin <=> 20alpha-hydroxycholesterol + H2O + 2 oxidized_ferredoxin 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving)
–
S-adenosyl-L-methionine + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose <=> S-adenosyl-L-homocysteine + dTDP-alpha-D-forosamine + H+ 2.1.1.324 dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase
–
UDP-MurNAc-L-Ala-L-Glu + ATP + H2O <=> UDP-MurNAc-L-Ala-D-Glu + AMP + diphosphate + H+ 5.1.1.23 UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase
–
gibberellin_A12 <=> Gibberellin_A53 not assigned
 –
[glycine_cleavage_system_H]-N6-octanoyl-L-lysine + an_[Fe-S]_cluster_scaffold_protein_carrying_a_[4Fe-4S]2+_cluster + 2 S-adenosyl-L-methionine + 2 [2Fe-2S]-center + 8 H+ <=> dihydrolipoylprotein + an_[Fe-S]_cluster_scaffold_protein + 2 Sulfide + 4 Fe2+ + 2 L-methionine + 2 5''-Deoxyadenosine + 2 [2Fe-2S]-center 2.8.1.8 lipoyl synthase
–
phosphatidylinositol_4,5-bisphosphate + ATP <=> phosphatidylinositol_3,4,5-trisphosphate + ADP + H+ 2.7.1.137 phosphatidylinositol 3-kinase
2.7.1.151 inositol-polyphosphate multikinase
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase
–
–
–
D-galactaro-1,5-lactone <=> D-galactaro-1,4-lactone 5.4.1.4 D-galactarolactone isomerase
–
geranyl_diphosphate + H2O <=> geraniol + diphosphate 3.1.7.11 geranyl diphosphate diphosphatase
3.1.7.3 monoterpenyl-diphosphatase
4.2.3.104 alpha-humulene synthase
–
–
–
19-hydroxytestosterone + O2 + reduced_flavodoxin <=> 19-oxotestosterone + 2 H2O + flavin 1.14.14.14 aromatase
–
H+ + salicylate + O2 + NADH <=> catechol + CO2 + H2O + NAD+ 1.14.13.1 salicylate 1-monooxygenase
–
CMP-N-acetylneuraminate + GT1c <=> CMP + GQ1c 2.4.99
–
D-galacturonate + NADH + H+ <=> L-galactonate + NAD+ 1.1.1
1.1.1.365 D-galacturonate reductase
–
–
2-oxoisovalerate + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
–
1-methoxy-1'-hydroxy-3,4-didehydrolycopene <=> 1-methoxy-1'-hydroxy-3,4,3',4'-tetradehydrolycopene 1.3.99.27 1-hydroxycarotenoid 3,4-desaturase
–
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ <=> (S)-2-Hydroxy-2-methyl-3-oxobutanoate + NADPH + H+ 1.1.1.383 ketol-acid reductoisomerase [NAD(P)+]
1.1.1.86 ketol-acid reductoisomerase (NADP+)
–
–
H2O + 5,6-dihydrouracil <=> H+ + N-Carbamoyl-beta-alanine 3.5.2.16 maleimide hydrolase
3.5.2.2 dihydropyrimidinase
–
–
2,3-Dihydroxy-p-cumate + O2 <=> 2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate + H+ 1.13.11
1.13.11.M5
–
–
18-hydroxycorticosterone + reduced_adrenodoxin + H+ + O2 <=> H2O + aldosterone + oxidized_ferredoxin 1.14.15.4 steroid 11beta-monooxygenase
1.14.15.5 corticosterone 18-monooxygenase
–
–
beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[beta-D-Gal-(1->4)-alpha-L-Fuc-(1->6)]-beta-D-GlcNAc-1-Asn + H2O <=> N-acetyl-D-glucosamine + alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[beta-D-Gal-(1->4)-alpha-L-Fuc-(1->6)]-beta-D-GlcNAc-1-Asn 3.2.1.52 beta-N-acetylhexosaminidase
–
ureidoacrylate + H2O <=> 2-aminoacrylate + Carbamate + H+ 3.5.1.110 ureidoacrylate amidohydrolase
–
methylamine + L-glutamate <=> N-Methyl-L-glutamate + NH3 2.1.1.21 methylamine---glutamate N-methyltransferase
–
9-cis-violaxanthin + O2 <=> 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12''-apo-beta-caroten-12''-al 1.13.11.51 9-cis-epoxycarotenoid dioxygenase
–
D-glycerate + NAD+ <=> H+ + Hydroxypyruvate + NADH 1.1.1.237 hydroxyphenylpyruvate reductase
1.1.1.26 glyoxylate reductase
1.1.1.27 L-lactate dehydrogenase
1.1.1.28 D-lactate dehydrogenase
1.1.1.29 glycerate dehydrogenase
1.1.1.60 2-hydroxy-3-oxopropionate reductase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.81 hydroxypyruvate reductase
1.1.1.92 oxaloglycolate reductase (decarboxylating)
–
–
–
–
–
–
–
–
–
S-adenosyl-L-methionine + (S)-norcoclaurine <=> H+ + S-adenosyl-L-homocysteine + (S)-Coclaurine 2.1.1.128 (RS)-norcoclaurine 6-O-methyltransferase
–
5-Aminopentanal <=> DELTA1-piperideine not assigned
 –
nicotinate + H2O + Ferrocytochrome <=> 6-Hydroxynicotinate + Ferrocytochrome + H+ 1.17.2.1 nicotinate dehydrogenase (cytochrome)
–
propionyl-CoA + L-lactate <=> propionate + lactoyl-CoA 2.8.3.1 propionate CoA-transferase
–
2-Hydroxy-2-hydropyrone-4,6-dicarboxylate + NAD+ <=> 2-Pyrone-4,6-dicarboxylate + NADH + H+ 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
–
dTTP + H2O <=> dTMP + diphosphate + H+ 3.6.1.12 dCTP diphosphatase
3.6.1.23 dUTP diphosphatase
3.6.1.39 thymidine-triphosphatase
3.6.1.55 8-oxo-dGTP diphosphatase
3.6.1.65 (d)CTP diphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
–
–
–
2''-deoxyguanosine + ATP <=> H+ + dGMP + ADP 2.7.1.113 deoxyguanosine kinase
2.7.1.145 deoxynucleoside kinase
2.7.1.20 adenosine kinase
2.7.1.74 deoxycytidine kinase
2.7.1.76 2'-deoxyadenosine kinase
–
–
–
–
–
(1R,5aS,6R)-4a-Hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate <=> (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H2O not assigned
 –
Lipoyl-protein + Lipoyl-carrier_protein_E2 <=> glycine_cleavage_system_H + Enzyme_N6-(lipoyl)lysine 2.3.1.200 lipoyl amidotransferase
–
1-Alkyl-2-acylglycerol + CDP-ethanolamine <=> O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H+ 2.7.8.1 ethanolaminephosphotransferase
–
(R)-mevalonate + ATP <=> (R)-3-phosphomevalonate + ADP + H+ 2.7.1.185 mevalonate 3-kinase
–
protein + lipoic_acid + ATP <=> [dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine + AMP + diphosphate + H+ 6.3.1.20 lipoate---protein ligase
–
4-hydroxybutyrate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + ADP + phosphate 6.2.1.56 4-hydroxybutyrate---CoA ligase (ADP-forming)
–
N-Monomethyl-2-aminoethylphosphonate <=> N-Dimethyl-2-aminoethylphosphonate not assigned
 –
D-Aspartate + (D)-4-hydroxy-alpha-ketoglutarate <=> oxaloacetate + L-erythro-4-hydroxyglutamate 2.6.1.21 D-amino-acid transaminase
–
H+ + 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone_5'-phosphate + H2O <=> 5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NH3 3.5.4.26 diaminohydroxyphosphoribosylaminopyrimidine deaminase
–
ascorbate <=> ascorbate + dehydroascorbate + H+ 1.11.1.11 L-ascorbate peroxidase
–
Theobromine + NADPH + O2 + H+ <=> 7-methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.179 methylxanthine N3-demethylase
–
nogalaviketone + NADPH + H+ <=> Nogalavinone + NADP+ 1.1.1
–
(6R)-L-erythro-6,7-dihydrobiopterin <=> dihydrobiopterin not assigned
 –
L-arabinopyranose <=> L-ribulose 5.3.1.4 L-arabinose isomerase
5.3.1.5 xylose isomerase
–
–
N2-(2-carboxyethyl)-L-arginine + ATP <=> deoxyamidinoproclavaminate + AMP + diphosphate 6.3.3.4 (carboxyethyl)arginine beta-lactam-synthase
–
trans-2-hexenoyl-CoA + NADPH <=> hexanoyl-CoA + NADP+ 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.44 trans-2-enoyl-CoA reductase (NAD+)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)
–
–
–
–
dethiobiotin + Sulfur_donor + 2 S-adenosyl-L-methionine + 2 e- + 2 H+ <=> biotin + 2 L-methionine + 2 5''-Deoxyadenosine 2.8.1.6 biotin synthase
–
staurosporine_aglycone + dTDP-L-ristosamine <=> H+ + Holyrine_A + dTDP 2.4
2.4.1
–
–
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP+ <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + NADPH + H+ 1.1.1.384 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase
–
15-hydroperoxyeicosatetraenoic_acid <=> 15H-11,12-EETA 1.14.14.1 unspecific monooxygenase
–
n-butane + NADH + O2 + H+ <=> 1-butanol + NAD+ + H2O 1.14.13.230 butane monooxygenase (soluble)
–
malonyl-CoA + (S)-methylmalonyl-CoA + NADPH + H+ + (2S)-ethylmalonyl-CoA <=> tylactone + CoA + CO2 + H2O + NADP+ 2.3.1
–
dimethyl_sulfone + 2 FMNH2 + 2 O2 <=> Methanesulfonic_acid + formaldehyde + 2 FMN + 2 H2O 1.14.14.35 dimethylsulfone monooxygenase
–
UDP-galactose + D-glucose <=> lactose + UDP + H+ 2.4.1.22 lactose synthase
2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
2.4.1.90 N-acetyllactosamine synthase
–
–
–
H+ + orotidine_5''-phosphate <=> CO2 + UMP 4.1.1.23 orotidine-5'-phosphate decarboxylase
–
oxaloacetate + ATP <=> CO2 + phosphoenolpyruvate + ADP 4.1.1.31 phosphoenolpyruvate carboxylase
4.1.1.38 phosphoenolpyruvate carboxykinase (diphosphate)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)
–
–
–
pyruvate + L-serine <=> L-alanine + Hydroxypyruvate 2.6.1.44 alanine---glyoxylate transaminase
2.6.1.45 serine---glyoxylate transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.64 glutamine---phenylpyruvate transaminase
2.6.1.B16
–
–
–
–
–
malonyl-CoA + NADPH + H+ <=> 3-oxopropanoyl-CoA + NADP+ + H2O not assigned
 –
vindoline + Catharanthine <=> 3'',4''-Anhydrovinblastine not assigned
 –
succinate + NAD+ <=> fumarate + NADH + H+ 1.3.1.6 fumarate reductase (NADH)
–
paraxanthine + NADH + H+ + O2 <=> 1-Methylxanthine + NAD+ + formaldehyde + H2O 1.13.12
–
NADP+ + H2O + L-glutamate <=> NADPH + 2-oxoglutarate + NH3 + H+ 1.4.1.13 glutamate synthase (NADPH)
1.4.1.2 glutamate dehydrogenase
1.4.1.3 glutamate dehydrogenase [NAD(P)+]
1.4.1.4 glutamate dehydrogenase (NADP+)
–
–
–
–
Dialdehyde + H+ <=> 4,21-Dehydrocorynantheine_aldehyde + H2O not assigned
 –
dTDP-3-O-methyl-beta-L-rhamnose + Calicheamicin_PsAg <=> dTDP + Calicheamicin_alpha3(I) 2.4.1
–
prephenate + NAD+ <=> 4-hydroxyphenylpyruvate + CO2 + NADH 1.3.1.12 prephenate dehydrogenase
1.3.1.13 prephenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]
–
–
–
gamma-L-Glutamyl-L-propargylglycine + 2-oxoglutarate + O2 <=> L-gamma-Glutamyl-(3R)-L-beta-ethynylserine + succinate + CO2 1.14.11
–
L-lysine <=> (3R)-3-methyl-D-ornithine 5.4.99.58 methylornithine synthase
–
H+ + methylglyoxal + NADH <=> Hydroxyacetone + NAD+ 1.1.1
1.1.1.1 alcohol dehydrogenase
1.1.1.21 aldose reductase
1.1.1.75 (R)-aminopropanol dehydrogenase
–
–
–
–
(R)-2-methylmalonyl-CoA <=> succinyl-CoA 5.4.99.2 methylmalonyl-CoA mutase
5.4.99.63 ethylmalonyl-CoA mutase
5.4.99.64 2-hydroxyisobutanoyl-CoA mutase
–
–
–
UDP-beta-L-arabinopyranose <=> UDP-D-xylose 5.1.3.2 UDP-glucose 4-epimerase
5.1.3.5 UDP-arabinose 4-epimerase
–
–
3-Dehydro-scyllo-inosose + H2O <=> 5-Dehydro-L-gluconate + H+ 3.7.1
–
thiamine_diphosphate + phosphate + H+ <=> thiamine_triphosphate + H2O + H+ 3.6.1.28 thiamine-triphosphatase
–
Betaine_aldehyde + O2 + H2O <=> betaine + H2O2 + H+ 1.1.3.17 choline oxidase
1.1.99.1 choline dehydrogenase
–
–
N1-methylnicotinamide + O2 + H2O <=> N1-methyl-4-pyridone-3-carboxamide + H2O2 + H+ 1.2.3.1 aldehyde oxidase
–
H+ + UDP-D-galacturonate <=> UDP-beta-L-arabinopyranose + CO2 4.1.1.67 UDP-galacturonate decarboxylase
–
chorismate + NH3 <=> anthranilate + pyruvate + H2O 4.1.3.27 anthranilate synthase
–
cyanide + 2 H2O <=> NH3 + formate 3.5.5
–
3-phosphoshikimate + phosphoenolpyruvate <=> 5-enolpyruvylshikimate_3-phosphate + phosphate 2.5.1.19 3-phosphoshikimate 1-carboxyvinyltransferase
–
2-Pyrone-4,6-dicarboxylate + H2O <=> 4-oxalomesaconate + H+ 3.1.1.57 2-pyrone-4,6-dicarboxylate lactonase
–
trans-2-decenoyl-CoA + NADPH <=> decanoyl-CoA + NADP+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)
–
–
spermidine + glutathione + ATP <=> H+ + glutathionylspermidine + ADP + phosphate 6.3.1.8 glutathionylspermidine synthase
6.3.1.9 trypanothione synthase
–
–
(S,S)-Tartrate <=> H2O + oxaloacetate 4.2.1.2 fumarate hydratase
4.2.1.32 L(+)-tartrate dehydratase
4.2.1.34 (S)-2-methylmalate dehydratase
4.2.1.81 D(-)-tartrate dehydratase
–
–
–
–
pyruvate + dATP <=> phosphoenolpyruvate + dADP + H+ 2.7.1.40 pyruvate kinase
–
25-hydroxyvitamin_D3 + reduced_adrenodoxin + H+ + O2 <=> secalciferol + oxidized_ferredoxin + H2O 1.14.15.16 vitamin D3 24-hydroxylase
–
Avermectin_B1a_aglycone + S-adenosyl-L-methionine <=> Avermectin_A1a_aglycone + S-adenosyl-L-homocysteine 2.1.1
–
O-phospho-L-homoserine + H2O <=> phosphate + L-threonine 4.2.3.1 threonine synthase
–
codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + CO2 1.14.11.32 codeine 3-O-demethylase
–
beta-Alanine + 2-oxoglutarate <=> malonate_semialdehyde + L-glutamate 2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.22 (S)-3-amino-2-methylpropionate transaminase
2.6.1.55 taurine---2-oxoglutarate transaminase
2.6.1.ak
–
–
–
–
–
L-asparagine + a_2-oxo_carboxylate <=> 2-oxosuccinamic_acid + an_L-amino_acid 2.6.1.14 asparagine---oxo-acid transaminase
–
L-pyrroline-5-carboxylate + NAD+ + H2O <=> H+ + L-glutamate + NADH 1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
–
–
episterol + O2 + ferricytochrome_b5 + H+ <=> 5-dehydroepisterol + H2O + ferricytochrome_b5 1.14.19.20 Delta7-sterol 5(6)-desaturase
–
GDP-L-fucose + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-1-Cer <=> GDP + Type_IIIH_glycolipid 2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase
–
Cathasterone + O2 + reduced_acceptor <=> Teasterone + H2O + acceptor 1.14
–
(R)-citramalate <=> citraconate + H2O 4.2.1.31 maleate hydratase
4.2.1.35 (R)-2-methylmalate dehydratase
–
–
H+ + acetyl_phosphate + sulfite <=> 2-sulfoacetaldehyde + phosphate 2.3.3.15 sulfoacetaldehyde acetyltransferase
–
7,9,9''-tricis-neurosporene + a_quinone <=> 7,9,7'',9''-tetracis-lycopene + a_quinol 1.3.5.6 9,9'-dicis-zeta-carotene desaturase
–
maltose <=> trehalose 5.4.99.16 maltose alpha-D-glucosyltransferase
–
ascorbate + H2O2 <=> dehydroascorbate + H2O 1.11.1.11 L-ascorbate peroxidase
1.11.1.5 cytochrome-c peroxidase
1.11.1.7 peroxidase
–
–
–
CO + H2O + oxidized_ferredoxin <=> CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.4 anaerobic carbon monoxide dehydrogenase
–
fatty_acid + CoA + ATP <=> stearoyl-CoA + AMP + diphosphate 1.13.12.7 firefly luciferase
6.2.1.12 4-coumarate---CoA ligase
6.2.1.3 long-chain-fatty-acid---CoA ligase
6.2.1.30 phenylacetate---CoA ligase
6.2.1.B3
–
–
–
–
–
CTP + D-tagatose_6-phosphate <=> CDP + D-tagatose_1,6-bisphosphate 2.7.1.11 6-phosphofructokinase
2.7.1.144 tagatose-6-phosphate kinase
–
–
oxaloacetate + acetyl-CoA + phosphate + ADP <=> citrate + CoA + ATP 2.3.3.8 ATP citrate synthase
–
dichlorochromopyrrolate + O2 + NADH + H+ <=> dichloroarcyriaflavin_A + CO2 + H2O + NAD+ 1.13.12.17 dichloroarcyriaflavin A synthase
–
Indole-3-acetamide <=> indole-3-acetonitrile + H2O 4.2.1.84 nitrile hydratase
–
beta-D-GlcNAc6S-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-6-S + H2O <=> beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-6-S + sulfate 3.1.6.14 N-acetylglucosamine-6-sulfatase
–
behenoyl-CoA + malonyl-CoA <=> a_very-long-chain_3-oxoacyl-CoA + CO2 + CoA 2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase
–
dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose + 2-oxoglutarate <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + L-glutamate 2.6.1
–
OPC8-CoA + FAD <=> trans-2-Enoyl-OPC8-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
–
acetate + diphosphate <=> phosphate + acetyl_phosphate 2.7.2.12 acetate kinase (diphosphate)
–
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate <=> 7,8-dihydroneopterin_3''-phosphate + H2O 4.2.1.160 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase
–
4-aminobutanoate + pyruvate <=> succinate_semialdehyde + L-alanine 2.6.1.116 6-aminohexanoate aminotransferase
2.6.1.18 beta-alanine---pyruvate transaminase
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.40 (R)-3-amino-2-methylpropionate---pyruvate transaminase
2.6.1.96 4-aminobutyrate---pyruvate transaminase
–
–
–
–
–
(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O <=> Salicylaldehyde + pyruvate 4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
–
butyryl-[acyl-carrier_protein] + NAD+ <=> trans-but-2-enoyl-[acyl-carrier_protein] + NADH + H+ 1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
2.3.1
–
–
(S)-ureidoglycolate <=> Urea + glyoxylate 3.5.3.21 methylenediurea deaminase
3.5.3.4 allantoicase
4.3.2.3 ureidoglycolate lyase
–
–
–
alpha-D-glucose_1-phosphate <=> alpha-D-glucose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.3 phosphoacetylglucosamine mutase
5.4.2.5 phosphoglucomutase (glucose-cofactor)
5.4.2.6 beta-phosphoglucomutase
5.4.2.8 phosphomannomutase
–
–
–
–
–
–
3-oxoadipate + NADP+ <=> maleylacetate + NADPH + H+ 1.3.1.32 maleylacetate reductase
–
N-succinyl-L-glutamate_5-semialdehyde + NAD+ + H2O <=> N2-succinylglutamate + NADH + H+ 1.2.1.71 succinylglutamate-semialdehyde dehydrogenase
–
S-adenosyl-L-methionine + nocardicin_G <=> isonocardicin_C + S-methyl-5''-thioadenosine + H+ 2.5.1.38 isonocardicin synthase
–
LysW-L-glutamyl_5-phosphate + NADPH + H+ <=> LysW-L-glutamate_5-semialdehyde + NADP+ + phosphate 1.2.1
–
cis-trans-nepetalactol + reduced_flavodoxin + O2 <=> 7-deoxyloganetic_alcohol + flavin + H2O 1.14.14.161 nepetalactol monooxygenase
–
L-methionine + H2O <=> methanethiol + 2-oxobutyrate + NH3 4.4.1.11 methionine gamma-lyase
–
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ <=> 3-hydroxy-3-methyl-2-oxobutanoic_acid + NADPH + H+ 1.1.1.86 ketol-acid reductoisomerase (NADP+)
–
phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O <=> phosphate + N-acetylneuraminate 2.5.1.56 N-acetylneuraminate synthase
–
5beta-Pregnan-3alpha-ol-20-one + NADH + H+ <=> 5beta-pregnane-3alpha,20alpha-diol + NAD+ 1.1.1.112 indanol dehydrogenase
1.1.1.149 20alpha-hydroxysteroid dehydrogenase
1.1.1.53 3alpha(or 20beta)-hydroxysteroid dehydrogenase
–
–
–
ADP + H2O <=> H+ + AMP + phosphate 3.1.15.1 venom exonuclease
3.1.3.1 alkaline phosphatase
3.1.3.10 glucose-1-phosphatase
3.1.3.2 acid phosphatase
3.1.3.26 4-phytase
3.1.3.31 nucleotidase
3.1.3.49 [pyruvate kinase]-phosphatase
3.1.3.5 5'-nucleotidase
3.1.3.8 3-phytase
3.1.4.1 phosphodiesterase I
3.1.4.12 sphingomyelin phosphodiesterase
3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase
3.6.1.1 inorganic diphosphatase
3.6.1.11 exopolyphosphatase
3.6.1.13 ADP-ribose diphosphatase
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.18 FAD diphosphatase
3.6.1.22 NAD+ diphosphatase
3.6.1.42 guanosine-diphosphatase
3.6.1.5 apyrase
3.6.1.53 Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
3.6.1.56 2-hydroxy-dATP diphosphatase
3.6.1.6 nucleoside diphosphate phosphatase
3.6.1.62 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase
3.6.1.64 inosine diphosphate phosphatase
3.6.1.9 nucleotide diphosphatase
6.1.1.14 glycine---tRNA ligase
7.6.2.9 ABC-type quaternary amine transporter
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
O2 + L-cysteine <=> H+ + L-cysteine_sulfinic_acid 1.13.11.20 cysteine dioxygenase
1.14.99.52 L-cysteinyl-L-histidinylsulfoxide synthase
–
–
(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP+ <=> H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH 1.3.1
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
–
–
L-tyrosine + O2 <=> L-Dopa 1.10.3.1 catechol oxidase
1.14.18.1 tyrosinase
–
–
3-Methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
–
–
propionyl-CoA + NADP+ <=> acryloyl-CoA + NADPH + H+ 1.3.1
1.3.1.84 acrylyl-CoA reductase (NADPH)
1.3.1.95 acrylyl-CoA reductase (NADH)
–
–
–
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-R <=> UDP + beta-D-GlcNAc-(1->6)-alpha-D-GalNAc-1-Ser/Thr 2.4.1.102 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
2.4.1.148 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
–
–
acetyl-CoA + propionate <=> acetate + propionyl-CoA 2.8.3.1 propionate CoA-transferase
2.8.3.12 glutaconate CoA-transferase
2.8.3.14 5-hydroxypentanoate CoA-transferase
2.8.3.18 succinyl-CoA:acetate CoA-transferase
–
–
–
–
acetyl-CoA + pyruvate + H2O <=> H+ + (R)-citramalate + CoA 2.3.1.182 (R)-citramalate synthase
2.3.3.13 2-isopropylmalate synthase
–
–
L-Histidinol_phosphate + 2-oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl_phosphate + L-glutamate 2.6.1.9 histidinol-phosphate transaminase
–
2-Hydroxy-6-oxoocta-2,4,7-trienoate + H2O <=> 2-hydroxy-2,4-pentadienoate + Acrylate 3.7.1.9 2-hydroxymuconate-6-semialdehyde hydrolase
–
trans-5-O-caffeoylshikimate + CoA <=> caffeoyl-CoA + shikimate 2.3.1
2.3.1.133 shikimate O-hydroxycinnamoyltransferase
2.3.1.99 quinate O-hydroxycinnamoyltransferase
–
–
–
p-coumaric_acid <=> caffeic_acid 1.14.13
–
UDP-glucose + H2O <=> UMP + alpha-D-aldose_1-phosphate + H+ 3.1.4.1 phosphodiesterase I
3.6.1.45 UDP-sugar diphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
cyclohex-1-ene-1-carbonyl-CoA + H2O <=> 2-hydroxycyclohexane-1-carbonyl-CoA 4.2.1
4.2.1.100 cyclohexa-1,5-dienecarbonyl-CoA hydratase
–
–
L-dihydroanticapsin + NAD+ <=> anticapsin + NADH + H+ 1.1.1.385 dihydroanticapsin dehydrogenase
–
pseudouridine + ATP <=> H+ + pseudouridine_5''-phosphate + ADP 2.7.1.83 pseudouridine kinase
–
glycine + protein + NAD+ <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + [Protein]-dehydroalanine + H2O + H+ 2.4.2.60 cysteine-dependent adenosine diphosphate thiazole synthase
–
ethanol + 2 ferricytochrome_c <=> acetaldehyde + 2 ferricytochrome_c 1.1.2.8 alcohol dehydrogenase (cytochrome c)
1.1.2.9 1-butanol dehydrogenase (cytochrome c)
–
–
phenol + O2 + NADH + H+ <=> catechol + H2O + NAD+ 1.14.13.244 phenol 2-monooxygenase (NADH)
1.14.13.7 phenol 2-monooxygenase (NADPH)
1.14.14.20 phenol 2-monooxygenase (FADH2)
–
–
–
cobalt-factor_III <=> cobalt-precorrin-3B not assigned
 –
7-hydroxymethylchlorophyll_a + NAD+ <=> chlorophyll_b + NADH 1.1.1.294 chlorophyll(ide) b reductase
–
acetaldehyde + NADP+ + H2O <=> acetate + NADPH + H+ 1.2.1
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
–
–
–
–
–
–
–
–
–
H+ + H2O + cytidine <=> uridine + NH3 3.5.4.5 cytidine deaminase
–
squalene + reduced_flavodoxin + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + flavin + H2O 1.14.14.17 squalene monooxygenase
–
coenzyme_B + coenzyme_M + methanophenazine <=> CoM-S-S-CoB + dihydromethanophenazine 1.8.98.1 dihydromethanophenazine:CoB-CoM heterodisulfide reductase
–
trans-aconitate <=> cis-aconitate 5.3.3.7 aconitate Delta-isomerase
–
(S)-3-hydroxybutyryl-CoA + NADP+ <=> acetoacetyl-CoA + NADPH + H+ 1.1.1.157 3-hydroxybutyryl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
neoxanthin <=> 9''-cis-neoxanthin 5.2.1
–
6-deoxocathasterone + O2 <=> 6-deoxoteasterone + H2O 1.14
–
putrescine + S-adenosylmethioninamine <=> H+ + spermidine + S-methyl-5''-thioadenosine 2.5.1.104 N1-aminopropylagmatine synthase
2.5.1.16 spermidine synthase
2.5.1.23 sym-norspermidine synthase
–
–
–
S-adenosyl-L-methionine + putrescine <=> H+ + S-adenosyl-L-homocysteine + N-methylputrescine 2.1.1.53 putrescine N-methyltransferase
–
L-threonine <=> glycine + acetaldehyde 4.1.2.26 phenylserine aldolase
4.1.2.42 D-threonine aldolase
4.1.2.48 low-specificity L-threonine aldolase
4.1.2.5 L-threonine aldolase
–
–
–
–
geranylgeranyl_diphosphate <=> diphosphate + taxa-4,11-diene 4.2.3.17 taxadiene synthase
–
N2-succinylglutamate + H2O <=> L-glutamate + succinate 3.5.1.96 succinylglutamate desuccinylase
–
S-adenosyl-L-methionine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil <=> coenzyme_F0 + 5''-deoxyadenosine + L-methionine + NH3 + H+ 4.3.1.32 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
–
Chloroacetaldehyde + H2O + NAD+ <=> H+ + Chloroacetate + NADH 1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.69 fluoroacetaldehyde dehydrogenase
–
–
–
–
D-glutamine + H2O <=> NH3 + D-glutamate 3.5.1.2 glutaminase
3.5.1.35 D-glutaminase
3.5.1.38 glutamin-(asparagin-)ase
–
–
–
acetyl-CoA + oxaloacetate <=> malonyl-CoA + pyruvate 2.1.3.1 methylmalonyl-CoA carboxytransferase
–
2,3-bisphospho-D-glycerate + protein_L-histidine <=> 3-phospho-D-glycerate + protein_Ntau-phospho-L-histidine 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
–
tryptamine + secologanin <=> strictosidine + H2O 4.3.3.2 strictosidine synthase
–
XMP + diphosphate <=> xanthine + 5-phospho-alpha-D-ribose_1-diphosphate 2.4.2.22 xanthine phosphoribosyltransferase
2.4.2.7 adenine phosphoribosyltransferase
2.4.2.8 hypoxanthine phosphoribosyltransferase
–
–
–
propionyl-CoA + O2 <=> acryloyl-CoA + H2O2 1.3.3.6 acyl-CoA oxidase
–
L-lactaldehyde + NADP+ <=> methylglyoxal + NADPH + H+ 1.1.1.156 glycerol 2-dehydrogenase (NADP+)
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.283 methylglyoxal reductase (NADPH)
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.72 glycerol dehydrogenase (NADP+)
1.1.1.78 methylglyoxal reductase (NADH)
1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+)
–
–
–
–
–
–
–
–
N-acetylneuraminate_9-phosphate + H2O <=> N-acetylneuraminate + phosphate 3.1.3.103 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
–
–
H2O + CTP <=> H+ + phosphate + CDP 3.1.3.2 acid phosphatase
3.1.3.31 nucleotidase
3.1.3.5 5'-nucleotidase
3.1.3.8 3-phytase
3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.28 thiamine-triphosphatase
3.6.1.3 adenosinetriphosphatase
3.6.1.5 apyrase
3.6.1.6 nucleoside diphosphate phosphatase
3.6.1.9 nucleotide diphosphatase
3.6.1.B17
3.6.4.12 DNA helicase
3.6.4.13 RNA helicase
3.6.4.B10
3.6.4.B6
5.6.1.5 proteasome ATPase
7.1.2.2 H+-transporting two-sector ATPase
7.6.2.2 ABC-type xenobiotic transporter
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
torulene + O2 <=> 4''-apo-beta-carotenal + 3-methylbut-2-enal 1.13.11.59 torulene dioxygenase
1.13.11.67 8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase
–
–
4''-apo-beta-carotenal + NAD+ + H2O <=> beta-apo-4'-carotenoic_acid + NADH + H+ 1.2.1.82 beta-apo-4'-carotenal oxygenase
–
4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD+ <=> cycloeucalenone + NADH + CO2 1.1.1.418 plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
–
alpha-Aminoadipoyl-S-acyl_enzyme + NADPH + H+ <=> (S)-2-amino-6-oxohexanoate + Holo-Lys2 + NADP+ 1.2.1.95 L-2-aminoadipate reductase
–
L-cystine + glutathione <=> GSSG + L-cysteine 1.8.1.6 cystine reductase
1.8.4.4 glutathione---cystine transhydrogenase
1.8.4.9 adenylyl-sulfate reductase (glutathione)
–
–
–
(5-hydroxy-1H-indol-3-yl)acetaldehyde + NAD+ + H2O <=> 5-hydroxyindoleacetate + NADH + H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
–
–
dolichyl_phosphate_D-mannose + alpha-D-Man-(1->6)-alpha-D-Man2P(EtN)-(1->4)-alpha-D-GlcN-(1->6)-Ino(acyl)-P <=> dolichyl_phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man2P(EtN)-(1->4)-alpha-D-GlcN-(1->6)-Ino(acyl)-P 2.4.1
–
(2R)-3-sulfolactate + NADP+ <=> 3-sulfopyruvate + NADPH + H+ 1.1.1.338 (2R)-3-sulfolactate dehydrogenase (NADP+)
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
–
–
propionate + ATP <=> propanoyl_phosphate + ADP 2.7.2.1 acetate kinase
2.7.2.14 branched-chain-fatty-acid kinase
2.7.2.15 propionate kinase
2.7.2.6 formate kinase
2.7.2.7 butyrate kinase
–
–
–
–
–
4-methyl-2-oxopentanoate + CoA + oxidized_ferredoxin <=> isovaleryl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
1.2.7.8 indolepyruvate ferredoxin oxidoreductase
–
–
4-hydroxybenzoyl-CoA + H2O <=> H+ + 4-hydroxybenzoate + CoA 3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.23 4-hydroxybenzoyl-CoA thioesterase
–
–
–
2-dehydro-3-deoxy-D-gluconate + ATP <=> H+ + 2-keto-3-deoxy_phosphogluconate + ADP 2.7.1.178 2-dehydro-3-deoxyglucono/galactono-kinase
2.7.1.45 2-dehydro-3-deoxygluconokinase
–
–
dTDP-beta-L-mycarose + NADP+ <=> dTDP-3-methyl-4-oxo-2,6-dideoxy-L-allose + NADPH + H+ 1.1.1
–
6-Deoxocastasterone + O2 + reduced_flavodoxin <=> 6alpha-Hydroxy-castasterone + H2O + flavin 1.14
–
alpha-amino-beta-carboxymuconate-epsilon-semialdehyde + H+ <=> 2-aminomuconate_6-semialdehyde + CO2 4.1.1.45 aminocarboxymuconate-semialdehyde decarboxylase
–
isonocardicin_A <=> nocardicin_A 5.1.1.14 nocardicin A epimerase
–
L-Dopa + O2 + H2O <=> 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2 4.1.1.107 3,4-dihydroxyphenylacetaldehyde synthase
4.1.1.108 4-hydroxyphenylacetaldehyde synthase
–
–
malonyl-CoA + 6 methylmalonyl-CoA + 6 NADPH + 6 H+ <=> 8,8a-deoxyoleandolide + 7 CoA + 7 CO2 + H2O + 6 NADP+ not assigned
 –
2,5-dihydroxybenzaldehyde + NAD+ <=> 2,5-Dihydroxybenzoate + NADH 1.2.1.29 aryl-aldehyde dehydrogenase
–
dolichyl_phosphate_D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> dolichyl_phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol 2.4.1.260 dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase
–
tryprostatin_B + reduced_flavodoxin + O2 <=> 6-hydroxytryprostatin_B + flavin + H2O 1.14.14.118 tryprostatin B 6-hydroxylase
–
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-idosamine + 2-oxoglutarate <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate 2.6.1
2.6.1.34 UDP-N-acetylbacillosamine transaminase
–
–
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose <=> dTDP-4-oxo-2,6-dideoxy-L-mannose 5.1.3
–
ATP + L-2,3-diaminopropionic_acid + citrate <=> AMP + diphosphate + 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H+ 6.3.2.54 L-2,3-diaminopropanoate---citrate ligase
–
H+ + UDP-glucuronate <=> UDPapiose + CO2 4.1.1
–
dATP + uridine <=> dADP + UMP 2.7.1.48 uridine/cytidine kinase
–
3-hydroxypropionate + NAD+ <=> malonate_semialdehyde + NADH + H+ 1.1.1.298 3-hydroxypropionate dehydrogenase (NADP+)
1.1.1.31 3-hydroxyisobutyrate dehydrogenase
1.1.1.59 3-hydroxypropionate dehydrogenase
1.1.1.60 2-hydroxy-3-oxopropionate reductase
–
–
–
–
UDP-N-acetyl-D-glucosamine + chitin <=> UDP + chitin 2.4.1.16 chitin synthase
–
NADPH + L-sorbose_1-phosphate + H+ <=> NADP+ + D-sorbitol_6-phosphate 1.1.1
–
H+ + 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O <=> N-isopropylammelide + ethylamine 3.5.4.43 hydroxydechloroatrazine ethylaminohydrolase
–
(S)-malate + H+ <=> L-lactate + CO2 4.1.1.101 malolactic enzyme
–
all-trans-retinol + NAD+ <=> all-trans-retinal + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.105 all-trans-retinol dehydrogenase (NAD+)
1.1.1.300 NADP-retinol dehydrogenase
1.1.1.315 11-cis-retinol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
–
–
–
–
–
CMP-N-acetylneuraminate + gibberellin_1 <=> CMP + GM1b 2.4.99.4 beta-galactoside alpha-2,3-sialyltransferase
–
alpha-D-glucose_1-phosphate <=> D-glucose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.3 phosphoacetylglucosamine mutase
5.4.2.5 phosphoglucomutase (glucose-cofactor)
5.4.2.8 phosphomannomutase
–
–
–
–
–
5-Aminopentanal + NAD+ + H2O <=> 5-Aminopentanoate + NADH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
–
–
cortisol + NAD+ <=> cortisone + NADH 1.1.1
1.1.1.146 11beta-hydroxysteroid dehydrogenase
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.B40
–
–
–
–
S-adenosyl-L-methionine + genistein <=> H+ + Biochanin_A + S-adenosyl-L-homocysteine 2.1.1.155 kaempferol 4'-O-methyltransferase
2.1.1.212 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
2.1.1.231 flavonoid 4'-O-methyltransferase
2.1.1.46 isoflavone 4'-O-methyltransferase
–
–
–
–
naringenin + O2 + reduced_flavodoxin <=> 2,4'',5,7-tetrahydroxyisoflavanone + H2O + flavin 1.14.14.87 2-hydroxyisoflavanone synthase
–
acetoacetyl-CoA + H2O + acetyl-CoA <=> H+ + CoA + (S)-3-hydroxy-3-methylglutaryl-CoA 2.3.3.10 hydroxymethylglutaryl-CoA synthase
–
CTP + diacylglycerol <=> CDP + phosphatidic_acid + H+ 2.7.1.174 diacylglycerol kinase (CTP)
–
O-mannose_core_M3 + ATP <=> Phospho-core_M3 + ADP 2.7.1.183 glycoprotein-mannosyl O6-kinase
–
S-adenosyl-L-methionine <=> H+ + S-methyl-5''-thioadenosine + 1-aminocyclopropane-1-carboxylate 4.4.1.14 1-aminocyclopropane-1-carboxylate synthase
–
benzoyl-CoA + oxidized_ferredoxin + H2O <=> 4-hydroxybenzoyl-CoA + reduced_ferredoxin 1.1.7.1 4-hydroxybenzoyl-CoA reductase
–
1-Nitropropane + H2O + O2 <=> acetone + nitrite + H2O2 1.7.3.1 nitroalkane oxidase
–
7alpha-hydroxy-4-cholesten-3-one + ferricytochrome_b5 + H+ + O2 <=> 7alpha,12alpha-dihydroxy-4-cholesten-3-one + ferricytochrome_b5 + H2O 1.14.18.8 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase
–
shikimate + ATP <=> H+ + 3-phosphoshikimate + ADP 2.7.1.71 shikimate kinase
–
L-pipecolic_acid + O2 <=> H+ + DELTA1-piperidine_6-carboxylate + H2O2 1.5.3.7 L-pipecolate oxidase
–
(2S,3S)-methylcitrate <=> H2O + 2-methyl-trans-aconitate 4.2.1.117 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
4.2.1.79 2-methylcitrate dehydratase
–
–
ATP + UMP <=> ADP + UDP 2.7.4.14 UMP/CMP kinase
2.7.4.22 UMP kinase
2.7.4.4 nucleoside-phosphate kinase
2.7.4.8 guanylate kinase
–
–
–
–
butyryl-CoA + FAD <=> crotonyl-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
1.3.8.1 short-chain acyl-CoA dehydrogenase
1.3.8.4 isovaleryl-CoA dehydrogenase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.99
–
–
–
–
–
Betaine_aldehyde + NAD+ + H2O <=> H+ + betaine + NADH 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.21 glycolaldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase
1.2.1.8 betaine-aldehyde dehydrogenase
–
–
–
–
–
–
5-COOH-porphyrinogen_I + acceptor <=> Coproporphyrin_I + reduced_acceptor + 6 H+ not assigned
 –
4-methyl-2-oxopentanoate + thiamine_diphosphate <=> 3-Methyl-1-hydroxybutyl-ThPP + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
–
N-Carbamoyl-beta-alanine + H2O + H+ <=> beta-Alanine + NH3 + CO2 3.5.1.6 beta-ureidopropionase
–
myristoyl-CoA + FAD <=> 2-tetradecenoyl-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.8.8 long-chain acyl-CoA dehydrogenase
1.3.8.9 very-long-chain acyl-CoA dehydrogenase
1.3.99
–
–
–
–
–
uridine + GTP <=> H+ + UMP + GDP 2.7.1.48 uridine/cytidine kinase
–
LysW-gamma-L-lysine + H2O <=> L-lysine + [LysW]-C-terminal-L-glutamate 3.5.1.130 [amino group carrier protein]-lysine hydrolase
–
an_alcohol + NADP+ <=> an_aldehyde + NADPH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.191 indole-3-acetaldehyde reductase (NADPH)
1.1.1.195 cinnamyl-alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.215 gluconate 2-dehydrogenase
1.1.1.263 1,5-anhydro-D-fructose reductase
1.1.1.265 3-methylbutanal reductase
1.1.1.283 methylglyoxal reductase (NADPH)
1.1.1.4 (R,R)-butanediol dehydrogenase
1.1.1.61 4-hydroxybutyrate dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.72 glycerol dehydrogenase (NADP+)
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.80 isopropanol dehydrogenase (NADP+)
1.1.1.91 aryl-alcohol dehydrogenase (NADP+)
1.1.1.97 3-hydroxybenzyl-alcohol dehydrogenase
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
H2O + GTP <=> H+ + diphosphate + 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate + formate 3.5.4.25 GTP cyclohydrolase II
–
L-arginine + succinyl-CoA <=> H+ + N2-succinyl-L-arginine + CoA 2.3.1.109 arginine N-succinyltransferase
–
cis-3,4-leucopelargonidin + NADP+ <=> (+)-dihydrokaempferol + NADPH + H+ 1.1.1.219 dihydroflavonol 4-reductase
–
L-gulono-1,4-lactone + NADP+ <=> D-glucuronolactone + NADPH + H+ 1.1.1.19 glucuronate reductase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.20 glucuronolactone reductase
1.1.1.21 aldose reductase
–
–
–
–
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate <=> CoA + 2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric_acid 2.3.1.105 alkylglycerophosphate 2-O-acetyltransferase
–
geranyl_diphosphate <=> (+)-camphene + diphosphate 4.2.3.116 (+)-camphene synthase
4.2.3.20 (R)-limonene synthase
–
–
Pectin + H2O <=> pectate + methanol + H+ 3.1.1.11 pectinesterase
–
ribitol + NAD+ <=> D-ribulose + NADH + H+ 1.1.1.114 apiose 1-reductase
1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.287 D-arabinitol dehydrogenase (NADP+)
1.1.1.56 ribitol 2-dehydrogenase
1.1.1.9 D-xylulose reductase
–
–
–
–
–
cathenamine <=> 4,21-Dehydrogeissoschizine not assigned
 –
dTDP-4-ethylamino-3-O-methyl-2,4-dideoxy-L-threo-pentopyranose + Calicheamicin_alpha3(I) <=> dTDP + Calicheamicin_gamma(1)I 2.4.2
–
4-coumaroyl-CoA + shikimate <=> 4-coumaroylshikimate + CoA 2.3.1.133 shikimate O-hydroxycinnamoyltransferase
2.3.1.140 rosmarinate synthase
2.3.1.99 quinate O-hydroxycinnamoyltransferase
–
–
–
D-ribulose_5-phosphate <=> H+ + formate + L-3,4-dihydroxybutan-2-one_4-phosphate 4.1.99.12 3,4-dihydroxy-2-butanone-4-phosphate synthase
–
2-deoxy-D-ribose + ATP <=> 2-deoxy-D-ribose_5-phosphate + ADP + H+ 2.7.1.15 ribokinase
2.7.1.229 deoxyribokinase
–
–
paraxanthine + NADPH + O2 + H+ <=> 7-methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
–
–
pyridoxamine_5''-phosphate + H2O <=> pyridoxamine + phosphate 3.1.3.2 acid phosphatase
3.1.3.74 pyridoxal phosphatase
–
–
UDP-N-acetyl-D-glucosamine + beta-D-GlcNAc-(1->6)-[beta-D-GlcNAc-(1->2)]-alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->4)-[beta-D-GlcNAc-(1->2)]-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> UDP + beta-D-GlcNAc-(1->6)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)]-alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->4)-[beta-D-GlcNAc-(1->2)]-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn 2.4.1.201 alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
–
ATP + alpha-D-glucose <=> ADP + alpha-D-glucose_6-phosphate 2.7.1.1 hexokinase
2.7.1.2 glucokinase
–
–
ITP + uridine <=> IDP + UMP 2.7.1.48 uridine/cytidine kinase
–
L-glutamate + L-2-aminobutanoate + ATP <=> gamma-Glu-2-aminobutyrate + ADP + phosphate + H+ 6.3.2.2 glutamate---cysteine ligase
–
Fe-coproporphyrin_III + H+ <=> coproporphyrin_III + Fe2+ 4.99.1.9 coproporphyrin ferrochelatase
–
1-phosphatidyl-1D-myo-inositol_3,5-bisphosphate + H2O <=> 1-phosphatidyl-1D-myo-inositol_5-phosphate + phosphate 3.1.3
3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.56 inositol-polyphosphate 5-phosphatase
3.1.3.95 phosphatidylinositol-3,5-bisphosphate 3-phosphatase
–
–
–
–
riboflavin + alpha-D-glucose_1-phosphate <=> FMN + D-glucose 2.7.1.42 riboflavin phosphotransferase
–
(2R)-3-sulfolactate <=> pyruvate + sulfite + H+ 4.4.1.24 (2R)-sulfolactate sulfo-lyase
–
L-glutamine + pyruvate <=> 2-Oxoglutaramate + L-alanine 2.6.1.15 glutamine---pyruvate transaminase
2.6.1.51 serine---pyruvate transaminase
–
–
(2E,4Z)-2-hydroxy-5-methylhexa-2,4-diendioate <=> 2-Oxo-5-methyl-cis-muconate 5.3.2.6 2-hydroxymuconate tautomerase
–
H2O + 2-O-(alpha-D-mannopyranosyl)-3-phospho-D-glycerate <=> 2-O-(alpha-D-mannopyranosyl)-D-glycerate + phosphate 3.1.3.70 mannosyl-3-phosphoglycerate phosphatase
3.1.3.85 glucosyl-3-phosphoglycerate phosphatase
–
–
H2O + 3-phospho-D-glycerate <=> D-glycerate + phosphate 3.1.3.10 glucose-1-phosphatase
3.1.3.19 glycerol-2-phosphatase
3.1.3.2 acid phosphatase
3.1.3.20 phosphoglycerate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.38 3-phosphoglycerate phosphatase
3.1.3.58 sugar-terminal-phosphatase
3.1.3.60 phosphoenolpyruvate phosphatase
3.1.3.8 3-phytase
–
–
–
–
–
–
–
–
–
–
UDP-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol <=> 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1->2)-O-alpha-D-glucopyranosyl)-sn-glycerol + UDP + H+ 2.4.1.208 diglucosyl diacylglycerol synthase (1,2-linking)
–
7,8-dihydroneopterin_3''-phosphate + H2O <=> 7,8-dihydroneopterin + phosphate 3.6.1
–
H+ + cumic_acid + NADH + O2 <=> cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ 1.14.12.25 p-cumate 2,3-dioxygenase
–
naringenin + 2-oxoglutarate + O2 <=> (+)-dihydrokaempferol + succinate + CO2 1.14.11.9 flavanone 3-dioxygenase
–
H2O + formyl-CoA <=> H+ + formate + CoA 3.1.2.10 formyl-CoA hydrolase
–
N-acetylneuraminate + CTP <=> CMP-N-acetylneuraminate + diphosphate 2.7.7.43 N-acylneuraminate cytidylyltransferase
2.7.7.92 3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase
–
–
GDP-L-fucose + paragloboside <=> GDP + Fuc-Lc4Cer 2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
–
Mithramycin_DK <=> mithramycin not assigned
 –
L-lactate <=> formate + acetaldehyde 4.1.2.36 lactate aldolase
–
D-myo-Inositol_3,4-bisphosphate + H2O <=> D-myo-Inositol_1-phosphate + phosphate 3.1.3.66 phosphatidylinositol-3,4-bisphosphate 4-phosphatase
–
nitroethane + O2 + FMNH2 <=> acetaldehyde + nitrite + H2O + FMN + H+ 1.13.12.16 nitronate monooxygenase
1.7.3.1 nitroalkane oxidase
–
–
Cl- + hydroquinone + GSSG + H+ <=> chlorohydroquinone + glutathione 2.5.1
–
NAD+ + glycine + Sulfide <=> nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + H2O + H+ 2.4.2.59 sulfide-dependent adenosine diphosphate thiazole synthase
–
trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide + H2O <=> 2-chloromaleylacetate + H+ 3.1.1.45 carboxymethylenebutenolidase
–
malonyl-[acyl-carrier_protein]_methyl_ester + malonyl-[acyl-carrier_protein] + H+ <=> 3-Ketoglutaryl-[acp]_methyl_ester + CO2 + [acyl-carrier_protein] 2.3.1.179 beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I
–
–
phenylpyruvate + acetyl-CoA + H2O <=> 2-Benzylmalate + CoA + H+ 2.3.3
–
D-ribulose_1,5-bisphosphate + O2 <=> 2-Phosphoglycolate + 3-phospho-D-glycerate + H+ 1.13.11
4.1.1.39 ribulose-bisphosphate carboxylase
–
–
L-adrenaline + H2O + O2 <=> 3,4-dihydroxyphenylglycolaldehyde + methylamine + H2O2 1.4.3.4 monoamine oxidase
–
acetaldehyde + CoA + NAD+ <=> acetyl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.42 hexadecanal dehydrogenase (acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)
–
–
–
–
loganin + reduced_flavodoxin + O2 <=> secologanin + flavin + 2 H2O 1.14.19.62 secologanin synthase
–
3-dehydro-L-gulonate + NADP+ <=> (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NADPH + H+ 1.1.1.130 3-dehydro-L-gulonate 2-dehydrogenase
–
S-adenosyl-L-methionine + Tetracenomycin_E <=> tetracenomycin_A2 + S-adenosyl-L-homocysteine 2.1.1
–
geranyl_diphosphate + H2O <=> Sabinene_hydrate + diphosphate 4.2.3.11 sabinene-hydrate synthase
–
H+ + alpha-D-mannose_1-phosphate + GTP <=> GDP-mannose + diphosphate 2.7.7.13 mannose-1-phosphate guanylyltransferase
2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
2.7.7.30 fucose-1-phosphate guanylyltransferase
2.7.7.34 glucose-1-phosphate guanylyltransferase
–
–
–
–
ATP + L-xylulose <=> ADP + L-xylulose_1-phosphate 2.7.1.5 rhamnulokinase
–
S-adenosyl-L-methionine + N-acetylserotonin <=> H+ + S-adenosyl-L-homocysteine + Melatonin 2.1.1.4 acetylserotonin O-methyltransferase
–
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA + NAD+ <=> H+ + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA + NADH 1.1.1
–
H+ + phosphoenolpyruvate <=> Phosphonopyruvate 5.4.2.9 phosphoenolpyruvate mutase
–
(3E,3'E)-1,1'-dimethoxy-3,3',4,4'-tetradehydro-1,1',2,2'-tetrahydro-psi,psi-caroten-2-one + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> 2,2''-dioxospirilloxanthin + oxidized_ferredoxin + H2O 1.14.15.9 spheroidene monooxygenase
–
O2 + L-tryptophan <=> Indole-3-acetamide + H2O + CO2 1.13.12.3 tryptophan 2-monooxygenase
–
L-Histidinol + NAD+ <=> H+ + L-histidinal + NADH 1.1.1.23 histidinol dehydrogenase
–
H+ + L-pyrroline-5-carboxylate + malonyl-CoA + H2O <=> (2S,5S)-5-carboxymethylproline + CoA + CO2 2.3.1.226 carboxymethylproline synthase
–
CoA + oxalate + ATP <=> oxalyl-CoA + diphosphate + AMP 6.2.1.8 oxalate---CoA ligase
–
meso-2,6-diaminoheptanedioate + NADP+ + H2O <=> L-2-amino-6-oxopimelate + NH3 + NADPH + H+ 1.4.1.16 diaminopimelate dehydrogenase
–
2-chloro-3-oxohexanedioic_acid <=> Chloroacetate + succinate not assigned
 –
N-formylmaleamic_acid + H2O <=> H+ + Maleamate + formate 3.5.1.106 N-formylmaleamate deformylase
–
L-Histidinol_phosphate + H2O <=> L-Histidinol + phosphate 3.1.3.15 histidinol-phosphatase
3.1.3.2 acid phosphatase
–
–
monoacylglycerol + H2O <=> glycerol + fatty_acid + H+ 3.1.1.23 acylglycerol lipase
3.1.1.3 triacylglycerol lipase
3.1.1.67 fatty-acyl-ethyl-ester synthase
3.1.1.79 hormone-sensitive lipase
–
–
–
–
Premithramycin_B + NADPH + H+ + O2 <=> Mithramycin_DK + NADP+ + CO2 1.14.13
–
3-Hydroxy-OPC8-CoA + NAD+ <=> 3-Oxo-OPC8-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
2,5-Dihydroxybenzoate + O2 <=> maleylpyruvate + H+ 1.13.11.4 gentisate 1,2-dioxygenase
1.13.11.86 5-aminosalicylate 1,2-dioxygenase
–
–
N,N-dihydroxy-L-phenylalanine + H+ <=> (E)-phenylacetaldoxime + CO2 + H2O 1.14.14.40 phenylalanine N-monooxygenase
–
ATP + N-Acetyl-L-Asp-L-Glu + L-glutamate <=> ADP + phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate 6.3.2.42 N-acetylaspartylglutamylglutamate synthase
–
linoleic_acid + O2 <=> (9Z,11E,13S)-13-hydroperoxy-9,11-octadecadienoate 1.13.11.12 linoleate 13S-lipoxygenase
1.13.11.31 arachidonate 12-lipoxygenase
1.13.11.33 arachidonate 15-lipoxygenase
1.13.11.34 arachidonate 5-lipoxygenase
–
–
–
–
ITP + D-tagatose_6-phosphate <=> IDP + D-tagatose_1,6-bisphosphate 2.7.1.11 6-phosphofructokinase
2.7.1.144 tagatose-6-phosphate kinase
–
–
ceramide + phosphatidylcholine <=> sphingomyelin + diacylglycerol 2.7.8.27 sphingomyelin synthase
–
S-adenosyl-L-methionine + gamma-tocotrienol <=> S-adenosyl-L-homocysteine + alpha-tocotrienol + H+ 2.1.1.95 tocopherol C-methyltransferase
–
phosphoenolpyruvate + 2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + H2O <=> 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic_acid + phosphate 2.5.1.97 pseudaminic acid synthase
–
S-adenosyl-L-methionine + 3-Indole-2-oxopropanoate <=> S-adenosyl-L-homocysteine + 3-Methylindolepyruvate 2.1.1.47 indolepyruvate C-methyltransferase
–
5,6-Dihydroxyindole-2-carboxylate + O2 <=> indole-5,6-quinone-2-carboxylic_acid + H2O 1.14.18
1.14.18.B1
–
–
3-(methylthio)propanoate + 5-methyltetrahydrofolate + H+ <=> dimethylsulfoniopropionate + tetrahydrofolate 2.1.1.269 dimethylsulfoniopropionate demethylase
–
Styrene + O2 + NADH + H+ <=> Styrene-cis-2,3-dihydrodiol + NAD+ 1.14.12
–
CoA + 4-hydroxybenzoate + ATP <=> 4-hydroxybenzoyl-CoA + diphosphate + AMP 6.2.1.27 4-hydroxybenzoate---CoA ligase
–
3-phospho-D-glycerate + NAD+ <=> H+ + 3-phosphohydroxypyruvate + NADH 1.1.1.95 phosphoglycerate dehydrogenase
–
D-glucose_6-phosphate <=> D-myo-Inositol_1-phosphate 5.5.1.4 inositol-3-phosphate synthase
–
glycine + H2O + 2 ferricytochrome_c <=> glyoxylate + NH3 + 2 ferricytochrome_c + 2 H+ 1.4.2.1 glycine dehydrogenase (cytochrome)
–
ATP + (R)-pantoate <=> H+ + ADP + (R)-4-phosphopantoate 2.7.1.169 pantoate kinase
–
3-ethylcatechol + O2 <=> 2-hydroxy-6-oxoocta-2,4-dienoate 1.13.11
1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
–
–
methanesulfonate + O2 + FMNH2 <=> formaldehyde + sulfite + FMN + H2O + H+ 1.14.14.34 methanesulfonate monooxygenase (FMNH2)
1.14.14.5 alkanesulfonate monooxygenase
–
–
2-deoxy-alpha-D-ribose_1-phosphate <=> 2-deoxy-D-ribose_5-phosphate 5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.7 phosphopentomutase
5.4.2.8 phosphomannomutase
–
–
–
[LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate + ATP <=> LysW-gamma-L-alpha-aminoadipyl_6-phosphate + ADP 2.7.2.17 [amino-group carrier protein]-L-2-aminoadipate 6-kinase
–
strictosidine + H2O <=> strictosidine_aglycone + D-glucose 3.2.1.105 3alpha(S)-strictosidine beta-glucosidase
3.2.1.125 raucaffricine beta-glucosidase
–
–
H+ + carboxynorspermidine <=> norspermidine + CO2 4.1.1.96 carboxynorspermidine decarboxylase
–
pyruvate + dGTP <=> phosphoenolpyruvate + dGDP + H+ 2.7.1.40 pyruvate kinase
–
beta-D-glucose_6-phosphate + NADP+ <=> 6-phospho-D-glucono-1,5-lactone + NADPH 1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)
–
–
–
H+ + lipoic_acid + ATP <=> lipoyl-AMP + diphosphate 6.3.1.20 lipoate---protein ligase
–
2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl_phosphate <=> 2-(2-carboxy-4-methylthiazol-5-yl)ethyl_phosphate 5.3.99.10 thiazole tautomerase
–
Cholesta-5,7,24-trienol + NADPH + H+ <=> 7-dehydrocholesterol + NADP+ 1.3.1.72 Delta24-sterol reductase
–
N,N-dihydroxy-L-valine + H+ <=> (E)-2-methylpropanal-oxime + CO2 + H2O 1.14.14.38 valine N-monooxygenase
1.14.14.39 isoleucine N-monooxygenase
–
–
H+ + Urea + H2O <=> NH3 + CO2 3.5.1.5 urease
–
8-demethyltetracenomycin_C + dTDP-L-rhamnose <=> 8-demethyl-8-alpha-L-rhamnosyl_tetracenomycin_C + dTDP + H+ 2.4.1.331 8-demethyltetracenomycin C L-rhamnosyltransferase
–
Chloroacetate + H2O <=> H+ + glycolate + Cl- 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)
3.8.1.2 (S)-2-haloacid dehalogenase
3.8.1.3 haloacetate dehalogenase
3.8.1.5 haloalkane dehalogenase
3.8.1.9 (R)-2-haloacid dehalogenase
–
–
–
–
–
D-ornithine + H+ <=> putrescine + CO2 4.1.1.116 D-ornithine/D-lysine decarboxylase
6707
–
–
S-adenosyl-L-methionine + demethylphylloquinol <=> vitamin_KH2 + S-adenosyl-L-homocysteine + H+ 2.1.1.329 demethylphylloquinol methyltransferase
–
5-Aminopentanoate <=> D-proline 1.21.4.1 D-proline reductase
1.4.1.12 2,4-diaminopentanoate dehydrogenase
–
–
H+ + AMP + H2O <=> IMP + NH3 3.5.4.17 adenosine-phosphate deaminase
3.5.4.4 adenosine deaminase
3.5.4.6 AMP deaminase
3.5.4.7 ADP deaminase
–
–
–
–
1-methyl-1H-imidazol-4-ylacetaldehyde + NAD+ + H2O <=> Methylimidazoleacetic_acid + NADH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
–
spermine + O2 + H2O <=> spermidine + 3-aminopropionaldehyde + H2O2 1.5.3.16 spermine oxidase
1.5.3.17 non-specific polyamine oxidase
–
–
glucobrassicin + H2O <=> indole-3-acetonitrile + D-glucose + sulfate + sulfur 3.2.1.147 thioglucosidase
–
2''-deoxyuridine + ATP <=> H+ + dUMP + ADP 2.7.1.145 deoxynucleoside kinase
2.7.1.21 thymidine kinase
2.7.1.74 deoxycytidine kinase
2.7.1.76 2'-deoxyadenosine kinase
–
–
–
–
L-cystathionine + H2O <=> L-homocysteine + pyruvate + NH3 2.5.1.48 cystathionine gamma-synthase
3.5.1.61 mimosinase
4.2.1.22 cystathionine beta-synthase
4.4.1.1 cystathionine gamma-lyase
4.4.1.13 cysteine-S-conjugate beta-lyase
4.4.1.28 L-cysteine desulfidase
4.4.1.3 dimethylpropiothetin dethiomethylase
–
–
–
–
–
–
–
ATP + dUMP <=> ADP + dUDP 2.7.4.13 (deoxy)nucleoside-phosphate kinase
2.7.4.14 UMP/CMP kinase
2.7.4.22 UMP kinase
2.7.4.25 (d)CMP kinase
2.7.4.4 nucleoside-phosphate kinase
2.7.4.9 dTMP kinase
2.7.4.B1
–
–
–
–
–
–
–
UDP-glucose + (1,4-beta-D-glucosyl)n <=> (1,4-beta-D-glucosyl)n + UDP 2.4.1.12 cellulose synthase (UDP-forming)
2.4.1.168 xyloglucan 4-glucosyltransferase
–
–
chlorophyllide_a + NADP+ <=> protochlorophyllide + NADPH + H+ 1.3.1.33 protochlorophyllide reductase
–
O-succinyl-L-homoserine + H2O <=> 2-oxobutyrate + succinate + NH3 + H+ 2.5.1.48 cystathionine gamma-synthase
4.3.1
4.4.1.13 cysteine-S-conjugate beta-lyase
–
–
–
succinate_semialdehyde + NADP+ + H2O <=> NADPH + succinate + H+ 1.1.1.21 aldose reductase
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)
–
–
–
–
–
D-myo-Inositol_1-phosphate + H2O <=> myo-inositol + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.2 acid phosphatase
3.1.3.23 sugar-phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.26 4-phytase
3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase
3.1.3.93 L-galactose 1-phosphate phosphatase
–
–
–
–
–
–
–
geranylgeranyl_diphosphate <=> prephytoene_diphosphate + diphosphate 2.5.1.148 lycopaoctaene synthase
2.5.1.32 15-cis-phytoene synthase
–
–
benzaldehyde + H2O + NAD+ <=> aromatic_carboxylate + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.29 aryl-aldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase
1.2.1.48 long-chain-aldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.67 vanillin dehydrogenase
1.2.1.69 fluoroacetaldehyde dehydrogenase
–
–
–
–
–
–
–
–
–
–
–
–
–
2''-deoxyuridine + phosphate <=> 2-deoxy-alpha-D-ribose_1-phosphate + Uracil 2.4.2.1 purine-nucleoside phosphorylase
2.4.2.2 pyrimidine-nucleoside phosphorylase
2.4.2.3 uridine phosphorylase
2.4.2.4 thymidine phosphorylase
–
–
–
–
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 <=> H+ + 3-(methylthio)propanoate + formate + CO 1.13.11.53 acireductone dioxygenase (Ni2+-requiring)
1.13.11.54 acireductone dioxygenase [iron(II)-requiring]
–
–
L-arogenate + NADP+ <=> L-tyrosine + CO2 + NADPH 1.3.1.43 arogenate dehydrogenase
1.3.1.78 arogenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]
–
–
–
coniferyl_alcohol <=> Guaiacyl_lignin 1.11.1.21 catalase-peroxidase
1.11.1.7 peroxidase
–
–
Dihydrolipoyl-AMP + Lipoyl-carrier_protein_E2 <=> Enzyme_N6-(lipoyl)lysine + AMP + 2 H+ not assigned
 –
6-phosphogluconate + NADP+ <=> 6-phospho-2-dehydro-D-gluconate + NADPH + H+ 1.1.1.43 phosphogluconate 2-dehydrogenase
–
2R,3R-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O 4.2.1.9 dihydroxy-acid dehydratase
–
8,8a-deoxyoleandolide + 2 NADPH + 2 H+ + 2 O2 <=> Oleandolide + 2 NADP+ + 3 H2O not assigned
 –
heme + H+ <=> protoporphyrin_IX + Fe2+ 4.99.1.1 protoporphyrin ferrochelatase
4.99.1.9 coproporphyrin ferrochelatase
–
–
beta-D-Gal6S-(1->4)-beta-D-GlcNAc6S-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-6-S + H2O <=> beta-D-Gal-(1->4)-beta-D-GlcNAc6S-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-6-S + sulfate 3.1.6.4 N-acetylgalactosamine-6-sulfatase
–
1-hydroxy-2-naphthoate + NADH + O2 + H+ <=> 1,2-dihydroxynaphthalene + NAD+ + H2O + CO2 1.14.13.1 salicylate 1-monooxygenase
1.14.13.135 1-hydroxy-2-naphthoate hydroxylase
–
–
geranyl_diphosphate + 2,4-dihydroxy-6-pentylbenzoate <=> cannabigerolate + diphosphate 2.5.1.102 geranyl-pyrophosphate---olivetolic acid geranyltransferase
–
(R)-mevalonate + ATP <=> H+ + (R)-5-phosphomevalonate + ADP 2.7.1.36 mevalonate kinase
–
2,6-dichlorohydroquinone + Cl- + GSSG + H+ <=> 2,3,5-trichlorohydroquinone + glutathione 1.21.4.5 tetrachlorohydroquinone reductive dehalogenase
–
UDP-N-acetyl-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->4)-[beta-D-GlcNAc-(1->2)]-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> UDP + beta-D-GlcNAc-(1->6)-[beta-D-GlcNAc-(1->2)]-alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->4)-[beta-D-GlcNAc-(1->2)]-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn 2.4.1.155 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase
–
1D-myo-inositol_1,3,4,5-tetrakisphosphate + H2O <=> inositol_1,3,4-trisphosphate + phosphate 3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.56 inositol-polyphosphate 5-phosphatase
–
–
ascorbate + O2 + H2O <=> L-threonate + oxalate not assigned
 –
FMNH2 + NADP+ <=> FMN + NADPH + H+ 1.18.1.2 ferredoxin---NADP+ reductase
1.5.1
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.39 FMN reductase [NAD(P)H]
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.42 FMN reductase (NADH)
1.5.1.45 FAD reductase [NAD(P)H]
–
–
–
–
–
–
–
–
–
(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate <=> H2O + (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate 4.2.1.92 hydroperoxide dehydratase
–
S-adenosyl-L-methionine + cobalt-precorrin-5B <=> cobalt-precorrin-6A + S-adenosyl-L-homocysteine 2.1.1.195 cobalt-precorrin-5B (C1)-methyltransferase
–
methanesulfonate + O2 + NADH <=> formaldehyde + sulfite + NAD+ + H2O 1.14.13.111 methanesulfonate monooxygenase (NADH)
–
beta-D-glucosyl-N-acylsphingosine + H2O <=> ceramide + D-glucose 3.2.1.104 steryl-beta-glucosidase
3.2.1.21 beta-glucosidase
3.2.1.45 glucosylceramidase
3.2.1.62 glycosylceramidase
–
–
–
–
ATP + pyridoxamine <=> H+ + ADP + pyridoxamine_5''-phosphate 2.7.1.35 pyridoxal kinase
2.7.1.49 hydroxymethylpyrimidine kinase
–
–
2-Oxo-5-methyl-cis-muconate <=> (2E,4Z)-2-hydroxyhexa-2,4-dienoate + CO2 4.1.1.77 2-oxo-3-hexenedioate decarboxylase
–
heme + (2E,6E)-farnesyl_diphosphate + H2O <=> heme_O + diphosphate 2.5.1.141 heme o synthase
–
geranylgeranyl_diphosphate <=> terpentedienyl_diphosphate 5.5.1.15 terpentedienyl-diphosphate synthase
–
Insulin + 2 glutathione <=> reduced_insulin + GSSG 1.8.4.2 protein-disulfide reductase (glutathione)
–
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate <=> L-pipecolic_acid not assigned
 –
5-Oxoavermectin_''''1a''''_aglycone + NADPH + H+ <=> Avermectin_B1a_aglycone + NADP+ not assigned
 –
copalyl_diphosphate <=> diphosphate + abieta-7,13-diene 4.2.3.18 abieta-7,13-diene synthase
–
putrescine + 2-oxoglutarate <=> L-glutamate + Aliphatic-Omega-Amino-Aldehydes 2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.29 diamine transaminase
2.6.1.82 putrescine---2-oxoglutarate transaminase
–
–
–
beta-D-fructose_6-phosphate + diphosphate <=> H+ + phosphate + D-fructose_1,6-bisphosphate 2.7.1.90 diphosphate---fructose-6-phosphate 1-phosphotransferase
–
H+ + alpha-D-glucose_1-phosphate + ATP <=> ADP-glucose + diphosphate 2.7.7.24 glucose-1-phosphate thymidylyltransferase
2.7.7.27 glucose-1-phosphate adenylyltransferase
2.7.7.9 UTP---glucose-1-phosphate uridylyltransferase
–
–
–
S-adenosyl-L-methionine + L-homocysteine <=> L-methionine + S-adenosyl-L-homocysteine + H+ 2.1.1.10 homocysteine S-methyltransferase
2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
2.1.1.280 selenocysteine Se-methyltransferase
–
–
–
–
Fumiquinazoline_A + O2 <=> Fumiquinazoline_C + H2O2 1.5.3
–
L-lactate + oxaloacetate <=> pyruvate + (S)-malate 1.1.99.7 lactate---malate transhydrogenase
–
8 malonyl-CoA + [acyl-carrier_protein] <=> 3,5,7,9,11,13,15-Heptaoxo-hexadecanoyl-[acp] + 8 CO2 + 8 CoA 2.3.1
–
(R)-1-aminopropan-2-ol + NAD+ <=> H+ + aminoacetone + NADH 1.1.1.75 (R)-aminopropanol dehydrogenase
–
L-rhamnose + NADP+ <=> L-Rhamno-1,4-lactone + NADPH + H+ 1.1.1.173 L-rhamnose 1-dehydrogenase
1.1.1.377 L-rhamnose 1-dehydrogenase (NADP+)
1.1.1.378 L-rhamnose 1-dehydrogenase [NAD(P)+]
–
–
–
L-ornithine <=> L-proline + NH3 4.3.1.12 ornithine cyclodeaminase
–
L-phenylalanine + O2 + H2O <=> phenylpyruvate + NH3 + H2O2 + H+ 1.13.12.9 phenylalanine 2-monooxygenase
1.4.3.14 L-lysine oxidase
1.4.3.2 L-amino-acid oxidase
–
–
–
glycolaldehyde + 2-oxobutyrate + L-alanine <=> pyridoxine not assigned
 –
5,10-methylenetetrahydrofolate + D-alanine + H2O <=> 2-methyl-DL-serine + tetrahydrofolate 2.1.2.1 glycine hydroxymethyltransferase
2.1.2.7 D-alanine 2-hydroxymethyltransferase
–
–
O-Phospho-DL-homoserine + L-selenocysteine <=> L-selenocystathionine + phosphate 2.5.1.48 cystathionine gamma-synthase
–
Avermectin_B1b_aglycone + S-adenosyl-L-methionine <=> Avermectin_A1b_aglycone + S-adenosyl-L-homocysteine 2.1.1
–
L-Tyrosyl-[pcp] + O2 <=> beta-Hydroxy-L-tyrosyl-[pcp] + H2O not assigned
 –
L-lysine + H+ <=> cadaverine + CO2 4.1.1.17 ornithine decarboxylase
4.1.1.18 lysine decarboxylase
4.1.1.19 arginine decarboxylase
4.1.1.50 adenosylmethionine decarboxylase
4.1.1.86 diaminobutyrate decarboxylase
4.1.1.B12
–
–
–
–
–
–
amylose + phosphate <=> amylose + alpha-D-glucose_1-phosphate 2.4.1.1 glycogen phosphorylase
–
D-ornithine <=> bacitracin not assigned
 –
4alpha-methyl-5alpha-ergosta-8,24-dien-3beta-ol + NADP+ <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+ 1.3.1.70 Delta14-sterol reductase
–
H2O + dGTP <=> H+ + tripolyphosphate + 2''-deoxyguanosine 3.1.5.1 dGTPase
–
H2O + beta-D-fructose_2,6-bisphosphate <=> phosphate + beta-D-fructose_6-phosphate 3.1.3.25 inositol-phosphate phosphatase
3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase
–
–
D-2,5-diaminohexanoate + H2O + NAD+ <=> 2-Amino-5-oxohexanoate + NH3 + NADH + H+ 1.4.1.12 2,4-diaminopentanoate dehydrogenase
–
(3S,5S)-carbapenam_3-carboxylate + 2-oxoglutarate + O2 <=> (5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O 1.14.20
1.14.20.3 (5R)-carbapenem-3-carboxylate synthase
–
–
(2E,6E)-farnesyl_diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphate 4.2.3.25 S-linalool synthase
4.2.3.26 R-linalool synthase
4.2.3.48 (3S,6E)-nerolidol synthase
4.2.3.49 (3R,6E)-nerolidol synthase
–
–
–
–
alpha-D-sedoheptulopyranose_7-phosphate <=> 2-epi-5-epi-valiolone + phosphate 4.2.3.152 2-epi-5-epi-valiolone synthase
–
(10aS)-10,10a-dihydrophenazine-1-carboxylate <=> 5,10-dihydrophenazine_1-carboxylate not assigned
 –
7,8-dihydroneopterin_3''-triphosphate <=> 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde_triphosphate 4.1.2.60 dihydroneopterin triphosphate aldolase
–
1-hydroxylycopene + acceptor <=> 1-hydroxy-3,4-didehydrolycopene + reduced_acceptor 1.3.99.27 1-hydroxycarotenoid 3,4-desaturase
1.3.99.30 phytoene desaturase (3,4-didehydrolycopene-forming)
1.3.99.37 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
–
–
–
xylitol + NAD+ <=> D-xylose + NADH + H+ 1.1.1.21 aldose reductase
1.1.1.307 D-xylose reductase
–
–
GDP-4-dehydro-6-deoxy-D-mannose + L-glutamate <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + 2-oxoglutarate + NH3 4.2.1.168 GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase
–
3-fumarylpyruvate + H2O <=> H+ + fumarate + pyruvate 3.7.1
3.7.1.20 3-fumarylpyruvate hydrolase
3.7.1.5 acylpyruvate hydrolase
4.1.1.112 oxaloacetate decarboxylase
–
–
–
–
chorismate <=> 4-hydroxybenzoate + pyruvate 4.1.3.40 chorismate lyase
–
D-mannitol + NADP+ <=> D-fructose + NADPH + H+ 1.1.1.138 mannitol 2-dehydrogenase (NADP+)
1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.21 aldose reductase
1.1.1.287 D-arabinitol dehydrogenase (NADP+)
1.1.1.289 sorbose reductase
1.1.1.67 mannitol 2-dehydrogenase
–
–
–
–
–
–
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O <=> UDP-3-O-((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine + acetate 3.5.1.108 UDP-3-O-acyl-N-acetylglucosamine deacetylase
–
valienone_7-phosphate <=> validone_7-phosphate not assigned
 –
lycopene <=> delta-carotene 5.5.1.18 lycopene epsilon-cyclase
–
H+ + 3-dehydro-L-gulonate <=> L-xylulose + CO2 4.1.1.34 dehydro-L-gulonate decarboxylase
–
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate <=> (S)-allantoin + CO2 4.1.1.97 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
–
(S)-3-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA 4.1.3.4 hydroxymethylglutaryl-CoA lyase
–
(S)-8-oxocitronellyl_enol + NAD+ <=> (6E)-8-oxogeranial + NADH + H+ 1.3.1.122 (S)-8-oxocitronellyl enol synthase
–
Gibberellin_A53 + O2 + 2-oxoglutarate <=> gibberellin_44 + CO2 + succinate 1.14.11
1.14.11.12 gibberellin-44 dioxygenase
–
–
1,4-androstadiene-3,17-dione + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 9alpha-hydroxy-1,4-androstadiene_3,17-dione + oxidized_ferredoxin + H2O 1.14.15.30 3-ketosteroid 9alpha-monooxygenase
–
Glycerophosphoglycoglycerolipid <=> lipoteichoic_acid not assigned
 –
gamma-glutamyl-gamma-aminobutyraldehyde + NADP+ + H2O <=> 4-(glutamylamino)_butanoate + NADPH + H+ 1.2.1.99 4-(gamma-glutamylamino)butanal dehydrogenase
–
fumitremorgin_C + 2 reduced_flavodoxin + 2 O2 <=> 12alpha,13alpha-dihydroxyfumitremorgin_C + 2 flavin + 2 H2O 1.14.14.119 fumitremorgin C monooxygenase
–
glycine + gamma-Glu-2-aminobutyrate + ATP <=> ophthalmate + ADP + phosphate + H+ 6.3.2.3 glutathione synthase
–
H+ + DELTA1-piperideine-2-carboxylate + H2O <=> 6-Amino-2-oxohexanoate not assigned
 –
H2O + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide <=> N-acetyl-D-galactosamine + globotriaosylceramide 3.2.1.52 beta-N-acetylhexosaminidase
–
ITP + H2O <=> IDP + phosphate + H+ 3.1.3.2 acid phosphatase
3.1.3.5 5'-nucleotidase
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.28 thiamine-triphosphatase
3.6.1.3 adenosinetriphosphatase
3.6.1.5 apyrase
3.6.1.6 nucleoside diphosphate phosphatase
3.6.1.62 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase
3.6.1.64 inosine diphosphate phosphatase
3.6.1.66 XTP/dITP diphosphatase
3.6.1.73 inosine/xanthosine triphosphatase
3.6.1.9 nucleotide diphosphatase
3.6.4.13 RNA helicase
3.6.5.3 protein-synthesizing GTPase
3.6.5.6 tubulin GTPase
7.1.2.1 P-type H+-exporting transporter
7.1.2.2 H+-transporting two-sector ATPase
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
argininosuccinate <=> L-arginine + fumarate 4.3.2.1 argininosuccinate lyase
4.3.2.2 adenylosuccinate lyase
–
–
1-hydroxy-2-naphthaldehyde + NAD+ + H2O <=> 1-hydroxy-2-naphthoate + NADH + H+ 1.2.1
–
4-coumaroyl-CoA + putrescine <=> CoA + N-coumaroylputrescine 2.3.1
2.3.1.138 putrescine N-hydroxycinnamoyltransferase
2.3.1.64 agmatine N4-coumaroyltransferase
–
–
–
2''-deoxyadenosine + phosphate <=> adenine + 2-deoxy-alpha-D-ribose_1-phosphate 2.4.2.1 purine-nucleoside phosphorylase
2.4.2.28 S-methyl-5'-thioadenosine phosphorylase
–
–
acetone + O2 + NADPH + H+ <=> methyl_acetate + NADP+ + H2O 1.14.13.226 acetone monooxygenase (methyl acetate-forming)
–
dihydrokaempferol + reduced_flavodoxin + O2 <=> dihydroquercetin + flavin + H2O 1.14.14.81 flavanoid 3',5'-hydroxylase
1.14.14.82 flavonoid 3'-monooxygenase
–
–
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylic_acid <=> (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate 5.3.3.17 trans-2,3-dihydro-3-hydroxyanthranilate isomerase
–
5-epi-valiolone <=> valienone + H2O 4.2.1
–
pregnenolone + reduced_flavodoxin + O2 <=> 17alpha-hydroxypregnenolone + flavin + H2O 1.14.14.19 steroid 17alpha-monooxygenase
1.14.14.32 17alpha-hydroxyprogesterone deacetylase
–
–
H+ + molybdopterin + ATP <=> adenylyl-molybdopterin + diphosphate 2.7.7.75 molybdopterin adenylyltransferase
–
H+ + H2O + adenine <=> NH3 + hypoxanthine 3.5.4.2 adenine deaminase
–
scyllo-Inositol + NADP+ <=> scyllo-inosose + NADPH + H+ 1.1.1
1.1.1.371 scyllo-inositol 2-dehydrogenase (NADP+)
–
–
beta-D-ribosylnicotinamide + ATP <=> H+ + NMN + ADP 2.7.1.173 nicotinate riboside kinase
2.7.1.22 ribosylnicotinamide kinase
–
–
L-methionine + 2-oxoglutarate <=> 4-methylsulfanyl-2-oxobutanoate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
2.6.1.73 methionine---glyoxylate transaminase
2.6.1.88 methionine transaminase
–
–
–
–
–
–
–
–
–
phosphocholine + H2O <=> choline + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
3.1.6.6 choline-sulfatase
–
–
–
–
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-D-GalNAc-4-S + H2O <=> chondroitin_4-sulfate + N-acetyl-D-galactosamine 3.2.1.35 hyaluronoglucosaminidase
–
acetyl-CoA + 2-hydroxyglutarate <=> acetate + (R)-2-hydroxyglutaryl-1-CoA 2.8.3.12 glutaconate CoA-transferase
–
ATP + pyridoxine <=> H+ + ADP + pyridoxine_5''-phosphate 2.7.1.35 pyridoxal kinase
2.7.1.49 hydroxymethylpyrimidine kinase
–
–
L-galactonate + NAD+ <=> D-tagaturonate + NADH + H+ 1.1.1.414 L-galactonate 5-dehydrogenase
–
versiconal_hemiacetal_acetate + H2O <=> versiconal + acetate 3.1.1.94 versiconal hemiacetal acetate esterase
–
linamarin + H2O <=> acetone_cyanohydrin + D-glucose 3.2.1.117 amygdalin beta-glucosidase
3.2.1.21 beta-glucosidase
–
–
reduced_ferredoxin_[iron-sulfur]_cluster + N2 + ATP + H2O <=> oxidized_ferredoxin + H2 + NH3 + ADP + phosphate + H+ 1.18.6.1 nitrogenase
1.18.6.2 vanadium-dependent nitrogenase
1.19.6.1 nitrogenase (flavodoxin)
–
–
–
violaxanthin <=> neoxanthin 5.3.99.9 neoxanthin synthase
–
S-formylglutathione + H2O <=> H+ + formate + glutathione 3.1.1.56 methylumbelliferyl-acetate deacetylase
3.1.2.12 S-formylglutathione hydrolase
3.1.2.6 hydroxyacylglutathione hydrolase
–
–
–
abieta-7,13-diene + reduced_flavodoxin + O2 <=> abietadienol + flavin + H2O 1.14.14.144 abieta-7,13-diene hydroxylase
–
S-adenosyl-L-methionine + cobalt-precorrin-4 <=> S-adenosyl-L-homocysteine + cobalt-precorrin-5A + H+ 2.1.1.271 cobalt-precorrin-4 methyltransferase
–
UDP-glucose + amylose <=> UDP + starch 2.4.1.11 glycogen(starch) synthase
2.4.1.21 starch synthase (glycosyl-transferring)
2.4.1.242 NDP-glucose---starch glucosyltransferase
–
–
–
quinate + NAD+ <=> 3-dehydroquinate + NADH + H+ 1.1.1.166 hydroxycyclohexanecarboxylate dehydrogenase
1.1.1.24 quinate dehydrogenase
1.1.1.25 shikimate dehydrogenase
1.1.1.282 quinate/shikimate dehydrogenase
–
–
–
–
L-allo-threonine <=> glycine + acetaldehyde 2.1.2.1 glycine hydroxymethyltransferase
4.1.2
4.1.2.26 phenylserine aldolase
4.1.2.48 low-specificity L-threonine aldolase
4.1.2.49 L-allo-threonine aldolase
4.1.3.14 L-erythro-3-hydroxyaspartate aldolase
–
–
–
–
–
–
N-methylmyosmine + H2O <=> 4-(methylamino)-1-(pyridin-3-yl)butan-1-one 1.5.3
–
taxifolin + 2-oxoglutarate + O2 <=> quercetin + succinate + CO2 + H2O 1.14.20.4 anthocyanidin synthase
1.14.20.6 flavonol synthase
–
–
N-(5-phospho-beta-D-ribosyl)anthranilate <=> 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate 5.3.1.24 phosphoribosylanthranilate isomerase
–
vitamin_D3 + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> 25-hydroxyvitamin_D3 + oxidized_ferredoxin + H2O 1.14.15.22 vitamin D 1,25-hydroxylase
–
UDP-glucose + quercetin <=> UDP + quercetin_3-O-glucoside + H+ 2.4.1.115 anthocyanidin 3-O-glucosyltransferase
2.4.1.177 cinnamate beta-D-glucosyltransferase
2.4.1.35 phenol beta-glucosyltransferase
2.4.1.357 phlorizin synthase
2.4.1.91 flavonol 3-O-glucosyltransferase
–
–
–
–
–
2-sulfoacetaldehyde <=> coenzyme_M not assigned
 –
L-threo-tetrahydrobiopterin + 2 NADP+ <=> 6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+ 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
1.1.1.325 sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)
–
–
2-dehydro-D-gluconate + ATP <=> H+ + 6-phospho-2-dehydro-D-gluconate + ADP 2.7.1.13 dehydrogluconokinase
2.7.1.45 2-dehydro-3-deoxygluconokinase
–
–
2,4-Diaminopentanoate + H2O + NAD+ <=> (2R)-2-amino-4-oxopentanoate + NH3 + NADH + H+ 1.4.1.12 2,4-diaminopentanoate dehydrogenase
1.4.1.26 2,4-diaminopentanoate dehydrogenase (NAD+)
–
–
3-phospho-D-glycerate + H+ <=> D-ribulose_1,5-bisphosphate + CO2 + H2O 4.1.1.39 ribulose-bisphosphate carboxylase
–
diacylglycerol + Phospholipid <=> triacylglycerol + Lysophospholipid 2.3.1.158 phospholipid:diacylglycerol acyltransferase
–
isethionate + 2 ferricytochrome_c <=> 2-sulfoacetaldehyde + 2 ferricytochrome_c + 2 H+ 1.1.2
–
5-Dehydro-L-gluconate <=> D-tagaturonate 5.1
5.3.3
–
–
3''-phosphoadenylyl-sulfate + desulfo-indol-3-yl-methyl_glucosinolate <=> adenosine_3,5''-bisphosphate + glucobrassicin + H+ 2.8.2.24 aromatic desulfoglucosinolate sulfotransferase
2.8.2.38 aliphatic desulfoglucosinolate sulfotransferase
–
–
L-aspartate + 2-oxoglutarate <=> oxaloacetate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.75 cysteine-conjugate transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase
–
–
–
–
–
–
–
–
–
–
L-aspartate + L-citrulline + ATP <=> H+ + argininosuccinate + diphosphate + AMP 6.3.4.5 argininosuccinate synthase
–
phosphatidylethanolamine + L-serine <=> phosphatidylserine + ethanolamine 2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase
–
L-dihydroorotate + NAD+ <=> H+ + Orotate + NADH 1.3.1.14 dihydroorotate dehydrogenase (NAD+)
–
L-fucose <=> L-Fuculose 5.3.1.25 L-fucose isomerase
5.3.1.3 D-arabinose isomerase
5.3.1.4 L-arabinose isomerase
–
–
–
L-glutamate + UDP-N-acetylmuramoyl-L-Ala + ATP <=> UDP-MurNAc-L-Ala-L-Glu + phosphate + ADP + H+ 6.3.2.53 UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase
–
Phthalate + O2 + NADH + H+ <=> cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ 1.14.12.7 phthalate 4,5-dioxygenase
–
butyryl-CoA + acetyl-CoA <=> 3-oxohexanoyl-CoA + CoA 2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase
–
–
–
(+)-dihydrokaempferol + 2-oxoglutarate + O2 <=> kaempferol + succinate + CO2 + H2O + H+ 1.14.20.5 flavone synthase I
1.14.20.6 flavonol synthase
–
–
UDP-N-acetyl-D-galactosamine + Type_IIIH_glycolipid <=> UDP + Type_IIIA_glycolipid 2.4.1.40 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
–
gamma-glutamyltyramine + [5-(aminomethyl)furan-3-yl]methyl_diphosphate <=> (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate 2.5.1.131 (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase
–
NADP+ + codeine <=> H+ + NADPH + codeinone 1.1.1.218 morphine 6-dehydrogenase
1.1.1.247 codeinone reductase (NADPH)
–
–
ATP + alpha,omega-dicarboxylate + CoA <=> malonyl-CoA + AMP + diphosphate 6.2.1
6.2.1.23 dicarboxylate---CoA ligase
–
–
7-Mercaptoheptanoylthreonine + ATP <=> H+ + coenzyme_B + ADP 2.7.1
–
(R)-reticuline + reduced_flavodoxin + O2 <=> salutaridine + flavin + 2 H2O 1.14.19.67 salutaridine synthase
–
D-galacturonate + NADPH + H+ <=> L-galactonate + NADP+ 1.1.1
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.203 uronate dehydrogenase
1.1.1.21 aldose reductase
1.1.1.365 D-galacturonate reductase
–
–
–
–
–
choloyl-CoA + H2O <=> H+ + cholic_acid + CoA 2.8.3.25 bile acid CoA-transferase
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.27 choloyl-CoA hydrolase
–
–
–
–
(2E,6E)-farnesyl_diphosphate <=> gamma-humulene + diphosphate 4.2.3.56 gamma-humulene synthase
–
pentalenolactone_D + 2-oxoglutarate + O2 <=> pentalenolactone_F + succinate + CO2 + H2O 1.14.11.36 pentalenolactone F synthase
–
H2O + UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D-glucosamine <=> H+ + lipid_X_(E._coli) + UMP 3.6.1.54 UDP-2,3-diacylglucosamine diphosphatase
–
5 ATP + 3 L-4-hydroxyphenylglycine + L-arginine + L-serine + H2O <=> 5 AMP + 5 diphosphate + nocardicin_G + L-4-Hydroxyphenylglycyl-L-arginine not assigned
 –
siroheme + H+ <=> 12,18-didecarboxysiroheme + CO2 4.1.1.111 siroheme decarboxylase
–
2-xylene + O2 + 2 reduced_ferredoxin_[iron-sulfur]_cluster + 2 H+ <=> 2-Methylbenzyl_alcohol + 2 oxidized_ferredoxin + H2O 1.14.15.26 toluene methyl-monooxygenase
–
L-glutamate + tyramine + ATP <=> gamma-glutamyltyramine + ADP + phosphate + H+ 6.3.4.24 tyramine---L-glutamate ligase
–
H2O + L-arabinono-1,4-lactone <=> H+ + L-arabinonate 3.1.1.15 L-arabinonolactonase
3.1.1.68 xylono-1,4-lactonase
–
–
ethanol + 2 ferricytochrome_b5 <=> acetaldehyde + 2 ferricytochrome_b5 1.1.2.7 methanol dehydrogenase (cytochrome c)
–
1,2-propanediol <=> propionaldehyde + H2O 4.2.1.28 propanediol dehydratase
4.2.1.30 glycerol dehydratase
–
–
cyclooctat-9-ene-5,7-diol + O2 + reduced_acceptor <=> cyclooctatin + H2O + acceptor 1.14.99.62 cyclooctatin synthase
–
palmitoyl-[acyl-carrier_protein] + NADP+ <=> trans-Hexadec-2-enoyl-[acp] + NADPH + H+ 1.3.1
1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
–
–
–
–
–
–
raffinose + H2O <=> D-galactose + sucrose 3.2.1
3.2.1.22 alpha-galactosidase
–
–
2-dehydro-3-deoxy-D-gluconate + NAD+ <=> (4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH + H+ 1.1.1.125 2-deoxy-D-gluconate 3-dehydrogenase
1.1.1.127 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
–
–
uridine + H2O <=> D-ribose + Uracil 3.2.2.1 purine nucleosidase
3.2.2.3 uridine nucleosidase
3.2.2.7 adenosine nucleosidase
3.2.2.8 ribosylpyrimidine nucleosidase
–
–
–
–
L-glutamine <=> D-glutamine 5.1.1.10 amino-acid racemase
5.1.1.18 serine racemase
–
–
sulfur + H2O + O2 <=> Sulfide + sulfite + H+ 1.13.11.55 sulfur oxygenase/reductase
–
L-arabitol + NAD+ <=> L-ribulose + NADH + H+ 1.1.1.13 L-arabinitol 2-dehydrogenase
1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.16 galactitol 2-dehydrogenase
–
–
–
H+ + H2O + Beta-cyanoalanine <=> NH3 + L-aspartate 3.5.5.4 cyanoalanine nitrilase
–
octanoyl-[acyl-carrier_protein] + NAD+ <=> 2-octenoyl-[acyl-carrier_protein] + NADH + H+ 1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
2.3.1
–
–
(R)-2-hydroxyglutaryl-1-CoA <=> H2O + glutaconyl-CoA 4.2.1
4.2.1.167 (R)-2-hydroxyglutaryl-CoA dehydratase
–
–
sucrose + inulin <=> D-glucose + inulin 2.4.1.9 inulosucrase
–
carbazole + O2 + NADH + H+ <=> 2''-aminobiphenyl-2,3-diol + NAD+ 1.14.12.22 carbazole 1,9a-dioxygenase
–
estriol + NADP+ <=> 16alpha-hydroxyestrone + NADPH + H+ 1.1.1.62 17beta-estradiol 17-dehydrogenase
–
H2O + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> beta-D-glucose + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn 3.2.1.106 mannosyl-oligosaccharide glucosidase
–
1-phosphatidyl-1D-myo-inositol_3,4-bisphosphate + H2O <=> 1-phosphatidyl-1D-myo-inositol_5-phosphate + phosphate 3.1.3.66 phosphatidylinositol-3,4-bisphosphate 4-phosphatase
–
L-arabinose + NADH <=> L-arabitol + NAD+ 1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.21 aldose reductase
1.1.1.255 mannitol dehydrogenase
1.1.1.307 D-xylose reductase
–
–
–
–
Gibberellin_A24 <=> gibberellin_a9 + CO2 1.14.11.12 gibberellin-44 dioxygenase
–
spheroiden-2-one + H2O <=> Hydroxyspheroidenone 4.2.1.131 carotenoid 1,2-hydratase
–
prostaglandin_I2 + H2O <=> 6-keto-prostaglandin_F1alpha not assigned
 –
H+ + H2O + (S)-ureidoglycolate <=> NH3 + CO2 + glyoxylate 3.5.1.116 ureidoglycolate amidohydrolase
–
Diacylglyceryl-2-aminoethylphosphonate <=> Diacylglyceryl-N-trimethyl-2-aminoethylphosphonate not assigned
 –
chitin + H2O <=> chitosan + acetate 3.5.1.104 peptidoglycan-N-acetylglucosamine deacetylase
3.5.1.41 chitin deacetylase
–
–
dTDP-L-rhamnose + NADP+ <=> dTDP-4-dehydro-beta-L-rhamnose + NADPH + H+ 1.1.1.133 dTDP-4-dehydrorhamnose reductase
–
UDP-galactose + lactosylceramide <=> UDP + iGb3-Cer 2.4.1.87 N-acetyllactosaminide 3-alpha-galactosyltransferase
–
5-dehydroepisterol + NADPH + H+ + O2 <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADP+ + 2 H2O 1.14.19.41 sterol 22-desaturase
–
1H-indole-5,6-dione + O2 <=> Eumelanin + H2O not assigned
 –
(3R)-hydroxybutyryl-CoA <=> crotonyl-CoA + H2O 4.2.1.119 enoyl-CoA hydratase 2
4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase
4.2.1.55 3-hydroxybutyryl-CoA dehydratase
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
–
–
–
–
–
(S)-3-methyl-2-oxopentanoate + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(2-methylbutanoyl)dihydrolipoyllysine + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
–
1,3,4,6-tetrachloro-1,4-cyclohexadiene + H2O <=> 2,4,5-trichloro-2,5-cyclohexadiene-1-ol + Cl- 3.8.1.5 haloalkane dehalogenase
–
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + O2 + ferricytochrome_b5 + H+ <=> 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + ferricytochrome_b5 + H2O 1.14.18.9 4alpha-methylsterol monooxygenase
–
S-adenosyl-L-methionine + (-)-pluviatolide <=> S-adenosyl-L-homocysteine + (-)-bursehernin + H+ 2.1.1.323 (-)-pluviatolide 4-O-methyltransferase
–
GDP-mannose + 1,4-beta-D-Mannan <=> GDP + 1,4-beta-D-Mannan 2.4.1
–
L-tryptophan + H2O <=> indole + pyruvate + NH3 4.1.99.1 tryptophanase
–
phosphatidylglycerol + diglucosyldiacylglycerol <=> diacylglycerol + Glycerophosphoglycoglycerolipid 2.7.8.20 phosphatidylglycerol---membrane-oligosaccharide glycerophosphotransferase
–
GDP-mannose + alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> GDP + alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol 2.4.1.257 GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase
–
L-allo-threonine + NADP+ <=> L-2-amino-3-oxobutanoate + NADPH + H+ 1.1.1.276 serine 3-dehydrogenase (NADP+)
1.1.1.381 3-hydroxy acid dehydrogenase
–
–
5-Carboxymethyl-2-hydroxymuconate <=> (3E,5R)-5-carboxy-2-oxohept-3-enedioate 5.3.3.10 5-carboxymethyl-2-hydroxymuconate Delta-isomerase
–
geranylgeranyl_diphosphate + indole-3-glycerol_phosphate <=> 3-Geranylgeranylindole + D-glyceraldehyde_3-phosphate + diphosphate not assigned
 –
3,4-dihydroxyphenylacetaldehyde + NADP+ + H2O <=> 3,4-Dihydroxyphenylacetate + NADPH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
–
anthracene + NADH + H+ + O2 <=> cis-Anthracene_dihydrodiol + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
–
–
ferulic_acid + ATP + CoA <=> feruloyl-CoA + AMP + diphosphate 6.2.1.12 4-coumarate---CoA ligase
6.2.1.34 trans-feruloyl-CoA synthase
–
–
10-formyltetrahydrofolate + 5-aminoimidazole-4-carboxamide_ribonucleotide <=> tetrahydrofolate + 5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide 2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase
–
geranylgeranyl_diphosphate + H2O <=> cyclooctat-9-en-7-ol + diphosphate 4.2.3.146 cyclooctat-9-en-7-ol synthase
–
2,3,5-Trichloro-cis,cis-muconate <=> 2,5-Dichloro-carboxymethylenebut-2-en-4-olide + Hydrochloric_acid 5.5.1.7 chloromuconate cycloisomerase
–
shikimate + pyrroloquinoline_quinone <=> 3-dehydroshikimate + reduced_pyrroloquinoline_quinone 1.1.5.8 quinate dehydrogenase (quinone)
–
L-erythro-3,5-diaminohexanoate + NAD+ + H2O <=> H+ + (S)-5-amino-3-oxohexanoate + NH3 + NADH 1.4.1.11 L-erythro-3,5-diaminohexanoate dehydrogenase
–
antheraxanthin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ + O2 <=> violaxanthin + oxidized_ferredoxin + H2O 1.14.15.21 zeaxanthin epoxidase
–
5beta-cholestane-3alpha,7alpha,26-triol <=> 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al 1.14.15.15 cholestanetriol 26-monooxygenase
–
N-acetylmuramic_acid + ATP <=> N-acetylmuramic_acid_1-phosphate + ADP + H+ 2.7.1.221 N-acetylmuramate 1-kinase
–
5-methyltetrahydrofolate + oxidized_ferredoxin <=> 5,10-methylenetetrahydrofolate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]
1.5.7.1 methylenetetrahydrofolate reductase (ferredoxin)
–
–
ATP + L-aspartate + NH3 <=> diphosphate + AMP + L-asparagine + H+ 6.3.1.1 aspartate---ammonia ligase
6.3.5.4 asparagine synthase (glutamine-hydrolysing)
–
–
7beta-(5-D-Aminoadipamido)-3-carbamoyloxymethylceph-3-em-4-carboxylic_acid + 2-oxoglutarate + O2 <=> 7a-Hydroxy-O-carbamoyl-deacetylcephalosporin_C + succinate + CO2 not assigned
 –
phytyl_diphosphate + homogentisate + H+ <=> 2-methyl-6-phytylbenzene-1,4-diol + CO2 + diphosphate 2.5.1.115 homogentisate phytyltransferase
–
GDP-mannose + Triacylated_phosphatidyl-myo-inositol_dimannoside <=> GDP + Triacylated_phosphatidyl-myo-inositol_trimannoside 2.4.1
–
5beta-pregnane-3,20-dione + acceptor <=> progesterone + reduced_acceptor 1.3.99.6 3-oxo-5beta-steroid 4-dehydrogenase
–
4-Guanidinobutanamide + H2O <=> NH3 + 4-Guanidinobutyrate 3.5.1.4 amidase
–
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced_adrenodoxin + H+ + O2 <=> (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized_ferredoxin + H2O 1.14.15.15 cholestanetriol 26-monooxygenase
–
5-guanidino-2-oxopentanoate + H2O <=> 5-amino-2-oxopentanoate + Urea 3.5.3.7 guanidinobutyrase
–
sulfite + 2 ferricytochrome_c + H2O <=> sulfate + 2 ferricytochrome_c + 2 H+ 1.8.2.1 sulfite dehydrogenase (cytochrome)
1.8.3.1 sulfite oxidase
–
–
4-chlorobiphenyl + O2 + NADPH + H+ <=> cis-2,3-Dihydro-2,3-dihydroxy-4''-chlorobiphenyl + NADP+ 1.14.12.18 biphenyl 2,3-dioxygenase
–
CMP-beta-Kdo + alpha-Kdo-(2rarr6)-lipid_IVA_(E._coli) <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid_IVA + CMP + H+ 2.4.99.13 (Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
–
nitrate + reduced_acceptor <=> nitrite + acceptor 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]
1.7.7.2 ferredoxin---nitrate reductase
1.7.99
1.9.6.1 nitrate reductase (cytochrome)
–
–
–
–
cinnamaldehyde + CoA + NADP+ <=> cinnamoyl-CoA + NADPH + H+ 1.2.1.44 cinnamoyl-CoA reductase
–
GDP-L-fucose + paragloboside <=> GDP + 1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl-R 2.4.1
2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
–
–
–
S-adenosyl-L-methionine + D-Cathine <=> (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol + S-adenosyl-L-homocysteine + H+ 2.1.1
2.1.1.M76
–
–
H+ + melilotate + O2 + NADH <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+ 1.14.13.4 melilotate 3-monooxygenase
–
diacylglycerol + CDP-ethanolamine <=> phosphatidylethanolamine + CMP + H+ 2.7.8.1 ethanolaminephosphotransferase
2.7.8.2 diacylglycerol cholinephosphotransferase
–
–
pyruvate + CoA + flavin + H+ <=> acetyl-CoA + CO2 + reduced_flavodoxin 1.2.7
1.2.7.1 pyruvate synthase
–
–
H2O + pyruvate + ATP <=> H+ + phosphate + phosphoenolpyruvate + AMP 2.7.1.40 pyruvate kinase
2.7.9.2 pyruvate, water dikinase
–
–
2-Hydroxy-beta-keto-L-tyrosyl-[pcp] <=> 3-amino-4,7-dihydroxycoumarin not assigned
 –
gamma-tocopherol <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol 5.5.1.24 tocopherol cyclase
–
O2 + L-gulono-1,4-lactone <=> L-xylo-hex-3-ulonolactone + H2O2 1.1.3.8 L-gulonolactone oxidase
–
L-rhamnulose_1-phosphate <=> L-lactaldehyde + dihydroxyacetone_phosphate 4.1.2.17 L-fuculose-phosphate aldolase
4.1.2.19 rhamnulose-1-phosphate aldolase
–
–
cis-Zeatin_riboside_monophosphate + H2O <=> cis-Zeatin_riboside + phosphate not assigned
 –
3-hydroxyisovaleryl-CoA <=> 3-methylcrotonoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
–
feruloyl-CoA + agmatine <=> CoA + feruloyl_agmatine 2.3.1.64 agmatine N4-coumaroyltransferase
–
D-arabinose_5-phosphate <=> D-ribulose_5-phosphate 5.3.1.13 arabinose-5-phosphate isomerase
–
UDP-galactose + glycoprotein_N-acetyl-D-galactosamine <=> beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R + UDP + H+ 2.4.1.122 N-acetylgalactosaminide beta-1,3-galactosyltransferase
–
LL-2,6-Diaminoheptanedioate <=> meso-2,6-diaminoheptanedioate 5.1.1.10 amino-acid racemase
5.1.1.7 diaminopimelate epimerase
–
–
7,9,12-Decaketide_intermediate_4 + NADPH + H+ <=> 7,9,12-Decaketide_intermediate_5 + NADP+ 1.1.1
–
ATP + L-alanine + anticapsin <=> ADP + phosphate + L-alanyl-L-anticapsin + H+ 6.3.2.49 L-alanine---L-anticapsin ligase
–
squalene + 2 ferricytochrome_b5 + O2 + 2 H+ <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + 2 ferricytochrome_b5 + H2O 1.14.19
–
N-acetyl-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-D-glucosamine <=> diphosphodolichyl-N-acetyl-D-glucosaminyl-N-acetyl-D-glucosamine + H+ + UDP 2.4.1.141 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase
–
diacylglycerol + CDP-choline <=> phosphatidylcholine + CMP + H+ 2.7.8.1 ethanolaminephosphotransferase
2.7.8.2 diacylglycerol cholinephosphotransferase
–
–
D-Cathinone <=> (-)-Norephedrine not assigned
 –
15,9''-di-cis-phytofluene + plastoquinone <=> 9,15,9''-tri-cis-zeta-carotene + plastoquinol 1.3.5.5 15-cis-phytoene desaturase
–
inositol_3,4,5,6-tetrakisphosphate + ATP <=> H+ + 1D-myo-inositol_1,3,4,5,6-pentakisphosphate + ADP 2.7.1.134 inositol-tetrakisphosphate 1-kinase
2.7.1.151 inositol-polyphosphate multikinase
2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinase
2.7.4.21 inositol-hexakisphosphate kinase
–
–
–
–
(22S)-22-hydroxycampesterol <=> (22S)-22-hydroxycampest-4-en-3-one not assigned
 –
trypanothione + dehydroascorbate <=> trypanothione_disulfide + ascorbate not assigned
 –
dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose 5.3.2.3 TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)
–
D-lactate + 2 ferricytochrome_c <=> pyruvate + 2 ferricytochrome_c + 2 H+ 1.1.2.4 D-lactate dehydrogenase (cytochrome)
–
coenzyme_B + coenzyme_M + reduced_ferredoxin_[iron-sulfur]_cluster + CO2 <=> CoM-S-S-CoB + formate + oxidized_ferredoxin 1.8.98.6 formate:CoB-CoM heterodisulfide,ferredoxin reductase
–
dichloroarcyriaflavin_A + D-glucose <=> 4''-O-demethylrebeccamycin + H2O 4.3.3.5 4'-demethylrebeccamycin synthase
–
amygdalin + H2O <=> prunasin + D-glucose 3.2.1.117 amygdalin beta-glucosidase
3.2.1.21 beta-glucosidase
–
–
9,14-Decaketide_intermediate_1 <=> tetracenomycin_F2 + [acyl-carrier_protein] not assigned
 –
dolichol + CTP <=> dolichyl_phosphate + H+ + CDP 2.7.1.108 dolichol kinase
–
D-Lactaldehyde + NAD+ <=> methylglyoxal + NADH + H+ 1.1.1.78 methylglyoxal reductase (NADH)
1.1.1.79 glyoxylate reductase (NADP+)
–
–
a_very-long-chain_(3R)-3-hydroxyacyl-CoA <=> very-long-chain_(2E)-2-enoyl-CoA + H2O 4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
–
thiamine + ATP <=> H+ + thiamine_phosphate + ADP 2.7.1.89 thiamine kinase
–
L-phenylalanine + O2 <=> phenylacetamide + CO2 + H2O 1.11.1.21 catalase-peroxidase
1.13.12.3 tryptophan 2-monooxygenase
1.13.12.9 phenylalanine 2-monooxygenase
–
–
–
H+ + L-ornithine <=> CO2 + putrescine 4.1.1.17 ornithine decarboxylase
4.1.1.18 lysine decarboxylase
4.1.1.19 arginine decarboxylase
4.1.1.86 diaminobutyrate decarboxylase
4.1.1.B12
–
–
–
–
–
benzoyl-CoA + glycine <=> H+ + hippuric_acid + CoA 2.3.1.13 glycine N-acyltransferase
2.3.1.14 glutamine N-phenylacetyltransferase
2.3.1.71 glycine N-benzoyltransferase
–
–
–
(R)-3-hydroxydodecanoyl-[acyl-carrier_protein] + NADP+ <=> 3-oxododecanoyl-[acyl-carrier_protein] + NADPH + H+ 1.1.1
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
–
–
–
–
–
mono(2-hydroxyethyl)_terephthalate + H2O <=> terephthalate + ethylene_glycol + H+ 3.1.1.102 mono(ethylene terephthalate) hydrolase
–
alpha-D-glucose_6-phosphate <=> beta-D-glucose_6-phosphate 5.1.3.15 glucose-6-phosphate 1-epimerase
5.1.3.3 aldose 1-epimerase
5.3.1.9 glucose-6-phosphate isomerase
–
–
–
gamma-carotene <=> beta-carotene 5.5.1.19 lycopene beta-cyclase
–
dTDP-4-hydroxyamino-4,6-dideoxy-alpha-D-glucose + Calicheamicinone <=> dTDP + Calicheamicin_T0 2.4.1
–
linoleic_acid + O2 + NADPH + H+ <=> (12Z,9R,10S)-9,10-epoxyoctadec-12-enoate + NADP+ + H2O 1.14.13
1.14.14
1.14.14.1 unspecific monooxygenase
–
–
–
L-serine + acetyl-CoA <=> O-acetyl-L-serine + CoA 2.3.1.30 serine O-acetyltransferase
–
S-adenosyl-L-methionine + Orsellinate-[acp] <=> S-adenosyl-L-homocysteine + 2-Methoxyorsellinate-[acp] 2.1.1
–
FMN + H2O <=> riboflavin + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.102 FMN hydrolase
3.1.3.104 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
3.1.3.2 acid phosphatase
3.1.3.8 3-phytase
–
–
–
–
–
pyridoxine_5''-phosphate + H2O <=> pyridoxine + phosphate 3.1.3.2 acid phosphatase
3.1.3.74 pyridoxal phosphatase
–
–
benzoate + NADPH + H+ + O2 <=> (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NADP+ 1.14.12.10 benzoate 1,2-dioxygenase
–
2,3-dehydroadipyl-CoA + acetyl-CoA <=> 3-oxo-5,6-dehydrosuberyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.223 3-oxo-5,6-didehydrosuberyl-CoA thiolase
–
–
protein_Npi-phospho-L-histidine + D-fructose <=> protein_L-histidine + D-Fructose_1-phosphate 2.7.1.202 protein-Npi-phosphohistidine---D-fructose phosphotransferase
–
(S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate + O2 <=> 4-hydroxyphenylglyoxylate + H2O2 1.1.3.46 4-hydroxymandelate oxidase
–
p-coumaryl_alcohol + NADP+ <=> 4-coumaraldehyde + NADPH + H+ 1.1.1.195 cinnamyl-alcohol dehydrogenase
–
Tropine + (R)-phenyllactyl-CoA <=> Littorine + CoA 2.3.1
2.3.1.185 tropine acyltransferase
–
–
(1''S)-averantin + NADP+ <=> norsolorinic_acid + NADPH + H+ 1.1.1.349 norsolorinic acid ketoreductase
1.1.1.B25
–
–
TDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + L-oleandrosyl-oleandolide <=> oleandomycin + dTDP + H+ 2.4.1
–
UDP-glucose + beta-D-glucosyl_crocetin <=> H+ + beta-D-gentiobiosyl_crocetin + UDP 2.4.1.330 beta-D-glucosyl crocetin beta-1,6-glucosyltransferase
–
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 <=> amidinoproclavaminate + succinate + CO2 1.14.11.21 clavaminate synthase
–
S-adenosyl-L-methionine + precorrin-3B <=> H+ + precorrin-4 + S-adenosyl-L-homocysteine 2.1.1.131 precorrin-3B C17-methyltransferase
–
O-phospho-L-serine + thiosulfate <=> S-sulfocysteine + phosphate 2.5.1.65 O-phosphoserine sulfhydrylase
2.8.5.1 S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)
–
–
(S)-cis-N-Methylstylopine + reduced_flavodoxin + O2 <=> protopine + flavin + H2O 1.14.14.97 methyltetrahydroprotoberberine 14-monooxygenase
–
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine <=> phosphatidylcholine + S-adenosyl-L-homocysteine + H+ 2.1.1.16 methylene-fatty-acyl-phospholipid synthase
2.1.1.17 phosphatidylethanolamine N-methyltransferase
2.1.1.71 phosphatidyl-N-methylethanolamine N-methyltransferase
–
–
–
2 3,5-diiodo-L-tyrosine + H2O2 <=> L-thyroxine + 2-aminoacrylate + 2 H2O 1.11.1.8 iodide peroxidase
–
5-diphosphomevalonate + ATP <=> isopentenyl_diphosphate + CO2 + ADP + phosphate 4.1.1.33 diphosphomevalonate decarboxylase
–
2-carboxymethyl-3-hydroxyphenylpropionyl-CoA + NAD+ <=> Benzoylsuccinyl-CoA + NADH + H+ 1.1.1
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
Leucocyanidin + 2-oxoglutarate + O2 + H+ <=> cyanidin + succinate + CO2 + 2 H2O 1.14.20.4 anthocyanidin synthase
–
catechol + O2 <=> H+ + cis,cis-muconate 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.3 protocatechuate 3,4-dioxygenase
1.13.11.37 hydroxyquinol 1,2-dioxygenase
–
–
–
2-Methylbenzyl_alcohol + NAD+ <=> 2-Methylbenzaldehyde + NADH 1.1.1.90 aryl-alcohol dehydrogenase
–
hercynine + L-cysteine + O2 <=> S-(hercyn-2-yl)-L-cysteine_S-oxide + H2O 1.14.99.51 hercynylcysteine S-oxide synthase
–
2-aminomuconate + H2O <=> 2-hydroxy-2,4-hexadienedioate + NH3 3.5.99.11 2-aminomuconate deaminase (2-hydroxymuconate-forming)
3.5.99.5 2-aminomuconate deaminase
–
–
cannabigerolate + O2 <=> cannabidiolate + H2O2 1.21.3.3 reticuline oxidase
1.21.3.8 cannabidiolic acid synthase
–
–
D-lactate + NAD+ <=> pyruvate + NADH + H+ 1.1.1.27 L-lactate dehydrogenase
1.1.1.28 D-lactate dehydrogenase
1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+)
–
–
–
N2-Acetyl-L-ornithine + Carbamoyl_phosphate <=> H+ + N-acetyl-L-citrulline + phosphate 2.1.3.11 N-succinylornithine carbamoyltransferase
2.1.3.9 N-acetylornithine carbamoyltransferase
–
–
S-(Indolylmethylthiohydroximoyl)-L-cysteine + H2O <=> 2-(3-indolyl)acetothiohydroximate + pyruvate + NH3 4.4.1
–
leukotriene_C4 <=> leukotriene_A4 + glutathione 4.4.1.20 leukotriene-C4 synthase
–
peptidyl-4-carboxyglutamate + 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + H+ + H2O <=> CO2 + peptidyl-glutamate + vitamin_KH2 + O2 4.1.1.90 peptidyl-glutamate 4-carboxylase
–
GTP + H2O <=> 7,8-dihydroneopterin_2,3''-cyclic_phosphate + formate + diphosphate + H+ 3.5.4.16 GTP cyclohydrolase I
3.5.4.39 GTP cyclohydrolase IV
–
–
L-aspartate + acetyl-CoA <=> N-acetyl-L-aspartate + CoA + H+ 2.3.1.17 aspartate N-acetyltransferase
–
trypanothione + Tryparedoxin_disulfide <=> trypanothione_disulfide + tryparedoxin not assigned
 –
D-Lactaldehyde + NAD+ + H2O <=> H+ + D-lactate + NADH 1.2.1.22 lactaldehyde dehydrogenase
1.2.1.23 2-oxoaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
–
–
–
7-hydroxychlorophyllide_a <=> chlorophyllide_a not assigned
 –
pyruvate + H2O + ubiquinone <=> CO2 + ubiquinol + acetate 1.2.5.1 pyruvate dehydrogenase (quinone)
–
O-succinyl-L-homoserine + L-selenocysteine <=> L-selenocystathionine + succinate 2.5.1.48 cystathionine gamma-synthase
–
[Lipoyl-carrier_protein_E2]-N6-octanoyl-L-lysine + an_[Fe-S]_cluster_scaffold_protein_carrying_a_[4Fe-4S]2+_cluster + 2 S-adenosyl-L-methionine + 2 [2Fe-2S]-center + 8 H+ <=> enzyme_N6-(dihydrolipoyl)lysine + an_[Fe-S]_cluster_scaffold_protein + 2 Sulfide + 4 Fe2+ + 2 L-methionine + 2 5''-Deoxyadenosine + 2 [2Fe-2S]-center 2.8.1.8 lipoyl synthase
–
D-ribitol_5-phosphate + NADP+ <=> D-ribulose_5-phosphate + NADPH + H+ 1.1.1.137 ribitol-5-phosphate 2-dehydrogenase
1.1.1.405 ribitol-5-phosphate 2-dehydrogenase (NADP+)
–
–
thiamine_diphosphate + H2O <=> H+ + thiamine_phosphate + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.100 thiamine phosphate phosphatase
3.1.3.2 acid phosphatase
3.6.1
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.28 thiamine-triphosphatase
3.6.1.5 apyrase
3.6.1.55 8-oxo-dGTP diphosphatase
3.6.1.6 nucleoside diphosphate phosphatase
–
–
–
–
–
–
–
–
–
H+ + Clavulanate-9-aldehyde + NADPH <=> clavulanic_acid + NADP+ not assigned
 –
2-carboxymethyl-3-hydroxyphenylpropionyl-CoA <=> (E)-2-benzylidenesuccinyl-CoA + H2O 4.2.1
–
lactoyl-CoA <=> acryloyl-CoA + H2O 4.2.1
4.2.1.54 lactoyl-CoA dehydratase
–
–
FMN + O2 <=> 8-demethyl-8-formylriboflavin_5''-phosphate + H2O 2.6.1.114 8-demethyl-8-aminoriboflavin-5'-phosphate synthase
–
L-homoserine + succinyl-CoA <=> O-succinyl-L-homoserine + CoA 2.3.1.46 homoserine O-succinyltransferase
–
(S)-3-hydroxy-2-methylpropanoyl-CoA <=> methacryloyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
–
4-Chlorophenol + O2 + NADPH + H+ <=> 4-Chlorocatechol + H2O + NADP+ 1.14.13.20 2,4-dichlorophenol 6-monooxygenase
1.14.13.7 phenol 2-monooxygenase (NADPH)
–
–
amylose <=> alpha-cyclodextrin 2.4.1.19 cyclomaltodextrin glucanotransferase
3.2.1.54 cyclomaltodextrinase
–
–
24-ethylidenelophenol + ferricytochrome_b5 + O2 + H+ <=> 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + ferricytochrome_b5 + H2O 1.14.18.11 plant 4alpha-monomethylsterol monooxygenase
–
cytidine + phosphate <=> cytosine + alpha-D-ribose_1-phosphate 2.4.2.2 pyrimidine-nucleoside phosphorylase
2.4.2.3 uridine phosphorylase
–
–
tetracenomycin_B2 + O2 + NADPH + H+ <=> 8-demethyltetracenomycin_C + H2O + NADP+ 1.14.13.200 tetracenomycin A2 monooxygenase-dioxygenase
–
S-adenosyl-L-methionine + L-histidine <=> hercynine + S-adenosyl-L-homocysteine + H+ 2.1.1.44 L-histidine Nalpha-methyltransferase
–
oxidized_ferredoxin + formylmethanofuran + H2O <=> reduced_ferredoxin_[iron-sulfur]_cluster + methanofuran + CO2 + H+ 1.2.7.12 formylmethanofuran dehydrogenase
–
3,4-dihydroxyphenyllactic_acid + NAD+ <=> 3,4-Dihydroxyphenylpyruvate + NADH + H+ 1.1.1.237 hydroxyphenylpyruvate reductase
1.1.1.28 D-lactate dehydrogenase
–
–
methylmalonate <=> L-2-methyl-3-oxopropionate not assigned
 –
2-phospho-D-glycerate <=> 3-phospho-D-glycerate 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
5.4.2.12 phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
–
–
O2 + H2O + pyridoxal <=> H+ + H2O2 + 4-pyridoxate 1.2.3.1 aldehyde oxidase
1.2.3.8 pyridoxal oxidase
–
–
ATP + CoA + 4-Chlorobenzoate <=> diphosphate + AMP + 4-chlorobenzoyl-CoA 6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.25 benzoate---CoA ligase
6.2.1.33 4-chlorobenzoate---CoA ligase
–
–
–
2,4-Dichlorobenzoate + CoA + ATP <=> 2,4-dichlorobenzoyl-CoA + AMP + diphosphate 6.2.1
–
UDP-galactose + beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-1-Cer <=> UDP + nLc6Cer 2.4.1
–
lanosterol + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized_ferredoxin + H2O 1.14.15.36 sterol 14alpha-demethylase (ferredoxin)
–
dTDP + ATP <=> dTTP + ADP 2.7.4.6 nucleoside-diphosphate kinase
–
4-deoxy-L-threo-5-hexosulose-uronate <=> (4S)-4,6-dihydroxy-2,5-dioxohexanoate 5.3.1.17 5-dehydro-4-deoxy-D-glucuronate isomerase
–
2-dehydro-3-deoxy-L-rhamnonate <=> pyruvate + L-lactaldehyde 4.1.2.53 2-keto-3-deoxy-L-rhamnonate aldolase
–
Leucocyanidin + NADP+ <=> taxifolin + NADPH + H+ 1.1.1.219 dihydroflavonol 4-reductase
–
3-dehydroshikimate <=> 3,4-dihydroxybenzoate + H2O 4.2.1.118 3-dehydroshikimate dehydratase
–
adenylyl-molybdopterin + molybdate + H+ <=> molybdenum_cofactor + AMP + H2O 2.10.1.1 molybdopterin molybdotransferase
–
UDP-glucose + bis(beta-D-glucosyl)_crocetin <=> H+ + beta-D-gentiobiosyl_beta-D-glucosyl_crocetin + UDP 2.4.1.330 beta-D-glucosyl crocetin beta-1,6-glucosyltransferase
–
ethanolamine_plasmalogen + H2O <=> 1-alkenylglycerophosphoethanolamine + a_carboxylate 3.1.1.4 phospholipase A2
–
H2O + 2-(5-oxo-4,5-dihydrofuran-2-yl)acetic_acid <=> H+ + 3-oxoadipate 3.1.1.24 3-oxoadipate enol-lactonase
–
adenosylcobyrinic_acid_a,c-diamide + L-glutamine + ATP + H2O <=> H+ + L-glutamate + adenosylcobyric_acid + ADP + phosphate 6.3.5.10 adenosylcobyric acid synthase (glutamine-hydrolysing)
–
1D-myo-inositol_1,4,5-trisphosphate + ATP <=> H+ + 1D-myo-inositol_1,4,5,6-tetrakisphosphate + ADP 2.7.1.151 inositol-polyphosphate multikinase
–
dihydroxyacetone_phosphate <=> methylglyoxal + phosphate 4.1.2.17 L-fuculose-phosphate aldolase
4.2.3.3 methylglyoxal synthase
5.3.1.1 triose-phosphate isomerase
–
–
–
D-glucose_6-phosphate <=> alpha-D-glucosamine_1-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.13 phosphogalactosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.3 phosphoacetylglucosamine mutase
5.4.2.8 phosphomannomutase
–
–
–
–
–
dTDP-3-O-methyl-4-oxo-2,6-dideoxy-L-mannose <=> dTDP-L-oleandrose not assigned
 –
glycolate + O2 <=> glyoxylate + H2O2 1.1.3.13 alcohol oxidase
1.1.3.15 (S)-2-hydroxy-acid oxidase
–
–
4-hydroxybutyrate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate 6.2.1.40 4-hydroxybutyrate---CoA ligase (AMP-forming)
–
L-dihydroorotate + fumarate <=> Orotate + succinate 1.3.98.1 dihydroorotate dehydrogenase (fumarate)
–
phenylpyruvate + O2 <=> 2-hydroxyphenylacetate + CO2 1.13.11.27 4-hydroxyphenylpyruvate dioxygenase
–
(6E)-8-hydroxygeraniol + NADP+ <=> (6E)-8-oxogeranial + NADPH + H+ 1.1.1.324 8-hydroxygeraniol dehydrogenase
–
Prostaglandin_A2 <=> Prostaglandin_C2 not assigned
 –
P1,P3-bis(5''-adenosyl)_triphosphate + H2O <=> H+ + AMP + ADP 3.1.4.1 phosphodiesterase I
3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
3.6.1.29 bis(5'-adenosyl)-triphosphatase
3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
3.6.1.71 adenosine-5'-diphospho-5'-[DNA] diphosphatase
3.6.1.9 nucleotide diphosphatase
6.1.1.14 glycine---tRNA ligase
–
–
–
–
–
–
–
Stemmadenine <=> Catharanthine not assigned
 –
bithionol + H2O <=> H+ + 3-hydroxypropionate + CoA 3.1.2.4 3-hydroxyisobutyryl-CoA hydrolase
–
Indole-3-acetaldehyde + O2 + H2O <=> H+ + indole-3-acetic_acid + H2O2 1.2.3.1 aldehyde oxidase
1.2.3.7 indole-3-acetaldehyde oxidase
–
–
NH3 + L-glutamate + ATP <=> H+ + L-glutamine + ADP + phosphate 6.3.1.2 glutamine synthetase
–
leukotriene_A4 + H2O <=> leukotriene_B4 3.3.2.6 leukotriene-A4 hydrolase
–
GDP-L-fucose + Sialyl-3-paragloboside <=> GDP + IV3NeuAc,III3Fuc-nLc4Cer 2.4.1
2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
–
–
Se-methyl-L-selenocysteine + H2O <=> methylselenol + pyruvate + NH3 4.4.1.1 cystathionine gamma-lyase
4.4.1.11 methionine gamma-lyase
4.4.1.13 cysteine-S-conjugate beta-lyase
–
–
–
O2 + (S)-reticuline <=> H+ + H2O2 + (S)-scoulerine 1.21.3.3 reticuline oxidase
–
4-hydroxy-6-methylpretetramide + NADPH + O2 + H+ <=> 4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O 1.14.13.233 4-hydroxy-6-methylpretetramide 12a-monooxygenase
–
2-oxoglutaryl-CoA + H2O <=> H+ + 2-oxoglutarate + CoA 3.1.2
–
alpha-D-glucose + ADP <=> alpha-D-glucose_6-phosphate + AMP 2.7.1.147 ADP-specific glucose/glucosamine kinase
–
(+)-citramalate <=> pyruvate + acetate 4.1.3.1 isocitrate lyase
4.1.3.22 citramalate lyase
–
–
L-proline + a_quinone <=> L-pyrroline-5-carboxylate + a_quinol 1.5.5.2 proline dehydrogenase
1.5.99.B2
–
–
1-phosphatidyl-1D-myo-inositol_3,5-bisphosphate + H2O <=> 1-phosphatidyl-1D-myo-inositol_5-phosphate + phosphate 3.1.3
3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.56 inositol-polyphosphate 5-phosphatase
3.1.3.95 phosphatidylinositol-3,5-bisphosphate 3-phosphatase
–
–
–
–
D-ribose_5-phosphate + Uracil <=> H2O + pseudouridine_5''-phosphate 4.2.1.70 pseudouridylate synthase
–
S-adenosyl-L-methionine + magnesium_protoporphyrin_monomethyl_ester + H2O <=> 131-hydroxy-magnesium-protoporphyrin_IX_13-monomethyl_ester + 5''-deoxyadenosine + L-methionine + H+ 1.21.98.3 anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase
–
(R)-2-Aza-beta-tyrosyl-[pcp] + FADH2 + Cl- + O2 + H+ <=> (R)-2-Aza-3-chloro-beta-tyrosyl-[pcp] + FAD + 2 H2O 1.14.19
–
glycine + tetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH 1.4.1.f
1.4.4.2 glycine dehydrogenase (aminomethyl-transferring)
1.8.1.4 dihydrolipoyl dehydrogenase
2.1.2.10 aminomethyltransferase
–
–
–
–
N-formylanthranilic_acid + H2O <=> formate + anthranilate 3.5.1.9 arylformamidase
–
coniferyl_alcohol + NADP+ <=> coniferyl_aldehyde + NADPH + H+ 1.1.1.194 coniferyl-alcohol dehydrogenase
1.1.1.195 cinnamyl-alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.90 aryl-alcohol dehydrogenase
1.1.1.91 aryl-alcohol dehydrogenase (NADP+)
–
–
–
–
–
(2S,5S)-5-carboxymethylproline + ATP <=> H+ + (3S,5S)-carbapenam_3-carboxylate + AMP + diphosphate 6.3.3.6 carbapenam-3-carboxylate synthase
–
Hypotaurine + H2O + NAD+ <=> taurine + NADH + H+ 1.8.1.3 hypotaurine dehydrogenase
–
1-butanol + NADP+ <=> H+ + Butyraldehyde + NADPH 1.1.1
1.1.1.1 alcohol dehydrogenase
1.1.1.183 geraniol dehydrogenase (NADP+)
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.188 prostaglandin-F synthase
1.1.1.191 indole-3-acetaldehyde reductase (NADPH)
1.1.1.195 cinnamyl-alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.265 3-methylbutanal reductase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.72 glycerol dehydrogenase (NADP+)
1.1.1.91 aryl-alcohol dehydrogenase (NADP+)
–
–
–
–
–
–
–
–
–
–
–
–
–
H2O + agmatine <=> Urea + putrescine 3.5.3.1 arginase
3.5.3.11 agmatinase
–
–
protodeoxyviolaceinate + O2 + NADPH + H+ <=> protoviolaceinate + NADP+ + H2O 1.14.13.217 protodeoxyviolaceinate monooxygenase
1.14.13.224 violacein synthase
–
–
thiamine_diphosphate + H2O <=> H+ + thiamine_phosphate + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.100 thiamine phosphate phosphatase
3.1.3.2 acid phosphatase
3.6.1
3.6.1.15 nucleoside-triphosphate phosphatase
3.6.1.28 thiamine-triphosphatase
3.6.1.5 apyrase
3.6.1.55 8-oxo-dGTP diphosphatase
3.6.1.6 nucleoside diphosphate phosphatase
–
–
–
–
–
–
–
–
–
5,10-methenyltetrahydrofolate + H2O <=> 10-formyltetrahydrofolate + H+ 3.5.4.9 methenyltetrahydrofolate cyclohydrolase
–
Epoxyethane + H2O <=> ethylene_glycol 3.3.2.10 soluble epoxide hydrolase
3.3.2.9 microsomal epoxide hydrolase
–
–
1,2-dihydroxynaphthalene + O2 <=> H+ + 2-hydroxy-2H-chromene-2-carboxylate 1.13.11.56 1,2-dihydroxynaphthalene dioxygenase
–
L-valine + reduced_flavodoxin + O2 <=> N-hydroxy-L-valine + flavin + H2O 1.14.14.38 valine N-monooxygenase
1.14.14.39 isoleucine N-monooxygenase
–
–
Trichloroethylene + 2 H+ <=> cis-1,2-dichloroethene + Hydrochloric_acid 1.21.99.5 tetrachloroethene reductive dehalogenase
–
CMP-N-acetylneuraminate + ganglioside_GT1b <=> CMP + GQ1b 2.4.99
–
DMSO + H2O + NAD+ <=> dimethyl_sulfone + NADH + H+ 1.8.1.17 dimethylsulfone reductase
–
Avermectin_A1b_aglycone + dTDP-L-oleandrose <=> Avermectin_A1b_monosaccharide + dTDP 2.4.1
–
UDP-galactose + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc-1-Asn <=> UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[beta-D-Gal-(1->4)-alpha-L-Fuc-(1->6)]-beta-D-GlcNAc-1-Asn 2.4.1
–
UDP-galactose + NORint <=> UDP + NOR2_antigen 2.4.1.228 lactosylceramide 4-alpha-galactosyltransferase
–
epsilon-N-biotinyl-L-lysine + 2 peptide <=> biotin-carboxyl-carrier_protein + 2 H2O 3.4
–
2-Phenylethylamine + H2O + acceptor <=> phenylacetaldehyde + NH3 + reduced_acceptor 1.4.9.1 methylamine dehydrogenase (amicyanin)
1.4.9.2 aralkylamine dehydrogenase (azurin)
1.4.98
–
–
–
5-Oxoavermectin_''''1b''''_aglycone + NADPH + H+ <=> Avermectin_B1b_aglycone + NADP+ not assigned
 –
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin_C + S-adenosyl-L-homocysteine + H+ 2.1.1.307 8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
–
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+ <=> (R)-allantoin + CO2 not assigned
 –
2-hydroxyethylphosphonate + NAD+ <=> phosphonoacetaldehyde + NADH + H+ 1.1.1.309 phosphonoacetaldehyde reductase (NADH)
–
dimethylallyl_diphosphate + adenine_in_tRNA <=> diphosphate + tRNA_containing_6-isopentenyladenosine 2.5.1.75 tRNA dimethylallyltransferase
–
(S)-3-sulfolactate + NAD+ <=> 3-sulfopyruvate + NADH + H+ 1.1.1.272 D-2-hydroxyacid dehydrogenase (NADP+)
1.1.1.310 (S)-sulfolactate dehydrogenase
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
–
–
–
–
obtusifoliol + reduced_flavodoxin + O2 <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + flavin + H2O 1.14.14.154 sterol 14alpha-demethylase
–
(2E,6E)-farnesyl_diphosphate <=> (E)-alpha-bisabolene + diphosphate 4.2.3.38 alpha-bisabolene synthase
–
dibenzo-p-dioxin + NADH + O2 <=> 2,2'',3-trihydroxybiphenyl_ether + NAD+ 1.14.12
1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
–
–
–
O2 + glutathione <=> GSSG + H2O2 1.8.3.2 thiol oxidase
1.8.3.3 glutathione oxidase
–
–
CDP-3,6-dideoxy-D-glucose + NADP+ <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADPH + H+ 1.1.1.342 CDP-paratose synthase
–
L-2-aminoadipate + L-cysteine + L-valine + ATP + H2O <=> H+ + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + AMP + diphosphate 6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
–
trimethylamine + coenzyme_M <=> methyl-CoM + Dimethylamine 2.1.1.247 [methyl-Co(III) methylamine-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.250 trimethylamine---corrinoid protein Co-methyltransferase
–
–
dTDP-L-olivose + NADP+ <=> dTDP-4-oxo-2,6-dideoxy-L-mannose + NADPH + H+ 1.1.1
–
2-methyl-4-amino-5-hydroxymethylpyrimidine_phosphate + ATP <=> 2-methyl-4-amino-5-hydroxymethylpyrimidine_diphosphate + ADP 2.7.1.49 hydroxymethylpyrimidine kinase
2.7.4.7 phosphooxymethylpyrimidine kinase
–
–
3-Oxo-3-ureidoisobutyrate + H2O <=> methylmalonate + Urea 3.5.1.95 N-malonylurea hydrolase
–
phosphate + maltose <=> beta-D-glucose_1-phosphate + D-glucose 2.4.1.8 maltose phosphorylase
–
(S)-scoulerine + reduced_flavodoxin + O2 <=> (S)-cheilanthifoline + flavin + 2 H2O 1.14.19.65 (S)-cheilanthifoline synthase
–
S-adenosyl-L-methionine + precorrin-2 <=> H+ + S-adenosyl-L-homocysteine + precorrin-3A 2.1.1.130 precorrin-2 C20-methyltransferase
–
N-acetyl-D-glucosamine_6-phosphate <=> N-acetyl-D-glucosamine_1-phosphate 5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.3 phosphoacetylglucosamine mutase
5.4.2.8 phosphomannomutase
–
–
–
N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate <=> anthranilate + 5-phospho-alpha-D-ribose_1-diphosphate 2.4.2.18 anthranilate phosphoribosyltransferase
–
bithionol <=> acryloyl-CoA + H2O 4.2.1
4.2.1.116 3-hydroxypropionyl-CoA dehydratase
4.2.1.17 enoyl-CoA hydratase
–
–
–
5beta-Pregnan-3alpha-ol-20-one + NADP+ <=> 5beta-pregnane-3,20-dione + NADPH 1.1.1.112 indanol dehydrogenase
1.1.1.149 20alpha-hydroxysteroid dehydrogenase
1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
–
–
–
–
–
–
–
Toluene + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> benzyl_alcohol + oxidized_ferredoxin + H2O 1.14.13
1.14.15.26 toluene methyl-monooxygenase
–
–
2-oxoadipate + NH3 + NAD+ <=> 2-aminomuconate + NADH + H+ + H2O 1.5.1
–
CMP-beta-Kdo + lipid_IVA_(E._coli) <=> alpha-Kdo-(2rarr6)-lipid_IVA_(E._coli) + CMP + H+ 2.4.99.12 lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
2.4.99.13 (Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
–
–
Emindole_SB + O2 + NADPH + H+ <=> 14,15-Epoxyemindole_SB + NADP+ + H2O 1.14.13
–
beta-tocopherol <=> alpha-tocopherol not assigned
 –
Cobalamin <=> hydroxycobalamin not assigned
 –
inositol_3,4,5,6-tetrakisphosphate + ATP <=> H+ + 1D-myo-inositol_1,3,4,5,6-pentakisphosphate + ADP 2.7.1.134 inositol-tetrakisphosphate 1-kinase
2.7.1.151 inositol-polyphosphate multikinase
2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinase
2.7.4.21 inositol-hexakisphosphate kinase
–
–
–
–
melilotate + NAD+ <=> H+ + NADH + coumaric_acid 1.3.1.11 2-coumarate reductase
1.3.1.31 2-enoate reductase
–
–
pentalenene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> pentalen-13-al + H2O + oxidized_ferredoxin 1.14.15.32 pentalenene oxygenase
–
dTDP-acarviose-7-phosphate <=> acarbose_7'''-phosphate not assigned
 –
2-oxobutyrate + CoA <=> propionyl-CoA + formate 2.3.1
2.3.1.54 formate C-acetyltransferase
–
–
a_very-long-chain_(3R)-3-hydroxyacyl-CoA + NADP+ <=> a_very-long-chain_3-oxoacyl-CoA + NADPH + H+ 1.1.1.330 very-long-chain 3-oxoacyl-CoA reductase
–
N-Acetyl-N6,O-didemethylpuromycin-5''-phosphate + S-adenosyl-L-methionine <=> N-Acetyl-O-demethylpuromycin-5''-phosphate + S-adenosyl-L-homocysteine 2
–
paraxanthine <=> 5-Acetylamino-6-formylamino-3-methyluracil 2.3.1.5 arylamine N-acetyltransferase
–
4-Chloro-L-lysine + reduced_acceptor + O2 <=> 2-Amino-4-chloro-4-pentenoic_acid + acceptor + formaldehyde + NH3 + H2O 1.14.99
–
1-hydroxy-2-naphthaldehyde + pyruvate <=> (3E)-4-(1-hydroxynaphthalen-2-yl)-2-oxobut-3-enoate + H2O 4.1.2
4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
–
–
imidazolinone + H2O <=> Formiminoglycine 3.5.2
–
palmitoyl-[acyl-carrier_protein] + CoA <=> palmitoyl-CoA + [acyl-carrier_protein] 2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
–
–
–
2-methylacetoacetyl-CoA + CoA <=> propionyl-CoA + acetyl-CoA 2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase
–
–
1,3-dicarboxyurea + H+ <=> allophanate + CO2 not assigned
 –
H+ + glycine + succinyl-CoA <=> CO2 + CoA + 5-aminolevulinate 2.3.1.37 5-aminolevulinate synthase
–
(E,Z)-indolyl-3-acetaldoxime <=> Indole-3-acetaldehyde 1.7.3
–
D-tagatose_6-phosphate + ATP <=> H+ + D-tagatose_1,6-bisphosphate + ADP 2.7.1.11 6-phosphofructokinase
2.7.1.144 tagatose-6-phosphate kinase
2.7.1.56 1-phosphofructokinase
–
–
–
lycopene + reduced_acceptor + O2 <=> all-trans-3,4-didehydrolycopene + acceptor + H2O 1.3.99.30 phytoene desaturase (3,4-didehydrolycopene-forming)
–
2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O <=> Isobutyrate + 2-hydroxy-2,4-pentadienoate 3.7.1
–
(1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate <=> (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate 4.2.99.20 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
–
nitrite + H2O + NADP+ <=> H+ + nitrate + NADPH 1.7.1.1 nitrate reductase (NADH)
1.7.1.2 nitrate reductase [NAD(P)H]
1.7.1.3 nitrate reductase (NADPH)
–
–
–
palmitoyl-CoA + L-serine + H+ <=> 3-dehydrosphinganine + CO2 + CoA 2.3.1.50 serine C-palmitoyltransferase
–
S-adenosyl-L-methionine + caffeic_acid <=> H+ + ferulic_acid + S-adenosyl-L-homocysteine 2.1.1.104 caffeoyl-CoA O-methyltransferase
2.1.1.68 caffeate O-methyltransferase
–
–
H2O + dTMP <=> phosphate + thymidine 3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.31 nucleotidase
3.1.3.32 polynucleotide 3'-phosphatase
3.1.3.34 deoxynucleotide 3'-phosphatase
3.1.3.35 thymidylate 5'-phosphatase
3.1.3.5 5'-nucleotidase
3.1.3.89 5'-deoxynucleotidase
–
–
–
–
–
–
–
–
2-dehydro-3-deoxy-D-glucarate <=> pyruvate + tartronate_semialdehyde 4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
–
tRNAMet + L-glutamate + ATP <=> Glu-tRNAGln + diphosphate + AMP 6.1.1.17 glutamate---tRNA ligase
6.1.1.24 glutamate---tRNAGln ligase
–
–
dihomocitrate <=> (-)-threo-iso(homo)2citrate 4.2.1.114 methanogen homoaconitase
–
gamma-tocotrienol <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol 5.5.1.24 tocopherol cyclase
–
beta-Ala-Arg + H2O <=> beta-Alanine + 2-amino-5-guanidinovalerate 3.4.13.18 cytosol nonspecific dipeptidase
3.4.13.4 Xaa-Arg dipeptidase
–
–
palmitoyl-CoA + NADP+ <=> trans-2-hexadecenoyl-CoA + NADPH + H+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)
–
–
S-adenosyl-L-methionine + Pretetramid <=> S-adenosyl-L-homocysteine + 6-methylpretetramide + H+ 2.1.1
2.1.1.M31
–
–
L-aspartate + NADP+ <=> iminosuccinate + NADPH + H+ 1.4.1.21 aspartate dehydrogenase
–
dodecanoyl-[acyl-carrier_protein] + H2O <=> [acyl-carrier_protein] + laurate + H+ 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase
3.1.2.21 dodecanoyl-[acyl-carrier-protein] hydrolase
–
–
Maleamate + H2O <=> Maleate + NH3 3.5.1.107 maleamate amidohydrolase
–
ATP + formylglycinamide_ribonucleotide + L-glutamine + H2O <=> H+ + L-glutamate + ADP + phosphate + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine 6.3.5.3 phosphoribosylformylglycinamidine synthase
–
Hydrogenobyrinate + L-glutamine + ATP + H2O <=> H+ + L-glutamate + hydrogenobyrinic_acid_a,c-diamide + ADP + phosphate 6.3.5.11 cobyrinate a,c-diamide synthase
6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
–
–
Hydroiodic_acid + 3,5-diiodo-L-tyrosine <=> 3-iodo-L-tyrosine + Iodine 1.11.1.8 iodide peroxidase
–
(3S)-citryl-CoA <=> oxaloacetate + acetyl-CoA 4.1.3.34 citryl-CoA lyase
–
L-serine + indole <=> L-tryptophan + H2O 4.1.99.1 tryptophanase
4.2.1.122 tryptophan synthase (indole-salvaging)
4.2.1.20 tryptophan synthase
–
–
–
acetyl-CoA + malonyl-CoA + NADPH + H+ <=> 2-hydroxy-5-methyl-1-naphthoate + CoA + CO2 + H2O + NADP+ 2.3.1.237 neocarzinostatin naphthoate synthase
–
D-ornithine <=> 2,4-Diaminopentanoate 5.4.3.5 D-ornithine 4,5-aminomutase
–
S-adenosyl-L-methionine + 2-methoxy-6-polyprenyl-1,4-benzoquinol <=> 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-homocysteine + H+ 2.1.1.201 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
–
5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + H2O <=> 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + phosphate 3.1.3.104 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
–
UDP-N-acetyl-D-galactosamine + Globotetraosylceramide <=> GalNAc-alpha-1,3-GalNAc-beta-1,3-Gal-alpha-1,4-Gal-beta-1,4-Glc-beta-1,1-ceramide + H+ + UDP 2.4.1.88 globoside alpha-N-acetylgalactosaminyltransferase
–
protoporphyrinogen-IX + 3 acceptor <=> protoporphyrin_IX + 3 reduced_acceptor 1.3.99
–
an_alcohol + NAD+ <=> an_aldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.103 L-threonine 3-dehydrogenase
1.1.1.11 D-arabinitol 4-dehydrogenase
1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.17 mannitol-1-phosphate 5-dehydrogenase
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.192 long-chain-alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.202 1,3-propanediol dehydrogenase
1.1.1.21 aldose reductase
1.1.1.244 methanol dehydrogenase
1.1.1.245 cyclohexanol dehydrogenase
1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase
1.1.1.306 S-(hydroxymethyl)mycothiol dehydrogenase
1.1.1.307 D-xylose reductase
1.1.1.6 glycerol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.73 octanol dehydrogenase
1.1.1.77 lactaldehyde reductase
1.1.1.78 methylglyoxal reductase (NADH)
1.1.1.80 isopropanol dehydrogenase (NADP+)
1.1.1.B4
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–
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–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
L-ectoine + 2-oxoglutarate + O2 <=> 5-hydroxyectoine + succinate + CO2 1.14.11.55 ectoine hydroxylase
–
N-acetyl-D-mannosamine_6-phosphate <=> N-acetyl-D-glucosamine_6-phosphate 5.1.3.9 N-acylglucosamine-6-phosphate 2-epimerase
–
UDP-N-acetyl-beta-L-fucosamine <=> UDP-2,6-dideoxy-2-acetamidino-beta-L-galactose not assigned
 –
CTP + N,N'-diacetyllegionaminate <=> CMP-N,N''-diacetyllegionaminate + diphosphate 2.7.7.82 CMP-N,N'-diacetyllegionaminic acid synthase
–
UDP-N-acetyl-D-glucosamine + alpha-D-Man-1-Ser/Thr <=> UDP + beta-D-GlcNAc-(1->4)-alpha-D-Man-1-Ser/Thr 2.4.1.312 protein O-mannose beta-1,4-N-acetylglucosaminyltransferase
–
carboxynorspermidine + NADP+ + H2O <=> L-aspartate_4-semialdehyde + 1,3-diaminopropane + NADPH + H+ 1.4.1.B4
1.5.1.43 carboxynorspermidine synthase
–
–
carboxybiuret + H+ <=> Biuret + CO2 not assigned
 –
3-geranyl-4-hydroxybenzoate + H+ <=> 2-polyprenylphenol + CO2 4.1.1.98 4-hydroxy-3-polyprenylbenzoate decarboxylase
–
tetrahydrofolate + acetyl-CoA <=> 5-methyltetrahydrofolate + CoA + CO 2.1.1.258 5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
2.3.1.169 CO-methylating acetyl-CoA synthase
–
–
ATP + citrate + L-glutamate <=> ADP + phosphate + beta-Citryl-L-glutamate + H+ 6.3.1.17 beta-citrylglutamate synthase
6.3.2.B11
–
–
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic_acid + H2O <=> (5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic_acid 3.3.2.10 soluble epoxide hydrolase
3.3.2.9 microsomal epoxide hydrolase
–
–
benzoylformate + CoA + NAD+ <=> benzoyl-CoA + CO2 + NADH 1.2.1.58 phenylglyoxylate dehydrogenase (acylating)
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
–
–
4-N-trimethylaminobutyraldehyde + NAD+ + H2O <=> gamma-butyrobetaine + NADH + H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase
1.2.1.8 betaine-aldehyde dehydrogenase
–
–
–
NADP+ + bilirubin <=> Biliverdin + NADPH + H+ 1.3.1.24 biliverdin reductase
–
2-aminobenzoyl-CoA + malonyl-CoA + H+ <=> 4-hydroxy-2-methylquinoline + CoA + CO2 2.3.1
–
ent-kaur-16-en-19-al + reduced_flavodoxin + O2 <=> ent-kaur-16-en-19-oate + flavin + H2O 1.14.14.86 ent-kaurene monooxygenase
–
acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H+ 2.3.1.197 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase
–
L-tyrosine + O2 <=> L-Dopa 1.10.3.1 catechol oxidase
1.14.18.1 tyrosinase
–
–
iminosuccinate + dihydroxyacetone_phosphate <=> quinolinic_acid + H2O + phosphate 2.5.1.72 quinolinate synthase
–
alpha-D-glucose_1-phosphate + UTP + H+ <=> UDP-glucose + diphosphate 2.7.7.23 UDP-N-acetylglucosamine diphosphorylase
2.7.7.24 glucose-1-phosphate thymidylyltransferase
2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
2.7.7.33 glucose-1-phosphate cytidylyltransferase
2.7.7.64 UTP-monosaccharide-1-phosphate uridylyltransferase
2.7.7.9 UTP---glucose-1-phosphate uridylyltransferase
–
–
–
–
–
–
2-Carboxy-2,3-dihydro-5,6-dihydroxyindole + dopaquinone <=> L-Dopachrome + L-Dopa not assigned
 –
phosphoribulosylformimino-AICAR-phosphate + L-glutamine <=> H+ + L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol_3-phosphate + 5-aminoimidazole-4-carboxamide_ribonucleotide 2.4.2
4.3.1.B2
4.3.2.10 imidazole glycerol-phosphate synthase
–
–
–
L-arabinose + NADP+ <=> L-arabinono-1,4-lactone + NADPH + H+ 1.1.1.120 galactose 1-dehydrogenase (NADP+)
1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)
1.1.1.376 L-arabinose 1-dehydrogenase [NAD(P)+]
1.1.1.46 L-arabinose 1-dehydrogenase
–
–
–
–
indole <=> indole-3-acetic_acid 2.5.1
–
tetracenomycin_A2 + O2 + NADPH + H+ <=> tetracenomycin_C + H2O + NADP+ 1.14.13.200 tetracenomycin A2 monooxygenase-dioxygenase
–
S-adenosyl-L-methionine + demethyldecarbamoylnovobiocin <=> S-adenosyl-L-homocysteine + decarbamoylnovobiocin + H+ 2.1.1.285 demethyldecarbamoylnovobiocin O-methyltransferase
–
3-[(2S,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate + L-phenylalanine <=> L-dihydroanticapsin + phenylpyruvate 2.6.1
–
O-phospho-L-serine + H2O <=> L-serine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.15 histidinol-phosphatase
3.1.3.16 protein-serine/threonine phosphatase
3.1.3.2 acid phosphatase
3.1.3.20 phosphoglycerate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.3 phosphoserine phosphatase
3.1.3.48 protein-tyrosine-phosphatase
3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
3.1.3.8 3-phytase
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pectate + H2O <=> D-galacturonate + pectate 3.2.1.15 endo-polygalacturonase
3.2.1.67 galacturonan 1,4-alpha-galacturonidase
–
–
(S)-3-hydroxyoctanoyl-CoA + NAD+ <=> 3-oxooctanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
octanoyl-[acyl-carrier_protein] + Lipoyl-carrier_protein_E2 <=> [Lipoyl-carrier_protein_E2]-N6-octanoyl-L-lysine + [acyl-carrier_protein] 2.3.1.181 lipoyl(octanoyl) transferase
–
Dimethylsulfide + O2 + NADH + H+ <=> methanethiol + formaldehyde + H2O + NAD+ 1.14.13.131 dissimilatory dimethyl sulfide monooxygenase
–
choloyl-CoA + taurine <=> H+ + taurocholate + CoA 2.3.1.65 bile acid-CoA:amino acid N-acyltransferase
–
3-Amino-4-hydroxybenzoic_acid + N-acetyl-L-cysteine + O2 + H+ <=> grixazone_B + H2O + CO2 1.10.3.15 grixazone synthase
–
L-3-hydroxykynurenine + H2O <=> H+ + 3-Hydroxyanthranilate + L-alanine 3.7.1.3 kynureninase
–
fluorene + O2 + NADH + H+ <=> 9-fluorenol + H2O + NAD+ 1.14.12
1.14.12.12 naphthalene 1,2-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
1.14.13
–
–
–
–
beta-cryptoxanthin + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> zeaxanthin + H2O + oxidized_ferredoxin 1.14
1.14.13
1.14.15.24 beta-carotene 3-hydroxylase
–
–
–
formate + acetyl-CoA <=> pyruvate + CoA 2.3.1.54 formate C-acetyltransferase
–
Toluene + O2 + NADH + H+ <=> (1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol + NAD+ 1.14.12.11 toluene dioxygenase
–
phosphatidylglycerol + phosphatidylglycerol <=> cardiolipin + glycerol 2.7.8
2.7.8.B10
–
–
D-erythro-3-Methylmalate + NAD+ <=> 2-oxobutyrate + CO2 + NADH 1.1.1
1.1.1.85 3-isopropylmalate dehydrogenase
–
–
S-adenosyl-L-methionine + phenazine-1-carboxylic_acid <=> 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine 2.1.1.327 phenazine-1-carboxylate N-methyltransferase
–
(-)-threo-iso(homo)3citrate + NAD+ <=> 2-Oxosuberate + CO2 + NADH 1.1.1
–
6-Oxocampestanol + O2 + NADPH <=> Cathasterone + NADP+ + H2O 1.14.13
–
NADP+ + 4-hydroxybutyrate <=> H+ + NADPH + succinate_semialdehyde 1.1.1
1.1.1.19 glucuronate reductase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.26 glyoxylate reductase
1.1.1.61 4-hydroxybutyrate dehydrogenase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.B47
1.1.1.co
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–
–
UDP-N-acetyl-D-galactosaminuronic_acid + ATP + L-glutamine + H2O <=> UDP-2-acetamido-2-deoxy-alpha-D-galacturonamide + AMP + L-glutamate + diphosphate 6.3.5
–
nicotinamide + H2O <=> NH3 + nicotinate 3.5.1.13 aryl-acylamidase
3.5.1.19 nicotinamidase
3.5.1.4 amidase
–
–
–
dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-4-dehydro-beta-L-rhamnose 5.1.3.13 dTDP-4-dehydrorhamnose 3,5-epimerase
–
DELTA5,7-avenasterol <=> isofucosterol 1.3.1.21 7-dehydrocholesterol reductase
–
O2 + H2O + putrescine <=> NH3 + H2O2 + 4-Aminobutyraldehyde 1.4.3.10 putrescine oxidase
1.4.3.21 primary-amine oxidase
1.4.3.22 diamine oxidase
–
–
–
(3R)-3-hydroxyhexanoyl-[acyl-carrier_protein] <=> trans-Hex-2-enoyl-[acp] + H2O 2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
4.2.1
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
–
–
–
–
–
trans-3-Chloroallyl_aldehyde + H2O <=> trans-3-Chloroacrylic_acid + 2 H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)
–
5-carboxymethyl-2-hydroxymuconate_semialdehyde + NAD+ + H2O <=> H+ + 5-Carboxymethyl-2-hydroxymuconate + NADH 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
1.2.1.60 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
–
–
theophylline + NADPH + O2 + H+ <=> 1-Methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.179 methylxanthine N3-demethylase
–
CMP-N-acetylneuraminate + GM1b <=> CMP + GD1a not assigned
 –
seleno-L-homocysteine + 5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate <=> seleno-L-methionine + tetrahydropteroyl-Glu3 2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
–
–
O-phospho-L-serine + 2-oxoglutarate <=> L-glutamate + 3-phosphohydroxypyruvate 2.6.1.52 phosphoserine transaminase
–
2 glutathione + protein_disulfide <=> GSSG + protein-dithiol 1.8.4.2 protein-disulfide reductase (glutathione)
–
dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-gulose 5.1.3.27 dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase
–
phosphatidylglycerol + phosphatidylethanolamine <=> cardiolipin + ethanolamine 2.7.8
2.7.8.B11
–
–
beta-D-ribosylnicotinate + ATP <=> H+ + nicotinic_acid_mononucleotide + ADP 2.7.1.173 nicotinate riboside kinase
–
oxalosuccinate + H+ <=> 2-oxoglutarate + CO2 1.1.1.42 isocitrate dehydrogenase (NADP+)
–
N-formyl-L-kynurenine + H2O <=> L-kynurenine + formate + H+ 3.5.1.9 arylformamidase
–
GDP-L-fucose + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> GDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-1-Asn 2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase
–
5-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ <=> 4-Fluorocatechol + NADH + CO2 + H+ 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
–
ATP + acetate <=> ADP + acetyl_phosphate 2.1.2.2 phosphoribosylglycinamide formyltransferase
2.7.2.1 acetate kinase
2.7.2.15 propionate kinase
2.7.2.2 carbamate kinase
–
–
–
–
UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate <=> UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate 2.6.1.87 UDP-4-amino-4-deoxy-L-arabinose aminotransferase
2.6.1.92 UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase
–
–
geranylgeranyl_diphosphate <=> diphosphate + casbene 4.2.3.8 casbene synthase
–
D-mannose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.8 mannose-6-phosphate isomerase
5.3.1.9 glucose-6-phosphate isomerase
–
–
formaldehyde + H2O <=> methanol + formate + H+ 1.2.98.1 formaldehyde dismutase
–
(2E,6E)-farnesyl_diphosphate <=> pentalenene + diphosphate 4.2.3.7 pentalenene synthase
–
2 3-Hydroxyanthranilate + 4 O2 <=> Cinnabarinic_acid + 2 O2- + 2 H2O2 + 2 H+ 1.11.1.21 catalase-peroxidase
1.11.1.6 catalase
–
–
L-2-aminoadipate_adenylate + Holo-Lys2 <=> alpha-Aminoadipoyl-S-acyl_enzyme + AMP 1.2.1.95 L-2-aminoadipate reductase
–
6-Hydroxynicotinate + NADH + H+ + O2 <=> 2,5-dihydroxypyridine + NAD+ + CO2 + H2O 1.14.13.114 6-hydroxynicotinate 3-monooxygenase
–
L-fuconolactone + H2O <=> L-fuconate 3.1.1
–
methanol + coenzyme_M <=> methyl-CoM + H2O 2.1.1.246 [methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase
2.1.1.90 methanol---corrinoid protein Co-methyltransferase
–
–
dTDP-4-ethylamino-3-O-methyl-2,4-dideoxy-L-threo-pentopyranose + Calicheamicin_PsAg <=> dTDP + Calicheamicin_alpha1(I) 2.4.2
–
2-dehydro-3-deoxy-D-galactonate_6-phosphate <=> D-glyceraldehyde_3-phosphate + pyruvate 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
4.1.2.21 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
–
–
–
dolichyl_phosphate + H2O <=> dolichol + phosphate 3.1.3.51 dolichyl-phosphatase
–
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-idosamine + acetyl-CoA <=> UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-idose + CoA + H+ 2.3.1
–
7,9,12-Decaketide_intermediate_2 <=> 7,9,12-Decaketide_intermediate_3 + 2 H2O 4.2.1
–
pre-queuine_1 + NADP+ <=> 7-cyano-7-carbaguanine + NADPH + H+ 1.7.1.13 preQ1 synthase
–
NAD+ + meso-tartrate <=> H+ + NADH + Dihydroxyfumarate 1.3.1.7 meso-tartrate dehydrogenase
–
alpha-D-glucose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.9 glucose-6-phosphate isomerase
–
dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O 4.2.1.159 dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
–
(2S)-lactyl-2-diphospho-5''-guanosine + coenzyme_F0 <=> GMP + coenzyme_F420-0 2.7.8.28 2-phospho-L-lactate transferase
–
Dihydroxyfumarate <=> Oxaloglycolate not assigned
 –
tetracycline + O2 + Cl- + FADH2 <=> 7-chlorotetracycline + H2O + FAD + H+ 1.14.19.49 tetracycline 7-halogenase
–
7,8-dihydroneopterin_3''-triphosphate <=> 6-pyruvoyltetrahydropterin + tripolyphosphate + H+ 4.2.3.12 6-pyruvoyltetrahydropterin synthase
–
2-Hydroxy-2H-benzo[h]chromene-2-carboxylate <=> cis-4-(1''-Hydroxynaphth-2''-yl)-2-oxobut-3-enoate 5.1.2
–
glycine + acceptor <=> cyanide + CO2 + reduced_acceptor 1.4.99.5 glycine dehydrogenase (cyanide-forming)
–
7,9,12-Decaketide_intermediate_1 + NADPH + H+ <=> 7,9,12-Decaketide_intermediate_2 + NADP+ 1.1.1
–
tryprostatin_A + reduced_flavodoxin + O2 <=> fumitremorgin_C + flavin + 2 H2O 1.14.19.71 fumitremorgin C synthase
–
4-Methylbenzoate + O2 + NADH + H+ <=> cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NAD+ 1.14.12
–
normetanephrine + H2O + O2 <=> 4-hydroxyphenyl-3-methoxyglycolaldehyde + NH3 + H2O2 1.4.3.4 monoamine oxidase
–
UDP-N-acetyl-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->4)-[beta-D-GlcNAc-(1->2)]-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn 2.4.1.145 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
–
galactarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O 4.2.1.42 galactarate dehydratase
–
glutathione + ROOH <=> GSSG + H2O + an_alcohol 1.11.1.27 glutathione-dependent peroxiredoxin
1.11.1.9 glutathione peroxidase
–
–
GDP-L-fucose + alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[beta-D-Gal-(1->4)-alpha-L-Fuc-(1->6)]-beta-D-GlcNAc-1-Asn <=> GDP + alpha-D-Man-(1->6)-[alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[beta-D-Gal-(1->4)-alpha-L-Fuc-(1->6)]-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-1-Asn 2.4.1
–
ATP + L-lysine + beta-Alanine <=> ADP + phosphate + beta-Ala-Lys 6.3.2.11 carnosine synthase
–
H2O + 1D-myo-inositol_1,4,5-trisphosphate <=> D-myo-inositol_(1,4)-bisphosphate + phosphate 3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.56 inositol-polyphosphate 5-phosphatase
–
–
7-chloro-L-tryptophan + O2 <=> 2-imino-3-(7-chloroindol-3-yl)propanoate + H2O2 + H+ 1.4.3.23 7-chloro-L-tryptophan oxidase
–
protein_Npi-phospho-L-histidine + D-glucose <=> protein_L-histidine + alpha-D-glucose_6-phosphate 2.7.1.199 protein-Npi-phosphohistidine---D-glucose phosphotransferase
–
uridine_3''-monophosphate + H2O <=> uridine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.31 nucleotidase
3.1.3.6 3'-nucleotidase
3.1.30.1 Aspergillus nuclease S1
3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
–
–
–
–
–
–
–
Caffeine + NADPH + O2 + H+ <=> paraxanthine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
1.14.14.1 unspecific monooxygenase
–
–
–
D-glyceraldehyde + H2O + oxidized_ferredoxin <=> D-glycerate + H+ + reduced_ferredoxin 1.2.7.5 aldehyde ferredoxin oxidoreductase
–
GDP-L-fucose + Galactosylgloboside <=> Globo-H + GDP + H+ 2.4.1
2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase
–
–
5-oxopent-3-ene-1,2,5-tricarboxylate + H+ <=> 2-hydroxyhepta-2,4-dienedioate + CO2 4.1.1.68 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
–
formate + coenzyme_F420 + H+ <=> CO2 + reduced_coenzyme_F420 1.17.1.9 formate dehydrogenase
1.17.98.3 formate dehydrogenase (coenzyme F420)
–
–
acyl-[acyl-carrier_protein] + phosphate <=> acyl_phosphate + [acyl-carrier_protein] 2.3.1.274 phosphate acyltransferase
–
ATP + (25R)-3alpha,7alpha-dihydroxy-5-beta-cholestanate + CoA <=> AMP + diphosphate + 3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA 6.2.1.28 3alpha,7alpha-dihydroxy-5beta-cholestanate---CoA ligase
6.2.1.7 cholate---CoA ligase
–
–
S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin_C + S-adenosyl-L-homocysteine + H+ 2.1.1.306 8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase
–
3,5-diphosphomevalonate + H+ <=> isopentenyl_phosphate + CO2 + phosphate 4.1.1.110 bisphosphomevalonate decarboxylase
–
L-arogenate + NAD+ <=> L-tyrosine + CO2 + NADH 1.3.1.12 prephenate dehydrogenase
1.3.1.43 arogenate dehydrogenase
1.3.1.78 arogenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]
–
–
–
–
alpha-D-GlcN-(1->6)-Ino-P + H2O <=> Glucosaminyl-alpha-1,6-D-myo-inositol + phosphatidic_acid 3.1.4.50 glycosylphosphatidylinositol phospholipase D
–
S-methyl-5''-thioadenosine + phosphate <=> adenine + S-methyl-5-thio-alpha-D-ribose_1-phosphate 2.4.2.1 purine-nucleoside phosphorylase
2.4.2.28 S-methyl-5'-thioadenosine phosphorylase
3.2.2.9 adenosylhomocysteine nucleosidase
–
–
–
futalosine + H2O <=> dehypoxanthine_futalosine + hypoxanthine 3.2.2.26 futalosine hydrolase
–
H+ + N-carbamoylsarcosine + H2O <=> NH3 + CO2 + sarcosine 3.5.1.59 N-carbamoylsarcosine amidase
–
L-tyrosine + O2 + reduced_flavodoxin <=> N-hydroxy-L-tyrosine + flavin + H2O 1.14.14.36 tyrosine N-monooxygenase
–
6-phospho-D-glucono-1,5-lactone + H2O <=> H+ + 6-phosphogluconate 3.1.1.31 6-phosphogluconolactonase
–
1alpha,25-dihydroxyvitamin_D3 + reduced_adrenodoxin + O2 + H+ <=> 1alpha,24R,25-trihydroxyvitamin_D3 + oxidized_ferredoxin + H2O 1.14.15.16 vitamin D3 24-hydroxylase
–
4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP+ <=> 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+ 1.2.1.83 3-succinoylsemialdehyde-pyridine dehydrogenase
–
pyridoxine + O2 <=> pyridoxal + H2O2 1.1.3.12 pyridoxine 4-oxidase
1.4.3.5 pyridoxal 5'-phosphate synthase
–
–
gamma-butyrobetaine + 2-oxoglutarate + O2 <=> L-carnitine + succinate + CO2 1.14.11.1 gamma-butyrobetaine dioxygenase
–
Hygrine <=> tropinone not assigned
 –
isovaleryl-CoA + FAD <=> 3-methylcrotonoyl-CoA + FADH2 1.3.8.4 isovaleryl-CoA dehydrogenase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
–
–
4-(glutamylamino)_butanoate + H2O <=> L-glutamate + 4-aminobutanoate 3.5.1.94 gamma-glutamyl-gamma-aminobutyrate hydrolase
–
guanosine + H2O <=> D-ribose + guanine 3.2.2.1 purine nucleosidase
3.2.2.2 inosine nucleosidase
3.2.2.7 adenosine nucleosidase
3.2.2.8 ribosylpyrimidine nucleosidase
–
–
–
–
dCTP + thioredoxin_disulfide + H2O <=> CTP + thioredoxin 1.17.4.1 ribonucleoside-diphosphate reductase
1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)
–
–
O-acetyl-L-serine + Hydroxyurea <=> O-ureido-L-serine + acetate + H+ 2.5.1.51 beta-pyrazolylalanine synthase
2.6.99.3 O-ureido-L-serine synthase
–
–
[glycine_cleavage_system_H]-N6-octanoyl-L-lysine + Lipoyl-carrier_protein_E2 <=> glycine_cleavage_system_H + [Lipoyl-carrier_protein_E2]-N6-octanoyl-L-lysine 2.3.1.204 octanoyl-[GcvH]:protein N-octanoyltransferase
–
citrate <=> isocitrate 4.2.1.3 aconitate hydratase
–
beta-D-GlcA2S-(1->4)-alpha-D-GlcNAc6S-(1->4)-D-GlcA + H2O <=>