|
|
2-oxoglutarate + (S)-3-amino-2-methylpropanoate <=> L-glutamate + L-2-methyl-3-oxopropionate
|
2.6.1.22
(S)-3-amino-2-methylpropionate transaminase
|
–
|
| |
KEGG:
R04188
MetaCyc:
2.6.1.22-RXN
SABIO-RK:
3906
|
|
|
|
(S)-3-hydroxy-2-methylpropanoyl-CoA + H2O <=> L-3-hydroxyisobutyrate + H+ + CoA
|
3.1.2.4
3-hydroxyisobutyryl-CoA hydrolase
|
–
|
| |
BRENDA:
BS364470;
BS446008
KEGG:
R05064
MetaCyc:
3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN
SABIO-RK:
4692
|
|
|
|
(S)-3-hydroxy-2-methylpropanoyl-CoA <=> methacryloyl-CoA + H2O
|
4.2.1.17
enoyl-CoA hydratase
|
–
|
| |
KEGG:
R04224
MetaCyc:
METHYLACYLYLCOA-HYDROXY-RXN
SABIO-RK:
3935
|
|
|
|
isobutyryl-CoA + oxidized_electron_transfer_flavoprotein + H+ <=> methacryloyl-CoA + reduced_flavodoxin
|
1.3.8.5
2-methyl-branched-chain-enoyl-CoA reductase
|
–
|
| |
MetaCyc:
MEPROPCOA-FAD-RXN
|
|
|
|
L-2-methyl-3-oxopropionate + CoA + NAD+ + H2O <=> propionyl-CoA + HCO3- + NADH + H+
|
1.2.1.27
methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
|
–
|
| |
MetaCyc:
RXN-11213
|
|
|
|
L-valine + 2-oxoglutarate <=> L-glutamate + 2-oxoisovalerate
|
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.6
leucine transaminase
2.6.1.66
valine---pyruvate transaminase
|
–
–
–
–
|
| |
BRENDA:
BS356553
KEGG:
R01214
MetaCyc:
BRANCHED-CHAINAMINOTRANSFERVAL-RXN
SABIO-RK:
1446
|
|
|
|
L-3-hydroxyisobutyrate + NAD+ <=> H+ + NADH + L-2-methyl-3-oxopropionate
|
1.1.1.291
2-hydroxymethylglutarate dehydrogenase
1.1.1.31
3-hydroxyisobutyrate dehydrogenase
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
|
–
–
–
|
| |
BRENDA:
BS188039
KEGG:
R05066
MetaCyc:
3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN
SABIO-RK:
4693
|
|
|
|
2-oxoisovalerate + CoA + NAD+ <=> isobutyryl-CoA + CO2 + NADH
|
1.2.1.25
branched-chain alpha-keto acid dehydrogenase system
1.2.4.1
pyruvate dehydrogenase (acetyl-transferring)
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
2.7.11.4
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase
|
–
–
–
–
|
| |
BRENDA:
BR36775
KEGG:
R01210
MetaCyc:
1.2.1.25-RXN
SABIO-RK:
1443;
1814
|
|
