|
|
citraconate + H2O <=> D-erythro-3-Methylmalate
|
4.2.1.35
(R)-2-methylmalate dehydratase
|
–
|
| |
KEGG:
R03898
MetaCyc:
RXN-7744
|
|
|
|
(R)-citramalate <=> citraconate + H2O
|
4.2.1.31
maleate hydratase
4.2.1.35
(R)-2-methylmalate dehydratase
|
–
–
|
| |
BRENDA:
BR415
KEGG:
R03896
MetaCyc:
R-2-METHYLMALATE-DEHYDRATASE-RXN
SABIO-RK:
3641
|
|
|
|
H+ + pyruvate + 2-oxobutyrate <=> (S)-2-hydroxy-2-ethyl-3-oxobutanoate + CO2
|
2.2.1.6
acetolactate synthase
|
–
|
| |
BRENDA:
BS386670;
BS454179
KEGG:
R08648
MetaCyc:
ACETOOHBUTSYN-RXN
SABIO-RK:
6688
|
|
|
|
2R,3R-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O
|
4.2.1.9
dihydroxy-acid dehydratase
|
–
|
| |
BRENDA:
BS453486
KEGG:
R05070
MetaCyc:
DIHYDROXYMETVALDEHYDRAT-RXN
|
|
|
|
L-isoleucine + 2-oxoglutarate <=> L-glutamate + (S)-3-methyl-2-oxopentanoate
|
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.67
2-aminohexanoate transaminase
|
–
–
|
| |
BRENDA:
BS356522;
BS452227
KEGG:
R02199
MetaCyc:
BRANCHED-CHAINAMINOTRANSFERILEU-RXN
SABIO-RK:
2171;
9086
|
|
|
|
acetyl-CoA + pyruvate + H2O <=> H+ + (R)-citramalate + CoA
|
2.3.1.182
(R)-citramalate synthase
2.3.3.13
2-isopropylmalate synthase
|
–
–
|
| |
BRENDA:
BR48833
KEGG:
R07399
MetaCyc:
RXN-7743
SABIO-RK:
9043
|
|
|
|
2R,3R-2,3-dihydroxy-3-methylpentanoate + NADP+ <=> (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
|
1.1.1.383
ketol-acid reductoisomerase [NAD(P)+]
|
–
|
| |
MetaCyc:
RXN-16062
|
|
|
|
D-erythro-3-Methylmalate + NAD+ <=> 2-oxobutyrate + CO2 + NADH
|
1.1.1
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
| |
KEGG:
R00994
MetaCyc:
RXN-7745
|
|
