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Drug metabolism - other enzymes

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
irinotecan <=> ApC 1.14.13
–
acetohydrazide + H2O <=> hydrazine + acetate 3.5.1
3.5.1.4 amidase
–
–
Isonicotinoyl_radical + NAD+ <=> Isonicotinoyl-NAD_adduct not assigned
 –
6-Thioinosine-5''-monophosphate + ATP <=> 6-Mercaptopurine_ribonucleoside_5''-diphosphate + ADP 2.7.4
–
isoniazid + pyruvate <=> Isoniazid_pyruvate + H2O not assigned
 –
ATP + 5-Fluorouridine_diphosphate <=> ADP + 5-fluorouridine_triphosphate 2.7.4.6 nucleoside-diphosphate kinase
–
NPC + H2O <=> SN-38 + 4-Amino-1-piperidinecarboxylic_acid 3.1.1.1 carboxylesterase
–
acetyl-CoA + hydrazine <=> CoA + acetohydrazide 2.3.1.5 arylamine N-acetyltransferase
–
6-Thioxanthine_5''-monophosphate + ATP + L-glutamine + H2O <=> 6-Thioguanosine_5'-phosphate + AMP + diphosphate + L-glutamate 6.3.5.2 GMP synthase (glutamine-hydrolysing)
–
6-thio-IMP + NAD+ + H2O <=> 6-thioXMP + NADH + H+ 1.1.1.205 IMP dehydrogenase
–
2-fluoro-3-ureidopropionic_acid + H2O <=> alpha-fluoro-beta-alanine + CO2 + NH3 3.5.1.6 beta-ureidopropionase
–
5-fluorodeoxyuridine_5'-diphosphate + thioredoxin_disulfide + H2O <=> 5-Fluorouridine_diphosphate + thioredoxin 1.17.4.1 ribonucleoside-diphosphate reductase
–
5-fluoro-2''-deoxyuridine + phosphate <=> 5-fluorouracil + 2-deoxy-D-ribose_1-phosphate 2.4.2.2 pyrimidine-nucleoside phosphorylase
2.4.2.3 uridine phosphorylase
2.4.2.4 thymidine phosphorylase
–
–
–
7-ethyl-camptothecin_lactone-10-yl-beta-D-glucuronate + H2O <=> SN-38 + D-glucuronate 3.2.1.31 beta-glucuronidase
–
SN-38 + UDP-glucuronate <=> UDP + 7-ethyl-camptothecin_lactone-10-yl-beta-D-glucuronate 2.4.1.17 glucuronosyltransferase
–
ATP + 5-fluoro-UMP <=> ADP + 5-Fluorouridine_diphosphate 2.7.4.14 UMP/CMP kinase
–
ATP + 5-fluorouridine <=> ADP + 5-fluorouridine_5''-monophosphate 2.7.1.48 uridine/cytidine kinase
–
ATP + 5-fluorodeoxyuridine_5'-diphosphate <=> ADP + 2'-deoxy-5-fluoro-UTP 2.7.4.6 nucleoside-diphosphate kinase
–
Isonicotinic_acid + glycine <=> Isonicotinylglycine not assigned
 –
6-mercaptopurine_riboside_5'-triphosphate + H2O <=> 6-Thioinosine-5''-monophosphate + diphosphate 3.6.1
–
acetyl-CoA + isoniazid <=> CoA + N-acetyl-isoniazid 2.3.1.118 N-hydroxyarylamine O-acetyltransferase
2.3.1.5 arylamine N-acetyltransferase
–
–
isoniazid + 2-oxoglutarate <=> Isoniazid_alpha-ketoglutaric_acid + H2O not assigned
 –
S-adenosyl-L-methionine + 6-Mercaptopurine <=> S-adenosyl-L-homocysteine + 6-methylthiopurine + H+ 2.1.1.67 thiopurine S-methyltransferase
2.1.1.9 thiol S-methyltransferase
–
–
irinotecan + H2O <=> SN-38 + 1,4''-bipiperidine-1''-carboxylic_acid 3.1.1.1 carboxylesterase
–
Azathioprine <=> 6-Mercaptopurine + 1-Methyl-4-nitroimidazole not assigned
 –
5''-Deoxy-5-fluorocytidine + H2O <=> 5''-Deoxy-5-fluorouridine + NH3 3.5.4.5 cytidine deaminase
–
ATP + 5-fluoro-2'-deoxyuridylic_acid <=> ADP + 5-fluorodeoxyuridine_5'-diphosphate 2.7.4.14 UMP/CMP kinase
–
acetyl-CoA + acetohydrazide <=> CoA + N,N''-Diacetylhydrazine 2.3.1.5 arylamine N-acetyltransferase
–
6-Mercaptopurine + 2 H2O + 2 O2 <=> 6-Thiourate + 2 H2O2 1.17.3.2 xanthine oxidase
–
5-fluorouridine + phosphate <=> 5-fluorouracil + alpha-D-ribose_1-phosphate 2.4.2.2 pyrimidine-nucleoside phosphorylase
2.4.2.3 uridine phosphorylase
2.4.2.4 thymidine phosphorylase
–
–
–
5''-deoxy-5-fluorouridine + phosphate <=> 5-fluorouracil + 5-deoxy-D-ribose_1-phosphate 2.4.2.3 uridine phosphorylase
2.4.2.4 thymidine phosphorylase
–
–
isoniazid + H2O2 <=> Isonicotinoyl_radical + H2O + diazene 1.11.1.21 catalase-peroxidase
1.11.2.2 myeloperoxidase
–
–
isoniazid + H2O <=> Isonicotinic_acid + hydrazine 3.1.1.1 carboxylesterase
3.5.1
–
–
6-methylthiopurine + 5-phospho-alpha-D-ribose_1-diphosphate <=> 6-Methylthiopurine_5''-monophosphate_ribonucleotide + diphosphate 2.4.2.8 hypoxanthine phosphoribosyltransferase
–
5-fluoro-5,6-dihydrouracil + H2O <=> 2-fluoro-3-ureidopropionic_acid 3.5.2.2 dihydropyrimidinase
–
S-adenosyl-L-methionine + 6-Thioguanosine_5'-phosphate <=> S-adenosyl-L-homocysteine + 6-methyl_thioguanosine_monophosphate 2.1.1.67 thiopurine S-methyltransferase
–
N-acetyl-isoniazid + H2O <=> acetohydrazide + Isonicotinic_acid 3.1.1.1 carboxylesterase
3.5.1
–
–
5-fluorouracil + NADPH <=> 5-fluoro-5,6-dihydrouracil + NADP+ 1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)
1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)
–
–
acetohydrazide + NADPH + H+ + O2 <=> Hepatotoxins + NADP+ + H2O 1.14.13
–
6-Mercaptopurine + 5-phospho-alpha-D-ribose_1-diphosphate <=> 6-thio-IMP + diphosphate 2.4.2.8 hypoxanthine phosphoribosyltransferase
–
6-thioguanine + 5-phospho-alpha-D-ribose_1-diphosphate <=> 6-Thioguanosine_5'-phosphate + diphosphate 2.4.2.8 hypoxanthine phosphoribosyltransferase
–
2''-deoxy-5-fluoro-UTP + H2O <=> 2''-deoxy-5-fluoro-UMP + diphosphate 3.6.1.23 dUTP diphosphatase
–
carmofur <=> 5-fluorouracil not assigned
 –
Isonicotinoyl_radical + NADP+ <=> Isonicotinoyl-NADP_adduct not assigned
 –
5-fluoro-2''-deoxyuridine + ATP <=> 5-fluoro-2''-deoxyuridine_5''-phosphate + ADP 2.7.1.145 deoxynucleoside kinase
2.7.1.21 thymidine kinase
–
–
S-adenosyl-L-methionine + 6-thio-IMP <=> S-adenosyl-L-homocysteine + 6-methylmercaptopurine-ribonucleotide 2.1.1.67 thiopurine S-methyltransferase
–
Hepatotoxins + glutathione <=> R-S-glutathione 2.5.1.18 glutathione transferase
–
capecitabine + H2O <=> 5''-Deoxy-5-fluorocytidine + 1-Pentanol + CO2 3.1.1.1 carboxylesterase
–
irinotecan + 2 reduced_flavodoxin + 2 O2 <=> NPC + Glutaraldehyde + 2 flavin + 2 H2O 1.14.13
–
Tegafur + reduced_flavodoxin + O2 <=> 5-fluorouracil + 1,4-butanedione + flavin + H2O 1.14.14.1 unspecific monooxygenase
–
5-fluorouracil + 5-phospho-alpha-D-ribose_1-diphosphate <=> 5-fluoro-UMP + diphosphate 2.4.2.10 orotate phosphoribosyltransferase
2.4.2.9 uracil phosphoribosyltransferase
–
–
6-Mercaptopurine_ribonucleoside_5''-diphosphate + ATP <=> 6-mercaptopurine_riboside_5'-triphosphate + ADP 2.7.4
–

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