|
|
carbamazepine-10,11-epoxide + H2O <=> Dihydroxycarbazepine
|
3.3.2
|
–
|
| |
KEGG:
R08314
|
|
|
|
UDP-glucuronate + morphine <=> UDP + morphine_6-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
| |
BRENDA:
BS378148
KEGG:
R08263
SABIO-RK:
11754
|
|
|
|
carbamazepine + NADPH + H+ + O2 <=> 3-hydroxycarbamazepine + NADP+ + H2O
|
1.14.13
|
–
|
| |
KEGG:
R08313
|
|
|
|
N-ethylglycine_xylidide <=> 3-Hydroxymonoethylglycinexylidide
|
not assigned
|
–
|
| |
KEGG:
R08298
|
|
|
|
4-Hydroxyifosfamide <=> Aldoifosfamide
|
not assigned
|
–
|
| |
KEGG:
R08288
|
|
|
|
2-Phenyl-1,3-propanediol_monocarbamate + NAD+ <=> 3-Carbamoyl-2-phenylpropionaldehyde + NADH + H+
|
1.1.1.1
alcohol dehydrogenase
|
–
|
| |
KEGG:
R08306
|
|
|
|
ifosfamide + NADPH + H+ + O2 <=> 4-Hydroxyifosfamide + NADP+ + H2O
|
1.14.13
1.14.14
|
–
–
|
| |
KEGG:
R08285
|
|
|
|
morphine + reduced_flavodoxin + O2 <=> normorphine + formaldehyde + flavin + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R08265
|
|
|
|
Valproic_acid <=> 2-n-Propyl-4-pentenoic_acid
|
1.14.13
1.14.14
|
–
–
|
| |
KEGG:
R08324
|
|
|
|
methadone <=> 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
|
1.14.13
|
–
|
| |
KEGG:
R08339
|
|
|
|
4-Hydroxyvalproic_acid <=> 2-n-Propyl-4-oxopentanoic_acid
|
not assigned
|
–
|
| |
KEGG:
R08330
|
|
|
|
N-ethylglycine_xylidide <=> glycinexylidide
|
not assigned
|
–
|
| |
KEGG:
R08296
|
|
|
|
Demethylcitalopram + O2 + H2O <=> Citalopram_aldehyde + methylamine + H2O2
|
1.4.3.4
monoamine oxidase
|
–
|
| |
KEGG:
R08347
|
|
|
|
3-Hydroxyvalproic_acid <=> 3-Oxovalproic_acid
|
not assigned
|
–
|
| |
KEGG:
R08335
|
|
|
|
morphine + flavin + formaldehyde + H2O <=> codeine + reduced_flavodoxin + O2
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R03697
|
|
|
|
carbamazepine <=> 2-Hydroxycarbamazepine
|
not assigned
|
–
|
| |
KEGG:
R08317
|
|
|
|
Oxcarbazepine <=> 10-Hydroxycarbazepine
|
not assigned
|
–
|
| |
KEGG:
R08321
|
|
|
|
N-Desmethyltamoxifen <=> N,N-Didesmethyltamoxifen
|
1.14.13
|
–
|
| |
KEGG:
R08272
|
|
|
|
2-n-Propyl-2-pentenoic_acid <=> 3-Hydroxyvalproic_acid
|
not assigned
|
–
|
| |
KEGG:
R08338
|
|
|
|
N-ethylglycine_xylidide + H2O <=> 2,6-dimethylaniline + N-ethylglycine
|
3.1.1.1
carboxylesterase
|
–
|
| |
BRENDA:
BS446310
KEGG:
R08295
|
|
|
|
aldophosphamide + NAD+ + H2O <=> Carboxyphosphamide + NADH + H+
|
1.2.1.5
aldehyde dehydrogenase [NAD(P)+]
|
–
|
| |
KEGG:
R08282
|
|
|
|
N-Desmethyltamoxifen + NADPH + H+ + O2 <=> alpha-Hydroxy-N-desmethyltamoxifen + H2O + NADP+
|
1.14.13
|
–
|
| |
KEGG:
R08274
|
|
|
|
ifosfamide <=> 2-Dechloroethylifosfamide + Chloroacetaldehyde
|
1.14.13
1.14.14.1
unspecific monooxygenase
|
–
–
|
| |
KEGG:
R08287
|
|
|
|
cyclophosphamide <=> Dechloroethylcyclophosphamide + Chloroacetaldehyde
|
1.14.13
|
–
|
| |
KEGG:
R08276
|
|
|
|
4-Hydroxycyclophosphamide <=> aldophosphamide
|
not assigned
|
–
|
| |
KEGG:
R08278
|
|
|
|
citalopram + O2 + H2O <=> Citalopram_aldehyde + Dimethylamine + H2O2
|
1.4.3.4
monoamine oxidase
|
–
|
| |
KEGG:
R08346
|
|
|
|
citalopram <=> Citalopram_N-oxide
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R08344
|
|
|
|
3-Hydroxylidocaine <=> 3-Hydroxymonoethylglycinexylidide
|
not assigned
|
–
|
| |
KEGG:
R08297
|
|
|
|
aldophosphamide + glutathione <=> 4-Glutathionyl_cyclophosphamide + H2O
|
2.5.1.18
glutathione transferase
|
–
|
| |
KEGG:
R08280
|
|
|
|
cyclophosphamide + NADPH + H+ + O2 <=> 4-Hydroxycyclophosphamide + NADP+ + H2O
|
1.14.13
1.14.14
1.14.14.1
unspecific monooxygenase
|
–
–
–
|
| |
KEGG:
R08275
SABIO-RK:
14203
|
|
|
|
lidocaine <=> N-ethylglycine_xylidide
|
1.14.13
1.14.14.1
unspecific monooxygenase
|
–
–
|
| |
KEGG:
R08293
|
|
|
|
aldophosphamide + NADH + H+ <=> Alcophosphamide + NAD+
|
1.1.1.1
alcohol dehydrogenase
|
–
|
| |
KEGG:
R08281
|
|
|
|
Didemethylcitalopram + H2O + O2 <=> Citalopram_aldehyde + NH3 + H2O2
|
1.4.3.4
monoamine oxidase
|
–
|
| |
KEGG:
R08348
|
|
|
|
2,3-Dihydroxycarbamazepine <=> Carbamazepine-o-quinone
|
not assigned
|
–
|
| |
KEGG:
R08316
|
|
|
|
2-Hydroxyiminostilbene <=> 2H-Dibenz[b,f]azepin-2-one
|
not assigned
|
–
|
| |
KEGG:
R08319
|
|
|
|
Valproic_acid + NADPH + H+ + O2 <=> 3-Hydroxyvalproic_acid + NADP+ + H2O
|
1.14.13
|
–
|
| |
KEGG:
R08327
|
|
|
|
lidocaine + H2O <=> 2,6-dimethylaniline + N,N-diethylglycine
|
3.1.1.1
carboxylesterase
|
–
|
| |
BRENDA:
BS447687
KEGG:
R08300
|
|
|
|
Citalopram_aldehyde + H2O + O2 <=> Citalopram_propionic_acid + H2O2
|
1.2.3.1
aldehyde oxidase
|
–
|
| |
KEGG:
R08349
|
|
|
|
codeine + reduced_flavodoxin + O2 <=> Norcodeine + formaldehyde + flavin + H2O
|
1.14.13
|
–
|
| |
KEGG:
R08264
|
|
|
|
tamoxifen <=> N-Desmethyltamoxifen
|
1.14.13
|
–
|
| |
KEGG:
R08268
|
|
|
|
cis-4-hydroxytamoxifen <=> trans-endoxifen
|
1.14.13
|
–
|
| |
KEGG:
R08269
|
|
|
|
2-Hydroxycarbamazepine <=> 2,3-Dihydroxycarbamazepine
|
not assigned
|
–
|
| |
KEGG:
R08320
|
|
|
|
Aldoifosfamide <=> Isophosphoramide_mustard + acrolein
|
not assigned
|
–
|
| |
KEGG:
R08289
|
|
|
|
2-n-Propyl-4-pentenoic_acid <=> 2-Propyl-2,4-pentadienoic_acid
|
not assigned
|
–
|
| |
KEGG:
R08329
|
|
|
|
2,6-dimethylaniline <=> 4-Hydroxy-2,6-dimethylaniline
|
not assigned
|
–
|
| |
KEGG:
R08301
|
|
|
|
Valproic_acid <=> 2-n-Propyl-2-pentenoic_acid
|
not assigned
|
–
|
| |
KEGG:
R08336
|
|
|
|
Valproic_acid <=> 2-n-Propyl-3-pentenoic_acid
|
not assigned
|
–
|
| |
KEGG:
R08337
|
|
|
|
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine <=> 2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
|
1.14.13
|
–
|
| |
KEGG:
R08340
|
|
|
|
Felbamate + NADPH + H+ + O2 <=> 2-Hydroxyfelbamate + NADP+ + H2O
|
1.14.13
|
–
|
| |
KEGG:
R08304
|
|
|
|
Aldoifosfamide <=> Carboxyifosfamide
|
not assigned
|
–
|
| |
KEGG:
R08292
|
|
|
|
4-Hydroxyifosfamide <=> 4-Ketoifosfamide
|
not assigned
|
–
|
| |
KEGG:
R08291
|
|
|
|
ifosfamide <=> Dechloroethylcyclophosphamide + Chloroacetaldehyde
|
1.14.13
1.14.14.1
unspecific monooxygenase
|
–
–
|
| |
KEGG:
R08286
|
|
|
|
codeine + UDP-glucuronate <=> codeine-6-glucuronide + UDP
|
2.4.1.17
glucuronosyltransferase
|
–
|
| |
BRENDA:
BS322215
KEGG:
R08261
SABIO-RK:
11755
|
|
|
|
Felbamate + NADPH + H+ + O2 <=> p-Hydroxyfelbamate + NADP+ + H2O
|
1.14.13
|
–
|
| |
KEGG:
R08303
|
|
|
|
2-Hydroxycarbamazepine <=> 2-Hydroxyiminostilbene
|
1.14.13
|
–
|
| |
KEGG:
R08318
|
|
|
|
3-Carbamoyl-2-phenylpropionaldehyde + NAD+ + H2O <=> 3-Carbamoyl-2-phenylpropionic_acid + NADH + H+
|
1.2.1.5
aldehyde dehydrogenase [NAD(P)+]
|
–
|
| |
KEGG:
R08307
|
|
|
|
carbamazepine + NADPH + H+ + O2 <=> carbamazepine-10,11-epoxide + NADP+ + H2O
|
1.14.13
1.14.14.1
unspecific monooxygenase
1.14.14.55
quinine 3-monooxygenase
|
–
–
–
|
| |
KEGG:
R08312
SABIO-RK:
7295
|
|
|
|
glycinexylidide <=> 2,6-dimethylaniline
|
not assigned
|
–
|
| |
KEGG:
R08299
|
|
|
|
tamoxifen + NADPH + O2 + H+ <=> cis-4-hydroxytamoxifen + NADP+ + H2O
|
1.14.14
1.14.14.1
unspecific monooxygenase
|
–
–
|
| |
KEGG:
R08267
|
|
|
|
tamoxifen + NADPH + O2 <=> tamoxifen_N-oxide + NADP+ + H2O
|
1.14.13.8
flavin-containing monooxygenase
|
–
|
| |
BRENDA:
BS386704
KEGG:
R08266
|
|
|
|
10-Hydroxycarbazepine <=> Dihydroxycarbazepine
|
not assigned
|
–
|
| |
KEGG:
R08322
|
|
|
|
4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one + NAD+ <=> 5-Phenyl-1,3-oxazinane-2,4-dione + NADH + H+
|
1.1.1.1
alcohol dehydrogenase
|
–
|
| |
KEGG:
R08310
|
|
|
|
lidocaine + NADPH + O2 + H+ <=> 3-Hydroxylidocaine + NADP+ + H2O
|
1.14.13
1.14.14.1
unspecific monooxygenase
|
–
–
|
| |
KEGG:
R08294
|
|
|
|
UDP-glucuronate + morphine <=> UDP + morphine_3-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
| |
BRENDA:
BS375362;
BS456010
KEGG:
R08262
SABIO-RK:
9918
|
|
|
|
N-Desmethyltamoxifen + NADPH + O2 + H+ <=> trans-endoxifen + NADP+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R08270
|
|
|
|
citalopram <=> Demethylcitalopram
|
1.14.13
1.14.14
1.14.14.1
unspecific monooxygenase
|
–
–
–
|
| |
KEGG:
R08343
|
|
|
|
3-Carbamoyl-2-phenylpropionaldehyde <=> 4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
|
not assigned
|
–
|
| |
KEGG:
R08309
|
|
|
|
5-Hydroxyvalproic_acid <=> 2-Propylglutaric_acid
|
not assigned
|
–
|
| |
KEGG:
R08334
|
|
|
|
2-n-Propyl-4-oxopentanoic_acid <=> 2-Propylsuccinic_acid
|
not assigned
|
–
|
| |
KEGG:
R08333
|
|
|
|
5-Phenyl-1,3-oxazinane-2,4-dione + H2O <=> 3-Carbamoyl-2-phenylpropionic_acid
|
not assigned
|
–
|
| |
KEGG:
R08311
|
|
|
|
2,6-dimethylaniline <=> 3-Methylanthranilate
|
not assigned
|
–
|
| |
KEGG:
R08302
|
|
|
|
3-hydroxycarbamazepine <=> 2,3-Dihydroxycarbamazepine
|
not assigned
|
–
|
| |
KEGG:
R08315
|
|
|
|
Valproic_acid + NADPH + H+ + O2 <=> 5-Hydroxyvalproic_acid + NADP+ + H2O
|
1.14.13
1.14.14
|
–
–
|
| |
KEGG:
R08326
|
|
|
|
L-alpha-Acetyl-N-normethadol <=> L-alpha-Acetyl-N,N-dinormethadol
|
1.14.13
|
–
|
| |
KEGG:
R08342
|
|
|
|
aldophosphamide + NADP+ + H2O <=> Carboxyphosphamide + NADPH + H+
|
1.2.1.5
aldehyde dehydrogenase [NAD(P)+]
|
–
|
| |
KEGG:
R08283
|
|
|
|
Valproic_acid + NADPH + H+ + O2 <=> 4-Hydroxyvalproic_acid + NADP+ + H2O
|
1.14.13
1.14.14
|
–
–
|
| |
KEGG:
R08325
|
|
|
|
4-Hydroxycyclophosphamide <=> 4-Ketocyclophosphamide
|
1.14.13
|
–
|
| |
KEGG:
R08277
|
|
|
|
aldophosphamide <=> Phosphoramide_mustard + acrolein
|
not assigned
|
–
|
| |
KEGG:
R08279
|
|
|
|
tamoxifen + NADPH + O2 + H+ <=> alpha-hydroxytamoxifen + NADP+ + H2O
|
1.14.13
|
–
|
| |
KEGG:
R08271
|
|
|
|
Levomethadyl_acetate <=> L-alpha-Acetyl-N-normethadol
|
1.14.13
|
–
|
| |
KEGG:
R08341
|
|
|
|
Carboxyphosphamide <=> Nornitrogen_mustard
|
not assigned
|
–
|
| |
KEGG:
R08284
|
|
|
|
Aldoifosfamide <=> Alcoifosfamide
|
not assigned
|
–
|
| |
KEGG:
R08290
|
|
|
|
Demethylcitalopram <=> Didemethylcitalopram
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R08345
|
|
|
|
Felbamate + H2O <=> 2-Phenyl-1,3-propanediol_monocarbamate + CO2 + NH3
|
not assigned
|
–
|
| |
KEGG:
R08305
|
|
