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Drug metabolism - cytochrome P450

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
carbamazepine-10,11-epoxide + H2O <=> Dihydroxycarbazepine 3.3.2

UDP-glucuronate + morphine <=> UDP + morphine_6-glucuronide 2.4.1.17 glucuronosyltransferase

carbamazepine + NADPH + H+ + O2 <=> 3-hydroxycarbamazepine + NADP+ + H2O 1.14.13

N-ethylglycine_xylidide <=> 3-Hydroxymonoethylglycinexylidide not assigned

4-Hydroxyifosfamide <=> Aldoifosfamide not assigned

2-Phenyl-1,3-propanediol_monocarbamate + NAD+ <=> 3-Carbamoyl-2-phenylpropionaldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase

ifosfamide + NADPH + H+ + O2 <=> 4-Hydroxyifosfamide + NADP+ + H2O 1.14.13
1.14.14


morphine + reduced_flavodoxin + O2 <=> normorphine + formaldehyde + flavin + H2O 1.14.14.1 unspecific monooxygenase

Valproic_acid <=> 2-n-Propyl-4-pentenoic_acid 1.14.13
1.14.14


methadone <=> 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine 1.14.13

4-Hydroxyvalproic_acid <=> 2-n-Propyl-4-oxopentanoic_acid not assigned

N-ethylglycine_xylidide <=> glycinexylidide not assigned

Demethylcitalopram + O2 + H2O <=> Citalopram_aldehyde + methylamine + H2O2 1.4.3.4 monoamine oxidase

3-Hydroxyvalproic_acid <=> 3-Oxovalproic_acid not assigned

morphine + flavin + formaldehyde + H2O <=> codeine + reduced_flavodoxin + O2 1.14.14.1 unspecific monooxygenase

carbamazepine <=> 2-Hydroxycarbamazepine not assigned

Oxcarbazepine <=> 10-Hydroxycarbazepine not assigned

N-Desmethyltamoxifen <=> N,N-Didesmethyltamoxifen 1.14.13

2-n-Propyl-2-pentenoic_acid <=> 3-Hydroxyvalproic_acid not assigned

N-ethylglycine_xylidide + H2O <=> 2,6-dimethylaniline + N-ethylglycine 3.1.1.1 carboxylesterase

aldophosphamide + NAD+ + H2O <=> Carboxyphosphamide + NADH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]

N-Desmethyltamoxifen + NADPH + H+ + O2 <=> alpha-Hydroxy-N-desmethyltamoxifen + H2O + NADP+ 1.14.13

ifosfamide <=> 2-Dechloroethylifosfamide + Chloroacetaldehyde 1.14.13
1.14.14.1 unspecific monooxygenase


cyclophosphamide <=> Dechloroethylcyclophosphamide + Chloroacetaldehyde 1.14.13

4-Hydroxycyclophosphamide <=> aldophosphamide not assigned

citalopram + O2 + H2O <=> Citalopram_aldehyde + Dimethylamine + H2O2 1.4.3.4 monoamine oxidase

citalopram <=> Citalopram_N-oxide 1.14.14.1 unspecific monooxygenase

3-Hydroxylidocaine <=> 3-Hydroxymonoethylglycinexylidide not assigned

aldophosphamide + glutathione <=> 4-Glutathionyl_cyclophosphamide + H2O 2.5.1.18 glutathione transferase

cyclophosphamide + NADPH + H+ + O2 <=> 4-Hydroxycyclophosphamide + NADP+ + H2O 1.14.13
1.14.14
1.14.14.1 unspecific monooxygenase



lidocaine <=> N-ethylglycine_xylidide 1.14.13
1.14.14.1 unspecific monooxygenase


aldophosphamide + NADH + H+ <=> Alcophosphamide + NAD+ 1.1.1.1 alcohol dehydrogenase

Didemethylcitalopram + H2O + O2 <=> Citalopram_aldehyde + NH3 + H2O2 1.4.3.4 monoamine oxidase

2,3-Dihydroxycarbamazepine <=> Carbamazepine-o-quinone not assigned

2-Hydroxyiminostilbene <=> 2H-Dibenz[b,f]azepin-2-one not assigned

Valproic_acid + NADPH + H+ + O2 <=> 3-Hydroxyvalproic_acid + NADP+ + H2O 1.14.13

lidocaine + H2O <=> 2,6-dimethylaniline + N,N-diethylglycine 3.1.1.1 carboxylesterase

Citalopram_aldehyde + H2O + O2 <=> Citalopram_propionic_acid + H2O2 1.2.3.1 aldehyde oxidase

codeine + reduced_flavodoxin + O2 <=> Norcodeine + formaldehyde + flavin + H2O 1.14.13

tamoxifen <=> N-Desmethyltamoxifen 1.14.13

cis-4-hydroxytamoxifen <=> trans-endoxifen 1.14.13

2-Hydroxycarbamazepine <=> 2,3-Dihydroxycarbamazepine not assigned

Aldoifosfamide <=> Isophosphoramide_mustard + acrolein not assigned

2-n-Propyl-4-pentenoic_acid <=> 2-Propyl-2,4-pentadienoic_acid not assigned

2,6-dimethylaniline <=> 4-Hydroxy-2,6-dimethylaniline not assigned

Valproic_acid <=> 2-n-Propyl-2-pentenoic_acid not assigned

Valproic_acid <=> 2-n-Propyl-3-pentenoic_acid not assigned

2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine <=> 2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline 1.14.13

Felbamate + NADPH + H+ + O2 <=> 2-Hydroxyfelbamate + NADP+ + H2O 1.14.13

Aldoifosfamide <=> Carboxyifosfamide not assigned

4-Hydroxyifosfamide <=> 4-Ketoifosfamide not assigned

ifosfamide <=> Dechloroethylcyclophosphamide + Chloroacetaldehyde 1.14.13
1.14.14.1 unspecific monooxygenase


codeine + UDP-glucuronate <=> codeine-6-glucuronide + UDP 2.4.1.17 glucuronosyltransferase

Felbamate + NADPH + H+ + O2 <=> p-Hydroxyfelbamate + NADP+ + H2O 1.14.13

2-Hydroxycarbamazepine <=> 2-Hydroxyiminostilbene 1.14.13

3-Carbamoyl-2-phenylpropionaldehyde + NAD+ + H2O <=> 3-Carbamoyl-2-phenylpropionic_acid + NADH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]

carbamazepine + NADPH + H+ + O2 <=> carbamazepine-10,11-epoxide + NADP+ + H2O 1.14.13
1.14.14.1 unspecific monooxygenase
1.14.14.55 quinine 3-monooxygenase



glycinexylidide <=> 2,6-dimethylaniline not assigned

tamoxifen + NADPH + O2 + H+ <=> cis-4-hydroxytamoxifen + NADP+ + H2O 1.14.14
1.14.14.1 unspecific monooxygenase


tamoxifen + NADPH + O2 <=> tamoxifen_N-oxide + NADP+ + H2O 1.14.13.8 flavin-containing monooxygenase

10-Hydroxycarbazepine <=> Dihydroxycarbazepine not assigned

4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one + NAD+ <=> 5-Phenyl-1,3-oxazinane-2,4-dione + NADH + H+ 1.1.1.1 alcohol dehydrogenase

lidocaine + NADPH + O2 + H+ <=> 3-Hydroxylidocaine + NADP+ + H2O 1.14.13
1.14.14.1 unspecific monooxygenase


UDP-glucuronate + morphine <=> UDP + morphine_3-glucuronide 2.4.1.17 glucuronosyltransferase

N-Desmethyltamoxifen + NADPH + O2 + H+ <=> trans-endoxifen + NADP+ + H2O 1.14.14.1 unspecific monooxygenase

citalopram <=> Demethylcitalopram 1.14.13
1.14.14
1.14.14.1 unspecific monooxygenase



3-Carbamoyl-2-phenylpropionaldehyde <=> 4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one not assigned

5-Hydroxyvalproic_acid <=> 2-Propylglutaric_acid not assigned

2-n-Propyl-4-oxopentanoic_acid <=> 2-Propylsuccinic_acid not assigned

5-Phenyl-1,3-oxazinane-2,4-dione + H2O <=> 3-Carbamoyl-2-phenylpropionic_acid not assigned

2,6-dimethylaniline <=> 3-Methylanthranilate not assigned

3-hydroxycarbamazepine <=> 2,3-Dihydroxycarbamazepine not assigned

Valproic_acid + NADPH + H+ + O2 <=> 5-Hydroxyvalproic_acid + NADP+ + H2O 1.14.13
1.14.14


L-alpha-Acetyl-N-normethadol <=> L-alpha-Acetyl-N,N-dinormethadol 1.14.13

aldophosphamide + NADP+ + H2O <=> Carboxyphosphamide + NADPH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]

Valproic_acid + NADPH + H+ + O2 <=> 4-Hydroxyvalproic_acid + NADP+ + H2O 1.14.13
1.14.14


4-Hydroxycyclophosphamide <=> 4-Ketocyclophosphamide 1.14.13

aldophosphamide <=> Phosphoramide_mustard + acrolein not assigned

tamoxifen + NADPH + O2 + H+ <=> alpha-hydroxytamoxifen + NADP+ + H2O 1.14.13

Levomethadyl_acetate <=> L-alpha-Acetyl-N-normethadol 1.14.13

Carboxyphosphamide <=> Nornitrogen_mustard not assigned

Aldoifosfamide <=> Alcoifosfamide not assigned

Demethylcitalopram <=> Didemethylcitalopram 1.14.14.1 unspecific monooxygenase

Felbamate + H2O <=> 2-Phenyl-1,3-propanediol_monocarbamate + CO2 + NH3 not assigned

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