|
|
2-hydroxyethyl-ThPP + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_acetyltransferase]_S-acetyldihydrolipoyllysine + thiamine_diphosphate
|
1.2.4.1
pyruvate dehydrogenase (acetyl-transferring)
|
–
|
| |
KEGG:
R03270
|
|
|
|
citrate <=> cis-aconitate + H2O
|
4.2.1.117
2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
4.2.1.3
aconitate hydratase
|
–
–
|
| |
BRENDA:
BR419
KEGG:
R01325
MetaCyc:
ACONITATEDEHYDR-RXN
SABIO-RK:
268
|
|
|
|
enzyme_N6-(dihydrolipoyl)lysine + NAD+ <=> [dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine + NADH + H+
|
1.8.1.4
dihydrolipoyl dehydrogenase
|
–
|
| |
BRENDA:
BR36970
KEGG:
R03815;
R07618;
R08550
MetaCyc:
1.8.1.4-RXN;
RXN-7716
SABIO-RK:
9140
|
|
|
|
succinate + CoA + ATP <=> succinyl-CoA + ADP + phosphate
|
6.2.1.13
acetate---CoA ligase (ADP-forming)
6.2.1.4
succinate---CoA ligase (GDP-forming)
6.2.1.5
succinate---CoA ligase (ADP-forming)
|
–
–
–
|
| |
BRENDA:
BR88
KEGG:
R00405
MetaCyc:
SUCCCOASYN-RXN
SABIO-RK:
260
|
|
|
|
isocitrate + NADP+ <=> oxalosuccinate + NADPH + H+
|
1.1.1.42
isocitrate dehydrogenase (NADP+)
|
–
|
| |
BRENDA:
BS438365
KEGG:
R01899
MetaCyc:
RXN-9951
SABIO-RK:
242
|
|
|
|
(S)-malate + NAD+ <=> oxaloacetate + NADH + H+
|
1.1.1.28
D-lactate dehydrogenase
1.1.1.299
malate dehydrogenase [NAD(P)+]
1.1.1.337
L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37
malate dehydrogenase
1.1.1.375
L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38
malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.81
hydroxypyruvate reductase
1.1.1.82
malate dehydrogenase (NADP+)
1.1.1.85
3-isopropylmalate dehydrogenase
1.1.1.95
phosphoglycerate dehydrogenase
1.1.1.96
diiodophenylpyruvate reductase
|
–
–
–
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29300;
BS188027
KEGG:
R00342
MetaCyc:
MALATE-DEH-RXN;
RXN-10813_WOP
|
|
|
|
acetyl-CoA + enzyme_N6-(dihydrolipoyl)lysine <=> CoA + enzyme_N6-(S-acetyldihydrolipoyl)lysine
|
2.3.1.12
dihydrolipoyllysine-residue acetyltransferase
|
–
|
| |
BRENDA:
BR43982
KEGG:
R02569
|
|
|
|
3-carboxy-1-hydroxypropyl-ThPP + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_succinyltransferase]_S-succinyldihydrolipoyllysine + thiamine_diphosphate
|
1.2.4.2
oxoglutarate dehydrogenase (succinyl-transferring)
|
–
|
| |
KEGG:
R03316
|
|
|
|
succinate + ITP + CoA <=> succinyl-CoA + IDP + phosphate
|
6.2.1.4
succinate---CoA ligase (GDP-forming)
|
–
|
| |
KEGG:
R00727
MetaCyc:
RXN-12511
|
|
|
|
2-oxoglutarate + CoA + oxidized_ferredoxin <=> succinyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+
|
1.2.7.11
2-oxoacid oxidoreductase (ferredoxin)
1.2.7.3
2-oxoglutarate synthase
|
–
–
|
| |
BRENDA:
BR50765
KEGG:
R01197
MetaCyc:
2-OXOGLUTARATE-SYNTHASE-RXN
|
|
|
|
cis-aconitate + H2O <=> isocitrate
|
4.2.1.3
aconitate hydratase
|
–
|
| |
BRENDA:
BS18708
KEGG:
R01900
MetaCyc:
ACONITATEHYDR-RXN
SABIO-RK:
273
|
|
|
|
succinate + a_quinone <=> fumarate + a_quinol
|
1.3.5.1
succinate dehydrogenase
1.3.5.4
fumarate reductase (quinol)
|
–
–
|
| |
BRENDA:
BR49374
KEGG:
R02164
|
|
|
|
succinyl-CoA + enzyme_N6-(dihydrolipoyl)lysine <=> CoA + enzyme_N6-(S-succinyldihydrolipoyl)lysine
|
2.3.1.61
dihydrolipoyllysine-residue succinyltransferase
|
–
|
| |
BRENDA:
BR44062
KEGG:
R02570
|
|
|
|
(S)-malate + a_quinone <=> oxaloacetate + a_quinol
|
1.1.5.4
malate dehydrogenase (quinone)
|
–
|
| |
BRENDA:
BR49054;
BS421758
KEGG:
R00361
|
|
|
|
succinate + GTP + CoA <=> succinyl-CoA + GDP + phosphate
|
6.2.1.4
succinate---CoA ligase (GDP-forming)
|
–
|
| |
BRENDA:
BR87
KEGG:
R00432
MetaCyc:
SUCCINATE--COA-LIGASE-GDP-FORMING-RXN
SABIO-RK:
259
|
|
|
|
(S)-malate <=> fumarate + H2O
|
4.2.1.2
fumarate hydratase
4.2.1.34
(S)-2-methylmalate dehydratase
|
–
–
|
| |
BRENDA:
BR3389
KEGG:
R01082
MetaCyc:
FUMHYDR-RXN
SABIO-RK:
256
|
|
|
|
oxaloacetate + GTP <=> CO2 + phosphoenolpyruvate + GDP
|
4.1.1.32
phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49
phosphoenolpyruvate carboxykinase (ATP)
|
–
–
|
| |
BRENDA:
BR291
KEGG:
R00431
MetaCyc:
4.1.1.32-RXN
SABIO-RK:
106
|
|
|
|
acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H+
|
2.3.3.1
citrate (Si)-synthase
2.3.3.14
homocitrate synthase
2.3.3.16
citrate synthase (unknown stereospecificity)
2.3.3.3
citrate (Re)-synthase
|
–
–
–
–
|
| |
BRENDA:
BR44118
KEGG:
R00351
MetaCyc:
CITSYN-RXN;
RXN-14905
SABIO-RK:
267
|
|
|
|
oxaloacetate + acetyl-CoA + phosphate + ADP <=> citrate + CoA + ATP
|
2.3.3.8
ATP citrate synthase
|
–
|
| |
BRENDA:
BR44130
KEGG:
R00352
MetaCyc:
ATP-CITRATE-PRO-S--LYASE-RXN
SABIO-RK:
266
|
|
|
|
pyruvate + CoA + oxidized_ferredoxin <=> acetyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+
|
1.2.7.1
pyruvate synthase
1.2.7.11
2-oxoacid oxidoreductase (ferredoxin)
1.2.7.7
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
|
–
–
–
|
| |
BRENDA:
BR29433
KEGG:
R01196
MetaCyc:
PYRUFLAVREDUCT-RXN
|
|
|
|
oxaloacetate + ITP <=> CO2 + phosphoenolpyruvate + IDP
|
4.1.1.32
phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49
phosphoenolpyruvate carboxykinase (ATP)
|
–
–
|
| |
BRENDA:
BS1402
KEGG:
R00726
MetaCyc:
RXN-12481
SABIO-RK:
583
|
|
|
|
oxalosuccinate + H+ <=> 2-oxoglutarate + CO2
|
1.1.1.42
isocitrate dehydrogenase (NADP+)
|
–
|
| |
BRENDA:
BR48779
KEGG:
R00268
MetaCyc:
RXN-8642
SABIO-RK:
241
|
|
|
|
succinyl-CoA + acetate <=> succinate + acetyl-CoA
|
2.8.3.1
propionate CoA-transferase
2.8.3.18
succinyl-CoA:acetate CoA-transferase
2.8.3.8
acetate CoA-transferase
|
–
–
–
|
| |
BRENDA:
BR50544
KEGG:
R10343
MetaCyc:
RXN-8807
SABIO-RK:
14383
|
|
|
|
H+ + pyruvate + thiamine_diphosphate <=> 2-hydroxyethyl-ThPP + CO2
|
1.2.4.1
pyruvate dehydrogenase (acetyl-transferring)
2.2.1.6
acetolactate synthase
4.1.1.1
pyruvate decarboxylase
|
–
–
–
|
| |
KEGG:
R00014
MetaCyc:
RXN-12583
SABIO-RK:
6479
|
|
|
|
2-oxoglutarate + thiamine_diphosphate <=> 3-carboxy-1-hydroxypropyl-ThPP + CO2
|
1.2.4.2
oxoglutarate dehydrogenase (succinyl-transferring)
|
–
|
| |
KEGG:
R00621
SABIO-RK:
243
|
|
|
|
oxaloacetate + ATP <=> CO2 + phosphoenolpyruvate + ADP
|
4.1.1.31
phosphoenolpyruvate carboxylase
4.1.1.38
phosphoenolpyruvate carboxykinase (diphosphate)
4.1.1.49
phosphoenolpyruvate carboxykinase (ATP)
|
–
–
–
|
| |
BRENDA:
BR308
KEGG:
R00341
MetaCyc:
PEPCARBOXYKIN-RXN
SABIO-RK:
151
|
|
|
|
pyruvate + HCO3- + ATP <=> H+ + oxaloacetate + ADP + phosphate
|
6.4.1.1
pyruvate carboxylase
|
–
|
| |
BRENDA:
BR153
KEGG:
R00344
MetaCyc:
PYRUVATE-CARBOXYLASE-RXN
SABIO-RK:
105
|
|
|
|
isocitrate + NAD+ <=> 2-oxoglutarate + CO2 + NADH
|
1.1.1.286
isocitrate---homoisocitrate dehydrogenase
1.1.1.41
isocitrate dehydrogenase (NAD+)
1.1.1.42
isocitrate dehydrogenase (NADP+)
1.1.1.87
homoisocitrate dehydrogenase
|
–
–
–
–
|
| |
BRENDA:
BR29304;
BS371189
KEGG:
R00709
MetaCyc:
ISOCITRATE-DEHYDROGENASE-NAD+-RXN
SABIO-RK:
15068;
270
|
|
