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Citrate cycle (TCA cycle)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
2-hydroxyethyl-ThPP + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_acetyltransferase]_S-acetyldihydrolipoyllysine + thiamine_diphosphate 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)

citrate <=> cis-aconitate + H2O 4.2.1.117 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
4.2.1.3 aconitate hydratase


enzyme_N6-(dihydrolipoyl)lysine + NAD+ <=> [dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine + NADH + H+ 1.8.1.4 dihydrolipoyl dehydrogenase

succinate + CoA + ATP <=> succinyl-CoA + ADP + phosphate 6.2.1.13 acetate---CoA ligase (ADP-forming)
6.2.1.4 succinate---CoA ligase (GDP-forming)
6.2.1.5 succinate---CoA ligase (ADP-forming)



isocitrate + NADP+ <=> oxalosuccinate + NADPH + H+ 1.1.1.42 isocitrate dehydrogenase (NADP+)

(S)-malate + NAD+ <=> oxaloacetate + NADH + H+ 1.1.1.28 D-lactate dehydrogenase
1.1.1.299 malate dehydrogenase [NAD(P)+]
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.81 hydroxypyruvate reductase
1.1.1.82 malate dehydrogenase (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase
1.1.1.95 phosphoglycerate dehydrogenase
1.1.1.96 diiodophenylpyruvate reductase











acetyl-CoA + enzyme_N6-(dihydrolipoyl)lysine <=> CoA + enzyme_N6-(S-acetyldihydrolipoyl)lysine 2.3.1.12 dihydrolipoyllysine-residue acetyltransferase

3-carboxy-1-hydroxypropyl-ThPP + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_succinyltransferase]_S-succinyldihydrolipoyllysine + thiamine_diphosphate 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)

succinate + ITP + CoA <=> succinyl-CoA + IDP + phosphate 6.2.1.4 succinate---CoA ligase (GDP-forming)

2-oxoglutarate + CoA + oxidized_ferredoxin <=> succinyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)
1.2.7.3 2-oxoglutarate synthase


cis-aconitate + H2O <=> isocitrate 4.2.1.3 aconitate hydratase

succinate + a_quinone <=> fumarate + a_quinol 1.3.5.1 succinate dehydrogenase
1.3.5.4 fumarate reductase (quinol)


succinyl-CoA + enzyme_N6-(dihydrolipoyl)lysine <=> CoA + enzyme_N6-(S-succinyldihydrolipoyl)lysine 2.3.1.61 dihydrolipoyllysine-residue succinyltransferase

(S)-malate + a_quinone <=> oxaloacetate + a_quinol 1.1.5.4 malate dehydrogenase (quinone)

succinate + GTP + CoA <=> succinyl-CoA + GDP + phosphate 6.2.1.4 succinate---CoA ligase (GDP-forming)

(S)-malate <=> fumarate + H2O 4.2.1.2 fumarate hydratase
4.2.1.34 (S)-2-methylmalate dehydratase


oxaloacetate + GTP <=> CO2 + phosphoenolpyruvate + GDP 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)


acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H+ 2.3.3.1 citrate (Si)-synthase
2.3.3.14 homocitrate synthase
2.3.3.16 citrate synthase (unknown stereospecificity)
2.3.3.3 citrate (Re)-synthase




oxaloacetate + acetyl-CoA + phosphate + ADP <=> citrate + CoA + ATP 2.3.3.8 ATP citrate synthase

pyruvate + CoA + oxidized_ferredoxin <=> acetyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.1 pyruvate synthase
1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)
1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)



oxaloacetate + ITP <=> CO2 + phosphoenolpyruvate + IDP 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)


oxalosuccinate + H+ <=> 2-oxoglutarate + CO2 1.1.1.42 isocitrate dehydrogenase (NADP+)

succinyl-CoA + acetate <=> succinate + acetyl-CoA 2.8.3.1 propionate CoA-transferase
2.8.3.18 succinyl-CoA:acetate CoA-transferase
2.8.3.8 acetate CoA-transferase



H+ + pyruvate + thiamine_diphosphate <=> 2-hydroxyethyl-ThPP + CO2 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
2.2.1.6 acetolactate synthase
4.1.1.1 pyruvate decarboxylase



2-oxoglutarate + thiamine_diphosphate <=> 3-carboxy-1-hydroxypropyl-ThPP + CO2 1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)

oxaloacetate + ATP <=> CO2 + phosphoenolpyruvate + ADP 4.1.1.31 phosphoenolpyruvate carboxylase
4.1.1.38 phosphoenolpyruvate carboxykinase (diphosphate)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)



pyruvate + HCO3- + ATP <=> H+ + oxaloacetate + ADP + phosphate 6.4.1.1 pyruvate carboxylase

isocitrate + NAD+ <=> 2-oxoglutarate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.41 isocitrate dehydrogenase (NAD+)
1.1.1.42 isocitrate dehydrogenase (NADP+)
1.1.1.87 homoisocitrate dehydrogenase




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