Copied!

Pathway Search


Carbon fixation pathways in prokaryotes

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(3S)-citramalyl-CoA <=> pyruvate + acetyl-CoA 2.3.1.182 (R)-citramalate synthase
4.1.3.25 (S)-citramalyl-CoA lyase
–
–
succinate + NAD+ <=> fumarate + NADH + H+ 1.3.1.6 fumarate reductase (NADH)
–
citrate <=> cis-aconitate + H2O 4.2.1.117 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
4.2.1.3 aconitate hydratase
–
–
phosphate + acetyl-CoA <=> acetyl_phosphate + CoA 2.3.1.19 phosphate butyryltransferase
2.3.1.222 phosphate propanoyltransferase
2.3.1.8 phosphate acetyltransferase
–
–
–
succinate + CoA + ATP <=> succinyl-CoA + ADP + phosphate 6.2.1.13 acetate---CoA ligase (ADP-forming)
6.2.1.4 succinate---CoA ligase (GDP-forming)
6.2.1.5 succinate---CoA ligase (ADP-forming)
–
–
–
tetrahydrofolate + acetyl-CoA <=> 5-methyltetrahydrofolate + CoA + CO 2.1.1.258 5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
2.3.1.169 CO-methylating acetyl-CoA synthase
–
–
propionyl-CoA + NADP+ <=> acryloyl-CoA + NADPH + H+ 1.3.1
1.3.1.84 acrylyl-CoA reductase (NADPH)
1.3.1.95 acrylyl-CoA reductase (NADH)
–
–
–
tetrahydrofolate + ATP + formate <=> 10-formyltetrahydrofolate + ADP + phosphate 6.3.4.3 formate---tetrahydrofolate ligase
–
bithionol + phosphate + ADP <=> 3-hydroxypropionate + CoA + ATP 6.2.1
–
formate + NADP+ <=> CO2 + NADPH 1.17.1.10 formate dehydrogenase (NADP+)
1.17.1.9 formate dehydrogenase
–
–
(S)-malate + NAD+ <=> oxaloacetate + NADH + H+ 1.1.1.28 D-lactate dehydrogenase
1.1.1.299 malate dehydrogenase [NAD(P)+]
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.81 hydroxypyruvate reductase
1.1.1.82 malate dehydrogenase (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase
1.1.1.95 phosphoglycerate dehydrogenase
1.1.1.96 diiodophenylpyruvate reductase
–
–
–
–
–
–
–
–
–
–
–
(R)-2-methylmalonyl-CoA <=> succinyl-CoA 5.4.99.2 methylmalonyl-CoA mutase
5.4.99.63 ethylmalonyl-CoA mutase
5.4.99.64 2-hydroxyisobutanoyl-CoA mutase
–
–
–
beta-methylmalyl-CoA <=> 2-methylfumaryl-CoA + H2O 4.2.1.148 2-methylfumaryl-CoA hydratase
4.2.1.153 3-methylfumaryl-CoA hydratase
–
–
5-methyltetrahydrofolate + corrinoid + H+ <=> methylcorrinoid_protein + tetrahydrofolate 2.1.1.258 5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
–
citrate + CoA + ATP <=> (3S)-citryl-CoA + ADP + phosphate 6.2.1.18 citrate---CoA ligase
–
4-hydroxybutanoyl-CoA <=> crotonyl-CoA + H2O 4.2.1.120 4-hydroxybutanoyl-CoA dehydratase
–
fumarate + coenzyme_M + coenzyme_B <=> succinate + CoM-S-S-CoB 1.3.4.1 fumarate reductase (CoM/CoB)
–
4-hydroxybutyrate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate 6.2.1.40 4-hydroxybutyrate---CoA ligase (AMP-forming)
–
pyruvate + CoA + flavin + H+ <=> acetyl-CoA + CO2 + reduced_flavodoxin 1.2.7
1.2.7.1 pyruvate synthase
–
–
H2O + pyruvate + ATP <=> H+ + phosphate + phosphoenolpyruvate + AMP 2.7.1.40 pyruvate kinase
2.7.9.2 pyruvate, water dikinase
–
–
2-oxoglutarate + CoA + oxidized_ferredoxin <=> succinyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)
1.2.7.3 2-oxoglutarate synthase
–
–
succinyl-CoA + (S)-malate <=> succinate + (3S)-3-carboxy-3-hydroxypropanoyl-CoA 2.8.3.18 succinyl-CoA:acetate CoA-transferase
2.8.3.22 succinyl-CoA---L-malate CoA-transferase
–
–
isocitrate + NADP+ <=> 2-oxoglutarate + CO2 + NADPH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.41 isocitrate dehydrogenase (NAD+)
1.1.1.42 isocitrate dehydrogenase (NADP+)
–
–
–
cis-aconitate + H2O <=> isocitrate 4.2.1.3 aconitate hydratase
–
succinate + a_quinone <=> fumarate + a_quinol 1.3.5.1 succinate dehydrogenase
1.3.5.4 fumarate reductase (quinol)
–
–
5,10-methenyltetrahydrofolate + H2O <=> 10-formyltetrahydrofolate + H+ 3.5.4.9 methenyltetrahydrofolate cyclohydrolase
–
5-methyltetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + H+ + NADH 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]
–
malonate_semialdehyde + CoA + NADP+ <=> malonyl-CoA + NADPH + H+ 1.2.1.18 malonate-semialdehyde dehydrogenase (acetylating)
1.2.1.75 malonyl-CoA reductase (malonate semialdehyde-forming)
–
–
beta-methylmalyl-CoA <=> glyoxylate + propionyl-CoA 4.1.3.24 malyl-CoA lyase
–
ATP + acetyl-CoA + HCO3- <=> ADP + phosphate + malonyl-CoA + H+ 6.4.1.2 acetyl-CoA carboxylase
6.4.1.3 propionyl-CoA carboxylase
6.4.1.4 methylcrotonoyl-CoA carboxylase
–
–
–
(S)-malate <=> fumarate + H2O 4.2.1.2 fumarate hydratase
4.2.1.34 (S)-2-methylmalate dehydratase
–
–
5,10-methylenetetrahydrofolate + NADP+ <=> 5,10-methenyltetrahydrofolate + NADPH 1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)
–
–
succinate_semialdehyde + NADP+ + CoA <=> succinyl-CoA + NADPH + H+ 1.2.1.75 malonyl-CoA reductase (malonate semialdehyde-forming)
1.2.1.76 succinate-semialdehyde dehydrogenase (acylating)
–
–
NADP+ + 4-hydroxybutyrate <=> H+ + NADPH + succinate_semialdehyde 1.1.1
1.1.1.19 glucuronate reductase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.26 glyoxylate reductase
1.1.1.61 4-hydroxybutyrate dehydrogenase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.B47
1.1.1.co
–
–
–
–
–
–
–
–
4-hydroxybutyrate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + ADP + phosphate 6.2.1.56 4-hydroxybutyrate---CoA ligase (ADP-forming)
–
CO + H2O + oxidized_ferredoxin <=> CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.4 anaerobic carbon monoxide dehydrogenase
–
acetyl-CoA <=> acetoacetyl-CoA + CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase
–
–
–
–
–
oxaloacetate + acetyl-CoA + phosphate + ADP <=> citrate + CoA + ATP 2.3.3.8 ATP citrate synthase
–
3-hydroxypropionate + NADP+ <=> malonate_semialdehyde + NADPH + H+ 1.1.1
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.276 serine 3-dehydrogenase (NADP+)
1.1.1.298 3-hydroxypropionate dehydrogenase (NADP+)
–
–
–
–
CoA + acetate + ATP <=> acetyl-CoA + diphosphate + AMP 6.2.1.1 acetate---CoA ligase
6.2.1.17 propionate---CoA ligase
6.2.1.36 3-hydroxypropionyl-CoA synthase
–
–
–
(3S)-citryl-CoA <=> oxaloacetate + acetyl-CoA 4.1.3.34 citryl-CoA lyase
–
pyruvate + CoA + oxidized_ferredoxin <=> acetyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.1 pyruvate synthase
1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)
1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
–
–
–
(R)-2-methylmalonyl-CoA <=> (S)-methylmalonyl-CoA 5.1.99.1 methylmalonyl-CoA epimerase
–
3-hydroxypropionate + ATP + CoA <=> bithionol + AMP + diphosphate 6.2.1.17 propionate---CoA ligase
6.2.1.36 3-hydroxypropionyl-CoA synthase
6.2.1.40 4-hydroxybutyrate---CoA ligase (AMP-forming)
–
–
–
(3S)-3-carboxy-3-hydroxypropanoyl-CoA <=> glyoxylate + acetyl-CoA 4.1.3.24 malyl-CoA lyase
–
(3S)-citramalyl-CoA <=> 3-methylfumaryl-CoA + H2O 4.2.1.148 2-methylfumaryl-CoA hydratase
4.2.1.153 3-methylfumaryl-CoA hydratase
–
–
2-methylfumaryl-CoA <=> 3-methylfumaryl-CoA 5.4.1.3 2-methylfumaryl-CoA isomerase
–
(S)-3-hydroxybutyryl-CoA + NAD+ <=> acetoacetyl-CoA + NADH + H+ 1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
1.1.1.36 acetoacetyl-CoA reductase
–
–
–
phosphoenolpyruvate + CO2 <=> phosphate + oxaloacetate 4.1.1.31 phosphoenolpyruvate carboxylase
–
pyruvate + phosphate + ATP <=> H+ + phosphoenolpyruvate + AMP + diphosphate 2.7.9.1 pyruvate, phosphate dikinase
–
pyruvate + HCO3- + ATP <=> H+ + oxaloacetate + ADP + phosphate 6.4.1.1 pyruvate carboxylase
–
ATP + propionyl-CoA + HCO3- <=> H+ + (S)-methylmalonyl-CoA + phosphate + ADP 6.4.1.2 acetyl-CoA carboxylase
6.4.1.3 propionyl-CoA carboxylase
–
–
ATP + acetate <=> ADP + acetyl_phosphate 2.1.2.2 phosphoribosylglycinamide formyltransferase
2.7.2.1 acetate kinase
2.7.2.15 propionate kinase
2.7.2.2 carbamate kinase
–
–
–
–
bithionol <=> acryloyl-CoA + H2O 4.2.1
4.2.1.116 3-hydroxypropionyl-CoA dehydratase
4.2.1.17 enoyl-CoA hydratase
–
–
–
(S)-3-hydroxybutyryl-CoA <=> H2O + crotonyl-CoA 1.3.8.7 medium-chain acyl-CoA dehydrogenase
4.2.1.116 3-hydroxypropionyl-CoA dehydratase
4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase
–
–
–
–

Visualization of the pathway