|
|
paraxanthine + NADH + H+ + O2 <=> 1-Methylxanthine + NAD+ + formaldehyde + H2O
|
1.13.12
|
–
|
| |
KEGG:
R07959
|
|
|
|
1-Methylxanthine + NADPH + O2 + H+ <=> xanthine + NADP+ + formaldehyde + H2O
|
1.14.13.178
methylxanthine N1-demethylase
|
–
|
| |
KEGG:
R07970
MetaCyc:
RXN-13111
|
|
|
|
3-Methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.179
methylxanthine N3-demethylase
|
–
–
|
| |
BRENDA:
BR50581-a
KEGG:
R07967
MetaCyc:
RXN-13109_WOP
|
|
|
|
7-methylxanthine + NADPH + O2 + H+ <=> xanthine + NADP+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
|
–
|
| |
BRENDA:
BR49432
KEGG:
R07966
MetaCyc:
RXN-11518
|
|
|
|
paraxanthine <=> 1,7-dimethyluric_acid
|
1.14.13
1.14.14.1
unspecific monooxygenase
|
–
–
|
| |
KEGG:
R07945
|
|
|
|
Caffeine + NADPH + O2 + H+ <=> Theobromine + NADP+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.178
methylxanthine N1-demethylase
|
–
–
|
| |
BRENDA:
BR50577
KEGG:
R07956
MetaCyc:
RXN-11513
|
|
|
|
Theobromine + O2 + H2O <=> 3,7-dimethyluric_acid + H2O2
|
1.17.3.2
xanthine oxidase
|
–
|
| |
KEGG:
R07978
MetaCyc:
RXN-11519
|
|
|
|
Caffeine + O2 + NADPH + H+ <=> theophylline + formaldehyde + NADP+ + H2O
|
1.13.12
1.14.13.128
7-methylxanthine demethylase
|
–
–
|
| |
BRENDA:
BS417831
KEGG:
R07972
|
|
|
|
7-methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
|
–
|
| |
BRENDA:
BR49432-a
KEGG:
R07965
MetaCyc:
RXN-11518_WOP
|
|
|
|
Theobromine + O2 + NADPH + H+ <=> 3-Methylxanthine + formaldehyde + NADP+
|
1.13.12
1.14.13.128
7-methylxanthine demethylase
|
–
–
|
| |
BRENDA:
BS418269
KEGG:
R07964
|
|
|
|
paraxanthine + NADH + O2 + H+ <=> 7-methylxanthine + NAD+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.178
methylxanthine N1-demethylase
|
–
–
|
| |
BRENDA:
BR50579-a
KEGG:
R07957
MetaCyc:
RXN-11517_WOP
|
|
|
|
1,3,7-trimethyluric_acid + O2 + 2 H2O <=> 3,6,8-Trimethylallantoin + CO2 + H2O2
|
1.7.3.3
factor-independent urate hydroxylase
|
–
|
| |
KEGG:
R07981
|
|
|
|
S-adenosyl-L-methionine + Theobromine <=> H+ + Caffeine + S-adenosyl-L-homocysteine
|
2.1.1.160
caffeine synthase
|
–
|
| |
BRENDA:
BR48814
KEGG:
R07920
MetaCyc:
RXN-7599
SABIO-RK:
14238
|
|
|
|
paraxanthine <=> 5-Acetylamino-6-formylamino-3-methyluracil
|
2.3.1.5
arylamine N-acetyltransferase
|
–
|
| |
KEGG:
R07940
|
|
|
|
S-adenosyl-L-methionine + Xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine
|
2.1.1.158
7-methylxanthosine synthase
|
–
|
| |
BRENDA:
BR48812
KEGG:
R07917
MetaCyc:
RXN-7596
SABIO-RK:
15254
|
|
|
|
theophylline + NADH + O2 + H+ <=> 3-Methylxanthine + NAD+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.178
methylxanthine N1-demethylase
|
–
–
|
| |
BRENDA:
BR50578-a
KEGG:
R07973
MetaCyc:
RXN-13108_WOP
|
|
|
|
S-adenosyl-L-methionine + paraxanthine <=> H+ + Caffeine + S-adenosyl-L-homocysteine
|
2.1.1.159
theobromine synthase
2.1.1.160
caffeine synthase
|
–
–
|
| |
BRENDA:
BR48815
KEGG:
R07921
MetaCyc:
RXN-7601
SABIO-RK:
14236
|
|
|
|
3,6,8-Trimethylallantoin + 2 H2O <=> N,N''-Dimethylurea + N-methylurea + glyoxylate
|
not assigned
|
–
|
| |
KEGG:
R07982
|
|
|
|
theophylline + NADH + O2 + H+ <=> 1-Methylxanthine + NAD+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.179
methylxanthine N3-demethylase
|
–
–
|
| |
BRENDA:
BS412972
KEGG:
R07975
MetaCyc:
RXN-13110_WOP
|
|
|
|
7-methylxanthine + O2 + H2O <=> 7-Methyluric_acid + H2O2
|
1.17.3.2
xanthine oxidase
|
–
|
| |
BRENDA:
BS376043
KEGG:
R07979
MetaCyc:
RXN-11521
|
|
|
|
Caffeine + NADH + O2 + H+ <=> Theobromine + NAD+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.178
methylxanthine N1-demethylase
|
–
–
|
| |
BRENDA:
BR50577-a
KEGG:
R07955
MetaCyc:
RXN-11513_WOP
|
|
|
|
S-adenosyl-L-methionine + 7-methylxanthine <=> H+ + paraxanthine + S-adenosyl-L-homocysteine
|
not assigned
|
–
|
| |
KEGG:
R07922
MetaCyc:
RXN-7600
|
|
|
|
1,3,7-trimethyluric_acid + O2 + NADH + H+ <=> 1,3,7-trimethyl-5-hydroxyisourate + NAD+ + H2O
|
1.14.13.212
1,3,7-trimethyluric acid 5-monooxygenase
|
–
|
| |
BRENDA:
BR51572
KEGG:
R11153
MetaCyc:
RXN-15454
|
|
|
|
7-methylxanthosine + H2O <=> D-ribose + 7-methylxanthine + H+
|
3.2.2.25
N-methyl nucleosidase
|
–
|
| |
BRENDA:
BR48807
KEGG:
R07918
MetaCyc:
RXN-7597
|
|
|
|
Caffeine + ubiquinone + H2O <=> 1,3,7-trimethyluric_acid + ubiquinol
|
1.17.5.2
caffeine dehydrogenase
|
–
|
| |
BRENDA:
BR49384
KEGG:
R07980
MetaCyc:
RXN-11523
|
|
|
|
paraxanthine + NADPH + H+ + O2 <=> 1-Methylxanthine + NADP+ + formaldehyde + H2O
|
1.13.12
|
–
|
| |
KEGG:
R07960
|
|
|
|
Caffeine + NADPH + O2 + H+ <=> paraxanthine + NADP+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.179
methylxanthine N3-demethylase
1.14.14.1
unspecific monooxygenase
|
–
–
–
|
| |
BRENDA:
BS417832
KEGG:
R07939
MetaCyc:
RXN-13106
|
|
|
|
paraxanthine + NADPH + O2 + H+ <=> 7-methylxanthine + NADP+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.178
methylxanthine N1-demethylase
|
–
–
|
| |
BRENDA:
BR50579
KEGG:
R07958
MetaCyc:
RXN-11517
|
|
|
|
Theobromine + O2 + NADH + H+ <=> 3-Methylxanthine + NAD+ + H2O + formaldehyde
|
1.13.12
1.14.13.128
7-methylxanthine demethylase
|
–
–
|
| |
BRENDA:
BS412968
KEGG:
R07963
|
|
|
|
Caffeine + NADH + O2 + H+ <=> paraxanthine + NAD+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.179
methylxanthine N3-demethylase
|
–
–
|
| |
BRENDA:
BS411830
KEGG:
R07954
MetaCyc:
RXN-13106_WOP
|
|
|
|
3-Methylxanthine + NADPH + O2 + H+ <=> xanthine + NADP+ + formaldehyde + H2O
|
1.14.13.179
methylxanthine N3-demethylase
|
–
|
| |
BRENDA:
BR50581
KEGG:
R07968
MetaCyc:
RXN-13109
|
|
|
|
theophylline + NADPH + O2 + H+ <=> 3-Methylxanthine + NADP+ + formaldehyde + H2O
|
1.14.13.178
methylxanthine N1-demethylase
|
–
|
| |
BRENDA:
BR50578
KEGG:
R07974
MetaCyc:
RXN-13108
|
|
|
|
paraxanthine + O2 + H2O <=> 1,7-dimethyluric_acid + H2O2
|
1.17.3.2
xanthine oxidase
|
–
|
| |
BRENDA:
BS375516
KEGG:
R07977
MetaCyc:
RXN-11520
|
|
|
|
Theobromine + NADPH + O2 + H+ <=> 7-methylxanthine + NADP+ + formaldehyde + H2O
|
1.14.13.179
methylxanthine N3-demethylase
|
–
|
| |
BRENDA:
BR50580
KEGG:
R07962
MetaCyc:
RXN-11516
|
|
|
|
theophylline + NADPH + O2 + H+ <=> 1-Methylxanthine + NADP+ + formaldehyde + H2O
|
1.14.13.179
methylxanthine N3-demethylase
|
–
|
| |
KEGG:
R07976
MetaCyc:
RXN-13110
|
|
|
|
1-Methylxanthine + H2O + O2 <=> 1-Methylurate + H2O2
|
1.17.3.2
xanthine oxidase
|
–
|
| |
BRENDA:
BS359332
KEGG:
R07942
|
|
|
|
5-Acetylamino-6-formylamino-3-methyluracil <=> 5-Acetylamino-6-amino-3-methyluracil
|
not assigned
|
–
|
| |
KEGG:
R07941
|
|
|
|
S-adenosyl-L-methionine + 7-methylxanthine <=> H+ + Theobromine + S-adenosyl-L-homocysteine
|
2.1.1.159
theobromine synthase
2.1.1.160
caffeine synthase
|
–
–
|
| |
BRENDA:
BR48813
KEGG:
R07919
MetaCyc:
RXN-7598
SABIO-RK:
14237
|
|
|
|
Caffeine + NADH + H+ + O2 <=> theophylline + NAD+ + formaldehyde + H2O
|
1.13.12
|
–
|
| |
KEGG:
R07971
|
|
|
|
Theobromine + NADH + O2 + H+ <=> 7-methylxanthine + NAD+ + formaldehyde + H2O
|
1.14.13.128
7-methylxanthine demethylase
1.14.13.179
methylxanthine N3-demethylase
|
–
–
|
| |
BRENDA:
BR50580-a
KEGG:
R07961
MetaCyc:
RXN-11516_WOP
|
|
|
|
paraxanthine <=> 1-Methylxanthine
|
1.14.14.1
unspecific monooxygenase
|
–
|
| |
KEGG:
R07943
|
|
|
|
1-Methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O
|
1.14.13.178
methylxanthine N1-demethylase
|
–
|
| |
BRENDA:
BS422267
KEGG:
R07969
MetaCyc:
RXN-13111_WOP
|
|
