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Caffeine metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
paraxanthine + NADH + H+ + O2 <=> 1-Methylxanthine + NAD+ + formaldehyde + H2O 1.13.12

1-Methylxanthine + NADPH + O2 + H+ <=> xanthine + NADP+ + formaldehyde + H2O 1.14.13.178 methylxanthine N1-demethylase

3-Methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase


7-methylxanthine + NADPH + O2 + H+ <=> xanthine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase

paraxanthine <=> 1,7-dimethyluric_acid 1.14.13
1.14.14.1 unspecific monooxygenase


Caffeine + NADPH + O2 + H+ <=> Theobromine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase


Theobromine + O2 + H2O <=> 3,7-dimethyluric_acid + H2O2 1.17.3.2 xanthine oxidase

Caffeine + O2 + NADPH + H+ <=> theophylline + formaldehyde + NADP+ + H2O 1.13.12
1.14.13.128 7-methylxanthine demethylase


7-methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase

Theobromine + O2 + NADPH + H+ <=> 3-Methylxanthine + formaldehyde + NADP+ 1.13.12
1.14.13.128 7-methylxanthine demethylase


paraxanthine + NADH + O2 + H+ <=> 7-methylxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase


1,3,7-trimethyluric_acid + O2 + 2 H2O <=> 3,6,8-Trimethylallantoin + CO2 + H2O2 1.7.3.3 factor-independent urate hydroxylase

S-adenosyl-L-methionine + Theobromine <=> H+ + Caffeine + S-adenosyl-L-homocysteine 2.1.1.160 caffeine synthase

paraxanthine <=> 5-Acetylamino-6-formylamino-3-methyluracil 2.3.1.5 arylamine N-acetyltransferase

S-adenosyl-L-methionine + Xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine 2.1.1.158 7-methylxanthosine synthase

theophylline + NADH + O2 + H+ <=> 3-Methylxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase


S-adenosyl-L-methionine + paraxanthine <=> H+ + Caffeine + S-adenosyl-L-homocysteine 2.1.1.159 theobromine synthase
2.1.1.160 caffeine synthase


3,6,8-Trimethylallantoin + 2 H2O <=> N,N''-Dimethylurea + N-methylurea + glyoxylate not assigned

theophylline + NADH + O2 + H+ <=> 1-Methylxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase


7-methylxanthine + O2 + H2O <=> 7-Methyluric_acid + H2O2 1.17.3.2 xanthine oxidase

Caffeine + NADH + O2 + H+ <=> Theobromine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase


S-adenosyl-L-methionine + 7-methylxanthine <=> H+ + paraxanthine + S-adenosyl-L-homocysteine not assigned

1,3,7-trimethyluric_acid + O2 + NADH + H+ <=> 1,3,7-trimethyl-5-hydroxyisourate + NAD+ + H2O 1.14.13.212 1,3,7-trimethyluric acid 5-monooxygenase

7-methylxanthosine + H2O <=> D-ribose + 7-methylxanthine + H+ 3.2.2.25 N-methyl nucleosidase

Caffeine + ubiquinone + H2O <=> 1,3,7-trimethyluric_acid + ubiquinol 1.17.5.2 caffeine dehydrogenase

paraxanthine + NADPH + H+ + O2 <=> 1-Methylxanthine + NADP+ + formaldehyde + H2O 1.13.12

Caffeine + NADPH + O2 + H+ <=> paraxanthine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
1.14.14.1 unspecific monooxygenase



paraxanthine + NADPH + O2 + H+ <=> 7-methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase


Theobromine + O2 + NADH + H+ <=> 3-Methylxanthine + NAD+ + H2O + formaldehyde 1.13.12
1.14.13.128 7-methylxanthine demethylase


Caffeine + NADH + O2 + H+ <=> paraxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase


3-Methylxanthine + NADPH + O2 + H+ <=> xanthine + NADP+ + formaldehyde + H2O 1.14.13.179 methylxanthine N3-demethylase

theophylline + NADPH + O2 + H+ <=> 3-Methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.178 methylxanthine N1-demethylase

paraxanthine + O2 + H2O <=> 1,7-dimethyluric_acid + H2O2 1.17.3.2 xanthine oxidase

Theobromine + NADPH + O2 + H+ <=> 7-methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.179 methylxanthine N3-demethylase

theophylline + NADPH + O2 + H+ <=> 1-Methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.179 methylxanthine N3-demethylase

1-Methylxanthine + H2O + O2 <=> 1-Methylurate + H2O2 1.17.3.2 xanthine oxidase

5-Acetylamino-6-formylamino-3-methyluracil <=> 5-Acetylamino-6-amino-3-methyluracil not assigned

S-adenosyl-L-methionine + 7-methylxanthine <=> H+ + Theobromine + S-adenosyl-L-homocysteine 2.1.1.159 theobromine synthase
2.1.1.160 caffeine synthase


Caffeine + NADH + H+ + O2 <=> theophylline + NAD+ + formaldehyde + H2O 1.13.12

Theobromine + NADH + O2 + H+ <=> 7-methylxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase


paraxanthine <=> 1-Methylxanthine 1.14.14.1 unspecific monooxygenase

1-Methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O 1.14.13.178 methylxanthine N1-demethylase

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