|
|
(3S)-citramalyl-CoA <=> pyruvate + acetyl-CoA
|
2.3.1.182
(R)-citramalate synthase
4.1.3.25
(S)-citramalyl-CoA lyase
|
–
–
|
|
BRENDA:
BR3372
KEGG:
R00237
MetaCyc:
CITRAMALYL-COA-LYASE-RXN
|
|
|
|
H+ + pyruvate <=> (S)-2-Hydroxy-2-methyl-3-oxobutanoate + CO2
|
2.2.1.6
acetolactate synthase
4.1.1.1
pyruvate decarboxylase
|
–
–
|
|
BRENDA:
BR37100;
BS386675
KEGG:
R00006;
R00226
MetaCyc:
ACETOLACTSYN-RXN
SABIO-RK:
6473;
749
|
|
|
|
citraconate + H2O <=> (2R,3R)-3-methyltartrate
|
not assigned
|
–
|
|
KEGG:
R03897
|
|
|
|
mesaconate + H2O <=> L-threo-3-methylmalate
|
not assigned
|
–
|
|
KEGG:
R03694
|
|
|
|
4-hydroxy-4-methyl-2-oxoglutarate + NH3 <=> 4-Hydroxy-4-methylglutamate + H2O
|
not assigned
|
–
|
|
KEGG:
R05077
|
|
|
|
(3S)-citramalyl-CoA <=> H2O + itaconyl-CoA
|
4.2.1.56
itaconyl-CoA hydratase
|
–
|
|
BRENDA:
BS429281
KEGG:
R02491
MetaCyc:
ITACONYL-COA-HYDRATASE-RXN
|
|
|
|
H+ + (S)-2-Hydroxy-2-methyl-3-oxobutanoate <=> (R)-acetoin + CO2
|
4.1.1.5
acetolactate decarboxylase
|
–
|
|
BRENDA:
BR309;
BS1472
KEGG:
R02948
MetaCyc:
ACETOLACTATE-DECARBOXYLASE-RXN
|
|
|
|
acetyl-CoA + pyruvate + H2O <=> H+ + (R)-citramalate + CoA
|
2.3.1.182
(R)-citramalate synthase
2.3.3.13
2-isopropylmalate synthase
|
–
–
|
|
BRENDA:
BR48833
KEGG:
R07399
MetaCyc:
RXN-7743
SABIO-RK:
9043
|
|
|
|
beta-methylmalyl-CoA <=> 2-methylfumaryl-CoA + H2O
|
4.2.1.148
2-methylfumaryl-CoA hydratase
4.2.1.153
3-methylfumaryl-CoA hydratase
|
–
–
|
|
BRENDA:
BR51001
KEGG:
R05076
MetaCyc:
RXN-8960
|
|
|
|
L-threo-3-methylaspartate <=> L-glutamate
|
5.4.99.1
methylaspartate mutase
|
–
|
|
BRENDA:
BR33
KEGG:
R00262
MetaCyc:
METHYLASPARTATE-MUTASE-RXN
SABIO-RK:
767
|
|
|
|
(+)-citramalate <=> pyruvate + acetate
|
4.1.3.1
isocitrate lyase
4.1.3.22
citramalate lyase
|
–
–
|
|
BRENDA:
BR3370
KEGG:
R00325
MetaCyc:
CITRAMALATE-LYASE-RXN
|
|
|
|
mesaconate + CoA <=> 2-methylfumaryl-CoA + H2O
|
not assigned
|
–
|
|
KEGG:
R03695
|
|
|
|
L-threo-3-methylaspartate + 2-oxoglutarate <=> L-glutamate + 3-methyloxaloacetate
|
2.6.1
|
–
|
|
KEGG:
R04269
MetaCyc:
RXN-7751
|
|
|
|
(R)-citramalate + CO2 <=> 4-hydroxy-4-methyl-2-oxoglutarate + H2O
|
not assigned
|
–
|
|
KEGG:
R03995
|
|
|
|
4-Methylene-2-oxoglutarate + H2O <=> 4-hydroxy-4-methyl-2-oxoglutarate
|
4.2.1
|
–
|
|
KEGG:
R05078
MetaCyc:
R108-RXN
|
|
|
|
trans-aconitate <=> cis-aconitate
|
5.3.3.7
aconitate Delta-isomerase
|
–
|
|
BRENDA:
BR5
KEGG:
R02244
MetaCyc:
ACONITATE-DELTA-ISOMERASE-RXN
SABIO-RK:
2214
|
|
|
|
trans-aconitate + H+ <=> Itaconate + CO2
|
4.1.1.113
trans-aconitate decarboxylase
|
–
|
|
BRENDA:
BR52552
KEGG:
R11749
MetaCyc:
RXN-19902
|
|
|
|
D-erythro-3-Methylmalate + NAD+ <=> 2-oxobutyrate + CO2 + NADH
|
1.1.1
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
|
KEGG:
R00994
MetaCyc:
RXN-7745
|
|
|
|
H+ + 3-methyloxaloacetate <=> 2-oxobutyrate + CO2
|
4.1.1.112
oxaloacetate decarboxylase
|
–
|
|
BRENDA:
BS390752
KEGG:
R00995
MetaCyc:
RXN-7746
|
|
|
|
beta-methylmalyl-CoA <=> glyoxylate + propionyl-CoA
|
4.1.3.24
malyl-CoA lyase
|
–
|
|
BRENDA:
BR50832
KEGG:
R00934
MetaCyc:
RXN-8961
|
|
|
|
succinyl-CoA + Itaconate <=> succinate + itaconyl-CoA
|
2.8.3
2.8.3.20
succinyl-CoA---D-citramalate CoA-transferase
2.8.3.22
succinyl-CoA---L-malate CoA-transferase
|
–
–
–
|
|
KEGG:
R02407
MetaCyc:
RXN-8987
|
|
|
|
acetyl-CoA + (+)-citramalate <=> acetate + (3S)-citramalyl-CoA
|
2.8.3.11
citramalate CoA-transferase
|
–
|
|
KEGG:
R03153
MetaCyc:
CITRAMALATE-COA-TRANSFERASE-RXN
|
|
|
|
propionyl-CoA + H2O + glyoxylate <=> 2-hydroxyglutarate + H+ + CoA
|
2.3.3.11
2-hydroxyglutarate synthase
|
–
|
|
BRENDA:
BR44120
KEGG:
R00932
MetaCyc:
HYDGLUTSYN-RXN
|
|
|
|
4-hydroxy-4-methyl-2-oxoglutarate <=> pyruvate
|
4.1.3.17
4-hydroxy-4-methyl-2-oxoglutarate aldolase
|
–
|
|
BRENDA:
BR3367
KEGG:
R00008
MetaCyc:
4.1.3.17-RXN
SABIO-RK:
6474
|
|
|
|
4-methylene-L-glutamate + NH3 + ATP <=> H+ + 4-methylene-L-glutamine + AMP + diphosphate
|
6.3.1.7
4-methyleneglutamate---ammonia ligase
|
–
|
|
BRENDA:
BR98
KEGG:
R02711
MetaCyc:
4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN
|
|
|
|
L-threo-3-methylaspartate <=> NH3 + mesaconate
|
4.3.1.2
methylaspartate ammonia-lyase
|
–
|
|
BRENDA:
BR487
KEGG:
R03696
MetaCyc:
METHYLASPARTATE-AMMONIA-LYASE-RXN
|
|
|
|
(R)-citramalate <=> citraconate + H2O
|
4.2.1.31
maleate hydratase
4.2.1.35
(R)-2-methylmalate dehydratase
|
–
–
|
|
BRENDA:
BR415
KEGG:
R03896
MetaCyc:
R-2-METHYLMALATE-DEHYDRATASE-RXN
SABIO-RK:
3641
|
|
|
|
2-oxobutyrate + phosphate + O2 <=> propanoyl_phosphate + CO2 + H2O2
|
1.2.3
|
–
|
|
KEGG:
R00993
|
|
|
|
H+ + cis-aconitate <=> CO2 + Itaconate
|
4.1.1.6
cis-aconitate decarboxylase
|
–
|
|
BRENDA:
BR320
KEGG:
R02243
MetaCyc:
ACONITATE-DECARBOXYLASE-RXN
|
|
|
|
4-Methylene-2-oxoglutarate + NH3 <=> 4-Methyl-L-glutamate + H2O
|
not assigned
|
–
|
|
KEGG:
R05079
|
|
|
|
(+)-citramalate <=> H2O + mesaconate
|
4.2.1.2
fumarate hydratase
4.2.1.34
(S)-2-methylmalate dehydratase
|
–
–
|
|
BRENDA:
BR414
KEGG:
R03693
MetaCyc:
S-2-METHYLMALATE-DEHYDRATASE-RXN
|
|
|
|
Itaconate <=> 2-Hydroxyparaconate
|
not assigned
|
–
|
|
KEGG:
R11750
|
|
|
|
ATP + Itaconate + CoA <=> ADP + phosphate + itaconyl-CoA
|
6.2.1.5
succinate---CoA ligase (ADP-forming)
|
–
|
|
BRENDA:
BS416615
KEGG:
R02404
|
|
|
|
4-methylene-L-glutamine + H2O <=> 4-methylene-L-glutamate + NH3
|
3.5.1.67
4-methyleneglutaminase
|
–
|
|
BRENDA:
BR19254
KEGG:
R02712
MetaCyc:
4-METHYLENEGLUTAMINASE-RXN
|
|
|
|
succinyl-CoA + (+)-citramalate <=> (3S)-citramalyl-CoA + succinate
|
2.8.3.22
succinyl-CoA---L-malate CoA-transferase
|
–
|
|
BRENDA:
BR50974
KEGG:
R03154
MetaCyc:
2.8.3.7-RXN
|
|
|
|
citraconate + H2O <=> D-erythro-3-Methylmalate
|
4.2.1.35
(R)-2-methylmalate dehydratase
|
–
|
|
KEGG:
R03898
MetaCyc:
RXN-7744
|
|
|
|
4-methylene-L-glutamate <=> 4-Methylene-2-oxoglutarate
|
not assigned
|
–
|
|
KEGG:
R02713
|
|