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C5-Branched dibasic acid metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(3S)-citramalyl-CoA <=> pyruvate + acetyl-CoA 2.3.1.182 (R)-citramalate synthase
4.1.3.25 (S)-citramalyl-CoA lyase
–
–
H+ + pyruvate <=> (S)-2-Hydroxy-2-methyl-3-oxobutanoate + CO2 2.2.1.6 acetolactate synthase
4.1.1.1 pyruvate decarboxylase
–
–
citraconate + H2O <=> (2R,3R)-3-methyltartrate not assigned
 –
mesaconate + H2O <=> L-threo-3-methylmalate not assigned
 –
4-hydroxy-4-methyl-2-oxoglutarate + NH3 <=> 4-Hydroxy-4-methylglutamate + H2O not assigned
 –
(3S)-citramalyl-CoA <=> H2O + itaconyl-CoA 4.2.1.56 itaconyl-CoA hydratase
–
H+ + (S)-2-Hydroxy-2-methyl-3-oxobutanoate <=> (R)-acetoin + CO2 4.1.1.5 acetolactate decarboxylase
–
acetyl-CoA + pyruvate + H2O <=> H+ + (R)-citramalate + CoA 2.3.1.182 (R)-citramalate synthase
2.3.3.13 2-isopropylmalate synthase
–
–
beta-methylmalyl-CoA <=> 2-methylfumaryl-CoA + H2O 4.2.1.148 2-methylfumaryl-CoA hydratase
4.2.1.153 3-methylfumaryl-CoA hydratase
–
–
L-threo-3-methylaspartate <=> L-glutamate 5.4.99.1 methylaspartate mutase
–
(+)-citramalate <=> pyruvate + acetate 4.1.3.1 isocitrate lyase
4.1.3.22 citramalate lyase
–
–
mesaconate + CoA <=> 2-methylfumaryl-CoA + H2O not assigned
 –
L-threo-3-methylaspartate + 2-oxoglutarate <=> L-glutamate + 3-methyloxaloacetate 2.6.1
–
(R)-citramalate + CO2 <=> 4-hydroxy-4-methyl-2-oxoglutarate + H2O not assigned
 –
4-Methylene-2-oxoglutarate + H2O <=> 4-hydroxy-4-methyl-2-oxoglutarate 4.2.1
–
trans-aconitate <=> cis-aconitate 5.3.3.7 aconitate Delta-isomerase
–
trans-aconitate + H+ <=> Itaconate + CO2 4.1.1.113 trans-aconitate decarboxylase
–
D-erythro-3-Methylmalate + NAD+ <=> 2-oxobutyrate + CO2 + NADH 1.1.1
1.1.1.85 3-isopropylmalate dehydrogenase
–
–
H+ + 3-methyloxaloacetate <=> 2-oxobutyrate + CO2 4.1.1.112 oxaloacetate decarboxylase
–
beta-methylmalyl-CoA <=> glyoxylate + propionyl-CoA 4.1.3.24 malyl-CoA lyase
–
succinyl-CoA + Itaconate <=> succinate + itaconyl-CoA 2.8.3
2.8.3.20 succinyl-CoA---D-citramalate CoA-transferase
2.8.3.22 succinyl-CoA---L-malate CoA-transferase
–
–
–
acetyl-CoA + (+)-citramalate <=> acetate + (3S)-citramalyl-CoA 2.8.3.11 citramalate CoA-transferase
–
propionyl-CoA + H2O + glyoxylate <=> 2-hydroxyglutarate + H+ + CoA 2.3.3.11 2-hydroxyglutarate synthase
–
4-hydroxy-4-methyl-2-oxoglutarate <=> pyruvate 4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
–
4-methylene-L-glutamate + NH3 + ATP <=> H+ + 4-methylene-L-glutamine + AMP + diphosphate 6.3.1.7 4-methyleneglutamate---ammonia ligase
–
L-threo-3-methylaspartate <=> NH3 + mesaconate 4.3.1.2 methylaspartate ammonia-lyase
–
(R)-citramalate <=> citraconate + H2O 4.2.1.31 maleate hydratase
4.2.1.35 (R)-2-methylmalate dehydratase
–
–
2-oxobutyrate + phosphate + O2 <=> propanoyl_phosphate + CO2 + H2O2 1.2.3
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H+ + cis-aconitate <=> CO2 + Itaconate 4.1.1.6 cis-aconitate decarboxylase
–
4-Methylene-2-oxoglutarate + NH3 <=> 4-Methyl-L-glutamate + H2O not assigned
 –
(+)-citramalate <=> H2O + mesaconate 4.2.1.2 fumarate hydratase
4.2.1.34 (S)-2-methylmalate dehydratase
–
–
Itaconate <=> 2-Hydroxyparaconate not assigned
 –
ATP + Itaconate + CoA <=> ADP + phosphate + itaconyl-CoA 6.2.1.5 succinate---CoA ligase (ADP-forming)
–
4-methylene-L-glutamine + H2O <=> 4-methylene-L-glutamate + NH3 3.5.1.67 4-methyleneglutaminase
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succinyl-CoA + (+)-citramalate <=> (3S)-citramalyl-CoA + succinate 2.8.3.22 succinyl-CoA---L-malate CoA-transferase
–
citraconate + H2O <=> D-erythro-3-Methylmalate 4.2.1.35 (R)-2-methylmalate dehydratase
–
4-methylene-L-glutamate <=> 4-Methylene-2-oxoglutarate not assigned
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