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Biosynthesis of various secondary metabolites - part 2

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
coniferyl_alcohol <=> (-)-pinoresinol not assigned
 –
feruloyl-CoA + H2O <=> 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA 4.1.2.61 feruloyl-CoA hydratase/lyase
4.2.1.101 trans-feruloyl-CoA hydratase
–
–
4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA <=> acetyl-CoA + Vanillin 4.1.2.41 vanillin synthase
4.1.2.61 feruloyl-CoA hydratase/lyase
–
–
anthranilate + L-tryptophan + L-alanine + ATP <=> Fumiquinazoline_F + diphosphate + AMP + H2O + H+ 6.3.2
–
aurachin_B + O2 + NADH + H+ <=> Aurachin_B_epoxide + NAD+ + H2O 1.14.13
–
CTP + 2-hydroxyethylphosphonate <=> cytidine_5''-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate 2.7.7.104 2-hydroxyethylphosphonate cytidylyltransferase
–
anthranilate + CoA + ATP <=> 2-aminobenzoyl-CoA + AMP + diphosphate 6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.25 benzoate---CoA ligase
6.2.1.32 anthranilate---CoA ligase
–
–
–
8-Methyl-6-nonenoic_acid <=> (6E)-8-methylnon-6-enoyl-CoA not assigned
 –
3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate <=> (3E)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate 5.3.3.19 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase
–
H+ + phosphoenolpyruvate <=> Phosphonopyruvate 5.4.2.9 phosphoenolpyruvate mutase
–
(-)-deoxypodophyllotoxin <=> podophyllotoxin not assigned
 –
2 N-Methyl-cyclo(L-Trp-L-Phe) <=> (-)-Ditryptophenaline 1
–
cyclo-L-Trp-L-Phe + S-adenosyl-L-methionine <=> N-Methyl-cyclo(L-Trp-L-Phe) + S-adenosyl-L-homocysteine 2.1.1
–
2-aminobenzoyl-CoA + malonyl-CoA + H+ <=> 4-hydroxy-2-methylquinoline + CoA + CO2 2.3.1
–
N-Acetyl-N6,O-didemethylpuromycin-5''-phosphate + S-adenosyl-L-methionine <=> N-Acetyl-O-demethylpuromycin-5''-phosphate + S-adenosyl-L-homocysteine 2
–
aurachin_B + O2 + NADPH + H+ <=> Aurachin_B_epoxide + NADP+ + H2O 1.14.13
–
L-dihydroanticapsin + NAD+ <=> anticapsin + NADH + H+ 1.1.1.385 dihydroanticapsin dehydrogenase
–
coniferyl_alcohol <=> (+)-pinoresinol not assigned
 –
N-Acetyl-O-demethylpuromycin-5''-phosphate <=> N-acetyl-O-demethylpuromycin not assigned
 –
(6E)-8-methylnon-6-enoyl-CoA + vanillylamine <=> capsaicin + CoA + H+ 2.3.2.35 capsaicin synthase
–
3-[(2S,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate + L-phenylalanine <=> L-dihydroanticapsin + phenylpyruvate 2.6.1
–
D-glucose_6-phosphate + NAD+ <=> 3-dehydro-D-glucose_6-phosphate + NADH + H+ 1.1.1.361 glucose-6-phosphate 3-dehydrogenase
–
L-tryptophan + L-phenylalanine <=> cyclo-L-Trp-L-Phe 6.3.2
–
S-adenosyl-L-methionine + N-acetyl-O-demethylpuromycin <=> H+ + N-acetylpuromycin + S-adenosyl-L-homocysteine 2.1.1.38 O-demethylpuromycin O-methyltransferase
–
N-Acetyl-N6,N6,O-tridemethylpuromycin-5''-phosphate + S-adenosyl-L-methionine <=> N-Acetyl-N6,O-didemethylpuromycin-5''-phosphate + S-adenosyl-L-homocysteine 2
–
(+)-lariciresinol + NADP+ <=> (+)-pinoresinol + NADPH + H+ 1.23.1.1 (+)-pinoresinol reductase
1.23.1.2 (+)-lariciresinol reductase
–
–
(+)-secoisolariciresinol + NADP+ <=> (-)-lariciresinol + NADPH + H+ 1.23.1.3 (-)-pinoresinol reductase
1.23.1.4 (-)-lariciresinol reductase
–
–
Fumiquinazoline_C <=> Fumiquinazoline_D not assigned
 –
(S)-2-hydroxypropylphosphonate + H2O2 <=> fosfomycin + H2O 1.11.1.23 (S)-2-hydroxypropylphosphonic acid epoxidase
–
3''-Keto-3''-deoxy-AMP <=> 3''-Amino-3''-deoxy-AMP 2
–
N-acetylpuromycin + H2O <=> puromycin + acetate not assigned
 –
S-adenosyl-L-methionine + (-)-5''-demethylyatein <=> S-adenosyl-L-homocysteine + (-)-yatein + H+ 2.1.1.330 5'-demethylyatein 5'-O-methyltransferase
–
ATP + L-alanine + anticapsin <=> ADP + phosphate + L-alanyl-L-anticapsin + H+ 6.3.2.49 L-alanine---L-anticapsin ligase
–
H+ + prephenate <=> 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 4.1.1.100 prephenate decarboxylase
–
phosphonoacetaldehyde + NADPH + H+ <=> 2-hydroxyethylphosphonate + NADP+ 1.1.1.309 phosphonoacetaldehyde reductase (NADH)
1.1.99.B6
–
–
(3E)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate <=> 3-[(2E,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-ylidene]-2-oxopropanoate not assigned
 –
(-)-matairesinol + reduced_flavodoxin + O2 <=> (-)-pluviatolide + flavin + 2 H2O 1.14.19.72 (-)-pluviatolide synthase
–
Fumiquinazoline_F + 3 reduced_flavodoxin + 2 O2 <=> Fumiquinazoline_F-indoline-2'',3''-diol + 3 flavin + 2 H2O 1.14.14
–
ATP + NAD+ <=> H+ + 3''-dehydro-ATP + NADH 1
–
Fumiquinazoline_A + O2 <=> Fumiquinazoline_C + H2O2 1.5.3
–
S-adenosyl-L-methionine + cytidine_5''-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + reduced_acceptor <=> 5''-deoxyadenosine + L-methionine + S-adenosyl-L-homocysteine + cytidine_5''-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + acceptor + H+ 2.1.1.308 cytidylyl-2-hydroxyethylphosphonate methyltransferase
–
(-)-bursehernin + reduced_flavodoxin + O2 <=> (-)-5''-demethylyatein + flavin + H2O 1.14.14.131 bursehernin 5'-monooxygenase
–
3''-Amino-3''-deoxy-AMP + L-tyrosine <=> N6,N6,O-Tridemethylpuromycin-5''-phosphate not assigned
 –
cytidine_5''-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + H2O <=> (S)-2-hydroxypropylphosphonate + CMP + H+ 3.6.1
–
fumiquinazoline_F-indoline-2,3''-diol + L-alanine + ATP <=> Fumiquinazoline_A + AMP + diphosphate + H2O + H+ 6.3.2
–
S-adenosyl-L-methionine + (-)-pluviatolide <=> S-adenosyl-L-homocysteine + (-)-bursehernin + H+ 2.1.1.323 (-)-pluviatolide 4-O-methyltransferase
–
(-)-yatein + 2-oxoglutarate + O2 <=> (-)-deoxypodophyllotoxin + succinate + CO2 + H2O 1.14.20.8 (-)-deoxypodophyllotoxin synthase
–
(2E,6E)-farnesyl_diphosphate + 4-hydroxy-2-methylquinoline <=> aurachin_D + diphosphate 2.5.1
–
3''-Keto-3''-deoxy-ATP <=> 3''-Keto-3''-deoxy-AMP + diphosphate 3
–
2-hydroxyethylphosphonate + NAD+ <=> phosphonoacetaldehyde + NADH + H+ 1.1.1.309 phosphonoacetaldehyde reductase (NADH)
–
aurachin_C + O2 + NADH + H+ <=> 4-hydroxy-2-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]quinolin-3(4H)-one_1-oxide + NAD+ + H2O 1.14.13.222 aurachin C monooxygenase/isomerase
–
N6,N6,O-Tridemethylpuromycin-5''-phosphate + acetyl-CoA <=> N-Acetyl-N6,N6,O-tridemethylpuromycin-5''-phosphate + CoA 2.3
–
aurachin_C + O2 + NADPH + H+ <=> 4-hydroxy-2-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]quinolin-3(4H)-one_1-oxide + NADP+ + H2O 1.14.13.222 aurachin C monooxygenase/isomerase
–
isobutyryl-CoA + 3 malonyl-CoA <=> 8-Methyl-6-nonenoic_acid not assigned
 –
3-[(2S,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate + NAD+ <=> 3-[(2E,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-ylidene]-2-oxopropanoate + NADH + H+ 1.3.1.aa
–
Aurachin_B_epoxide <=> aurachin_A not assigned
 –
kanosamine_6-phosphate + 2-oxoglutarate <=> 3-dehydro-D-glucose_6-phosphate + L-glutamate 2.6.1.104 3-dehydro-glucose-6-phosphate---glutamate transaminase
–
(-)-lariciresinol + NADP+ <=> (-)-pinoresinol + NADPH + H+ 1.23.1.3 (-)-pinoresinol reductase
1.23.1.4 (-)-lariciresinol reductase
–
–
aurachin_B + NAD+ + H2O <=> 4-hydroxy-2-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]quinolin-3(4H)-one_1-oxide + NADH + H+ 1.1.1.394 aurachin B dehydrogenase
–
L-alanine + Vanillin <=> pyruvate + vanillylamine 2.6.1.119 vanillin aminotransferase
–
kanosamine_6-phosphate + H2O <=> kanosamine + phosphate 3.1.3.92 kanosamine-6-phosphate phosphatase
–
H+ + Phosphonopyruvate <=> phosphonoacetaldehyde + CO2 4.1.1.82 phosphonopyruvate decarboxylase
–
(-)-secoisolariciresinol + NADP+ <=> (+)-lariciresinol + NADPH + H+ 1.23.1.2 (+)-lariciresinol reductase
–
aurachin_D + O2 + NADPH + H+ <=> aurachin_C + H2O + NADP+ 1.14.13
–
(-)-secoisolariciresinol + NAD+ <=> (-)-matairesinol + NADH + H+ 1.1.1.331 secoisolariciresinol dehydrogenase
–

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