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Biosynthesis of unsaturated fatty acids

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
lignoceroyl-CoA + H2O <=> CoA + n-tetracosanoic_acid 3.1.2
3.1.2.2 palmitoyl-CoA hydrolase


eicosenoyl-CoA + 2 ferricytochrome_b5 + O2 + 2 H+ <=> (8Z,11Z)-Icosadienoyl-CoA + 2 ferricytochrome_b5 + 2 H2O 1.14.19.3 acyl-CoA 6-desaturase

(4Z,7Z,10Z,13Z,16Z)-Docosapentaenoyl-CoA + acetyl-CoA <=> (6Z,9Z,12Z,15Z,18Z)-3-Oxotetracosapentaenoyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.176 propanoyl-CoA C-acyltransferase


arachidoyl-CoA + H2O <=> eicosanoic_acid + CoA + H+ 3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase


docosahexaenoyl-CoA + H2O <=> docosahexaenoic_acid + CoA + H+ 3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase


(9Z,12Z,15Z,18Z)-Tetracosatetraenoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> (6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA + H2O + ferricytochrome_b5 1.14.19.3 acyl-CoA 6-desaturase

linoleoyl-CoA + H2O <=> H+ + linoleic_acid + CoA 3.1.2
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase



(6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexaenoyl-CoA + H2O2 1.3.3.6 acyl-CoA oxidase

(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + H2O <=> 11,14,17-Eicosatrienoic_acid + CoA + H+ 3.1.2

(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + H2O + ferricytochrome_b5 1.14.19
1.14.19.3 acyl-CoA 6-desaturase


erucoyl-CoA + H2O <=> CoA + erucic_acid 3.1.2

oleoyl-CoA + 2 ferricytochrome_b5 + O2 + 2 H+ <=> (6Z,9Z)-Octadecadienoyl-CoA + 2 ferricytochrome_b5 + 2 H2O 1.14.19.3 acyl-CoA 6-desaturase

docosahexaenoyl-CoA + acetyl-CoA <=> (6Z,9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosahexaenoyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.176 propanoyl-CoA C-acyltransferase


oleoyl-CoA + H2O <=> H+ + oleic_acid + CoA 2.3.1.9 acetyl-CoA C-acetyltransferase
3.1.1.1 carboxylesterase
3.1.2.1 acetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.22 palmitoyl[protein] hydrolase






linoleoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> linolenoyl-CoA + H2O + ferricytochrome_b5 1.14.19
1.14.19.13 acyl-CoA 15-desaturase


(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosaheptaenoyl-CoA + H2O2 1.3.3.6 acyl-CoA oxidase

oleoyl-CoA + ferricytochrome_b5 + O2 + H+ <=> linoleoyl-CoA + ferricytochrome_b5 + H2O 1.14.19.22 acyl-lipid omega-6 desaturase (cytochrome b5)
1.14.19.6 acyl-CoA (9+3)-desaturase


malonyl-CoA + palmitoyl-CoA + H+ <=> 3-oxostearoyl-CoA + CO2 + CoA 2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase

palmitoyl-CoA + H2O <=> H+ + palmitate + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
3.1.1.1 carboxylesterase
3.1.1.23 acylglycerol lipase
3.1.1.5 lysophospholipase
3.1.2
3.1.2.1 acetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.22 palmitoyl[protein] hydrolase
3.1.2.25 phenylacetyl-CoA hydrolase










8,11,14-eicosatrienoic_acid + O2 + ferricytochrome_b5 + H+ <=> Arachidonoyl-CoA + H2O + ferricytochrome_b5 1.14.19.44 acyl-CoA (8-3)-desaturase

linoleoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> gamma-linolenoyl-CoA + H2O + ferricytochrome_b5 1.14.19.3 acyl-CoA 6-desaturase

(11Z,14Z)-icosa-11,14-dienoyl-CoA + H2O <=> CoA + eicosadienoic_acid 3.1.2

behenoyl-CoA + H2O <=> CoA + behenic_acid 3.1.2
3.1.2.2 palmitoyl-CoA hydrolase


stearoyl-CoA + NADPH + O2 + H+ <=> oleoyl-CoA + NADP+ + H2O 1.14.19
1.14.19.1 stearoyl-CoA 9-desaturase
1.14.19.M26



3-hydroxystearoyl-CoA <=> trans-2-octadecenoyl-CoA + H2O 4.2.1.119 enoyl-CoA hydratase 2
4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase


(3R,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-CoA <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosaheptaenoyl-CoA + H2O 4.2.1.119 enoyl-CoA hydratase 2

(13Z,16Z)-Docosadienoyl-CoA + H2O <=> CoA + (13Z,16Z)-Docosadienoic_acid 3.1.2

stearoyl-CoA + ferricytochrome_b5 + O2 + H+ <=> oleoyl-CoA + ferricytochrome_b5 + H2O 1.14.19.1 stearoyl-CoA 9-desaturase

(3R,6Z,9Z,12Z,15Z,18Z)-3-Hydroxytetracosapentaenoyl-CoA <=> (2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexaenoyl-CoA + H2O 4.2.1.119 enoyl-CoA hydratase 2

3-hydroxystearoyl-CoA + NADP+ <=> 3-oxostearoyl-CoA + NADPH + H+ 1.1.1
1.1.1.330 very-long-chain 3-oxoacyl-CoA reductase


eicosapentaenoyl-CoA + H2O <=> eicosapentaenoic_acid + CoA + H+ 3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase


Arachidonoyl-CoA + H2O <=> CoA + arachidonic_acid 3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.25 phenylacetyl-CoA hydrolase



linolenoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> stearidonoyl-CoA + H2O + ferricytochrome_b5 1.14.19.3 acyl-CoA 6-desaturase

stearoyl-CoA + NADP+ <=> trans-2-octadecenoyl-CoA + NADPH + H+ 1.3.1
1.3.1.93 very-long-chain enoyl-CoA reductase


(7Z,10Z,13Z,16Z)-Docosatetraenoyl-CoA + H2O <=> CoA + cis-7,10,13,16-docosatetraenoic_acid 3.1.2

(15Z)-tetracosenoyl-CoA + H2O <=> CoA + nervonic_acid 3.1.2

(9Z,12Z,15Z,18Z,21Z)-Tetracosapentaenoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> (6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA + H2O + ferricytochrome_b5 1.14.19.3 acyl-CoA 6-desaturase

(3R,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-CoA + NAD+ <=> (6Z,9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosahexaenoyl-CoA + NADH + H+ 1.1.1

palmitoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> Sapienoyl-CoA + H2O + ferricytochrome_b5 1.14.19.3 acyl-CoA 6-desaturase

palmitoyl-CoA + ferricytochrome_b5 + O2 + H+ <=> palmitoleoyl-CoA + ferricytochrome_b5 + H2O 1.14.19.1 stearoyl-CoA 9-desaturase

docosapentaenoyl-CoA + H2O <=> docosapentaenoic_acid + CoA + H+ 3.1.2

(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> eicosapentaenoyl-CoA + H2O + ferricytochrome_b5 1.14.19.44 acyl-CoA (8-3)-desaturase

(11Z,14Z)-icosa-11,14-dienoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> 8,11,14-eicosatrienoic_acid + H2O + ferricytochrome_b5 1.14.19
1.14.19.3 acyl-CoA 6-desaturase


(3R,6Z,9Z,12Z,15Z,18Z)-3-Hydroxytetracosapentaenoyl-CoA + NAD+ <=> (6Z,9Z,12Z,15Z,18Z)-3-Oxotetracosapentaenoyl-CoA + NADH + H+ 1.1.1

linolenoyl-CoA + H2O <=> CoA + linolenic_acid 3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase


stearoyl-[acyl-carrier_protein] + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> oleoyl-[acyl-carrier_protein] + oxidized_ferredoxin + H2O 1.14.19.2 stearoyl-[acyl-carrier-protein] 9-desaturase

palmitoyl-CoA + H2O <=> H+ + palmitate + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
3.1.1.1 carboxylesterase
3.1.1.23 acylglycerol lipase
3.1.1.5 lysophospholipase
3.1.2
3.1.2.1 acetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.22 palmitoyl[protein] hydrolase
3.1.2.25 phenylacetyl-CoA hydrolase










8,11,14-eicosatrienoic_acid + H2O <=> 8,11,14-eicosatrienoic_acid + CoA + H+ 3.1.2.2 palmitoyl-CoA hydrolase

(8Z,11Z)-Icosadienoyl-CoA + 2 ferricytochrome_b5 + O2 + 2 H+ <=> 5,8,11-eicosatrienoyl-CoA + 2 ferricytochrome_b5 + 2 H2O 1.14.19.44 acyl-CoA (8-3)-desaturase

gamma-linolenoyl-CoA + H2O <=> CoA + gamma-linolenic_acid 3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase


eicosenoyl-CoA + H2O <=> CoA + 11-eicosenoic_acid 3.1.2

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