|
|
Nonaketamide_tricyclic_intermediate <=> Pretetramid
|
not assigned
|
–
|
|
KEGG:
R09196
|
|
|
|
8-D-Olivosyl-landomycin <=> Landomycin_D
|
not assigned
|
–
|
|
KEGG:
R09348
|
|
|
|
[4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate + O2 <=> [4,5-dihydroxy-9,10-dioxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate + H2O
|
1.13.12.22
deoxynogalonate monooxygenase
|
–
|
|
BRENDA:
BR51205
KEGG:
R09327
MetaCyc:
RXN-16270
|
|
|
|
aclacinomycin_S <=> aclacinomycin_N
|
not assigned
|
–
|
|
KEGG:
R09333
|
|
|
|
Tetrangomycin <=> Rabelomycin
|
not assigned
|
–
|
|
KEGG:
R06656
|
|
|
|
UWM6 <=> Rabelomycin
|
not assigned
|
–
|
|
KEGG:
R09341
|
|
|
|
(R)-Chiral_alcohol <=> (R)-Hemiketal
|
not assigned
|
–
|
|
KEGG:
R09310
|
|
|
|
S-adenosyl-L-methionine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> elloramycin + S-adenosyl-L-homocysteine + H+
|
2.1.1
|
–
|
|
KEGG:
R10959
MetaCyc:
RXN-15402
|
|
|
|
aclacinomycin_N + O2 <=> Aclarubicin + H2O2
|
1.1.3.45
aclacinomycin-N oxidase
|
–
|
|
BRENDA:
BR50598
KEGG:
R09334
MetaCyc:
RXN-14689
|
|
|
|
tetracycline + O2 + Cl- + FADH2 <=> 7-chlorotetracycline + H2O + FAD + H+
|
1.14.19.49
tetracycline 7-halogenase
|
–
|
|
BRENDA:
BR51837
KEGG:
R11478
MetaCyc:
RXN-17996
|
|
|
|
S-adenosyl-L-methionine + aklanonate <=> S-adenosyl-L-homocysteine + methyl_aklanonate
|
2.1.1.288
aklanonic acid methyltransferase
|
–
|
|
BRENDA:
BR50636
KEGG:
R06680
MetaCyc:
RXN-14831
|
|
|
|
daunorubicin <=> 13-dihydrodaunorubicin
|
not assigned
|
–
|
|
KEGG:
R06694
|
|
|
|
15-Demethoxy-epsilon-rhodomycin + O2 + 2 glutathione <=> beta-Rhodomycin + CO2 + H2O + GSSG
|
not assigned
|
–
|
|
KEGG:
R09338
|
|
|
|
13-dihydrocarminomycin + NADPH + H+ + O2 <=> carminomycin + NADP+ + H2O
|
1.14.13.181
13-deoxydaunorubicin hydroxylase
|
–
|
|
BRENDA:
BS421771
KEGG:
R06692
MetaCyc:
RXN-16479
|
|
|
|
4-de(dimethylamino)-4-oxoanhydrotetracycline <=> 4-amino-4-de(dimethylamino)anhydrotetracycline
|
not assigned
|
–
|
|
KEGG:
R09197
|
|
|
|
Premithramycin_A3 + dTDP-D-boivinose <=> 3A-Deolivosylpremithramycin_B + dTDP + H+
|
2.4.1
|
–
|
|
KEGG:
R09351
MetaCyc:
RXN-13380
|
|
|
|
auraviketone + NADPH + H+ <=> Auramycinone + NADP+
|
1.1.1.362
aklaviketone reductase
|
–
|
|
KEGG:
R06677
|
|
|
|
tetracenomycin_B2 + O2 + NADPH + H+ <=> 8-demethyltetracenomycin_C + H2O + NADP+
|
1.14.13.200
tetracenomycin A2 monooxygenase-dioxygenase
|
–
|
|
BRENDA:
BS429406
KEGG:
R10954
MetaCyc:
RXN-15407
|
|
|
|
5a,11a-dehydrotetracycline + O2 + NADPH + H+ <=> 5a,11a-dehydrooxytetracycline + H2O + NADP+
|
1.14.13.234
5a,11a-dehydrotetracycline 5-monooxygenase
|
–
|
|
BRENDA:
BR51809
KEGG:
R09198
MetaCyc:
RXN-17976
|
|
|
|
auraviketone <=> methyl_nogalonate
|
5.5.1.23
aklanonic acid methyl ester cyclase
5.5.1.B6
|
–
–
|
|
BRENDA:
BS431080
KEGG:
R06676
MetaCyc:
RXN-14876
|
|
|
|
S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin_C + S-adenosyl-L-homocysteine + H+
|
2.1.1.306
8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase
|
–
|
|
BRENDA:
BR50858
KEGG:
R10957
MetaCyc:
RXN-15404
|
|
|
|
Nogalavinone <=> 1-OH-Nogalamycinone
|
not assigned
|
–
|
|
KEGG:
R09330
|
|
|
|
tetracenomycin_F2 <=> tetracenomycin_F1 + H2O
|
4.2.1.154
tetracenomycin F2 cyclase
|
–
|
|
BRENDA:
BR51058
KEGG:
R06699
MetaCyc:
RXN-15056
|
|
|
|
(R)-Hemiketal <=> (R)-DNPA + H2O
|
not assigned
|
–
|
|
KEGG:
R09311
|
|
|
|
10-carboxy-13-deoxycarminomycin + H+ <=> 13-deoxycarminomycin + CO2
|
4.1.1
|
–
|
|
KEGG:
R06686
MetaCyc:
RXN-14827
|
|
|
|
13-deoxycarminomycin + NADPH + H+ + O2 <=> 13-dihydrocarminomycin + NADP+ + H2O
|
1.14.13.181
13-deoxydaunorubicin hydroxylase
|
–
|
|
BRENDA:
BS421769
KEGG:
R06691
MetaCyc:
RXN-16478
|
|
|
|
6-Deoxydihydrokalafungin + O2 <=> Dihydrokalafungin + H2O
|
not assigned
|
–
|
|
KEGG:
R06696
|
|
|
|
S-adenosyl-L-methionine + tetracenomycin_B3 <=> tetracenomycin_B2 + S-adenosyl-L-homocysteine
|
2.1.1
|
–
|
|
KEGG:
R06713
MetaCyc:
RXN-15408
|
|
|
|
UWM6 <=> 2,3-Dehydro-UWM6 + H2O
|
4.2.1
|
–
|
|
KEGG:
R09342
MetaCyc:
RXN-11981
|
|
|
|
7,9,12-Decaketide_intermediate_3 <=> UWM6
|
not assigned
|
–
|
|
KEGG:
R09340
|
|
|
|
Tetrangulol <=> 8-O-Methyltetrangulol
|
not assigned
|
–
|
|
KEGG:
R06651
|
|
|
|
S-adenosyl-L-methionine + 4-amino-4-de(dimethylamino)anhydrotetracycline <=> anhydrotetracycline + S-adenosyl-L-homocysteine + H+
|
2.1.1.335
4-amino-anhydrotetracycline N4-methyltransferase
|
–
|
|
BRENDA:
BR51855
KEGG:
R09191;
R11520
MetaCyc:
RXN-17977
|
|
|
|
aklaviketone <=> methyl_aklanonate
|
5.5.1.23
aklanonic acid methyl ester cyclase
|
–
|
|
BRENDA:
BR50726
KEGG:
R06681
MetaCyc:
RXN-14844
|
|
|
|
11-Deoxylandomycinone <=> Landomycin_H
|
not assigned
|
–
|
|
KEGG:
R09347
|
|
|
|
Octaketide_bicyclic_intermediate + NADPH + H+ <=> (R)-Chiral_alcohol + NADP+
|
1.1.1
|
–
|
|
KEGG:
R09309
|
|
|
|
aggreticin + dTDP-D-boivinose <=> kerriamycin_B + dTDP
|
2.4.1
|
–
|
|
KEGG:
R06668
|
|
|
|
epsilon-rhodomycinone <=> epsilon-Rhodomycin_T
|
not assigned
|
–
|
|
KEGG:
R09336
|
|
|
|
4-hydroxy-6-methylpretetramide + NADPH + O2 + H+ <=> 4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O
|
1.14.13.233
4-hydroxy-6-methylpretetramide 12a-monooxygenase
|
–
|
|
BRENDA:
BR51808
KEGG:
R05462
MetaCyc:
RXN-17980
|
|
|
|
Aquayamycin + dTDP-L-rhodinose <=> 100-2 + dTDP
|
not assigned
|
–
|
|
KEGG:
R06666
|
|
|
|
5a,11a-dehydrooxytetracycline + reduced_coenzyme_F420 <=> oxytetracycline + coenzyme_F420
|
1.3.98.4
5a,11a-dehydrotetracycline reductase
|
–
|
|
KEGG:
R09192
MetaCyc:
RXN-17975
|
|
|
|
tetracenomycin_F1 <=> Decarboxytetracenomycin_F1
|
not assigned
|
–
|
|
KEGG:
R06707
|
|
|
|
Dihydrokalafungin <=> Medermycin
|
not assigned
|
–
|
|
KEGG:
R06698
|
|
|
|
aklavinone + dTDP-beta-L-rhodosamine <=> aclacinomycin_T + dTDP + H+
|
2.4.1.326
aklavinone 7-L-rhodosaminyltransferase
|
–
|
|
BRENDA:
BR51043
KEGG:
R09331
MetaCyc:
RXN-14853
|
|
|
|
aclacinomycin_T + dTDP-2-deoxy-alpha-L-fucose <=> aclacinomycin_S + dTDP + H+
|
2.4.1.327
aclacinomycin-T 2-deoxy-L-fucose transferase
|
–
|
|
BRENDA:
BR51044;
BS430146
KEGG:
R09332
MetaCyc:
RXN-14852
SABIO-RK:
14528
|
|
|
|
Stealthin_C <=> Prekinamycin
|
not assigned
|
–
|
|
KEGG:
R06673
|
|
|
|
methyl_nogalonate <=> Dihydro-NAME
|
not assigned
|
–
|
|
KEGG:
R06678
|
|
|
|
3A-Deolivosylpremithramycin_B + dTDP-D-boivinose <=> Premithramycin_B + dTDP + H+
|
2.4.1
|
–
|
|
KEGG:
R09352
MetaCyc:
RXN-13381
|
|
|
|
2,3-Dehydro-UWM6 + L-isoleucine <=> Jadomycin_A + CO2 + H2O
|
not assigned
|
–
|
|
KEGG:
R09344
|
|
|
|
tetracenomycin_B3 <=> Tetracenomycin_B1
|
not assigned
|
–
|
|
KEGG:
R06711
|
|
|
|
8-O-Methyltetrangulol <=> 19-Hydroxy-8-O-methyltetrangulol
|
not assigned
|
–
|
|
KEGG:
R06652
|
|
|
|
13-deoxydaunorubicin + NADPH + H+ + O2 <=> 13-dihydrodaunorubicin + NADP+ + H2O
|
1.14.13.181
13-deoxydaunorubicin hydroxylase
|
–
|
|
BRENDA:
BR50584
KEGG:
R06688
MetaCyc:
RXN-14829
|
|
|
|
6-methylpretetramide + 2 NADPH + 2 H+ + 2 O2 <=> 4-de(dimethylamino)-4-oxoanhydrotetracycline + 2 NADP+ + 2 H2O
|
1.14.13.232
6-methylpretetramide 4-monooxygenase
1.14.13.233
4-hydroxy-6-methylpretetramide 12a-monooxygenase
|
–
–
|
|
KEGG:
R09190
|
|
|
|
tetracenomycin_D3 <=> tetracenomycin_B3
|
not assigned
|
–
|
|
KEGG:
R06701
|
|
|
|
aklavinone + NADP+ <=> aklaviketone + NADPH + H+
|
1.1.1.362
aklaviketone reductase
|
–
|
|
BRENDA:
BR50595
KEGG:
R06682
MetaCyc:
RXN-14818
|
|
|
|
Landomycin_D <=> Landomycin_E
|
not assigned
|
–
|
|
KEGG:
R09349
|
|
|
|
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin_C + S-adenosyl-L-homocysteine + H+
|
2.1.1.307
8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
|
–
|
|
BRENDA:
BR50859
KEGG:
R10958
MetaCyc:
RXN-15403
|
|
|
|
Urdamycinone_F <=> Aquayamycin + H2O
|
not assigned
|
–
|
|
KEGG:
R06665
|
|
|
|
Kinobscurinone <=> Stealthin_C
|
not assigned
|
–
|
|
KEGG:
R06672
|
|
|
|
[4,5-dihydroxy-9,10-dioxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate + S-adenosyl-L-methionine <=> methyl_nogalonate + S-adenosyl-L-homocysteine
|
2.1.1
|
–
|
|
KEGG:
R06675
|
|
|
|
Premithramycin_A2' + dTDP-D-mycarose <=> Premithramycin_A3 + dTDP + H+
|
2.4.1
|
–
|
|
KEGG:
R06718
MetaCyc:
RXN-13377
|
|
|
|
5a,11a-dehydrotetracycline + reduced_coenzyme_F420 <=> tetracycline + coenzyme_F420
|
1.3.98.4
5a,11a-dehydrotetracycline reductase
|
–
|
|
BRENDA:
BR51789
KEGG:
R05459
MetaCyc:
RXN-17988
|
|
|
|
(S)-4-(3''-acetyl-5''-hydroxy-4''-oxo-1,4''-dihydronapthalen-2''-yl)-3-hydroxybutanoate <=> 2-((1R,3S),-1,9''-dihydroxy-1''-methyl-10''-oxo-3,4,5,10''-tetrahydro-1H-benzo[g]isochromen-3''-yl)acetate
|
5.5.1
|
–
|
|
KEGG:
R09307
MetaCyc:
RXN1A0-6312
|
|
|
|
Dihydrokalafungin_dihydroquinone_form + O2 + FMNH2 <=> 1,3,6,8-Tetrahydroxynaphthalene + H2O + FMN + H+
|
1.14.14
|
–
|
|
KEGG:
R09313
MetaCyc:
RXN-18115
|
|
|
|
7,9,12-Decaketide_intermediate_3 <=> [4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate
|
not assigned
|
–
|
|
KEGG:
R09325
|
|
|
|
4-Demethylpremithramycinone + S-adenosyl-L-methionine <=> Premithramycinone + S-adenosyl-L-homocysteine
|
2.1.1
|
–
|
|
KEGG:
R06715
|
|
|
|
6-Deoxydihydrokalafungin + FMNH2 + O2 <=> Dihydrokalafungin + FMN + H2O
|
1.14.14
|
–
|
|
KEGG:
R09314
|
|
|
|
FMNH2 + NAD+ <=> FMN + NADH + H+
|
1.14.13.7
phenol 2-monooxygenase (NADPH)
1.18.1.4
rubredoxin---NAD(P)+ reductase
1.5.1
1.5.1.30
flavin reductase (NADPH)
1.5.1.36
flavin reductase (NADH)
1.5.1.37
FAD reductase (NADH)
1.5.1.38
FMN reductase (NADPH)
1.5.1.39
FMN reductase [NAD(P)H]
1.5.1.41
riboflavin reductase [NAD(P)H]
1.5.1.42
FMN reductase (NADH)
|
–
–
–
–
–
–
–
–
–
–
|
|
BRENDA:
BR36899-a
KEGG:
R05705
MetaCyc:
FMNREDUCT-RXN_WOP;
RXN-9510
SABIO-RK:
5301
|
|
|
|
rhodomycin_D + H2O <=> 10-carboxy-13-deoxycarminomycin + methanol + H+
|
3.1.1
|
–
|
|
KEGG:
R06685
MetaCyc:
RXN-14856
|
|
|
|
UWM6 + dTDP-D-boivinose <=> C1''-C9-Glycosylated_UWM6 + dTDP
|
2.4.1
|
–
|
|
KEGG:
R09345
|
|
|
|
aclacinomycin_T + H2O <=> 15-demethylaclacinomycin_T + methanol + H+
|
3.1.1.95
aclacinomycin methylesterase
|
–
|
|
BRENDA:
BR50683
KEGG:
R10545
MetaCyc:
RXN-14703
|
|
|
|
Prekinamycin <=> Kinamycin_D
|
not assigned
|
–
|
|
KEGG:
R06674
|
|
|
|
Nonaketamide_monocyclic_intermediate <=> Nonaketamide_tricyclic_intermediate
|
not assigned
|
–
|
|
KEGG:
R09188
|
|
|
|
Landomycin_H <=> 8-D-Olivosyl-landomycin
|
not assigned
|
–
|
|
KEGG:
R09357
|
|
|
|
tetracenomycin_D3 <=> Tetracenomycin_D1
|
not assigned
|
–
|
|
KEGG:
R06710
|
|
|
|
nogalaviketone <=> methyl_nogalonate
|
5.5.1.26
nogalonic acid methyl ester cyclase
|
–
|
|
BRENDA:
BR51253
KEGG:
R09328
MetaCyc:
RXN-16288
|
|
|
|
7,9,12-Octaketide_intermediate_3 <=> Octaketide_bicyclic_intermediate + H2O
|
4
|
–
|
|
KEGG:
R09305
|
|
|
|
6-methylpretetramide + NADPH + O2 + H+ <=> 4-hydroxy-6-methylpretetramide + NADP+ + H2O
|
1.14.13.232
6-methylpretetramide 4-monooxygenase
|
–
|
|
BRENDA:
BR51807
KEGG:
R05463
MetaCyc:
RXN-17981
|
|
|
|
Urdamycinone_F + 2 dTDP-L-rhodinose + dTDP-D-boivinose <=> Urdamycin_F + 3 dTDP
|
not assigned
|
–
|
|
KEGG:
R06664
|
|
|
|
S-adenosyl-L-methionine + Premithramycin_A3 <=> Premithramycin_A3 + S-adenosyl-L-homocysteine + H+
|
2.1.1
|
–
|
|
KEGG:
R06719
MetaCyc:
RXN-13378
SABIO-RK:
6294
|
|
|
|
100-1 + dTDP-D-boivinose <=> Urdamycin_B + dTDP
|
2.4.1
|
–
|
|
KEGG:
R06660
|
|
|
|
Dehydrorabelomycin <=> Kinobscurinone
|
not assigned
|
–
|
|
KEGG:
R06671
|
|
|
|
Premithramycin_A1 + dTDP-D-oliose <=> Premithramycin_A2' + dTDP + H+
|
2.4.1
|
–
|
|
KEGG:
R06717
MetaCyc:
RXN-13376
|
|
|
|
S-adenosyl-L-methionine + Pretetramid <=> S-adenosyl-L-homocysteine + 6-methylpretetramide + H+
|
2.1.1
2.1.1.M31
|
–
–
|
|
KEGG:
R09189
MetaCyc:
RXN-17982
|
|
|
|
7,12-Decaketide_intermediate_1 <=> Decaketide_tricyclic_intermediate
|
not assigned
|
–
|
|
KEGG:
R09350
|
|
|
|
Jadomycin_A <=> Jadomycin_B
|
2.4.1
|
–
|
|
KEGG:
R06670
|
|
|
|
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl_tetracenomycin_C <=> 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin_C + S-adenosyl-L-homocysteine + H+
|
2.1.1.305
8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
|
–
|
|
BRENDA:
BR50857
KEGG:
R10956
MetaCyc:
RXN-15405
|
|
|
|
12-deoxyaklanoate + O2 <=> aklanonate + H2O
|
1.13.12
|
–
|
|
KEGG:
R06679
MetaCyc:
RXN-14854
|
|
|
|
2,3-Dehydro-UWM6 <=> Dehydrorabelomycin
|
not assigned
|
–
|
|
KEGG:
R09343
|
|
|
|
Mithramycin_DK <=> mithramycin
|
not assigned
|
–
|
|
KEGG:
R09354
|
|
|
|
aklavinone + NADPH + H+ + O2 <=> epsilon-rhodomycinone + NADP+ + H2O
|
1.14.13.180
aklavinone 12-hydroxylase
|
–
|
|
BRENDA:
BR50586
KEGG:
R06683
MetaCyc:
RXN-14824
|
|
|
|
S-adenosyl-L-methionine + 13-deoxycarminomycin <=> 13-deoxydaunorubicin + S-adenosyl-L-homocysteine + H+
|
2.1.1.292
carminomycin 4-O-methyltransferase
|
–
|
|
BRENDA:
BS424026
KEGG:
R06687
MetaCyc:
RXN-14826
|
|
|
|
S-adenosyl-L-methionine + Tetracenomycin_E <=> tetracenomycin_A2 + S-adenosyl-L-homocysteine
|
2.1.1
|
–
|
|
KEGG:
R06703
MetaCyc:
RXN-15436
|
|
|
|
Tetrangulol <=> 19-Hydroxytetrangulol
|
not assigned
|
–
|
|
KEGG:
R06653
|
|
|
|
tetracenomycin_D3 <=> Tetracenomycin_D3_methylester
|
not assigned
|
–
|
|
KEGG:
R06709
|
|
|
|
Urdamycinone_B <=> 104-2
|
not assigned
|
–
|
|
KEGG:
R06661
|
|
|
|
tetracenomycin_B3 <=> Tetracenomycin_E
|
not assigned
|
–
|
|
KEGG:
R06702
|
|
|
|
(S)-DNPA <=> 6-Deoxydihydrokalafungin
|
not assigned
|
–
|
|
KEGG:
R06695
|
|
|
|
Premithramycin_B + NADPH + H+ + O2 <=> Mithramycin_DK + NADP+ + CO2
|
1.14.13
|
–
|
|
KEGG:
R09353
|
|
|
|
Octaketide_bicyclic_intermediate + NADPH + H+ <=> (S)-Chiral_alcohol + NADP+
|
1.1.1
|
–
|
|
KEGG:
R09306
|
|
|
|
epsilon-Rhodomycin_T + H2O <=> 15-Demethoxy-epsilon-rhodomycin + methanol
|
3.1.1.95
aclacinomycin methylesterase
|
–
|
|
KEGG:
R09337
|
|
|
|
7,9,12-Decaketide_intermediate_6 <=> 12-Deoxyaklanonic_acid
|
not assigned
|
–
|
|
KEGG:
R09326
|
|
|
|
daunorubicin + NADPH + H+ + O2 <=> doxorubicin + NADP+ + H2O
|
1.14.13.181
13-deoxydaunorubicin hydroxylase
|
–
|
|
BRENDA:
BS421946
KEGG:
R06690
MetaCyc:
RXN-14855
|
|
|
|
104-2 + dTDP-L-rhodinose + dTDP-D-boivinose <=> 124-1 + 2 dTDP
|
not assigned
|
–
|
|
KEGG:
R06662
|
|
|
|
tetracenomycin_A2 + O2 + NADPH + H+ <=> tetracenomycin_C + H2O + NADP+
|
1.14.13.200
tetracenomycin A2 monooxygenase-dioxygenase
|
–
|
|
BRENDA:
BR51077
KEGG:
R06704
MetaCyc:
RXN-15434
|
|
|
|
Dihydrokalafungin + NADH + H+ <=> Dihydrokalafungin_dihydroquinone_form + NAD+
|
not assigned
|
–
|
|
KEGG:
R09312
|
|
|
|
anhydrotetracycline + O2 + NADPH + H+ <=> 5a,11a-dehydrotetracycline + H2O + NADP+
|
1.14.13.38
anhydrotetracycline 6-monooxygenase
|
–
|
|
BRENDA:
BR40419
KEGG:
R04060
MetaCyc:
ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN
|
|
|
|
19-Hydroxy-8-O-methyltetrangulol <=> PD116740
|
not assigned
|
–
|
|
KEGG:
R06655
|
|
|
|
2-((1R,3S),-1,9''-dihydroxy-1''-methyl-10''-oxo-3,4,5,10''-tetrahydro-1H-benzo[g]isochromen-3''-yl)acetate <=> (S)-DNPA + H2O
|
4.2.1
|
–
|
|
KEGG:
R09308
MetaCyc:
RXN1A0-6314
|
|
|
|
epsilon-rhodomycinone + dTDP-L-daunosamine <=> rhodomycin_D + dTDP + H+
|
2.4.1
|
–
|
|
KEGG:
R06684
MetaCyc:
RXN-14825
|
|
|
|
13-dihydrodaunorubicin + NADPH + H+ + O2 <=> daunorubicin + NADP+ + H2O
|
1.14.13.181
13-deoxydaunorubicin hydroxylase
|
–
|
|
BRENDA:
BR50585
KEGG:
R06689
MetaCyc:
RXN-14830
|
|
|
|
Urdamycinone_B + dTDP-L-rhodinose <=> 100-1 + dTDP
|
not assigned
|
–
|
|
KEGG:
R06659
|
|
|
|
tetracenomycin_A2 <=> Tetracenomycin_X
|
not assigned
|
–
|
|
KEGG:
R06714
|
|
|
|
Rabelomycin <=> 11-Deoxylandomycinone
|
not assigned
|
–
|
|
KEGG:
R09346
|
|
|
|
Tetrangomycin <=> Tetrangulol + H2O
|
not assigned
|
–
|
|
KEGG:
R06650
|
|
|
|
tetracenomycin_F1 + O2 <=> tetracenomycin_D3 + H2O + H+
|
1.13.12.21
tetracenomycin-F1 monooxygenase
|
–
|
|
BRENDA:
BR50567
KEGG:
R06700
MetaCyc:
RXN-14695
|
|
|
|
8-demethyltetracenomycin_C + dTDP-L-rhamnose <=> 8-demethyl-8-alpha-L-rhamnosyl_tetracenomycin_C + dTDP + H+
|
2.4.1.331
8-demethyltetracenomycin C L-rhamnosyltransferase
|
–
|
|
BRENDA:
BR50871
KEGG:
R10955
MetaCyc:
RXN-15406
|
|
|
|
Premithramycinone + dTDP-D-boivinose <=> Premithramycin_A1 + dTDP + H+
|
2.4.1
|
–
|
|
KEGG:
R06716
MetaCyc:
RXN-13375
|
|
|
|
Aclarubicin + O2 <=> aclacinomycin_Y + H2O2
|
1.3.3.14
aclacinomycin-A oxidase
|
–
|
|
BRENDA:
BR50611
KEGG:
R09335
MetaCyc:
RXN-14688
|
|
|
|
S-adenosyl-L-methionine + carminomycin <=> daunorubicin + S-adenosyl-L-homocysteine + H+
|
2.1.1.292
carminomycin 4-O-methyltransferase
|
–
|
|
BRENDA:
BR50635
KEGG:
R06693
MetaCyc:
RXN-14828
|
|
|
|
nogalaviketone + NADPH + H+ <=> Nogalavinone + NADP+
|
1.1.1
|
–
|
|
KEGG:
R09329
|
|
|
|
9,14-Decaketide_intermediate_1 <=> tetracenomycin_F2 + [acyl-carrier_protein]
|
not assigned
|
–
|
|
KEGG:
R09355
|
|
|
|
19-Hydroxytetrangulol <=> 19-Hydroxy-8-O-methyltetrangulol
|
not assigned
|
–
|
|
KEGG:
R06654
|
|
|
|
tetracenomycin_F1 <=> Tetracenomycin_F1_methylester
|
not assigned
|
–
|
|
KEGG:
R06706
|
|
|
|
100-2 + dTDP-L-rhodinose <=> aggreticin + dTDP
|
not assigned
|
–
|
|
KEGG:
R06667
|
|