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Biosynthesis of type II polyketide products

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
Nonaketamide_tricyclic_intermediate <=> Pretetramid not assigned
 –
8-D-Olivosyl-landomycin <=> Landomycin_D not assigned
 –
[4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate + O2 <=> [4,5-dihydroxy-9,10-dioxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate + H2O 1.13.12.22 deoxynogalonate monooxygenase
–
aclacinomycin_S <=> aclacinomycin_N not assigned
 –
Tetrangomycin <=> Rabelomycin not assigned
 –
UWM6 <=> Rabelomycin not assigned
 –
(R)-Chiral_alcohol <=> (R)-Hemiketal not assigned
 –
S-adenosyl-L-methionine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> elloramycin + S-adenosyl-L-homocysteine + H+ 2.1.1
–
aclacinomycin_N + O2 <=> Aclarubicin + H2O2 1.1.3.45 aclacinomycin-N oxidase
–
tetracycline + O2 + Cl- + FADH2 <=> 7-chlorotetracycline + H2O + FAD + H+ 1.14.19.49 tetracycline 7-halogenase
–
S-adenosyl-L-methionine + aklanonate <=> S-adenosyl-L-homocysteine + methyl_aklanonate 2.1.1.288 aklanonic acid methyltransferase
–
daunorubicin <=> 13-dihydrodaunorubicin not assigned
 –
15-Demethoxy-epsilon-rhodomycin + O2 + 2 glutathione <=> beta-Rhodomycin + CO2 + H2O + GSSG not assigned
 –
13-dihydrocarminomycin + NADPH + H+ + O2 <=> carminomycin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase
–
4-de(dimethylamino)-4-oxoanhydrotetracycline <=> 4-amino-4-de(dimethylamino)anhydrotetracycline not assigned
 –
Premithramycin_A3 + dTDP-D-boivinose <=> 3A-Deolivosylpremithramycin_B + dTDP + H+ 2.4.1
–
auraviketone + NADPH + H+ <=> Auramycinone + NADP+ 1.1.1.362 aklaviketone reductase
–
tetracenomycin_B2 + O2 + NADPH + H+ <=> 8-demethyltetracenomycin_C + H2O + NADP+ 1.14.13.200 tetracenomycin A2 monooxygenase-dioxygenase
–
5a,11a-dehydrotetracycline + O2 + NADPH + H+ <=> 5a,11a-dehydrooxytetracycline + H2O + NADP+ 1.14.13.234 5a,11a-dehydrotetracycline 5-monooxygenase
–
auraviketone <=> methyl_nogalonate 5.5.1.23 aklanonic acid methyl ester cyclase
5.5.1.B6
–
–
S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin_C + S-adenosyl-L-homocysteine + H+ 2.1.1.306 8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase
–
Nogalavinone <=> 1-OH-Nogalamycinone not assigned
 –
tetracenomycin_F2 <=> tetracenomycin_F1 + H2O 4.2.1.154 tetracenomycin F2 cyclase
–
(R)-Hemiketal <=> (R)-DNPA + H2O not assigned
 –
10-carboxy-13-deoxycarminomycin + H+ <=> 13-deoxycarminomycin + CO2 4.1.1
–
13-deoxycarminomycin + NADPH + H+ + O2 <=> 13-dihydrocarminomycin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase
–
6-Deoxydihydrokalafungin + O2 <=> Dihydrokalafungin + H2O not assigned
 –
S-adenosyl-L-methionine + tetracenomycin_B3 <=> tetracenomycin_B2 + S-adenosyl-L-homocysteine 2.1.1
–
UWM6 <=> 2,3-Dehydro-UWM6 + H2O 4.2.1
–
7,9,12-Decaketide_intermediate_3 <=> UWM6 not assigned
 –
Tetrangulol <=> 8-O-Methyltetrangulol not assigned
 –
S-adenosyl-L-methionine + 4-amino-4-de(dimethylamino)anhydrotetracycline <=> anhydrotetracycline + S-adenosyl-L-homocysteine + H+ 2.1.1.335 4-amino-anhydrotetracycline N4-methyltransferase
–
aklaviketone <=> methyl_aklanonate 5.5.1.23 aklanonic acid methyl ester cyclase
–
11-Deoxylandomycinone <=> Landomycin_H not assigned
 –
Octaketide_bicyclic_intermediate + NADPH + H+ <=> (R)-Chiral_alcohol + NADP+ 1.1.1
–
aggreticin + dTDP-D-boivinose <=> kerriamycin_B + dTDP 2.4.1
–
epsilon-rhodomycinone <=> epsilon-Rhodomycin_T not assigned
 –
4-hydroxy-6-methylpretetramide + NADPH + O2 + H+ <=> 4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O 1.14.13.233 4-hydroxy-6-methylpretetramide 12a-monooxygenase
–
Aquayamycin + dTDP-L-rhodinose <=> 100-2 + dTDP not assigned
 –
5a,11a-dehydrooxytetracycline + reduced_coenzyme_F420 <=> oxytetracycline + coenzyme_F420 1.3.98.4 5a,11a-dehydrotetracycline reductase
–
tetracenomycin_F1 <=> Decarboxytetracenomycin_F1 not assigned
 –
Dihydrokalafungin <=> Medermycin not assigned
 –
aklavinone + dTDP-beta-L-rhodosamine <=> aclacinomycin_T + dTDP + H+ 2.4.1.326 aklavinone 7-L-rhodosaminyltransferase
–
aclacinomycin_T + dTDP-2-deoxy-alpha-L-fucose <=> aclacinomycin_S + dTDP + H+ 2.4.1.327 aclacinomycin-T 2-deoxy-L-fucose transferase
–
Stealthin_C <=> Prekinamycin not assigned
 –
methyl_nogalonate <=> Dihydro-NAME not assigned
 –
3A-Deolivosylpremithramycin_B + dTDP-D-boivinose <=> Premithramycin_B + dTDP + H+ 2.4.1
–
2,3-Dehydro-UWM6 + L-isoleucine <=> Jadomycin_A + CO2 + H2O not assigned
 –
tetracenomycin_B3 <=> Tetracenomycin_B1 not assigned
 –
8-O-Methyltetrangulol <=> 19-Hydroxy-8-O-methyltetrangulol not assigned
 –
13-deoxydaunorubicin + NADPH + H+ + O2 <=> 13-dihydrodaunorubicin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase
–
6-methylpretetramide + 2 NADPH + 2 H+ + 2 O2 <=> 4-de(dimethylamino)-4-oxoanhydrotetracycline + 2 NADP+ + 2 H2O 1.14.13.232 6-methylpretetramide 4-monooxygenase
1.14.13.233 4-hydroxy-6-methylpretetramide 12a-monooxygenase
–
–
tetracenomycin_D3 <=> tetracenomycin_B3 not assigned
 –
aklavinone + NADP+ <=> aklaviketone + NADPH + H+ 1.1.1.362 aklaviketone reductase
–
Landomycin_D <=> Landomycin_E not assigned
 –
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin_C + S-adenosyl-L-homocysteine + H+ 2.1.1.307 8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
–
Urdamycinone_F <=> Aquayamycin + H2O not assigned
 –
Kinobscurinone <=> Stealthin_C not assigned
 –
[4,5-dihydroxy-9,10-dioxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate + S-adenosyl-L-methionine <=> methyl_nogalonate + S-adenosyl-L-homocysteine 2.1.1
–
Premithramycin_A2' + dTDP-D-mycarose <=> Premithramycin_A3 + dTDP + H+ 2.4.1
–
5a,11a-dehydrotetracycline + reduced_coenzyme_F420 <=> tetracycline + coenzyme_F420 1.3.98.4 5a,11a-dehydrotetracycline reductase
–
(S)-4-(3''-acetyl-5''-hydroxy-4''-oxo-1,4''-dihydronapthalen-2''-yl)-3-hydroxybutanoate <=> 2-((1R,3S),-1,9''-dihydroxy-1''-methyl-10''-oxo-3,4,5,10''-tetrahydro-1H-benzo[g]isochromen-3''-yl)acetate 5.5.1
–
Dihydrokalafungin_dihydroquinone_form + O2 + FMNH2 <=> 1,3,6,8-Tetrahydroxynaphthalene + H2O + FMN + H+ 1.14.14
–
7,9,12-Decaketide_intermediate_3 <=> [4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate not assigned
 –
4-Demethylpremithramycinone + S-adenosyl-L-methionine <=> Premithramycinone + S-adenosyl-L-homocysteine 2.1.1
–
6-Deoxydihydrokalafungin + FMNH2 + O2 <=> Dihydrokalafungin + FMN + H2O 1.14.14
–
FMNH2 + NAD+ <=> FMN + NADH + H+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.18.1.4 rubredoxin---NAD(P)+ reductase
1.5.1
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.37 FAD reductase (NADH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.39 FMN reductase [NAD(P)H]
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.42 FMN reductase (NADH)
–
–
–
–
–
–
–
–
–
–
rhodomycin_D + H2O <=> 10-carboxy-13-deoxycarminomycin + methanol + H+ 3.1.1
–
UWM6 + dTDP-D-boivinose <=> C1''-C9-Glycosylated_UWM6 + dTDP 2.4.1
–
aclacinomycin_T + H2O <=> 15-demethylaclacinomycin_T + methanol + H+ 3.1.1.95 aclacinomycin methylesterase
–
Prekinamycin <=> Kinamycin_D not assigned
 –
Nonaketamide_monocyclic_intermediate <=> Nonaketamide_tricyclic_intermediate not assigned
 –
Landomycin_H <=> 8-D-Olivosyl-landomycin not assigned
 –
tetracenomycin_D3 <=> Tetracenomycin_D1 not assigned
 –
nogalaviketone <=> methyl_nogalonate 5.5.1.26 nogalonic acid methyl ester cyclase
–
7,9,12-Octaketide_intermediate_3 <=> Octaketide_bicyclic_intermediate + H2O 4
–
6-methylpretetramide + NADPH + O2 + H+ <=> 4-hydroxy-6-methylpretetramide + NADP+ + H2O 1.14.13.232 6-methylpretetramide 4-monooxygenase
–
Urdamycinone_F + 2 dTDP-L-rhodinose + dTDP-D-boivinose <=> Urdamycin_F + 3 dTDP not assigned
 –
S-adenosyl-L-methionine + Premithramycin_A3 <=> Premithramycin_A3 + S-adenosyl-L-homocysteine + H+ 2.1.1
–
100-1 + dTDP-D-boivinose <=> Urdamycin_B + dTDP 2.4.1
–
Dehydrorabelomycin <=> Kinobscurinone not assigned
 –
Premithramycin_A1 + dTDP-D-oliose <=> Premithramycin_A2' + dTDP + H+ 2.4.1
–
S-adenosyl-L-methionine + Pretetramid <=> S-adenosyl-L-homocysteine + 6-methylpretetramide + H+ 2.1.1
2.1.1.M31
–
–
7,12-Decaketide_intermediate_1 <=> Decaketide_tricyclic_intermediate not assigned
 –
Jadomycin_A <=> Jadomycin_B 2.4.1
–
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl_tetracenomycin_C <=> 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin_C + S-adenosyl-L-homocysteine + H+ 2.1.1.305 8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
–
12-deoxyaklanoate + O2 <=> aklanonate + H2O 1.13.12
–
2,3-Dehydro-UWM6 <=> Dehydrorabelomycin not assigned
 –
Mithramycin_DK <=> mithramycin not assigned
 –
aklavinone + NADPH + H+ + O2 <=> epsilon-rhodomycinone + NADP+ + H2O 1.14.13.180 aklavinone 12-hydroxylase
–
S-adenosyl-L-methionine + 13-deoxycarminomycin <=> 13-deoxydaunorubicin + S-adenosyl-L-homocysteine + H+ 2.1.1.292 carminomycin 4-O-methyltransferase
–
S-adenosyl-L-methionine + Tetracenomycin_E <=> tetracenomycin_A2 + S-adenosyl-L-homocysteine 2.1.1
–
Tetrangulol <=> 19-Hydroxytetrangulol not assigned
 –
tetracenomycin_D3 <=> Tetracenomycin_D3_methylester not assigned
 –
Urdamycinone_B <=> 104-2 not assigned
 –
tetracenomycin_B3 <=> Tetracenomycin_E not assigned
 –
(S)-DNPA <=> 6-Deoxydihydrokalafungin not assigned
 –
Premithramycin_B + NADPH + H+ + O2 <=> Mithramycin_DK + NADP+ + CO2 1.14.13
–
Octaketide_bicyclic_intermediate + NADPH + H+ <=> (S)-Chiral_alcohol + NADP+ 1.1.1
–
epsilon-Rhodomycin_T + H2O <=> 15-Demethoxy-epsilon-rhodomycin + methanol 3.1.1.95 aclacinomycin methylesterase
–
7,9,12-Decaketide_intermediate_6 <=> 12-Deoxyaklanonic_acid not assigned
 –
daunorubicin + NADPH + H+ + O2 <=> doxorubicin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase
–
104-2 + dTDP-L-rhodinose + dTDP-D-boivinose <=> 124-1 + 2 dTDP not assigned
 –
tetracenomycin_A2 + O2 + NADPH + H+ <=> tetracenomycin_C + H2O + NADP+ 1.14.13.200 tetracenomycin A2 monooxygenase-dioxygenase
–
Dihydrokalafungin + NADH + H+ <=> Dihydrokalafungin_dihydroquinone_form + NAD+ not assigned
 –
anhydrotetracycline + O2 + NADPH + H+ <=> 5a,11a-dehydrotetracycline + H2O + NADP+ 1.14.13.38 anhydrotetracycline 6-monooxygenase
–
19-Hydroxy-8-O-methyltetrangulol <=> PD116740 not assigned
 –
2-((1R,3S),-1,9''-dihydroxy-1''-methyl-10''-oxo-3,4,5,10''-tetrahydro-1H-benzo[g]isochromen-3''-yl)acetate <=> (S)-DNPA + H2O 4.2.1
–
epsilon-rhodomycinone + dTDP-L-daunosamine <=> rhodomycin_D + dTDP + H+ 2.4.1
–
13-dihydrodaunorubicin + NADPH + H+ + O2 <=> daunorubicin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase
–
Urdamycinone_B + dTDP-L-rhodinose <=> 100-1 + dTDP not assigned
 –
tetracenomycin_A2 <=> Tetracenomycin_X not assigned
 –
Rabelomycin <=> 11-Deoxylandomycinone not assigned
 –
Tetrangomycin <=> Tetrangulol + H2O not assigned
 –
tetracenomycin_F1 + O2 <=> tetracenomycin_D3 + H2O + H+ 1.13.12.21 tetracenomycin-F1 monooxygenase
–
8-demethyltetracenomycin_C + dTDP-L-rhamnose <=> 8-demethyl-8-alpha-L-rhamnosyl_tetracenomycin_C + dTDP + H+ 2.4.1.331 8-demethyltetracenomycin C L-rhamnosyltransferase
–
Premithramycinone + dTDP-D-boivinose <=> Premithramycin_A1 + dTDP + H+ 2.4.1
–
Aclarubicin + O2 <=> aclacinomycin_Y + H2O2 1.3.3.14 aclacinomycin-A oxidase
–
S-adenosyl-L-methionine + carminomycin <=> daunorubicin + S-adenosyl-L-homocysteine + H+ 2.1.1.292 carminomycin 4-O-methyltransferase
–
nogalaviketone + NADPH + H+ <=> Nogalavinone + NADP+ 1.1.1
–
9,14-Decaketide_intermediate_1 <=> tetracenomycin_F2 + [acyl-carrier_protein] not assigned
 –
19-Hydroxytetrangulol <=> 19-Hydroxy-8-O-methyltetrangulol not assigned
 –
tetracenomycin_F1 <=> Tetracenomycin_F1_methylester not assigned
 –
100-2 + dTDP-L-rhodinose <=> aggreticin + dTDP not assigned
 –

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