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Biosynthesis of secondary metabolites

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
Hydroxyspheroidene + 2 O2 + 4 reduced_ferredoxin + 4 H+ <=> Hydroxyspheroidenone + 3 H2O + 4 oxidized_ferredoxin 1.14.15.9 spheroidene monooxygenase
–
acetyl-CoA + malonyl-CoA + NADPH + H+ <=> 6-Methylsalicylate + CoA + CO2 + NADP+ + H2O 2.3.1.165 6-methylsalicylic-acid synthase
–
Carbamoyl_phosphate + kanamycin_B + ATP + H2O <=> 6''''-O-carbamoylkanamycin_B + AMP + diphosphate + phosphate + H+ 6.1.2.2 nebramycin 5' synthase
–
S-adenosyl-L-methionine + 5-hydroxyferulic_acid <=> H+ + Sinapic_acid + S-adenosyl-L-homocysteine 2.1.1.104 caffeoyl-CoA O-methyltransferase
2.1.1.42 flavone 3'-O-methyltransferase
2.1.1.68 caffeate O-methyltransferase
–
–
–
3-Hydroxy-6,7,8-trimethoxy-2-naphthoate <=> 3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoate not assigned
 –
1-epi-Valienol_1-phosphate + NTP <=> NDP-1-epi-valienol + diphosphate 2.7.7.91 valienol-1-phosphate guanylyltransferase
–
S-adenosyl-L-methionine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> elloramycin + S-adenosyl-L-homocysteine + H+ 2.1.1
–
Roquefortine_D <=> Roquefortine_C 1
–
5-Hydroxy-1-(4-hydroxyphenyl)-3-decanone <=> 1-(3,4-Dihydroxyphenyl)-5-hydroxy-3-decanone not assigned
 –
6,8a-Seco-6,8a-deoxy-5-oxoavermectin_''''1a''''_aglycone + NADPH + O2 <=> 5-Oxoavermectin_''''1a''''_aglycone + NADP+ + H2O 1.14
–
catechin + NADP+ + H2O <=> Leucocyanidin + NADPH + H+ 1.17.1.3 leucoanthocyanidin reductase
–
S-adenosyl-L-methionine + aklanonate <=> S-adenosyl-L-homocysteine + methyl_aklanonate 2.1.1.288 aklanonic acid methyltransferase
–
UDP-N-acetyl-D-glucosamine + ribostamycin <=> 2''''''-acetyl-6''''''-deamino-6''''''-hydroxyneomycin_C + UDP + H+ 2.4.1.285 UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase
–
Sinapic_acid + CoA + ATP <=> sinapoyl-CoA + AMP + diphosphate 6.2.1.12 4-coumarate---CoA ligase
–
4-coumaraldehyde <=> caffeoyl_aldehyde 1.14.13
–
beta-Hydroxy-L-tyrosyl-[pcp] <=> beta-Keto-L-tyrosyl-[pcp] not assigned
 –
Tabtoxin + H2O <=> Tabtoxinine-beta-lactam + L-threonine 3.4
3.4.11
–
–
(S)-beta-Tyrosyl-[pcp] + FADH2 + Cl- + O2 + H+ <=> (S)-3-Chloro-beta-tyrosyl-[pcp] + FAD + 2 H2O 1.14.19
–
glycine + 2-oxoglutarate <=> glyoxylate + L-glutamate 2.6.1.2 alanine transaminase
2.6.1.4 glycine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.48 5-aminovalerate transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
–
–
–
–
–
–
–
D-erythrose_4-phosphate + D-xylulose_5-phosphate <=> beta-D-fructose_6-phosphate + D-glyceraldehyde_3-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase
–
–
Premithramycin_A3 + dTDP-D-boivinose <=> 3A-Deolivosylpremithramycin_B + dTDP + H+ 2.4.1
–
UDP-glucose + alpha-D-glucose_6-phosphate <=> UDP + alpha,alpha''-Trehalose_6-phosphate 2.4.1.15 alpha,alpha-trehalose-phosphate synthase (UDP-forming)
–
L-tryptophan + FADH2 + Cl- + O2 <=> 7-chloro-L-tryptophan + FAD + H2O 1.14.19.9 tryptophan 7-halogenase
–
4-coumaroyl-CoA + NADPH + H+ <=> 4-coumaraldehyde + CoA + NADP+ 1.2.1.44 cinnamoyl-CoA reductase
–
5,10-Dihydrophenazine + O2 <=> phenazine + H2O2 not assigned
 –
OPC6-CoA + FAD <=> trans-2-Enoyl-OPC6-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
–
gibberellin_A51 <=> Gibberellin_A51-catabolite 1.14.11.13 gibberellin 2beta-dioxygenase
–
Terpendole_G <=> Terpendole_B not assigned
 –
geranylgeranyl_diphosphate <=> fusicocca-2,10(14)-diene + diphosphate 4.2.3.43 fusicocca-2,10(14)-diene synthase
–
delta-tocotrienol <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol 5.5.1.24 tocopherol cyclase
–
chlorogenic_acid + CoA <=> caffeoyl-CoA + quinate 2.3.1
2.3.1.133 shikimate O-hydroxycinnamoyltransferase
2.3.1.99 quinate O-hydroxycinnamoyltransferase
–
–
–
9-cis-violaxanthin <=> 9''-cis-Neoxanthin 5.3.99.9 neoxanthin synthase
–
oxaloacetate + ITP <=> CO2 + phosphoenolpyruvate + IDP 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)
–
–
H+ + (-)-tetrahydropalmatine + O2 <=> palmatine + H2O2 1.21.3.3 reticuline oxidase
1.3.3.8 tetrahydroberberine oxidase
–
–
dTDP-4-amino-2,4-dideoxy-beta-L-xylose + 2-oxoglutarate <=> dTDP-4-oxo-2-deoxy-beta-L-xylose + L-glutamate 2.6.1
–
(R)-Hemiketal <=> (R)-DNPA + H2O not assigned
 –
dTDP-4-oxo-2,6-dideoxy-D-allose <=> dTDP-4-oxo-2,6-dideoxy-L-mannose 5.1.3
–
2-epi-5-epi-valiolone <=> 5-epi-valiolone 5.1.3.33 2-epi-5-epi-valiolone epimerase
–
ent-cassa-12,15-diene + 3 reduced_flavodoxin + 3 O2 <=> ent-3beta-hydroxycassa-12,15-dien-2-one + 3 flavin + 4 H2O 1.14.14.69 ent-cassadiene hydroxylase
–
D-ribose_5-phosphate <=> D-ribulose_5-phosphate 5.3.1.6 ribose-5-phosphate isomerase
–
bilirubin + coenzyme_F420-1 <=> Biliverdin + Reduced_coenzyme_F420-(gamma-Glu)n 1.3.98
–
H+ + 6,7-dimethyl-8-(1'-D-ribityl)lumazine <=> 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + riboflavin 2.5.1.9 riboflavin synthase
–
campesterol <=> Campest-4-en-3beta-ol 5.3.3.1 steroid Delta-isomerase
–
(S)-reticuline + reduced_flavodoxin + O2 <=> (S)-corytuberine + flavin + 2 H2O 1.14.19.51 (S)-corytuberine synthase
–
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate <=> H+ + ADP + phosphate + 5''-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole 6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase
–
Aquayamycin + dTDP-L-rhodinose <=> 100-2 + dTDP not assigned
 –
10-deoxymethymycin + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> methymycin + oxidized_ferredoxin + H2O 1.14.15.33 pikromycin synthase
–
S-(Hydroxyphenylacetothiohydroximoyl)-L-cysteine + H2O <=> p-Hydroxyphenylacetothiohydroximate + pyruvate + NH3 + H+ 4.4.1
4.4.1.13 cysteine-S-conjugate beta-lyase
–
–
dihydrozeatin_riboside + H2O <=> dihydrozeatin + D-ribose not assigned
 –
ent-kaur-16-en-19-oate + reduced_flavodoxin + O2 <=> ent-7alpha-hydroxykaur-16-en-19-oate + flavin + H2O 1.14.14.107 ent-kaurenoic acid monooxygenase
–
neoabietadiene <=> Neoabietinol 1.14.13
–
4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2 <=> 2 dichlorochromopyrrolate + 2 NH3 + 2 H2O 1.21.98.2 dichlorochromopyrrolate synthase
–
heme + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> Biliverdin + Fe2+ + CO + oxidized_ferredoxin + H2O 1.14.15.20 heme oxygenase (biliverdin-producing, ferredoxin)
–
DELTA1-piperideine + trans-cinnamate + benzoyl-CoA <=> Lobelanine + CoA not assigned
 –
sitosterol + NADPH + H+ + O2 <=> stigmasterol + NADP+ + H2O 1.14.19.41 sterol 22-desaturase
–
N-Methylpelletierine <=> Pseudopelletierine not assigned
 –
Rifamycin_W <=> Rifamycin_W-hemiacetal not assigned
 –
beta-D-glucose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.9 glucose-6-phosphate isomerase
–
crocetin_dialdehyde <=> crocetin not assigned
 –
paromamine + O2 <=> 6''-dehydroparomamine + H2O2 1.1.3.43 paromamine 6'-oxidase
–
Fumiquinazoline_F + 3 reduced_flavodoxin + 2 O2 <=> Fumiquinazoline_F-indoline-2'',3''-diol + 3 flavin + 2 H2O 1.14.14
–
UDP-alpha-D-kanosamine <=> kanosamine not assigned
 –
strictosidine <=> Strychnine not assigned
 –
cocaine + H2O <=> H+ + methyl_ecgonine + benzoate 3.1.1.1 carboxylesterase
3.1.1.8 cholinesterase
3.1.1.84 cocaine esterase
–
–
–
UDP-glucose + beta-D-fructose_6-phosphate <=> sucrose_6F-phosphate + UDP + H+ 2.4.1.13 sucrose synthase
2.4.1.14 sucrose-phosphate synthase
–
–
Terpendole_E + 4 NADPH + 4 O2 + 4 H+ <=> 13-Desoxyterpendole_I + formate + 4 NADP+ + 5 H2O 1.14.13
–
5-methyl-3-oxo-4-hexenoyl-CoA + CoA <=> 3-methylcrotonoyl-CoA + acetyl-CoA 2.3.1
2.3.1.16 acetyl-CoA C-acyltransferase
–
–
ATP + psilocin <=> ADP + psilocybin + H+ 2.7.1.222 4-hydroxytryptamine kinase
–
4''-O-Desmethyl-3-O-acetylpapaveroxine + H2O <=> 4''-O-Desmethylpapaveroxine + acetate 3.1.1.105 3-O-acetylpapaveroxine carboxylesterase
–
H+ + sulfate + ATP <=> adenosine_5''-phosphosulfate + diphosphate 2.7.7.4 sulfate adenylyltransferase
–
beta-PC-M6 + O2 + NADPH + H+ <=> 13-Desoxypaxilline + NADP+ + 2 H2O 1.14.13
–
NDP-2-amino-4-oxo-2,6-dideoxy-D-galactose <=> NDP-2-amino-2,6-dideoxy-D-galactose not assigned
 –
1-amino-1-deoxy-scyllo-inositol + ATP <=> H+ + 1-amino-1-deoxy-scyllo-inositol_4-phosphate + ADP 2.7.1.65 scyllo-inosamine 4-kinase
–
S-adenosyl-L-methionine + 24(28)-methylene_lophenol <=> H+ + 24-ethylidenelophenol + S-adenosyl-L-homocysteine 2.1.1.142 cycloartenol 24-C-methyltransferase
2.1.1.143 24-methylenesterol C-methyltransferase
2.1.1.41 sterol 24-C-methyltransferase
–
–
–
8-O-methyldihydrosterigmatocystin <=> Aflatoxin_G2 not assigned
 –
24(28)-methylene_lophenol <=> 4alpha-methyl-5alpha-ergosta-8,24-dien-3beta-ol 5.3.3.5 cholestenol Delta-isomerase
–
L-arogenate + oxaloacetate <=> prephenate + L-aspartate 2.6.1.1 aspartate transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase
–
–
–
–
geranyl_diphosphate + H2O <=> (3R)-linalool + diphosphate 4.2.3.25 S-linalool synthase
4.2.3.26 R-linalool synthase
–
–
dihydro-4-coumaroyl-CoA + NADP+ <=> 4-coumaroyl-CoA + NADPH + H+ 1.3.1.117 hydroxycinnamoyl-CoA reductase
–
ATP + (S)-beta-tyrosine + pC3'p <=> AMP + diphosphate + (S)-beta-Tyrosyl-[pcp] 6.2.1
–
S-adenosyl-L-methionine + 12-ethyl-8-propyl-3-vinyl-bacteriochlorophyllide_d <=> S-adenosyl-L-homocysteine + 12-ethyl-8-isobutyl-3-vinyl-bacteriochlorophyllide_d + H+ 2.1.1.332 bacteriochlorophyllide d C-82-methyltransferase
–
7-hydroxychlorophyllide_a + NADP+ <=> chlorophyllide_b + NADPH + H+ 1.1.1.294 chlorophyll(ide) b reductase
–
cyclo-L-Trp-L-Phe + S-adenosyl-L-methionine <=> N-Methyl-cyclo(L-Trp-L-Phe) + S-adenosyl-L-homocysteine 2.1.1
–
1,4-dihydroxy-2-naphthoyl-CoA + H2O <=> H+ + 1,4-dihydroxy-2-naphthoate + CoA 3.1.2.28 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
–
S-adenosyl-L-methionine + 4-hydroxy-N-methyltryptamine_4-phosphate <=> S-adenosyl-L-homocysteine + psilocybin + H+ 2.1.1.345 psilocybin synthase
–
malonyl-CoA + acetyl-CoA <=> dodecanoyl-[acyl-carrier_protein] not assigned
 –
cannabigerolate + O2 <=> DELTA9-tetrahydrocannabinolate + H2O2 1.21.3.7 tetrahydrocannabinolic acid synthase
–
3-dehydro-6-deoxoteasterone <=> 6-deoxotyphasterol not assigned
 –
sucrose_6F-phosphate + H2O <=> sucrose + phosphate 3.1.3.24 sucrose-phosphate phosphatase
–
UDP-L-rhamnose + kaempferol_3-O-glucoside <=> UDP + kaempferol_3-O-rutinoside 2.4.1.159 flavonol-3-O-glucoside L-rhamnosyltransferase
2.4.1.B53
–
–
(2R)-2-hydroxy-2-methylbutanenitrile <=> cyanide + 2-butanone 4.1.2.10 (R)-mandelonitrile lyase
4.1.2.46 aliphatic (R)-hydroxynitrile lyase
4.1.2.47 (S)-hydroxynitrile lyase
–
–
–
4-dimethylallyl-L-abrine <=> chanoclavine-I not assigned
 –
S-adenosyl-L-methionine + daidzein <=> H+ + formononetin + S-adenosyl-L-homocysteine 2.1.1.212 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
2.1.1.231 flavonoid 4'-O-methyltransferase
2.1.1.46 isoflavone 4'-O-methyltransferase
–
–
–
ATP + NAD+ <=> H+ + 3''-dehydro-ATP + NADH 1
–
3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp] <=> 7,12-Decaketide_intermediate_1 + H2O 4.2.1
–
XMP + H2O <=> Xanthosine + phosphate 3.1.3.5 5'-nucleotidase
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Premithramycin_A1 + dTDP-D-oliose <=> Premithramycin_A2' + dTDP + H+ 2.4.1
–
naringenin_chalcone <=> naringenin 5.5.1.6 chalcone isomerase
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D-fructose_1,6-bisphosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde_3-phosphate 4.1.2.13 fructose-bisphosphate aldolase
4.1.2.40 tagatose-bisphosphate aldolase
–
–
L-tryptophan + L-proline + 2 ATP <=> brevianamide_F + 2 AMP + 2 diphosphate not assigned
 –
13-Desoxypaxilline + NADPH + H+ + O2 <=> Paxilline + NADP+ + H2O 1.14.13
–
D-fructose_1,6-bisphosphate + H2O <=> beta-D-fructose_6-phosphate + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase
–
–
–
–
3-oxo-2-(cis-2''-pentenyl)-cyclopentane-1-butanoyl-CoA + acetyl-CoA <=> 3-oxo-2-(cis-2''-pentenyl)-cyclopentane-1-(3-oxohexanoyl)-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
–
UDP-glucose + an_(E)-omega-(methylthio)alkyl-thiohydroximate <=> H+ + an_aliphatic_desulfoglucosinolate + UDP 2.4.1.195 N-hydroxythioamide S-beta-glucosyltransferase
–
L-aspartate + ATP <=> L-4-aspartyl_phosphate + ADP 2.7.2.4 aspartate kinase
–
myo-inositol + ATP <=> H+ + D-myo-Inositol_1-phosphate + ADP 2.7.1.64 inositol 3-kinase
–
geranylgeranyl_diphosphate + isopentenyl_diphosphate <=> all-trans-hexaprenyl_diphosphate + diphosphate 2.5.1.82 hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
2.5.1.B41
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–
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O <=> geosmin + acetone 4.1.99.16 geosmin synthase
–
geranylgeranyl_diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate 3.1.7.10 (13E)-labda-7,13-dien-15-ol synthase
–
ADP + ATP <=> ATP + ADP 2.4.2.12 nicotinamide phosphoribosyltransferase
2.7.1.20 adenosine kinase
2.7.4.6 nucleoside-diphosphate kinase
3.6.4.10 non-chaperonin molecular chaperone ATPase
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–
–
–
beta-L-galactose_1-phosphate + H2O <=> L-galactopyranose + phosphate 3.1.3.93 L-galactose 1-phosphate phosphatase
3.1.3.B9
–
–
4'',6,7-Trihydroxyisoflavone <=> glycitein not assigned
 –
6-hydroxyprotopine <=> Dihydrosanguinarine + H2O not assigned
 –
feruloyl-CoA + feruloylacetyl-CoA + H2O <=> curcumin + CoA + CO2 2.3.1.217 curcumin synthase
–
Terpendole_I + dimethylallyl_diphosphate <=> 20,21-Diprenylterpendole_I + diphosphate 2.5.1
–
3beta-hydroxyergosta-7,24(241)-dien-4alpha-carboxylate + NAD+ <=> Episterone + NADH + CO2 1.1.1.418 plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
–
gibberellin_a15 + 2-oxoglutarate + O2 <=> Gibberellin_A24 + succinate + CO2 + H2O 1.14.11.12 gibberellin-44 dioxygenase
1.14.20
–
–
kanamycin_C + O2 <=> 6''-Oxokanamycin_C + H2O2 1.1.3
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ferruginol + 3 reduced_flavodoxin + 3 O2 <=> pisiferic_acid + 3 flavin + 4 H2O 1.14.14.61 carnosic acid synthase
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L-arginine + NADPH + H+ + O2 <=> L-citrulline + NO + NADP+ + H2O 1.14.13.39 nitric-oxide synthase (NADPH)
1.14.14.47 nitric-oxide synthase (flavodoxin)
–
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N-hydroxy-L-phenylalanine + reduced_flavodoxin + O2 <=> N,N-dihydroxy-L-phenylalanine + flavin + H2O 1.14.14.40 phenylalanine N-monooxygenase
–
3-Hydroxy-OPC4-CoA + NAD+ <=> 3-Oxo-OPC4-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
2-Amino-4-chloro-4-pentenoic_acid <=> DL-propargylglycine + Cl- + H+ 4.5.1
–
(-)-limonene + reduced_flavodoxin + O2 <=> (-)-trans-isopiperitenol + flavin + H2O 1.14.14.99 (S)-limonene 3-monooxygenase
–
gibberellin_a15 <=> gibberellin_a37 not assigned
 –
p-coumaric_acid + CoA + ATP <=> 4-coumaroyl-CoA + AMP + diphosphate 6.2.1.12 4-coumarate---CoA ligase
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.30 phenylacetate---CoA ligase
–
–
–
pseudobaptigenin + reduced_flavodoxin + O2 <=> 2'',7-Dihydroxy-4'',5''-methylenedioxyisoflavone + flavin + H2O 1.14.14.90 isoflavone 2'-hydroxylase
–
(1''S,5''R)-hydroxyaverantin + NAD+ <=> H+ + 5''-oxoaverantin + NADH 1.1.1.352 5'-hydroxyaverantin dehydrogenase
–
O2 + Columbamine <=> H2O + Berberine 1.21.3.2 columbamine oxidase
–
7,9,12-Decaketide_intermediate_6 <=> 12-Deoxyaklanonic_acid not assigned
 –
S-adenosyl-L-methionine + norbelladine <=> 4''-O-methylnorbelladine + S-adenosyl-L-homocysteine + H+ 2.1.1.336 norbelladine O-methyltransferase
–
H2O + Chlorophyll <=> chlorophyllide_a + phytol 3.1.1.14 chlorophyllase
–
H+ + L-Dopa <=> dopamine + CO2 4.1.1.22 histidine decarboxylase
4.1.1.25 tyrosine decarboxylase
4.1.1.28 aromatic-L-amino-acid decarboxylase
4.1.1.53 phenylalanine decarboxylase
–
–
–
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neomycin_C + 2-oxoglutarate <=> 6''''''-deamino-6''''''-oxoneomycin_C + L-glutamate 2.6.1.95 neomycin C transaminase
–
D-glucose_6-phosphate + NAD+ <=> 3-dehydro-D-glucose_6-phosphate + NADH + H+ 1.1.1.361 glucose-6-phosphate 3-dehydrogenase
–
(+)-limonene + reduced_flavodoxin + O2 <=> (+)-trans-carveol + flavin + H2O 1.14.14.53 (R)-limonene 6-monooxygenase
–
S-adenosyl-L-methionine + uroporphyrinogen_III <=> S-adenosyl-L-homocysteine + precorrin-2 + H+ 2.1.1.107 uroporphyrinogen-III C-methyltransferase
–
5-aminoimidazole-4-carboxamide_ribonucleotide + formate + ATP <=> 5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide + ADP + phosphate 6.3.4.23 formate---phosphoribosylaminoimidazolecarboxamide ligase
–
UDP-glucose + coumaric_acid <=> H+ + 2-O-(beta-D-glucosyl)-2-hydroxycinnamate + UDP 2.4.1.114 2-coumarate O-beta-glucosyltransferase
2.4.1.35 phenol beta-glucosyltransferase
–
–
2-((1R,3S),-1,9''-dihydroxy-1''-methyl-10''-oxo-3,4,5,10''-tetrahydro-1H-benzo[g]isochromen-3''-yl)acetate <=> (S)-DNPA + H2O 4.2.1
–
dTDP-4-oxo-alpha-D-xylose <=> dTDP-3-methyl-4-oxo-alpha-D-ribopyranose 2.1.1
–
4-coumaroyl-CoA + feruloylacetyl-CoA + H2O <=> demethoxycurcumin + CoA + CO2 2.3.1.219 demethoxycurcumin synthase
–
amidinoproclavaminate + H2O <=> proclavaminate + Urea 3.5.3.22 proclavaminate amidinohydrolase
–
3-Hydroxy-OPC6-CoA <=> trans-2-Enoyl-OPC6-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase
–
–
amylose <=> glycogen 2.4.1.18 1,4-alpha-glucan branching enzyme
2.4.1.25 4-alpha-glucanotransferase
3.2.1.1 alpha-amylase
3.2.1.116 glucan 1,4-alpha-maltotriohydrolase
3.2.1.133 glucan 1,4-alpha-maltohydrolase
3.2.1.135 neopullulanase
3.2.1.41 pullulanase
3.2.1.54 cyclomaltodextrinase
3.2.1.68 isoamylase
–
–
–
–
–
–
–
–
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4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD+ <=> avenastenone + NADH + CO2 1.1.1.418 plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
–
(+)-7-Isojasmonate_CoA + acetyl-CoA <=> 3-oxo-2-(cis-2''-pentenyl)-cyclopentane-1-(3-oxobutanoyl)-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
–
3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O 4.2.1.57 isohexenylglutaconyl-CoA hydratase
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5,10-methylenetetrahydrofolate + 2-oxoisovalerate + H2O <=> ketopantoate + tetrahydrofolate 2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase
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aurachin_B + NAD+ + H2O <=> 4-hydroxy-2-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]quinolin-3(4H)-one_1-oxide + NADH + H+ 1.1.1.394 aurachin B dehydrogenase
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phosphatidylethanolamine + H2O <=> ethanolamine + phosphatidic_acid 3.1.4.4 phospholipase D
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dTDP-3-O-methyl-beta-L-rhamnose + Calicheamicin_alpha1(I) <=> dTDP + Calicheamicin_gamma(1)I 2.4.1
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ent-copalyl_diphosphate <=> diphosphate + ent-kaurene 4.2.3.19 ent-kaurene synthase
5.5.1.13 ent-copalyl diphosphate synthase
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–
S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan <=> 4-dimethylallyl-L-abrine + S-adenosyl-L-homocysteine + H+ 2.1.1.261 4-dimethylallyltryptophan N-methyltransferase
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bacteriochlorophyll_a + NADP+ <=> geranylgeranyl-bacteriochlorophyllide_a + NADPH + H+ 1.3.1.111 geranylgeranyl-bacteriochlorophyllide a reductase
1.3.1.83 geranylgeranyl diphosphate reductase
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L-N-acetyl-2-amino-6-oxopimelate + L-glutamate <=> N-acetyl-L,L-2,6-diaminopimelate + 2-oxoglutarate 2.6.1
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C20818 <=> C20819 2.1.1
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S-adenosyl-L-methionine + Demethylmacrocin <=> H+ + S-adenosyl-L-homocysteine + macrocin 2.1.1.102 demethylmacrocin O-methyltransferase
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p-hydroxyphenylacetaldoxime + L-cysteine + NADPH + O2 + H+ <=> S-(Hydroxyphenylacetothiohydroximoyl)-L-cysteine + NADP+ + 2 H2O 1.14.14.45 aromatic aldoxime N-monooxygenase
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2-aminobenzoyl-CoA + L-Cysteinyl-protein <=> S-Anthraniloyl-L-cysteinyl-protein + CoA 2.3.1.262 anthraniloyl-CoA anthraniloyltransferase
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Nonaketamide_tricyclic_intermediate <=> Pretetramid not assigned
 –
3,4-Dihydroxybenzaldehyde + tyramine <=> Norcraugsodine + H2O + H+ 4.3.3
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Caffeine + NADPH + O2 + H+ <=> Theobromine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
–
–
2-Amino-5-epi-valiolone <=> 2-Aminovalienone not assigned
 –
geranyl_diphosphate + H2O <=> (-)-alpha-terpineol + diphosphate 4.2.3.108 1,8-cineole synthase
4.2.3.111 (-)-alpha-terpineol synthase
4.2.3.112 (+)-alpha-terpineol synthase
–
–
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heme_O <=> heme_a not assigned
 –
1-hydroxyneurosporene <=> all-trans-neurosporene + H2O 4.2.1.131 carotenoid 1,2-hydratase
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2-heptyl-4(1H)-quinolone + NADH + O2 + H+ <=> 2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O 1.14.13.182 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
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valienol_7-phosphate <=> valienol_1-phosphate not assigned
 –
JI-20A <=> gentamicin_C1a not assigned
 –
spheroidene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> spheroiden-2-one + H2O + oxidized_ferredoxin 1.14.15.9 spheroidene monooxygenase
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S-adenosyl-L-methionine + Xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine 2.1.1.158 7-methylxanthosine synthase
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S-farnesyl_protein + H2O <=> protein_C-terminal_S-farnesyl-L-cysteine + peptide 3.4.22
3.4.24.84 Ste24 endopeptidase
–
–
divinyl_protochlorophyllide_a + 2 H+ <=> protochlorophyllide not assigned
 –
OA-6129_A + 2-oxoglutarate + O2 <=> OA-6129_B2 + succinate + CO2 1.14.20
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dTDP-3-dehydro-2,6-dideoxy-alpha-D-glucose <=> TDP-3-amino-2,3,6-trideoxy-alpha-D-glucose not assigned
 –
geraniol <=> Actinidine not assigned
 –
ent-7alpha-hydroxykaur-16-en-19-oate + reduced_flavodoxin + O2 <=> gibberellin_A12_aldehyde + flavin + 2 H2O 1.14.14.107 ent-kaurenoic acid monooxygenase
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L-N-acetylphosphinothricin_bialophos + H2O <=> phosphinotricyl-alanyl-alanine/out + acetate 3.1.1
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