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Biosynthesis of secondary metabolites

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
Hydroxyspheroidene + 2 O2 + 4 reduced_ferredoxin + 4 H+ <=> Hydroxyspheroidenone + 3 H2O + 4 oxidized_ferredoxin 1.14.15.9 spheroidene monooxygenase
–
acetyl-CoA + malonyl-CoA + NADPH + H+ <=> 6-Methylsalicylate + CoA + CO2 + NADP+ + H2O 2.3.1.165 6-methylsalicylic-acid synthase
–
Carbamoyl_phosphate + kanamycin_B + ATP + H2O <=> 6''''-O-carbamoylkanamycin_B + AMP + diphosphate + phosphate + H+ 6.1.2.2 nebramycin 5' synthase
–
S-adenosyl-L-methionine + 5-hydroxyferulic_acid <=> H+ + Sinapic_acid + S-adenosyl-L-homocysteine 2.1.1.104 caffeoyl-CoA O-methyltransferase
2.1.1.42 flavone 3'-O-methyltransferase
2.1.1.68 caffeate O-methyltransferase
–
–
–
3-Hydroxy-6,7,8-trimethoxy-2-naphthoate <=> 3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoate not assigned
 –
1-epi-Valienol_1-phosphate + NTP <=> NDP-1-epi-valienol + diphosphate 2.7.7.91 valienol-1-phosphate guanylyltransferase
–
S-adenosyl-L-methionine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> elloramycin + S-adenosyl-L-homocysteine + H+ 2.1.1
–
Roquefortine_D <=> Roquefortine_C 1
–
5-Hydroxy-1-(4-hydroxyphenyl)-3-decanone <=> 1-(3,4-Dihydroxyphenyl)-5-hydroxy-3-decanone not assigned
 –
6,8a-Seco-6,8a-deoxy-5-oxoavermectin_''''1a''''_aglycone + NADPH + O2 <=> 5-Oxoavermectin_''''1a''''_aglycone + NADP+ + H2O 1.14
–
catechin + NADP+ + H2O <=> Leucocyanidin + NADPH + H+ 1.17.1.3 leucoanthocyanidin reductase
–
S-adenosyl-L-methionine + aklanonate <=> S-adenosyl-L-homocysteine + methyl_aklanonate 2.1.1.288 aklanonic acid methyltransferase
–
UDP-N-acetyl-D-glucosamine + ribostamycin <=> 2''''''-acetyl-6''''''-deamino-6''''''-hydroxyneomycin_C + UDP + H+ 2.4.1.285 UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase
–
Sinapic_acid + CoA + ATP <=> sinapoyl-CoA + AMP + diphosphate 6.2.1.12 4-coumarate---CoA ligase
–
4-coumaraldehyde <=> caffeoyl_aldehyde 1.14.13
–
beta-Hydroxy-L-tyrosyl-[pcp] <=> beta-Keto-L-tyrosyl-[pcp] not assigned
 –
Tabtoxin + H2O <=> Tabtoxinine-beta-lactam + L-threonine 3.4
3.4.11
–
–
(S)-beta-Tyrosyl-[pcp] + FADH2 + Cl- + O2 + H+ <=> (S)-3-Chloro-beta-tyrosyl-[pcp] + FAD + 2 H2O 1.14.19
–
glycine + 2-oxoglutarate <=> glyoxylate + L-glutamate 2.6.1.2 alanine transaminase
2.6.1.4 glycine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.48 5-aminovalerate transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
–
–
–
–
–
–
–
D-erythrose_4-phosphate + D-xylulose_5-phosphate <=> beta-D-fructose_6-phosphate + D-glyceraldehyde_3-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase
–
–
Premithramycin_A3 + dTDP-D-boivinose <=> 3A-Deolivosylpremithramycin_B + dTDP + H+ 2.4.1
–
UDP-glucose + alpha-D-glucose_6-phosphate <=> UDP + alpha,alpha''-Trehalose_6-phosphate 2.4.1.15 alpha,alpha-trehalose-phosphate synthase (UDP-forming)
–
L-tryptophan + FADH2 + Cl- + O2 <=> 7-chloro-L-tryptophan + FAD + H2O 1.14.19.9 tryptophan 7-halogenase
–
4-coumaroyl-CoA + NADPH + H+ <=> 4-coumaraldehyde + CoA + NADP+ 1.2.1.44 cinnamoyl-CoA reductase
–
5,10-Dihydrophenazine + O2 <=> phenazine + H2O2 not assigned
 –
OPC6-CoA + FAD <=> trans-2-Enoyl-OPC6-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
–
gibberellin_A51 <=> Gibberellin_A51-catabolite 1.14.11.13 gibberellin 2beta-dioxygenase
–
Terpendole_G <=> Terpendole_B not assigned
 –
geranylgeranyl_diphosphate <=> fusicocca-2,10(14)-diene + diphosphate 4.2.3.43 fusicocca-2,10(14)-diene synthase
–
delta-tocotrienol <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol 5.5.1.24 tocopherol cyclase
–
chlorogenic_acid + CoA <=> caffeoyl-CoA + quinate 2.3.1
2.3.1.133 shikimate O-hydroxycinnamoyltransferase
2.3.1.99 quinate O-hydroxycinnamoyltransferase
–
–
–
9-cis-violaxanthin <=> 9''-cis-Neoxanthin 5.3.99.9 neoxanthin synthase
–
oxaloacetate + ITP <=> CO2 + phosphoenolpyruvate + IDP 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)
–
–
H+ + (-)-tetrahydropalmatine + O2 <=> palmatine + H2O2 1.21.3.3 reticuline oxidase
1.3.3.8 tetrahydroberberine oxidase
–
–
dTDP-4-amino-2,4-dideoxy-beta-L-xylose + 2-oxoglutarate <=> dTDP-4-oxo-2-deoxy-beta-L-xylose + L-glutamate 2.6.1
–
(R)-Hemiketal <=> (R)-DNPA + H2O not assigned
 –
dTDP-4-oxo-2,6-dideoxy-D-allose <=> dTDP-4-oxo-2,6-dideoxy-L-mannose 5.1.3
–
2-epi-5-epi-valiolone <=> 5-epi-valiolone 5.1.3.33 2-epi-5-epi-valiolone epimerase
–
ent-cassa-12,15-diene + 3 reduced_flavodoxin + 3 O2 <=> ent-3beta-hydroxycassa-12,15-dien-2-one + 3 flavin + 4 H2O 1.14.14.69 ent-cassadiene hydroxylase
–
D-ribose_5-phosphate <=> D-ribulose_5-phosphate 5.3.1.6 ribose-5-phosphate isomerase
–
bilirubin + coenzyme_F420-1 <=> Biliverdin + Reduced_coenzyme_F420-(gamma-Glu)n 1.3.98
–
H+ + 6,7-dimethyl-8-(1'-D-ribityl)lumazine <=> 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + riboflavin 2.5.1.9 riboflavin synthase
–
campesterol <=> Campest-4-en-3beta-ol 5.3.3.1 steroid Delta-isomerase
–
(S)-reticuline + reduced_flavodoxin + O2 <=> (S)-corytuberine + flavin + 2 H2O 1.14.19.51 (S)-corytuberine synthase
–
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate <=> H+ + ADP + phosphate + 5''-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole 6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase
–
Aquayamycin + dTDP-L-rhodinose <=> 100-2 + dTDP not assigned
 –
10-deoxymethymycin + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> methymycin + oxidized_ferredoxin + H2O 1.14.15.33 pikromycin synthase
–
S-(Hydroxyphenylacetothiohydroximoyl)-L-cysteine + H2O <=> p-Hydroxyphenylacetothiohydroximate + pyruvate + NH3 + H+ 4.4.1
4.4.1.13 cysteine-S-conjugate beta-lyase
–
–
dihydrozeatin_riboside + H2O <=> dihydrozeatin + D-ribose not assigned
 –
ent-kaur-16-en-19-oate + reduced_flavodoxin + O2 <=> ent-7alpha-hydroxykaur-16-en-19-oate + flavin + H2O 1.14.14.107 ent-kaurenoic acid monooxygenase
–
neoabietadiene <=> Neoabietinol 1.14.13
–
4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2 <=> 2 dichlorochromopyrrolate + 2 NH3 + 2 H2O 1.21.98.2 dichlorochromopyrrolate synthase
–
heme + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> Biliverdin + Fe2+ + CO + oxidized_ferredoxin + H2O 1.14.15.20 heme oxygenase (biliverdin-producing, ferredoxin)
–
DELTA1-piperideine + trans-cinnamate + benzoyl-CoA <=> Lobelanine + CoA not assigned
 –
sitosterol + NADPH + H+ + O2 <=> stigmasterol + NADP+ + H2O 1.14.19.41 sterol 22-desaturase
–
N-Methylpelletierine <=> Pseudopelletierine not assigned
 –
Rifamycin_W <=> Rifamycin_W-hemiacetal not assigned
 –
beta-D-glucose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.9 glucose-6-phosphate isomerase
–
crocetin_dialdehyde <=> crocetin not assigned
 –
paromamine + O2 <=> 6''-dehydroparomamine + H2O2 1.1.3.43 paromamine 6'-oxidase
–
Fumiquinazoline_F + 3 reduced_flavodoxin + 2 O2 <=> Fumiquinazoline_F-indoline-2'',3''-diol + 3 flavin + 2 H2O 1.14.14
–
UDP-alpha-D-kanosamine <=> kanosamine not assigned
 –
strictosidine <=> Strychnine not assigned
 –
cocaine + H2O <=> H+ + methyl_ecgonine + benzoate 3.1.1.1 carboxylesterase
3.1.1.8 cholinesterase
3.1.1.84 cocaine esterase
–
–
–
UDP-glucose + beta-D-fructose_6-phosphate <=> sucrose_6F-phosphate + UDP + H+ 2.4.1.13 sucrose synthase
2.4.1.14 sucrose-phosphate synthase
–
–
Terpendole_E + 4 NADPH + 4 O2 + 4 H+ <=> 13-Desoxyterpendole_I + formate + 4 NADP+ + 5 H2O 1.14.13
–
5-methyl-3-oxo-4-hexenoyl-CoA + CoA <=> 3-methylcrotonoyl-CoA + acetyl-CoA 2.3.1
2.3.1.16 acetyl-CoA C-acyltransferase
–
–
ATP + psilocin <=> ADP + psilocybin + H+ 2.7.1.222 4-hydroxytryptamine kinase
–
4''-O-Desmethyl-3-O-acetylpapaveroxine + H2O <=> 4''-O-Desmethylpapaveroxine + acetate 3.1.1.105 3-O-acetylpapaveroxine carboxylesterase
–
H+ + sulfate + ATP <=> adenosine_5''-phosphosulfate + diphosphate 2.7.7.4 sulfate adenylyltransferase
–
beta-PC-M6 + O2 + NADPH + H+ <=> 13-Desoxypaxilline + NADP+ + 2 H2O 1.14.13
–
NDP-2-amino-4-oxo-2,6-dideoxy-D-galactose <=> NDP-2-amino-2,6-dideoxy-D-galactose not assigned
 –
1-amino-1-deoxy-scyllo-inositol + ATP <=> H+ + 1-amino-1-deoxy-scyllo-inositol_4-phosphate + ADP 2.7.1.65 scyllo-inosamine 4-kinase
–
S-adenosyl-L-methionine + 24(28)-methylene_lophenol <=> H+ + 24-ethylidenelophenol + S-adenosyl-L-homocysteine 2.1.1.142 cycloartenol 24-C-methyltransferase
2.1.1.143 24-methylenesterol C-methyltransferase
2.1.1.41 sterol 24-C-methyltransferase
–
–
–
8-O-methyldihydrosterigmatocystin <=> Aflatoxin_G2 not assigned
 –
24(28)-methylene_lophenol <=> 4alpha-methyl-5alpha-ergosta-8,24-dien-3beta-ol 5.3.3.5 cholestenol Delta-isomerase
–
L-arogenate + oxaloacetate <=> prephenate + L-aspartate 2.6.1.1 aspartate transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase
–
–
–
–
geranyl_diphosphate + H2O <=> (3R)-linalool + diphosphate 4.2.3.25 S-linalool synthase
4.2.3.26 R-linalool synthase
–
–
dihydro-4-coumaroyl-CoA + NADP+ <=> 4-coumaroyl-CoA + NADPH + H+ 1.3.1.117 hydroxycinnamoyl-CoA reductase
–
ATP + (S)-beta-tyrosine + pC3'p <=> AMP + diphosphate + (S)-beta-Tyrosyl-[pcp] 6.2.1
–
S-adenosyl-L-methionine + 12-ethyl-8-propyl-3-vinyl-bacteriochlorophyllide_d <=> S-adenosyl-L-homocysteine + 12-ethyl-8-isobutyl-3-vinyl-bacteriochlorophyllide_d + H+ 2.1.1.332 bacteriochlorophyllide d C-82-methyltransferase
–
7-hydroxychlorophyllide_a + NADP+ <=> chlorophyllide_b + NADPH + H+ 1.1.1.294 chlorophyll(ide) b reductase
–
cyclo-L-Trp-L-Phe + S-adenosyl-L-methionine <=> N-Methyl-cyclo(L-Trp-L-Phe) + S-adenosyl-L-homocysteine 2.1.1
–
1,4-dihydroxy-2-naphthoyl-CoA + H2O <=> H+ + 1,4-dihydroxy-2-naphthoate + CoA 3.1.2.28 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
–
S-adenosyl-L-methionine + 4-hydroxy-N-methyltryptamine_4-phosphate <=> S-adenosyl-L-homocysteine + psilocybin + H+ 2.1.1.345 psilocybin synthase
–
malonyl-CoA + acetyl-CoA <=> dodecanoyl-[acyl-carrier_protein] not assigned
 –
cannabigerolate + O2 <=> DELTA9-tetrahydrocannabinolate + H2O2 1.21.3.7 tetrahydrocannabinolic acid synthase
–
3-dehydro-6-deoxoteasterone <=> 6-deoxotyphasterol not assigned
 –
sucrose_6F-phosphate + H2O <=> sucrose + phosphate 3.1.3.24 sucrose-phosphate phosphatase
–
UDP-L-rhamnose + kaempferol_3-O-glucoside <=> UDP + kaempferol_3-O-rutinoside 2.4.1.159 flavonol-3-O-glucoside L-rhamnosyltransferase
2.4.1.B53
–
–
(2R)-2-hydroxy-2-methylbutanenitrile <=> cyanide + 2-butanone 4.1.2.10 (R)-mandelonitrile lyase
4.1.2.46 aliphatic (R)-hydroxynitrile lyase
4.1.2.47 (S)-hydroxynitrile lyase
–
–
–
4-dimethylallyl-L-abrine <=> chanoclavine-I not assigned
 –
S-adenosyl-L-methionine + daidzein <=> H+ + formononetin + S-adenosyl-L-homocysteine 2.1.1.212 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
2.1.1.231 flavonoid 4'-O-methyltransferase
2.1.1.46 isoflavone 4'-O-methyltransferase
–
–
–
ATP + NAD+ <=> H+ + 3''-dehydro-ATP + NADH 1
–
3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp] <=> 7,12-Decaketide_intermediate_1 + H2O 4.2.1
–
XMP + H2O <=> Xanthosine + phosphate 3.1.3.5 5'-nucleotidase
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Premithramycin_A1 + dTDP-D-oliose <=> Premithramycin_A2' + dTDP + H+ 2.4.1
–
naringenin_chalcone <=> naringenin 5.5.1.6 chalcone isomerase
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D-fructose_1,6-bisphosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde_3-phosphate 4.1.2.13 fructose-bisphosphate aldolase
4.1.2.40 tagatose-bisphosphate aldolase
–
–
L-tryptophan + L-proline + 2 ATP <=> brevianamide_F + 2 AMP + 2 diphosphate not assigned
 –
13-Desoxypaxilline + NADPH + H+ + O2 <=> Paxilline + NADP+ + H2O 1.14.13
–
D-fructose_1,6-bisphosphate + H2O <=> beta-D-fructose_6-phosphate + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase
–
–
–
–
3-oxo-2-(cis-2''-pentenyl)-cyclopentane-1-butanoyl-CoA + acetyl-CoA <=> 3-oxo-2-(cis-2''-pentenyl)-cyclopentane-1-(3-oxohexanoyl)-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
–
UDP-glucose + an_(E)-omega-(methylthio)alkyl-thiohydroximate <=> H+ + an_aliphatic_desulfoglucosinolate + UDP 2.4.1.195 N-hydroxythioamide S-beta-glucosyltransferase
–
L-aspartate + ATP <=> L-4-aspartyl_phosphate + ADP 2.7.2.4 aspartate kinase
–
myo-inositol + ATP <=> H+ + D-myo-Inositol_1-phosphate + ADP 2.7.1.64 inositol 3-kinase
–
geranylgeranyl_diphosphate + isopentenyl_diphosphate <=> all-trans-hexaprenyl_diphosphate + diphosphate 2.5.1.82 hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
2.5.1.B41
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–
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O <=> geosmin + acetone 4.1.99.16 geosmin synthase
–
geranylgeranyl_diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate 3.1.7.10 (13E)-labda-7,13-dien-15-ol synthase
–
ADP + ATP <=> ATP + ADP 2.4.2.12 nicotinamide phosphoribosyltransferase
2.7.1.20 adenosine kinase
2.7.4.6 nucleoside-diphosphate kinase
3.6.4.10 non-chaperonin molecular chaperone ATPase
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–
–
–
beta-L-galactose_1-phosphate + H2O <=> L-galactopyranose + phosphate 3.1.3.93 L-galactose 1-phosphate phosphatase
3.1.3.B9
–
–
4'',6,7-Trihydroxyisoflavone <=> glycitein not assigned
 –
6-hydroxyprotopine <=> Dihydrosanguinarine + H2O not assigned
 –
feruloyl-CoA + feruloylacetyl-CoA + H2O <=> curcumin + CoA + CO2 2.3.1.217 curcumin synthase
–
Terpendole_I + dimethylallyl_diphosphate <=> 20,21-Diprenylterpendole_I + diphosphate 2.5.1
–
3beta-hydroxyergosta-7,24(241)-dien-4alpha-carboxylate + NAD+ <=> Episterone + NADH + CO2 1.1.1.418 plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
–
gibberellin_a15 + 2-oxoglutarate + O2 <=> Gibberellin_A24 + succinate + CO2 + H2O 1.14.11.12 gibberellin-44 dioxygenase
1.14.20
–
–
kanamycin_C + O2 <=> 6''-Oxokanamycin_C + H2O2 1.1.3
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ferruginol + 3 reduced_flavodoxin + 3 O2 <=> pisiferic_acid + 3 flavin + 4 H2O 1.14.14.61 carnosic acid synthase
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L-arginine + NADPH + H+ + O2 <=> L-citrulline + NO + NADP+ + H2O 1.14.13.39 nitric-oxide synthase (NADPH)
1.14.14.47 nitric-oxide synthase (flavodoxin)
–
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N-hydroxy-L-phenylalanine + reduced_flavodoxin + O2 <=> N,N-dihydroxy-L-phenylalanine + flavin + H2O 1.14.14.40 phenylalanine N-monooxygenase
–
3-Hydroxy-OPC4-CoA + NAD+ <=> 3-Oxo-OPC4-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
2-Amino-4-chloro-4-pentenoic_acid <=> DL-propargylglycine + Cl- + H+ 4.5.1
–
(-)-limonene + reduced_flavodoxin + O2 <=> (-)-trans-isopiperitenol + flavin + H2O 1.14.14.99 (S)-limonene 3-monooxygenase
–
gibberellin_a15 <=> gibberellin_a37 not assigned
 –
p-coumaric_acid + CoA + ATP <=> 4-coumaroyl-CoA + AMP + diphosphate 6.2.1.12 4-coumarate---CoA ligase
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.30 phenylacetate---CoA ligase
–
–
–
pseudobaptigenin + reduced_flavodoxin + O2 <=> 2'',7-Dihydroxy-4'',5''-methylenedioxyisoflavone + flavin + H2O 1.14.14.90 isoflavone 2'-hydroxylase
–
(1''S,5''R)-hydroxyaverantin + NAD+ <=> H+ + 5''-oxoaverantin + NADH 1.1.1.352 5'-hydroxyaverantin dehydrogenase
–
O2 + Columbamine <=> H2O + Berberine 1.21.3.2 columbamine oxidase
–
7,9,12-Decaketide_intermediate_6 <=> 12-Deoxyaklanonic_acid not assigned
 –
S-adenosyl-L-methionine + norbelladine <=> 4''-O-methylnorbelladine + S-adenosyl-L-homocysteine + H+ 2.1.1.336 norbelladine O-methyltransferase
–
H2O + Chlorophyll <=> chlorophyllide_a + phytol 3.1.1.14 chlorophyllase
–
H+ + L-Dopa <=> dopamine + CO2 4.1.1.22 histidine decarboxylase
4.1.1.25 tyrosine decarboxylase
4.1.1.28 aromatic-L-amino-acid decarboxylase
4.1.1.53 phenylalanine decarboxylase
–
–
–
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neomycin_C + 2-oxoglutarate <=> 6''''''-deamino-6''''''-oxoneomycin_C + L-glutamate 2.6.1.95 neomycin C transaminase
–
D-glucose_6-phosphate + NAD+ <=> 3-dehydro-D-glucose_6-phosphate + NADH + H+ 1.1.1.361 glucose-6-phosphate 3-dehydrogenase
–
(+)-limonene + reduced_flavodoxin + O2 <=> (+)-trans-carveol + flavin + H2O 1.14.14.53 (R)-limonene 6-monooxygenase
–
S-adenosyl-L-methionine + uroporphyrinogen_III <=> S-adenosyl-L-homocysteine + precorrin-2 + H+ 2.1.1.107 uroporphyrinogen-III C-methyltransferase
–
5-aminoimidazole-4-carboxamide_ribonucleotide + formate + ATP <=> 5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide + ADP + phosphate 6.3.4.23 formate---phosphoribosylaminoimidazolecarboxamide ligase
–
UDP-glucose + coumaric_acid <=> H+ + 2-O-(beta-D-glucosyl)-2-hydroxycinnamate + UDP 2.4.1.114 2-coumarate O-beta-glucosyltransferase
2.4.1.35 phenol beta-glucosyltransferase
–
–
2-((1R,3S),-1,9''-dihydroxy-1''-methyl-10''-oxo-3,4,5,10''-tetrahydro-1H-benzo[g]isochromen-3''-yl)acetate <=> (S)-DNPA + H2O 4.2.1
–
dTDP-4-oxo-alpha-D-xylose <=> dTDP-3-methyl-4-oxo-alpha-D-ribopyranose 2.1.1
–
4-coumaroyl-CoA + feruloylacetyl-CoA + H2O <=> demethoxycurcumin + CoA + CO2 2.3.1.219 demethoxycurcumin synthase
–
amidinoproclavaminate + H2O <=> proclavaminate + Urea 3.5.3.22 proclavaminate amidinohydrolase
–
3-Hydroxy-OPC6-CoA <=> trans-2-Enoyl-OPC6-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase
–
–
amylose <=> glycogen 2.4.1.18 1,4-alpha-glucan branching enzyme
2.4.1.25 4-alpha-glucanotransferase
3.2.1.1 alpha-amylase
3.2.1.116 glucan 1,4-alpha-maltotriohydrolase
3.2.1.133 glucan 1,4-alpha-maltohydrolase
3.2.1.135 neopullulanase
3.2.1.41 pullulanase
3.2.1.54 cyclomaltodextrinase
3.2.1.68 isoamylase
–
–
–
–
–
–
–
–
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4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD+ <=> avenastenone + NADH + CO2 1.1.1.418 plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
–
(+)-7-Isojasmonate_CoA + acetyl-CoA <=> 3-oxo-2-(cis-2''-pentenyl)-cyclopentane-1-(3-oxobutanoyl)-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
–
3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O 4.2.1.57 isohexenylglutaconyl-CoA hydratase
–
5,10-methylenetetrahydrofolate + 2-oxoisovalerate + H2O <=> ketopantoate + tetrahydrofolate 2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase
–
aurachin_B + NAD+ + H2O <=> 4-hydroxy-2-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]quinolin-3(4H)-one_1-oxide + NADH + H+ 1.1.1.394 aurachin B dehydrogenase
–
phosphatidylethanolamine + H2O <=> ethanolamine + phosphatidic_acid 3.1.4.4 phospholipase D
–
dTDP-3-O-methyl-beta-L-rhamnose + Calicheamicin_alpha1(I) <=> dTDP + Calicheamicin_gamma(1)I 2.4.1
–
ent-copalyl_diphosphate <=> diphosphate + ent-kaurene 4.2.3.19 ent-kaurene synthase
5.5.1.13 ent-copalyl diphosphate synthase
–
–
S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan <=> 4-dimethylallyl-L-abrine + S-adenosyl-L-homocysteine + H+ 2.1.1.261 4-dimethylallyltryptophan N-methyltransferase
–
bacteriochlorophyll_a + NADP+ <=> geranylgeranyl-bacteriochlorophyllide_a + NADPH + H+ 1.3.1.111 geranylgeranyl-bacteriochlorophyllide a reductase
1.3.1.83 geranylgeranyl diphosphate reductase
–
–
L-N-acetyl-2-amino-6-oxopimelate + L-glutamate <=> N-acetyl-L,L-2,6-diaminopimelate + 2-oxoglutarate 2.6.1
–
C20818 <=> C20819 2.1.1
–
S-adenosyl-L-methionine + Demethylmacrocin <=> H+ + S-adenosyl-L-homocysteine + macrocin 2.1.1.102 demethylmacrocin O-methyltransferase
–
p-hydroxyphenylacetaldoxime + L-cysteine + NADPH + O2 + H+ <=> S-(Hydroxyphenylacetothiohydroximoyl)-L-cysteine + NADP+ + 2 H2O 1.14.14.45 aromatic aldoxime N-monooxygenase
–
2-aminobenzoyl-CoA + L-Cysteinyl-protein <=> S-Anthraniloyl-L-cysteinyl-protein + CoA 2.3.1.262 anthraniloyl-CoA anthraniloyltransferase
–
Nonaketamide_tricyclic_intermediate <=> Pretetramid not assigned
 –
3,4-Dihydroxybenzaldehyde + tyramine <=> Norcraugsodine + H2O + H+ 4.3.3
–
Caffeine + NADPH + O2 + H+ <=> Theobromine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
–
–
2-Amino-5-epi-valiolone <=> 2-Aminovalienone not assigned
 –
geranyl_diphosphate + H2O <=> (-)-alpha-terpineol + diphosphate 4.2.3.108 1,8-cineole synthase
4.2.3.111 (-)-alpha-terpineol synthase
4.2.3.112 (+)-alpha-terpineol synthase
–
–
–
heme_O <=> heme_a not assigned
 –
1-hydroxyneurosporene <=> all-trans-neurosporene + H2O 4.2.1.131 carotenoid 1,2-hydratase
–
2-heptyl-4(1H)-quinolone + NADH + O2 + H+ <=> 2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O 1.14.13.182 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
–
valienol_7-phosphate <=> valienol_1-phosphate not assigned
 –
JI-20A <=> gentamicin_C1a not assigned
 –
spheroidene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> spheroiden-2-one + H2O + oxidized_ferredoxin 1.14.15.9 spheroidene monooxygenase
–
S-adenosyl-L-methionine + Xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine 2.1.1.158 7-methylxanthosine synthase
–
S-farnesyl_protein + H2O <=> protein_C-terminal_S-farnesyl-L-cysteine + peptide 3.4.22
3.4.24.84 Ste24 endopeptidase
–
–
divinyl_protochlorophyllide_a + 2 H+ <=> protochlorophyllide not assigned
 –
OA-6129_A + 2-oxoglutarate + O2 <=> OA-6129_B2 + succinate + CO2 1.14.20
–
dTDP-3-dehydro-2,6-dideoxy-alpha-D-glucose <=> TDP-3-amino-2,3,6-trideoxy-alpha-D-glucose not assigned
 –
geraniol <=> Actinidine not assigned
 –
ent-7alpha-hydroxykaur-16-en-19-oate + reduced_flavodoxin + O2 <=> gibberellin_A12_aldehyde + flavin + 2 H2O 1.14.14.107 ent-kaurenoic acid monooxygenase
–
L-N-acetylphosphinothricin_bialophos + H2O <=> phosphinotricyl-alanyl-alanine/out + acetate 3.1.1
–
TDP-3-amino-2,3,6-trideoxy-alpha-D-glucose <=> dTDP-D-angolosamine not assigned
 –
geneticin + FAD <=> 6''-Oxo-G418 + FADH2 not assigned
 –
succinate + GTP + CoA <=> succinyl-CoA + GDP + phosphate 6.2.1.4 succinate---CoA ligase (GDP-forming)
–
farnesyl_phosphate + CTP <=> (2E,6E)-farnesyl_diphosphate + CDP 2.7.4.32 farnesyl phosphate kinase
–
avenasterol + ferricytochrome_b5 + O2 + H+ <=> DELTA5,7-avenasterol + ferricytochrome_b5 + H2O 1.14.19.20 Delta7-sterol 5(6)-desaturase
–
H+ + (2S)-2-isopropyl-3-oxosuccinate <=> 4-methyl-2-oxopentanoate + CO2 0.0.0.0
1.1.1.85 3-isopropylmalate dehydrogenase
–
–
p-hydroxyphenylacetaldoxime + reduced_flavodoxin + O2 <=> (S)-4-hydroxymandelonitrile + flavin + 2 H2O 1.14.14.37 4-hydroxyphenylacetaldehyde oxime monooxygenase
–
(1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate <=> o-succinylbenzoate + H2O 4.2.1.113 o-succinylbenzoate synthase
–
nocardicin_G <=> nocardicin_E not assigned
 –
fecosterol <=> episterol not assigned
 –
dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose <=> dTDP-3-dehydro-2,6-dideoxy-alpha-D-glucose not assigned
 –
alpha-D-mannose_1-phosphate <=> D-mannose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.8 phosphomannomutase
–
–
–
Avermectin_B1b_aglycone + dTDP-L-oleandrose <=> Avermectin_B1b_monosaccharide + dTDP 2.4.1
–
demethylphylloquinone + NADPH + H+ <=> demethylphylloquinol + NADP+ 1.6.5.12 demethylphylloquinone reductase
–
(-)-limonene + reduced_flavodoxin + O2 <=> (-)-trans-carveol + flavin + H2O 1.14.14.51 (S)-limonene 6-monooxygenase
–
ATP + 4-methoxy-2,2''-bipyrrole-5-carbaldehyde + 2-Methyl-3-n-amyl-pyrrole <=> ADP + phosphate + prodigiosin + H+ 6.4.1
–
copalyl_diphosphate <=> stemar-13-ene + diphosphate 4.2.3.33 stemar-13-ene synthase
–
NADP+ + CoA + (R)-mevalonate <=> H+ + NADPH + (S)-3-hydroxy-3-methylglutaryl-CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
1.1.1.88 hydroxymethylglutaryl-CoA reductase
1.1.1.B38
–
–
–
(S)-2-Hydroxy-2-methyl-3-oxobutanoate <=> 3-hydroxy-3-methyl-2-oxobutanoic_acid 1.1.1.86 ketol-acid reductoisomerase (NADP+)
5.4.99.3 2-acetolactate mutase
–
–
DELTA1-piperideine + acetoacetyl-CoA + H2O <=> Pelletierine + CoA + CO2 not assigned
 –
S-adenosyl-L-methionine + 1-hydroxyneurosporene <=> 1-methoxyneurosporene + S-adenosyl-L-homocysteine + H+ 2.1.1
2.1.1.210 demethylspheroidene O-methyltransferase
–
–
Caffeine + O2 + NADPH + H+ <=> theophylline + formaldehyde + NADP+ + H2O 1.13.12
1.14.13.128 7-methylxanthine demethylase
–
–
feruloyl-CoA + malonyl-CoA + hexanoyl-CoA + H2O <=> 1-Dehydro-[6]-gingerdione + 3 CoA + 2 CO2 not assigned
 –
aggreticin + dTDP-D-boivinose <=> kerriamycin_B + dTDP 2.4.1
–
L-glutamyl_gamma-phosphinic_acid + acetyl-CoA <=> H+ + N-acetyldemethylphosphinothricin + CoA 2.3.1.183 phosphinothricin acetyltransferase
–
S-adenosyl-L-methionine + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol <=> plastoquinol + S-adenosyl-L-homocysteine + H+ 2.1.1.295 2-methyl-6-phytyl-1,4-hydroquinone methyltransferase
–
(3R,4R)-7,2''-dihydroxy-4''-methoxyisoflavanol <=> medicarpin + H2O 4.2.1.139 pterocarpan synthase
–
2-(or_4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + reduced_flavodoxin + O2 <=> glyceollin + flavin + 2 H2O 1.14.14.135 glyceollin synthase
–
UDP-glucose + D-fructose <=> sucrose + UDP + H+ 2.4.1.13 sucrose synthase
2.4.1.14 sucrose-phosphate synthase
–
–
S-adenosyl-L-methionine + 8-demethylnovobiocic_acid <=> S-adenosyl-L-homocysteine + novobiocic_acid + H+ 2.1.1.284 8-demethylnovobiocic acid C8-methyltransferase
–
L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + 4a-hydroxytetrahydrobiopterin 1.14.16.2 tyrosine 3-monooxygenase
–
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol 5.4.99.17 squalene---hopene cyclase
5.4.99.7 lanosterol synthase
–
–
(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + reduced_flavodoxin + O2 <=> (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + flavin + H2O 1.14.14.167 (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase
–
D-glucose_6-phosphate <=> beta-D-fructose_6-phosphate 2.6.1.16 glutamine---fructose-6-phosphate transaminase (isomerizing)
5.3.1.8 mannose-6-phosphate isomerase
5.3.1.9 glucose-6-phosphate isomerase
–
–
–
fumiquinazoline_F-indoline-2,3''-diol + L-alanine + ATP <=> Fumiquinazoline_A + AMP + diphosphate + H2O + H+ 6.3.2
–
S-adenosyl-L-methionine + 3''-O-demethyl-staurosporine <=> staurosporine + S-adenosyl-L-homocysteine + H+ 2.1.1.139 3'-demethylstaurosporine O-methyltransferase
–
Caffeine + NADH + O2 + H+ <=> paraxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
–
–
S-adenosyl-L-methionine + dihydrosterigmatocystin <=> H+ + 8-O-methyldihydrosterigmatocystin + S-adenosyl-L-homocysteine 2.1.1.110 sterigmatocystin 8-O-methyltransferase
–
UDP-glucose + scopoletin <=> H+ + scopolin + UDP 2.4.1.111 coniferyl-alcohol glucosyltransferase
2.4.1.126 hydroxycinnamate 4-beta-glucosyltransferase
2.4.1.128 scopoletin glucosyltransferase
2.4.1.170 isoflavone 7-O-glucosyltransferase
2.4.1.218 hydroquinone glucosyltransferase
2.4.1.237 flavonol 7-O-beta-glucosyltransferase
2.4.1.35 phenol beta-glucosyltransferase
2.4.1.358 acylphloroglucinol glucosyltransferase
–
–
–
–
–
–
–
–
CoA + acetate + ATP <=> acetyl-CoA + diphosphate + AMP 6.2.1.1 acetate---CoA ligase
6.2.1.17 propionate---CoA ligase
6.2.1.36 3-hydroxypropionyl-CoA synthase
–
–
–
S-adenosyl-L-methionine + (S)-norreticuline <=> S-adenosyl-L-homocysteine + (S)-reticuline 2.1.1.115 (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
–
malonyl-CoA + H+ <=> 3,5-dihydroxyphenylacetyl-CoA + CoA + CO2 + H2O 2.3.1.246 3,5-dihydroxyphenylacetyl-CoA synthase
–
S-adenosyl-L-methionine + 3-O-acetyl-4''-O-demethylpapaveroxine <=> 3-O-acetylpapaveroxine + S-adenosyl-L-homocysteine + H+ 2.1.1.352 3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase
–
D-glucose <=> D-glucose 5.1.3.21 maltose epimerase
5.1.3.3 aldose 1-epimerase
–
–
H2O + 2-Phosphoglycolate <=> glycolate + phosphate 3.1.3.18 phosphoglycolate phosphatase
3.1.3.2 acid phosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.71 2-phosphosulfolactate phosphatase
5.4.2.4 bisphosphoglycerate mutase
–
–
–
–
–
TDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + 3-alpha-mycarosylerythronolide_B <=> erythromycin_D + dTDP + H+ 2.4.1.278 3-alpha-mycarosylerythronolide B desosaminyl transferase
–
20-O-Methyl-19-chloroproansamitocin + Carbamoyl_phosphate <=> N-Demethyl-desepoxymaytansinol + phosphate 2.1.3
–
H+ + Phosphonopyruvate <=> phosphonoacetaldehyde + CO2 4.1.1.82 phosphonopyruvate decarboxylase
–
phenylacetonitrile + reduced_flavodoxin + O2 <=> (R)-mandelonitrile + flavin + H2O 1.14.14.44 phenylacetaldehyde oxime monooxygenase
1.14.14.77 phenylacetonitrile alpha-monooxygenase
–
–
retronecine + 2 L-isoleucine <=> senecionine not assigned
 –
8-Methyl-6-nonenoic_acid <=> (6E)-8-methylnon-6-enoyl-CoA not assigned
 –
5-[[(4,7-Dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]carbonyl]-4-methyl-1H-pyrrole-3-carboxylate + 3-amino-4,7-dihydroxycoumarin + ATP + 2 S-adenosyl-L-methionine <=> Coumermic_acid + AMP + diphosphate + 2 S-adenosyl-L-homocysteine not assigned
 –
L-tyrosine + pyruvate <=> 4-hydroxyphenylpyruvate + L-alanine 2.6.1.12 alanine---oxo-acid transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.5 tyrosine transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.58 phenylalanine(histidine) transaminase
–
–
–
–
–
dopamine + 4-hydroxyphenylacetaldehyde <=> H2O + (S)-norcoclaurine 4.2.1.78 (S)-norcoclaurine synthase
–
(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate <=> 5,10-Dihydrophenazine-1,6-dicarboxylate not assigned
 –
salutaridinol + acetyl-CoA <=> 7-O-acetylsalutaridinol + CoA 2.3.1.150 salutaridinol 7-O-acetyltransferase
–
all-trans-zeta-carotene + reduced_acceptor + O2 <=> all-trans-neurosporene + A + H2O 1.3.5.6 9,9'-dicis-zeta-carotene desaturase
1.3.99.26 all-trans-zeta-carotene desaturase
1.3.99.28 phytoene desaturase (neurosporene-forming)
1.3.99.30 phytoene desaturase (3,4-didehydrolycopene-forming)
1.3.99.31 phytoene desaturase (lycopene-forming)
–
–
–
–
–
phosphatidylcholine + H2O <=> lysophosphatidylcholine + linolenic_acid 3.1.1.4 phospholipase A2
–
isopenicillin_N + acyl-CoA + H2O <=> penicillin + CoA + L-2-aminoadipate 2.3.1.164 isopenicillin-N N-acyltransferase
–
S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O <=> (2E,6E)-farnesal + L-cysteine + H2O2 1.8.3.5 prenylcysteine oxidase
1.8.3.6 farnesylcysteine lyase
–
–
L-proline + pC3'p + ATP <=> (L-prolyl)-[peptidyl-carrier_protein] + AMP + diphosphate 6.2.1.53 L-proline---[L-prolyl-carrier protein] ligase
–
C20912 <=> C20913 not assigned
 –
campesterol + O2 + reduced_acceptor <=> 6alpha-Hydroxycampestanol + H2O + acceptor 1.14.99
–
S-adenosyl-L-methionine + N-acetyl-O-demethylpuromycin <=> H+ + N-acetylpuromycin + S-adenosyl-L-homocysteine 2.1.1.38 O-demethylpuromycin O-methyltransferase
–
neamine + S-adenosyl-L-methionine + reduced_acceptor <=> 4''-Oxonebramine + L-methionine + 5''-Deoxyadenosine + acceptor + H2O not assigned
 –
Aminofructose_6-phosphate + D-ribose_5-phosphate <=> Iminoerythrose_4-phosphate + sedoheptulose_7-phosphate 2.2.1.1 transketolase
–
ent-sandaracopimaradien-3beta-ol + reduced_flavodoxin + O2 <=> oryzalexin_D + flavin + H2O 1.14.14.123 oryzalexin D synthase
–
ubiquinone + D-glucose <=> ubiquinol + D-glucono-1,5-lactone 1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone)
1.1.5.9 glucose 1-dehydrogenase (FAD, quinone)
–
–
Terpendole_E <=> Terpendole_G not assigned
 –
(S)-reticuline + S-adenosyl-L-methionine <=> laudanine + S-adenosyl-L-homocysteine 2.1.1.291 (R,S)-reticuline 7-O-methyltransferase
–
chlorophyllide_a + O2 + NADPH + H+ <=> 7-hydroxychlorophyllide_a + H2O + NADP+ 1.14.13.122 chlorophyllide-a oxygenase
–
UDP-glucose + beta-D-gentiobiosyl_beta-D-glucosyl_crocetin <=> crocin + UDP + H+ 2.4.1.330 beta-D-glucosyl crocetin beta-1,6-glucosyltransferase
–
behenoyl-CoA + NADP+ <=> trans-docos-2-enoyl-CoA + NADPH + H+ 1.3.1.93 very-long-chain enoyl-CoA reductase
–
D-glycerate + ATP <=> H+ + 3-phospho-D-glycerate + ADP 2.7.1.165 glycerate 2-kinase
2.7.1.31 glycerate 3-kinase
–
–
campesterol + NADPH + H+ + O2 <=> (22S)-22-hydroxycampesterol + NADP+ + H2O 1.14.13
1.14.99.B1
–
–
3''-Keto-3''-deoxy-ATP <=> 3''-Keto-3''-deoxy-AMP + diphosphate 3
–
zeaxanthin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ + O2 <=> antheraxanthin + oxidized_ferredoxin + H2O 1.14.15.21 zeaxanthin epoxidase
–
pyruvate + trans-2-octenal + H+ <=> (S)-3-acetyloctanal + CO2 2.2.1.12 3-acetyloctanal synthase
–
L-phenylalanine <=> tropate not assigned
 –
loganic_acid + reduced_flavodoxin + O2 <=> secologanate + flavin + 2 H2O 1.14.19.62 secologanin synthase
–
(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 + H+ <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + H2O2 + CO2 not assigned
 –
phosphatidylethanolamine + H2O <=> diacylglycerol + Phosphoethanolamine 3.1.4.12 sphingomyelin phosphodiesterase
3.1.4.3 phospholipase C
–
–
UDP-glucose + trans-zeatin <=> UDP + trans-zeatin_7-beta-D-glucoside 2.4.1
2.4.1.118 cytokinin 7-beta-glucosyltransferase
–
–
S-adenosyl-L-methionine + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose <=> S-adenosyl-L-homocysteine + dTDP-alpha-D-forosamine + H+ 2.1.1.324 dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase
–
gibberellin_A12 <=> Gibberellin_A53 not assigned
 –
geranyl_phosphate + H2O <=> geraniol + phosphate 3.1.3
3.1.3.76 lipid-phosphate phosphatase
3.1.7.1 prenyl-diphosphatase
–
–
–
ent-sandaracopimaradien-3beta-ol + reduced_flavodoxin + O2 <=> oryzalexin_E + flavin + H2O 1.14.14.122 oryzalexin E synthase
–
S-adenosyl-L-methionine + 13-deoxycarminomycin <=> 13-deoxydaunorubicin + S-adenosyl-L-homocysteine + H+ 2.1.1.292 carminomycin 4-O-methyltransferase
–
UDP-glucose + phenylacetothiohydroximate <=> desulfoglucotropaeolin + UDP 2.4.1.195 N-hydroxythioamide S-beta-glucosyltransferase
–
geranyl_diphosphate + H2O <=> geraniol + diphosphate 3.1.7.11 geranyl diphosphate diphosphatase
3.1.7.3 monoterpenyl-diphosphatase
4.2.3.104 alpha-humulene synthase
–
–
–
3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 7-methyl-3-oxooct-6-enoyl-CoA + acetate 4.1.3.26 3-hydroxy-3-isohexenylglutaryl-CoA lyase
4.1.3.4 hydroxymethylglutaryl-CoA lyase
–
–
(1E,2S)-2-methylbutanal_oxime <=> (Z)-2-methylbutanal_oxime 1.14.14.41 (E)-2-methylbutanal oxime monooxygenase
–
L-histidine + Isovalerate <=> Dolichotheline not assigned
 –
9-cis-violaxanthin + O2 <=> 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12''-apo-beta-caroten-12''-al 1.13.11.51 9-cis-epoxycarotenoid dioxygenase
–
D-glycerate + NAD+ <=> H+ + Hydroxypyruvate + NADH 1.1.1.237 hydroxyphenylpyruvate reductase
1.1.1.26 glyoxylate reductase
1.1.1.27 L-lactate dehydrogenase
1.1.1.28 D-lactate dehydrogenase
1.1.1.29 glycerate dehydrogenase
1.1.1.60 2-hydroxy-3-oxopropionate reductase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.81 hydroxypyruvate reductase
1.1.1.92 oxaloglycolate reductase (decarboxylating)
–
–
–
–
–
–
–
–
–
S-adenosyl-L-methionine + (S)-norcoclaurine <=> H+ + S-adenosyl-L-homocysteine + (S)-Coclaurine 2.1.1.128 (RS)-norcoclaurine 6-O-methyltransferase
–
5-Aminopentanal <=> DELTA1-piperideine not assigned
 –
caffeoyl_aldehyde + NADPH <=> caffeoyl_alcohol + NADP+ 1.1.1.195 cinnamyl-alcohol dehydrogenase
–
(1R,5aS,6R)-4a-Hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate <=> (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H2O not assigned
 –
(R)-mevalonate + ATP <=> (R)-3-phosphomevalonate + ADP + H+ 2.7.1.185 mevalonate 3-kinase
–
ATP + L-glutamate + [acyl-carrier_protein] <=> ADP + phosphate + gamma-L-Glutamyl-[acp] 6.2.1.39 [butirosin acyl-carrier protein]---L-glutamate ligase
–
Tetrangomycin <=> Tetrangulol + H2O not assigned
 –
(2E,6E)-farnesyl_diphosphate + protein <=> S-farnesyl_protein + diphosphate 2.5.1.58 protein farnesyltransferase
–
(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD+ <=> 2,3-Dihydroxybenzoate + NADH + H+ 1.3.1.28 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
–
UDP-glucose + kaempferol <=> kaempferol_3-O-glucoside + UDP + H+ 2.4.1.115 anthocyanidin 3-O-glucosyltransferase
2.4.1.237 flavonol 7-O-beta-glucosyltransferase
2.4.1.357 phlorizin synthase
2.4.1.91 flavonol 3-O-glucosyltransferase
–
–
–
–
Theobromine + NADPH + O2 + H+ <=> 7-methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.179 methylxanthine N3-demethylase
–
feruloyl-CoA + (4-coumaroyl)acetyl-CoA + H2O <=> demethoxycurcumin + CoA + CO2 2.3.1.217 curcumin synthase
2.3.1.219 demethoxycurcumin synthase
–
–
Iminoerythrose_4-phosphate + phosphoenolpyruvate + H2O <=> AminoDAHP + phosphate 2.5.1
–
nogalaviketone + NADPH + H+ <=> Nogalavinone + NADP+ 1.1.1
–
Paspaline + O2 + NADPH + H+ <=> Terpendole_E + NADP+ + H2O 1.14.13
–
N2-(2-carboxyethyl)-L-arginine + ATP <=> deoxyamidinoproclavaminate + AMP + diphosphate 6.3.3.4 (carboxyethyl)arginine beta-lactam-synthase
–
staurosporine_aglycone + dTDP-L-ristosamine <=> H+ + Holyrine_A + dTDP 2.4
2.4.1
–
–
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP+ <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + NADPH + H+ 1.1.1.384 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase
–
geranyl_diphosphate + H2O <=> geranyl_phosphate + phosphate + H+ 3.6.1.68 geranyl diphosphate phosphohydrolase
–
malonyl-CoA + (S)-methylmalonyl-CoA + NADPH + H+ + (2S)-ethylmalonyl-CoA <=> tylactone + CoA + CO2 + H2O + NADP+ 2.3.1
–
oxaloacetate + ATP <=> CO2 + phosphoenolpyruvate + ADP 4.1.1.31 phosphoenolpyruvate carboxylase
4.1.1.38 phosphoenolpyruvate carboxykinase (diphosphate)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)
–
–
–
2,6,7,4''-tetrahydroxyisoflavanone <=> 6,7,4''-trihydroxyisoflavone + H2O 4.2.1
–
2,3-Dihydrothienamycin + 2-oxoglutarate + O2 <=> Thienamycin + succinate + CO2 + H2O 1.14.20
–
coniferyl_alcohol <=> (-)-pinoresinol not assigned
 –
vindoline + Catharanthine <=> 3'',4''-Anhydrovinblastine not assigned
 –
paraxanthine + NADH + H+ + O2 <=> 1-Methylxanthine + NAD+ + formaldehyde + H2O 1.13.12
–
Dialdehyde + H+ <=> 4,21-Dehydrocorynantheine_aldehyde + H2O not assigned
 –
kanosamine + ATP <=> H+ + kanosamine_6-phosphate + ADP 2.7.1.179 kanosamine kinase
–
dTDP-3-O-methyl-beta-L-rhamnose + Calicheamicin_PsAg <=> dTDP + Calicheamicin_alpha3(I) 2.4.1
–
sugiol + reduced_flavodoxin + O2 <=> 11-hydroxysugiol + flavin + H2O 1.14.14.60 ferruginol monooxygenase
–
prephenate + NAD+ <=> 4-hydroxyphenylpyruvate + CO2 + NADH 1.3.1.12 prephenate dehydrogenase
1.3.1.13 prephenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]
–
–
–
gamma-L-Glutamyl-L-propargylglycine + 2-oxoglutarate + O2 <=> L-gamma-Glutamyl-(3R)-L-beta-ethynylserine + succinate + CO2 1.14.11
–
UDP-glucose + phloretin <=> phlorizin + UDP 2.4.1.357 phlorizin synthase
–
Tetrangomycin <=> Rabelomycin not assigned
 –
chorismate + NH3 <=> anthranilate + pyruvate + H2O 4.1.3.27 anthranilate synthase
–
3-phosphoshikimate + phosphoenolpyruvate <=> 5-enolpyruvylshikimate_3-phosphate + phosphate 2.5.1.19 3-phosphoshikimate 1-carboxyvinyltransferase
–
3-geranyl-4-hydroxybenzoate <=> geranylhydroquinone not assigned
 –
geranyl_diphosphate + 4-hydroxybenzoate <=> 3-geranyl-4-hydroxybenzoate + diphosphate 2.5.1.39 4-hydroxybenzoate polyprenyltransferase
2.5.1.93 4-hydroxybenzoate geranyltransferase
–
–
aclacinomycin_N + O2 <=> Aclarubicin + H2O2 1.1.3.45 aclacinomycin-N oxidase
–
Carbamoyl_phosphate + tobramycin + ATP + H2O <=> nebramycin_5'' + AMP + diphosphate + phosphate + H+ 6.1.2.2 nebramycin 5' synthase
–
geranyl_diphosphate <=> citronellol not assigned
 –
S-adenosyl-L-methionine + 2-deoxy-scyllo-inosamine <=> 3-amino-2,3-dideoxy-scyllo-inosose + 5''-deoxyadenosine + L-methionine + H+ 1.1.99.38 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)
–
1alpha(S)-6-O-methyl-N-deacetylisoipecoside + H2O <=> 1alpha(S)-6-O-methyl-N-deacetylisoipecoside_aglycone + D-glucose 3.2.1
3.2.1.B16
–
–
S-adenosyl-L-methionine + 16-hydroxytabersonine <=> H+ + S-adenosyl-L-homocysteine + 16-methoxytabersonine 2.1.1.94 tabersonine 16-O-methyltransferase
–
Avermectin_B1a_aglycone + S-adenosyl-L-methionine <=> Avermectin_A1a_aglycone + S-adenosyl-L-homocysteine 2.1.1
–
O-phospho-L-homoserine + H2O <=> phosphate + L-threonine 4.2.3.1 threonine synthase
–
3-devinyl-3-(1-hydroxyethyl)chlorophyllide_a <=> chlorophyllide_a + H2O 4.2.1.165 chlorophyllide a 31-hydratase
4.2.1.169 3-vinyl bacteriochlorophyllide d 31-hydratase
–
–
codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + CO2 1.14.11.32 codeine 3-O-demethylase
–
episterol + O2 + ferricytochrome_b5 + H+ <=> 5-dehydroepisterol + H2O + ferricytochrome_b5 1.14.19.20 Delta7-sterol 5(6)-desaturase
–
(13E)-8alpha-hydroxylabd-13-en-15-yl_diphosphate + H2O <=> sclareol + diphosphate 4.2.3.141 sclareol synthase
4.2.3.B31
–
–
Cathasterone + O2 + reduced_acceptor <=> Teasterone + H2O + acceptor 1.14
–
CDP-diacylglycerol + H2O <=> phosphatidic_acid + CMP + H+ 2.7.8.8 CDP-diacylglycerol---serine O-phosphatidyltransferase
3.6.1.26 CDP-diacylglycerol diphosphatase
–
–
1-Indolizidinone <=> Slaframine not assigned
 –
7,9,9''-tricis-neurosporene + a_quinone <=> 7,9,7'',9''-tetracis-lycopene + a_quinol 1.3.5.6 9,9'-dicis-zeta-carotene desaturase
–
(20S)-dammarenediol <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O 4.2.1.125 dammarenediol II synthase
–
oxaloacetate + acetyl-CoA + phosphate + ADP <=> citrate + CoA + ATP 2.3.3.8 ATP citrate synthase
–
valienone_7-phosphate <=> valienol_7-phosphate not assigned
 –
dichlorochromopyrrolate + O2 + NADH + H+ <=> dichloroarcyriaflavin_A + CO2 + H2O + NAD+ 1.13.12.17 dichloroarcyriaflavin A synthase
–
behenoyl-CoA + malonyl-CoA <=> a_very-long-chain_3-oxoacyl-CoA + CO2 + CoA 2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase
–
(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 + H+ <=> 5,10-Dihydrophenazine + H2O2 + CO2 not assigned
 –
dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose + 2-oxoglutarate <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + L-glutamate 2.6.1
–
OPC8-CoA + FAD <=> trans-2-Enoyl-OPC8-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
–
neamine + 2-oxoglutarate <=> 6''-dehydroparomamine + L-glutamate 2.6.1.93 neamine transaminase
–
6-Oxocineole + O2 + NADPH + H+ <=> 1,6,6-Trimethyl-2,7-dioxa(3,2,2)bicyclononan-3-one + H2O + NADP+ 1.14.13.51 6-oxocineole dehydrogenase
–
alpha-D-glucose_1-phosphate <=> alpha-D-glucose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.3 phosphoacetylglucosamine mutase
5.4.2.5 phosphoglucomutase (glucose-cofactor)
5.4.2.6 beta-phosphoglucomutase
5.4.2.8 phosphomannomutase
–
–
–
–
–
–
S-adenosyl-L-methionine + nocardicin_G <=> isonocardicin_C + S-methyl-5''-thioadenosine + H+ 2.5.1.38 isonocardicin synthase
–
cis-trans-nepetalactol + reduced_flavodoxin + O2 <=> 7-deoxyloganetic_alcohol + flavin + H2O 1.14.14.161 nepetalactol monooxygenase
–
deacetoxyvindoline + 2-oxoglutarate + O2 <=> deacetylvindoline + succinate + CO2 1.14.11.20 deacetoxyvindoline 4-hydroxylase
–
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ <=> 3-hydroxy-3-methyl-2-oxobutanoic_acid + NADPH + H+ 1.1.1.86 ketol-acid reductoisomerase (NADP+)
–
3-Methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
–
–
loganic_acid <=> 10-Deoxygeniposidic_acid not assigned
 –
L-tyrosine + O2 <=> L-Dopa 1.10.3.1 catechol oxidase
1.14.18.1 tyrosinase
–
–
(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP+ <=> H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH 1.3.1
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
–
–
heme + reduced_acceptor + O2 + H+ <=> 5-oxo-delta-bilirubin + Fe2+ + formaldehyde + acceptor + H2O 1.14.99.48 heme oxygenase (staphylobilin-producing)
–
L-Histidinol_phosphate + 2-oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl_phosphate + L-glutamate 2.6.1.9 histidinol-phosphate transaminase
–
p-coumaric_acid <=> caffeic_acid 1.14.13
–
trans-5-O-caffeoylshikimate + CoA <=> caffeoyl-CoA + shikimate 2.3.1
2.3.1.133 shikimate O-hydroxycinnamoyltransferase
2.3.1.99 quinate O-hydroxycinnamoyltransferase
–
–
–
UDP-glucose + H2O <=> UMP + alpha-D-aldose_1-phosphate + H+ 3.1.4.1 phosphodiesterase I
3.6.1.45 UDP-sugar diphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
Coumermic_acid + 2 dTDP-beta-L-noviose + 2 S-adenosyl-L-methionine <=> N,N'-bis(7-[[(2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)-3-methyl-1H-pyrrole-2,4-dicarboxamide + 2 dTDP + 2 S-adenosyl-L-homocysteine not assigned
 –
9-cis-beta-carotene + O2 <=> 9-cis-10''-apo-beta-carotenal + beta-ionone 1.13.11.68 9-cis-beta-carotene 9',10'-cleaving dioxygenase
1.13.11.71 carotenoid-9',10'-cleaving dioxygenase
–
–
L-dihydroanticapsin + NAD+ <=> anticapsin + NADH + H+ 1.1.1.385 dihydroanticapsin dehydrogenase
–
(2Z,6E)-farnesyl_diphosphate + n isopentenyl_diphosphate <=> n diphosphate + trans,poly-cis-polyprenyl_diphosphate 2.5.1.88 trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
–
ethanol + 2 ferricytochrome_c <=> acetaldehyde + 2 ferricytochrome_c 1.1.2.8 alcohol dehydrogenase (cytochrome c)
1.1.2.9 1-butanol dehydrogenase (cytochrome c)
–
–
(2E,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> octaprenyl_diphosphate + diphosphate 2.5.1.90 all-trans-octaprenyl-diphosphate synthase
2.5.1.91 all-trans-decaprenyl-diphosphate synthase
–
–
aklavinone + dTDP-beta-L-rhodosamine <=> aclacinomycin_T + dTDP + H+ 2.4.1.326 aklavinone 7-L-rhodosaminyltransferase
–
7-hydroxymethylchlorophyll_a + NAD+ <=> chlorophyll_b + NADH 1.1.1.294 chlorophyll(ide) b reductase
–
acetaldehyde + NADP+ + H2O <=> acetate + NADPH + H+ 1.2.1
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
–
–
–
–
–
–
–
–
–
squalene + reduced_flavodoxin + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + flavin + H2O 1.14.14.17 squalene monooxygenase
–
C20817 <=> C20818 2.1.1
–
neoxanthin <=> 9''-cis-neoxanthin 5.2.1
–
6-deoxocathasterone + O2 <=> 6-deoxoteasterone + H2O 1.14
–
S-adenosyl-L-methionine + putrescine <=> H+ + S-adenosyl-L-homocysteine + N-methylputrescine 2.1.1.53 putrescine N-methyltransferase
–
L-threonine <=> glycine + acetaldehyde 4.1.2.26 phenylserine aldolase
4.1.2.42 D-threonine aldolase
4.1.2.48 low-specificity L-threonine aldolase
4.1.2.5 L-threonine aldolase
–
–
–
–
geranylgeranyl_diphosphate <=> diphosphate + taxa-4,11-diene 4.2.3.17 taxadiene synthase
–
adonirubin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ + O2 <=> (3S,3''S)-astaxanthin + oxidized_ferredoxin + H2O 1.14.15.24 beta-carotene 3-hydroxylase
–
5-epi-valiolone <=> 2-Keto-5-epi-valiolone not assigned
 –
tryptamine + secologanin <=> strictosidine + H2O 4.3.3.2 strictosidine synthase
–
OA-6129_B2 <=> OA-6129_B1 not assigned
 –
XMP + diphosphate <=> xanthine + 5-phospho-alpha-D-ribose_1-diphosphate 2.4.2.22 xanthine phosphoribosyltransferase
2.4.2.7 adenine phosphoribosyltransferase
2.4.2.8 hypoxanthine phosphoribosyltransferase
–
–
–
3-devinyl-3-(1-hydroxyethyl)chlorophyllide_a <=> 3-deacetyl-3-vinylbacteriochlorophyllide_a + H2O 4.2.1.165 chlorophyllide a 31-hydratase
4.2.1.169 3-vinyl bacteriochlorophyllide d 31-hydratase
–
–
4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD+ <=> cycloeucalenone + NADH + CO2 1.1.1.418 plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
–
alpha-Aminoadipoyl-S-acyl_enzyme + NADPH + H+ <=> (S)-2-amino-6-oxohexanoate + Holo-Lys2 + NADP+ 1.2.1.95 L-2-aminoadipate reductase
–
phenazine-1-carboxylic_acid + NADH + O2 + H+ <=> 1-hydroxyphenazine + NAD+ + CO2 + H2O 1.14.13.218 5-methylphenazine-1-carboxylate 1-monooxygenase
–
4-hydroxybenzoyl-CoA + H2O <=> H+ + 4-hydroxybenzoate + CoA 3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.23 4-hydroxybenzoyl-CoA thioesterase
–
–
–
dTDP-beta-L-mycarose + NADP+ <=> dTDP-3-methyl-4-oxo-2,6-dideoxy-L-allose + NADPH + H+ 1.1.1
–
6-Deoxocastasterone + O2 + reduced_flavodoxin <=> 6alpha-Hydroxy-castasterone + H2O + flavin 1.14
–
isonocardicin_A <=> nocardicin_A 5.1.1.14 nocardicin A epimerase
–
malonyl-CoA + 6 methylmalonyl-CoA + 6 NADPH + 6 H+ <=> 8,8a-deoxyoleandolide + 7 CoA + 7 CO2 + H2O + 6 NADP+ not assigned
 –
5-O-p-coumaroylquinic_acid + reduced_flavodoxin + O2 <=> chlorogenic_acid + flavin + H2O 1.14.14.96 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase
–
geraniol <=> beta-Skytanthine not assigned
 –
tryprostatin_B + reduced_flavodoxin + O2 <=> 6-hydroxytryprostatin_B + flavin + H2O 1.14.14.118 tryprostatin B 6-hydroxylase
–
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose <=> dTDP-4-oxo-2,6-dideoxy-L-mannose 5.1.3
–
ATP + L-2,3-diaminopropionic_acid + citrate <=> AMP + diphosphate + 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H+ 6.3.2.54 L-2,3-diaminopropanoate---citrate ligase
–
CMP-5'-phosphonoformate + 3-phospho-D-glycerate <=> 1-carboxyvinyl_carboxyphosphonate + CMP + phosphate not assigned
 –
alpha-D-glucose_1-phosphate <=> D-glucose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.3 phosphoacetylglucosamine mutase
5.4.2.5 phosphoglucomutase (glucose-cofactor)
5.4.2.8 phosphomannomutase
–
–
–
–
–
20,21-Diprenylterpendole_J + 3 O2 + 3 NADPH + 3 H+ <=> Lolitrem_E + 3 NADP+ + 4 H2O 1.14.13
–
Papaveroxine <=> narcotine_hemiacetal not assigned
 –
S-adenosyl-L-methionine + genistein <=> H+ + Biochanin_A + S-adenosyl-L-homocysteine 2.1.1.155 kaempferol 4'-O-methyltransferase
2.1.1.212 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
2.1.1.231 flavonoid 4'-O-methyltransferase
2.1.1.46 isoflavone 4'-O-methyltransferase
–
–
–
–
naringenin + O2 + reduced_flavodoxin <=> 2,4'',5,7-tetrahydroxyisoflavanone + H2O + flavin 1.14.14.87 2-hydroxyisoflavanone synthase
–
acetoacetyl-CoA + H2O + acetyl-CoA <=> H+ + CoA + (S)-3-hydroxy-3-methylglutaryl-CoA 2.3.3.10 hydroxymethylglutaryl-CoA synthase
–
CTP + diacylglycerol <=> CDP + phosphatidic_acid + H+ 2.7.1.174 diacylglycerol kinase (CTP)
–
rhodomycin_D + H2O <=> 10-carboxy-13-deoxycarminomycin + methanol + H+ 3.1.1
–
S-adenosyl-L-methionine <=> H+ + S-methyl-5''-thioadenosine + 1-aminocyclopropane-1-carboxylate 4.4.1.14 1-aminocyclopropane-1-carboxylate synthase
–
shikimate + ATP <=> H+ + 3-phosphoshikimate + ADP 2.7.1.71 shikimate kinase
–
5-COOH-porphyrinogen_I + acceptor <=> Coproporphyrin_I + reduced_acceptor + 6 H+ not assigned
 –
butyryl-CoA + FAD <=> crotonyl-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
1.3.8.1 short-chain acyl-CoA dehydrogenase
1.3.8.4 isovaleryl-CoA dehydrogenase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.99
–
–
–
–
–
gentamicin_A2 + NAD+ <=> 3''''-Oxogentamicin_A2 + NADH + H+ 1.1.1
–
Phosphonoformate + CTP <=> CMP-5''-phosphonoformate + diphosphate 2.7.7.93 phosphonoformate cytidylyltransferase
–
an_alcohol + NADP+ <=> an_aldehyde + NADPH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.191 indole-3-acetaldehyde reductase (NADPH)
1.1.1.195 cinnamyl-alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.215 gluconate 2-dehydrogenase
1.1.1.263 1,5-anhydro-D-fructose reductase
1.1.1.265 3-methylbutanal reductase
1.1.1.283 methylglyoxal reductase (NADPH)
1.1.1.4 (R,R)-butanediol dehydrogenase
1.1.1.61 4-hydroxybutyrate dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.72 glycerol dehydrogenase (NADP+)
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.80 isopropanol dehydrogenase (NADP+)
1.1.1.91 aryl-alcohol dehydrogenase (NADP+)
1.1.1.97 3-hydroxybenzyl-alcohol dehydrogenase
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
H2O + GTP <=> H+ + diphosphate + 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate + formate 3.5.4.25 GTP cyclohydrolase II
–
cis-3,4-leucopelargonidin + NADP+ <=> (+)-dihydrokaempferol + NADPH + H+ 1.1.1.219 dihydroflavonol 4-reductase
–
geranyl_diphosphate <=> (+)-camphene + diphosphate 4.2.3.116 (+)-camphene synthase
4.2.3.20 (R)-limonene synthase
–
–
N-acetyldemethyl_phosphinothricin_tripeptide + methylcobalamin + S-adenosyl-L-methionine + H+ + e- <=> L-N-acetylphosphinothricin_bialophos + Cobalamin + 5''-Deoxyadenosine + L-methionine 2.1.1.326 N-acetyldemethylphosphinothricin P-methyltransferase
–
cathenamine <=> 4,21-Dehydrogeissoschizine not assigned
 –
dTDP-4-ethylamino-3-O-methyl-2,4-dideoxy-L-threo-pentopyranose + Calicheamicin_alpha3(I) <=> dTDP + Calicheamicin_gamma(1)I 2.4.2
–
4-coumaroyl-CoA + shikimate <=> 4-coumaroylshikimate + CoA 2.3.1.133 shikimate O-hydroxycinnamoyltransferase
2.3.1.140 rosmarinate synthase
2.3.1.99 quinate O-hydroxycinnamoyltransferase
–
–
–
D-ribulose_5-phosphate <=> H+ + formate + L-3,4-dihydroxybutan-2-one_4-phosphate 4.1.99.12 3,4-dihydroxy-2-butanone-4-phosphate synthase
–
paraxanthine + NADPH + O2 + H+ <=> 7-methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
–
–
S-adenosyl-L-methionine + 8,12-diethyl-3-vinyl-bacteriochlorophyllide_d <=> S-adenosyl-L-homocysteine + 12-ethyl-8-propyl-3-vinyl-bacteriochlorophyllide_d + H+ 2.1.1.332 bacteriochlorophyllide d C-82-methyltransferase
–
(+)-epi-isozizaene + O2 + NADPH + H+ <=> (5R)-albaflavenol + H2O + NADP+ 1.14.13.106 epi-isozizaene 5-monooxygenase
–
dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose <=> dTDP-3-amino-4-oxo-2,3,6-trideoxy-L-allose not assigned
 –
ATP + alpha-D-glucose <=> ADP + alpha-D-glucose_6-phosphate 2.7.1.1 hexokinase
2.7.1.2 glucokinase
–
–
CoA + H2O <=> adenosine_3,5''-bisphosphate + 4''-phosphopantetheine + H+ 3.6.1
3.6.1.22 NAD+ diphosphatase
3.6.1.55 8-oxo-dGTP diphosphatase
3.6.1.M6
–
–
–
–
acetyl-CoA + Thienamycin <=> CoA + N-Acetylthienamycin 2.3.1
–
Fe-coproporphyrin_III + H+ <=> coproporphyrin_III + Fe2+ 4.99.1.9 coproporphyrin ferrochelatase
–
naringenin + 2-oxoglutarate + O2 <=> (+)-dihydrokaempferol + succinate + CO2 1.14.11.9 flavanone 3-dioxygenase
–
Mithramycin_DK <=> mithramycin not assigned
 –
2,4-dihydroxycinnamoyl-CoA <=> umbelliferone + CoA not assigned
 –
D-ribulose_1,5-bisphosphate + O2 <=> 2-Phosphoglycolate + 3-phospho-D-glycerate + H+ 1.13.11
4.1.1.39 ribulose-bisphosphate carboxylase
–
–
loganin + reduced_flavodoxin + O2 <=> secologanin + flavin + 2 H2O 1.14.19.62 secologanin synthase
–
S-adenosyl-L-methionine + Tetracenomycin_E <=> tetracenomycin_A2 + S-adenosyl-L-homocysteine 2.1.1
–
geranyl_diphosphate + H2O <=> Sabinene_hydrate + diphosphate 4.2.3.11 sabinene-hydrate synthase
–
H+ + alpha-D-mannose_1-phosphate + GTP <=> GDP-mannose + diphosphate 2.7.7.13 mannose-1-phosphate guanylyltransferase
2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
2.7.7.30 fucose-1-phosphate guanylyltransferase
2.7.7.34 glucose-1-phosphate guanylyltransferase
–
–
–
–
S-adenosyl-L-methionine + N-acetylserotonin <=> H+ + S-adenosyl-L-homocysteine + Melatonin 2.1.1.4 acetylserotonin O-methyltransferase
–
H+ + phosphoenolpyruvate <=> Phosphonopyruvate 5.4.2.9 phosphoenolpyruvate mutase
–
L-Histidinol + NAD+ <=> H+ + L-histidinal + NADH 1.1.1.23 histidinol dehydrogenase
–
H+ + L-pyrroline-5-carboxylate + malonyl-CoA + H2O <=> (2S,5S)-5-carboxymethylproline + CoA + CO2 2.3.1.226 carboxymethylproline synthase
–
meso-2,6-diaminoheptanedioate + NADP+ + H2O <=> L-2-amino-6-oxopimelate + NH3 + NADPH + H+ 1.4.1.16 diaminopimelate dehydrogenase
–
L-Histidinol_phosphate + H2O <=> L-Histidinol + phosphate 3.1.3.15 histidinol-phosphatase
3.1.3.2 acid phosphatase
–
–
Premithramycin_B + NADPH + H+ + O2 <=> Mithramycin_DK + NADP+ + CO2 1.14.13
–
(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O <=> 9-Hydroxy-12-oxo-10(E),15(Z)-octadecadienoic_acid not assigned
 –
3-Hydroxy-OPC8-CoA + NAD+ <=> 3-Oxo-OPC8-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
–
anabasine + CO2 <=> DELTA1-piperideine + nicotinate not assigned
 –
N,N-dihydroxy-L-phenylalanine + H+ <=> (E)-phenylacetaldoxime + CO2 + H2O 1.14.14.40 phenylalanine N-monooxygenase
–
4,21-Dehydrogeissoschizine <=> 19-epi-Cathenamine not assigned
 –
S-adenosyl-L-methionine + gamma-tocotrienol <=> S-adenosyl-L-homocysteine + alpha-tocotrienol + H+ 2.1.1.95 tocopherol C-methyltransferase
–
UDP-glucose + Vomilenine <=> H+ + Raucaffricine + UDP 2.4.1.219 vomilenine glucosyltransferase
–
chanoclavine-I + NAD+ <=> chanoclavine-I_aldehyde + NADH + H+ 1.1.1.332 chanoclavine-I dehydrogenase
–
Narcotoline + S-adenosyl-L-methionine <=> noscapine + S-adenosyl-L-homocysteine 2.1.1.352 3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase
–
3-phospho-D-glycerate + NAD+ <=> H+ + 3-phosphohydroxypyruvate + NADH 1.1.1.95 phosphoglycerate dehydrogenase
–
D-glucose_6-phosphate <=> D-myo-Inositol_1-phosphate 5.5.1.4 inositol-3-phosphate synthase
–
Neoabietal <=> Neoabietic_acid not assigned
 –
bilirubin + O2 <=> Biliverdin + H2O 1.3.3.5 bilirubin oxidase
–
strictosidine + H2O <=> strictosidine_aglycone + D-glucose 3.2.1.105 3alpha(S)-strictosidine beta-glucosidase
3.2.1.125 raucaffricine beta-glucosidase
–
–
(2Z,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl_diphosphate + diphosphate 2.5.1.86 trans,polycis-decaprenyl diphosphate synthase
–
beta-D-glucose_6-phosphate + NADP+ <=> 6-phospho-D-glucono-1,5-lactone + NADPH 1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)
–
–
–
N,N-dihydroxy-L-valine + H+ <=> (E)-2-methylpropanal-oxime + CO2 + H2O 1.14.14.38 valine N-monooxygenase
1.14.14.39 isoleucine N-monooxygenase
–
–
8-demethyltetracenomycin_C + dTDP-L-rhamnose <=> 8-demethyl-8-alpha-L-rhamnosyl_tetracenomycin_C + dTDP + H+ 2.4.1.331 8-demethyltetracenomycin C L-rhamnosyltransferase
–
3-O-acetylpapaveroxine + H2O <=> Papaveroxine + acetate 3.1.1.105 3-O-acetylpapaveroxine carboxylesterase
–
S-adenosyl-L-methionine + demethylphylloquinol <=> vitamin_KH2 + S-adenosyl-L-homocysteine + H+ 2.1.1.329 demethylphylloquinol methyltransferase
–
H+ + AMP + H2O <=> IMP + NH3 3.5.4.17 adenosine-phosphate deaminase
3.5.4.4 adenosine deaminase
3.5.4.6 AMP deaminase
3.5.4.7 ADP deaminase
–
–
–
–
L-cystathionine + H2O <=> L-homocysteine + pyruvate + NH3 2.5.1.48 cystathionine gamma-synthase
3.5.1.61 mimosinase
4.2.1.22 cystathionine beta-synthase
4.4.1.1 cystathionine gamma-lyase
4.4.1.13 cysteine-S-conjugate beta-lyase
4.4.1.28 L-cysteine desulfidase
4.4.1.3 dimethylpropiothetin dethiomethylase
–
–
–
–
–
–
–
chlorophyllide_a + NADP+ <=> protochlorophyllide + NADPH + H+ 1.3.1.33 protochlorophyllide reductase
–
arabidiol <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O 4.2.1.124 arabidiol synthase
–
(S)-1-hydroxy-N-methylcanadine + reduced_flavodoxin + O2 <=> (13S,14R)-1,13-dihydroxy-N-methylcanadine + flavin + H2O 1.14.14.163 (S)-1-hydroxy-N-methylcanadine 13-hydroxylase
–
D-myo-Inositol_1-phosphate + H2O <=> myo-inositol + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.2 acid phosphatase
3.1.3.23 sugar-phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.26 4-phytase
3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase
3.1.3.93 L-galactose 1-phosphate phosphatase
–
–
–
–
–
–
–
geranylgeranyl_diphosphate <=> prephytoene_diphosphate + diphosphate 2.5.1.148 lycopaoctaene synthase
2.5.1.32 15-cis-phytoene synthase
–
–
L-arogenate + NADP+ <=> L-tyrosine + CO2 + NADPH 1.3.1.43 arogenate dehydrogenase
1.3.1.78 arogenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]
–
–
–
coniferyl_alcohol <=> Guaiacyl_lignin 1.11.1.21 catalase-peroxidase
1.11.1.7 peroxidase
–
–
2R,3R-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O 4.2.1.9 dihydroxy-acid dehydratase
–
8,8a-deoxyoleandolide + 2 NADPH + 2 H+ + 2 O2 <=> Oleandolide + 2 NADP+ + 3 H2O not assigned
 –
heme + H+ <=> protoporphyrin_IX + Fe2+ 4.99.1.1 protoporphyrin ferrochelatase
4.99.1.9 coproporphyrin ferrochelatase
–
–
geranyl_diphosphate + 2,4-dihydroxy-6-pentylbenzoate <=> cannabigerolate + diphosphate 2.5.1.102 geranyl-pyrophosphate---olivetolic acid geranyltransferase
–
(R)-mevalonate + ATP <=> H+ + (R)-5-phosphomevalonate + ADP 2.7.1.36 mevalonate kinase
–
S-adenosyl-L-methionine + 1-(3,4-Dihydroxyphenyl)-5-hydroxy-3-decanone <=> [6]-gingerol + S-adenosyl-L-homocysteine + H+ 2.1.1
–
(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate <=> H2O + (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate 4.2.1.92 hydroperoxide dehydratase
–
3,6-Dihydronicotinic_acid <=> 3,6-Dihydropyridine not assigned
 –
malonyl-CoA + cinnamoyl-CoA + H+ <=> CoA + pinosylvin + CO2 2.3.1.146 pinosylvin synthase
2.3.1.95 trihydroxystilbene synthase
–
–
heme + (2E,6E)-farnesyl_diphosphate + H2O <=> heme_O + diphosphate 2.5.1.141 heme o synthase
–
geranylgeranyl_diphosphate <=> terpentedienyl_diphosphate 5.5.1.15 terpentedienyl-diphosphate synthase
–
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate <=> L-pipecolic_acid not assigned
 –
5-Oxoavermectin_''''1a''''_aglycone + NADPH + H+ <=> Avermectin_B1a_aglycone + NADP+ not assigned
 –
16-methoxy-2,3-dihydro-3-hydroxytabersonine + acceptor <=> (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + reduced_acceptor 1.1.99.41 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase
–
copalyl_diphosphate <=> diphosphate + abieta-7,13-diene 4.2.3.18 abieta-7,13-diene synthase
–
beta-D-fructose_6-phosphate + diphosphate <=> H+ + phosphate + D-fructose_1,6-bisphosphate 2.7.1.90 diphosphate---fructose-6-phosphate 1-phosphotransferase
–
H+ + alpha-D-glucose_1-phosphate + ATP <=> ADP-glucose + diphosphate 2.7.7.24 glucose-1-phosphate thymidylyltransferase
2.7.7.27 glucose-1-phosphate adenylyltransferase
2.7.7.9 UTP---glucose-1-phosphate uridylyltransferase
–
–
–
S-adenosyl-L-methionine + L-homocysteine <=> L-methionine + S-adenosyl-L-homocysteine + H+ 2.1.1.10 homocysteine S-methyltransferase
2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
2.1.1.280 selenocysteine Se-methyltransferase
–
–
–
–
Fumiquinazoline_A + O2 <=> Fumiquinazoline_C + H2O2 1.5.3
–
8 malonyl-CoA + [acyl-carrier_protein] <=> 3,5,7,9,11,13,15-Heptaoxo-hexadecanoyl-[acp] + 8 CO2 + 8 CoA 2.3.1
–
tabersonine <=> Minovincinine not assigned
 –
L-ornithine <=> L-proline + NH3 4.3.1.12 ornithine cyclodeaminase
–
Avermectin_B1b_aglycone + S-adenosyl-L-methionine <=> Avermectin_A1b_aglycone + S-adenosyl-L-homocysteine 2.1.1
–
L-Tyrosyl-[pcp] + O2 <=> beta-Hydroxy-L-tyrosyl-[pcp] + H2O not assigned
 –
L-lysine + H+ <=> cadaverine + CO2 4.1.1.17 ornithine decarboxylase
4.1.1.18 lysine decarboxylase
4.1.1.19 arginine decarboxylase
4.1.1.50 adenosylmethionine decarboxylase
4.1.1.86 diaminobutyrate decarboxylase
4.1.1.B12
–
–
–
–
–
–
amylose + phosphate <=> amylose + alpha-D-glucose_1-phosphate 2.4.1.1 glycogen phosphorylase
–
4alpha-methyl-5alpha-ergosta-8,24-dien-3beta-ol + NADP+ <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+ 1.3.1.70 Delta14-sterol reductase
–
6''''''-deamino-6''''''-hydroxyneomycin_C + O2 <=> 6''''''-deamino-6''''''-oxoneomycin_C + H2O2 1.1.3.44 6'''-hydroxyneomycin C oxidase
–
(3S,5S)-carbapenam_3-carboxylate + 2-oxoglutarate + O2 <=> (5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O 1.14.20
1.14.20.3 (5R)-carbapenem-3-carboxylate synthase
–
–
paromomycin <=> 5''''''-epi-Lividomycin_B not assigned
 –
alpha-D-sedoheptulopyranose_7-phosphate <=> 2-epi-5-epi-valiolone + phosphate 4.2.3.152 2-epi-5-epi-valiolone synthase
–
(10aS)-10,10a-dihydrophenazine-1-carboxylate <=> 5,10-dihydrophenazine_1-carboxylate not assigned
 –
chorismate <=> 4-hydroxybenzoate + pyruvate 4.1.3.40 chorismate lyase
–
gentamicin_X2 + FAD <=> 6''-Oxogentamicin_X2 + FADH2 not assigned
 –
valienone_7-phosphate <=> validone_7-phosphate not assigned
 –
lycopene <=> delta-carotene 5.5.1.18 lycopene epsilon-cyclase
–
Paspalicine + O2 + NADPH + H+ <=> Paspalinine + NADP+ + H2O 1.14.13
–
(S)-8-oxocitronellyl_enol + NAD+ <=> (6E)-8-oxogeranial + NADH + H+ 1.3.1.122 (S)-8-oxocitronellyl enol synthase
–
Gibberellin_A53 + O2 + 2-oxoglutarate <=> gibberellin_44 + CO2 + succinate 1.14.11
1.14.11.12 gibberellin-44 dioxygenase
–
–
fumitremorgin_C + 2 reduced_flavodoxin + 2 O2 <=> 12alpha,13alpha-dihydroxyfumitremorgin_C + 2 flavin + 2 H2O 1.14.14.119 fumitremorgin C monooxygenase
–
argininosuccinate <=> L-arginine + fumarate 4.3.2.1 argininosuccinate lyase
4.3.2.2 adenylosuccinate lyase
–
–
dihydrokaempferol + reduced_flavodoxin + O2 <=> dihydroquercetin + flavin + H2O 1.14.14.81 flavanoid 3',5'-hydroxylase
1.14.14.82 flavonoid 3'-monooxygenase
–
–
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylic_acid <=> (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate 5.3.3.17 trans-2,3-dihydro-3-hydroxyanthranilate isomerase
–
5-epi-valiolone <=> valienone + H2O 4.2.1
–
(2E,6E)-farnesyl_diphosphate <=> (3E,6E)-alpha-farnesene + diphosphate 4.2.3.46 alpha-farnesene synthase
–
gentamicin_A + methylcobalamin + S-adenosyl-L-methionine + H+ + e- <=> gentamicin_X2 + Cobalamin + 5''-Deoxyadenosine + L-methionine 2.1.1
–
N-acetyldemethylphosphinothricin + methylcobalamin + S-adenosyl-L-methionine + H+ + e- <=> N-acetylphosphinothricin + Cobalamin + 5''-Deoxyadenosine + L-methionine 2.1.1.326 N-acetyldemethylphosphinothricin P-methyltransferase
–
kanamycin_A + NADP+ <=> 2''-dehydrokanamycin_A + NADPH + H+ 1.1.1.355 2'-dehydrokanamycin reductase
–
N-methylanthraniloyl-CoA + malonyl-CoA <=> CO2 + 1,3-dihydroxy-N-methylacridone + CoA 2.3.1.159 acridone synthase
–
UDP-glucose + 2-deoxystreptamine <=> 2''-deamino-2''-hydroxyparomamine + UDP + H+ 2.4.1.284 2-deoxystreptamine glucosyltransferase
–
versiconal_hemiacetal_acetate + H2O <=> versiconal + acetate 3.1.1.94 versiconal hemiacetal acetate esterase
–
3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NADP+ <=> momilactone_A + NADPH + H+ 1.1.1.295 momilactone-A synthase
–
daidzein <=> Anhydroglycinol not assigned
 –
violaxanthin <=> neoxanthin 5.3.99.9 neoxanthin synthase
–
abieta-7,13-diene + reduced_flavodoxin + O2 <=> abietadienol + flavin + H2O 1.14.14.144 abieta-7,13-diene hydroxylase
–
UDP-glucose + amylose <=> UDP + starch 2.4.1.11 glycogen(starch) synthase
2.4.1.21 starch synthase (glycosyl-transferring)
2.4.1.242 NDP-glucose---starch glucosyltransferase
–
–
–
Urdamycinone_F <=> Aquayamycin + H2O not assigned
 –
taxifolin + 2-oxoglutarate + O2 <=> quercetin + succinate + CO2 + H2O 1.14.20.4 anthocyanidin synthase
1.14.20.6 flavonol synthase
–
–
2''-deamino-2''-hydroxyneamine + UDP-alpha-D-kanosamine <=> kanamycin_A + UDP + H+ 2.4.1.301 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
–
N-(5-phospho-beta-D-ribosyl)anthranilate <=> 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate 5.3.1.24 phosphoribosylanthranilate isomerase
–
vitamin_D3 + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> 25-hydroxyvitamin_D3 + oxidized_ferredoxin + H2O 1.14.15.22 vitamin D 1,25-hydroxylase
–
UDP-glucose + quercetin <=> UDP + quercetin_3-O-glucoside + H+ 2.4.1.115 anthocyanidin 3-O-glucosyltransferase
2.4.1.177 cinnamate beta-D-glucosyltransferase
2.4.1.35 phenol beta-glucosyltransferase
2.4.1.357 phlorizin synthase
2.4.1.91 flavonol 3-O-glucosyltransferase
–
–
–
–
–
NADP+ + (+)-neomenthol <=> H+ + NADPH + (-)-menthone 1.1.1.208 (+)-neomenthol dehydrogenase
–
UDP-3-ketoglucose + L-glutamate <=> UDP-alpha-D-kanosamine + 2-oxoglutarate 2.6.1
–
Anhydroglycinol <=> coumestrol not assigned
 –
Strigolactone_ABC-rings <=> 5-Deoxystrigol not assigned
 –
3''-phosphoadenylyl-sulfate + desulfo-indol-3-yl-methyl_glucosinolate <=> adenosine_3,5''-bisphosphate + glucobrassicin + H+ 2.8.2.24 aromatic desulfoglucosinolate sulfotransferase
2.8.2.38 aliphatic desulfoglucosinolate sulfotransferase
–
–
L-aspartate + 2-oxoglutarate <=> oxaloacetate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.75 cysteine-conjugate transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase
–
–
–
–
–
–
–
–
–
–
L-aspartate + L-citrulline + ATP <=> H+ + argininosuccinate + diphosphate + AMP 6.3.4.5 argininosuccinate synthase
–
echinenone + reduced_acceptor + O2 <=> canthaxanthin + acceptor + H2O 1.14.99.63 beta-carotene 4-ketolase
–
phosphatidylethanolamine + L-serine <=> phosphatidylserine + ethanolamine 2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase
–
(+)-dihydrokaempferol + 2-oxoglutarate + O2 <=> kaempferol + succinate + CO2 + H2O + H+ 1.14.20.5 flavone synthase I
1.14.20.6 flavonol synthase
–
–
S-adenosyl-L-methionine + jasmonic_acid <=> S-adenosyl-L-homocysteine + methyl_jasmonate 2.1.1.141 jasmonate O-methyltransferase
2.1.1.274 salicylate 1-O-methyltransferase
2.1.1.B126
–
–
–
NADP+ + codeine <=> H+ + NADPH + codeinone 1.1.1.218 morphine 6-dehydrogenase
1.1.1.247 codeinone reductase (NADPH)
–
–
(R)-reticuline + reduced_flavodoxin + O2 <=> salutaridine + flavin + 2 H2O 1.14.19.67 salutaridine synthase
–
(2E,6E)-farnesyl_diphosphate <=> gamma-humulene + diphosphate 4.2.3.56 gamma-humulene synthase
–
pentalenolactone_D + 2-oxoglutarate + O2 <=> pentalenolactone_F + succinate + CO2 + H2O 1.14.11.36 pentalenolactone F synthase
–
5 ATP + 3 L-4-hydroxyphenylglycine + L-arginine + L-serine + H2O <=> 5 AMP + 5 diphosphate + nocardicin_G + L-4-Hydroxyphenylglycyl-L-arginine not assigned
 –
siroheme + H+ <=> 12,18-didecarboxysiroheme + CO2 4.1.1.111 siroheme decarboxylase
–
ethanol + 2 ferricytochrome_b5 <=> acetaldehyde + 2 ferricytochrome_b5 1.1.2.7 methanol dehydrogenase (cytochrome c)
–
violaxanthin <=> 9-cis-violaxanthin not assigned
 –
geranylgeranyl_diphosphate + isopentenyl_diphosphate <=> nonaprenyl_diphosphate + diphosphate 2.5.1.84 all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific]
2.5.1.85 all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
–
–
neamine + UDP-alpha-D-kanosamine <=> kanamycin_B + UDP + H+ 2.4.1.301 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
–
cyclooctat-9-ene-5,7-diol + O2 + reduced_acceptor <=> cyclooctatin + H2O + acceptor 1.14.99.62 cyclooctatin synthase
–
N-Demethylnarwedine + NADPH <=> Norgalanthamine + NADP+ 1.1.1
–
H+ + H2O + Beta-cyanoalanine <=> NH3 + L-aspartate 3.5.5.4 cyanoalanine nitrilase
–
NAD+ + morphine <=> NADH + morphinone + H+ 1.1.1.218 morphine 6-dehydrogenase
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
–
–
benzoate + NADPH + O2 <=> salicylate + NADP+ + H2O 1.14.13
–
Gibberellin_A24 <=> gibberellin_a9 + CO2 1.14.11.12 gibberellin-44 dioxygenase
–
spheroiden-2-one + H2O <=> Hydroxyspheroidenone 4.2.1.131 carotenoid 1,2-hydratase
–
dTDP-L-rhamnose + NADP+ <=> dTDP-4-dehydro-beta-L-rhamnose + NADPH + H+ 1.1.1.133 dTDP-4-dehydrorhamnose reductase
–
N1,N5,N10-Tri(hydroxyferuloyl)_spermidine + S-adenosyl-L-methionine <=> N1,N5-Di(hydroxyferuloyl)-N10-sinapoyl_spermidine + S-adenosyl-L-homocysteine 2.1.1
–
5-dehydroepisterol + NADPH + H+ + O2 <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADP+ + 2 H2O 1.14.19.41 sterol 22-desaturase
–
(R)-mevalonate + NAD+ + CoA <=> (S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
1.1.1.88 hydroxymethylglutaryl-CoA reductase
1.1.1.B38
–
–
–
(S)-3-methyl-2-oxopentanoate + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(2-methylbutanoyl)dihydrolipoyllysine + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
–
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + O2 + ferricytochrome_b5 + H+ <=> 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + ferricytochrome_b5 + H2O 1.14.18.9 4alpha-methylsterol monooxygenase
–
S-adenosyl-L-methionine + (-)-pluviatolide <=> S-adenosyl-L-homocysteine + (-)-bursehernin + H+ 2.1.1.323 (-)-pluviatolide 4-O-methyltransferase
–
Roquefortine_C + 2 reduced_flavodoxin + 2 O2 <=> Glandicoline_A + 2 flavin + 3 H2O 1.14.14
–
3-Amino-4,7-dihydroxy-8-chlorocoumarin + 3-dimethylallyl-4-hydroxybenzoate <=> Chlorobiocic_acid not assigned
 –
S-adenosyl-L-methionine + naringenin <=> H+ + isosakuranetin + S-adenosyl-L-homocysteine 2.1.1.231 flavonoid 4'-O-methyltransferase
–
(3Z)-phycoerythrobilin + oxidized_ferredoxin <=> 15,16-dihydrobiliverdin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.3 phycoerythrobilin:ferredoxin oxidoreductase
–
Polyphosphate + beta-D-glucose <=> Polyphosphate + beta-D-glucose_6-phosphate 2.7.1.63 polyphosphate---glucose phosphotransferase
–
5-amino-5-deoxy-3-dehydroshikimate <=> H+ + 3-amino-5-hydroxybenzoate + H2O 4.2.1.144 3-amino-5-hydroxybenzoate synthase
–
geranylgeranyl_diphosphate + indole-3-glycerol_phosphate <=> 3-Geranylgeranylindole + D-glyceraldehyde_3-phosphate + diphosphate not assigned
 –
(-)-limonene + reduced_flavodoxin + O2 <=> (S)-perillyl_alcohol + flavin + H2O 1.14.14.52 (S)-limonene 7-monooxygenase
–
ferulic_acid + ATP + CoA <=> feruloyl-CoA + AMP + diphosphate 6.2.1.12 4-coumarate---CoA ligase
6.2.1.34 trans-feruloyl-CoA synthase
–
–
11-hydroxyferruginol + reduced_flavodoxin + O2 <=> 11,20-dihydroxyferruginol + flavin + H2O 1.14.14.67 11-hydroxysugiol 20-monooxygenase
–
10-formyltetrahydrofolate + 5-aminoimidazole-4-carboxamide_ribonucleotide <=> tetrahydrofolate + 5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide 2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase
–
geranylgeranyl_diphosphate + H2O <=> cyclooctat-9-en-7-ol + diphosphate 4.2.3.146 cyclooctat-9-en-7-ol synthase
–
shikimate + pyrroloquinoline_quinone <=> 3-dehydroshikimate + reduced_pyrroloquinoline_quinone 1.1.5.8 quinate dehydrogenase (quinone)
–
antheraxanthin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ + O2 <=> violaxanthin + oxidized_ferredoxin + H2O 1.14.15.21 zeaxanthin epoxidase
–
Antibiotic_JI-20B <=> Antibiotic_JI-20Ba not assigned
 –
Terpendole_B <=> 13-Desoxyterpendole_I not assigned
 –
phytyl_diphosphate + homogentisate + H+ <=> 2-methyl-6-phytylbenzene-1,4-diol + CO2 + diphosphate 2.5.1.115 homogentisate phytyltransferase
–
ATP + L-aspartate + NH3 <=> diphosphate + AMP + L-asparagine + H+ 6.3.1.1 aspartate---ammonia ligase
6.3.5.4 asparagine synthase (glutamine-hydrolysing)
–
–
7beta-(5-D-Aminoadipamido)-3-carbamoyloxymethylceph-3-em-4-carboxylic_acid + 2-oxoglutarate + O2 <=> 7a-Hydroxy-O-carbamoyl-deacetylcephalosporin_C + succinate + CO2 not assigned
 –
kanosamine_6-phosphate <=> Aminofructose_6-phosphate 5.3.1
–
dimethylallyl_diphosphate + oxidized_ferredoxin + H2O <=> (E)-4-hydroxy-3-methylbut-2-en-1-yl_diphosphate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.17.7.4 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase
–
Demethyl-desacetyl-rifamycin_S <=> 27-O-Demethyl-25-O-desacetylrifamycin_SV not assigned
 –
UDP-alpha-D-kanosamine + nebramine <=> UDP + tobramycin 2.4.1
–
cinnamaldehyde + CoA + NADP+ <=> cinnamoyl-CoA + NADPH + H+ 1.2.1.44 cinnamoyl-CoA reductase
–
diacylglycerol + CDP-ethanolamine <=> phosphatidylethanolamine + CMP + H+ 2.7.8.1 ethanolaminephosphotransferase
2.7.8.2 diacylglycerol cholinephosphotransferase
–
–
H2O + pyruvate + ATP <=> H+ + phosphate + phosphoenolpyruvate + AMP 2.7.1.40 pyruvate kinase
2.7.9.2 pyruvate, water dikinase
–
–
2-Hydroxy-beta-keto-L-tyrosyl-[pcp] <=> 3-amino-4,7-dihydroxycoumarin not assigned
 –
gamma-tocopherol <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol 5.5.1.24 tocopherol cyclase
–
cis-Zeatin_riboside_monophosphate + H2O <=> cis-Zeatin_riboside + phosphate not assigned
 –
ATP + Tabtoxinine-beta-lactam + L-threonine <=> ADP + phosphate + Tabtoxin 6.3.2
–
squalene + 2 ferricytochrome_b5 + O2 + 2 H+ <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + 2 ferricytochrome_b5 + H2O 1.14.19
–
LL-2,6-Diaminoheptanedioate <=> meso-2,6-diaminoheptanedioate 5.1.1.10 amino-acid racemase
5.1.1.7 diaminopimelate epimerase
–
–
scyllo-inosose + L-glutamine <=> 1-amino-1-deoxy-scyllo-inositol + 2-Oxoglutaramate 2.6.1.50 glutamine---scyllo-inositol transaminase
–
7,9,12-Decaketide_intermediate_4 + NADPH + H+ <=> 7,9,12-Decaketide_intermediate_5 + NADP+ 1.1.1
–
ATP + L-alanine + anticapsin <=> ADP + phosphate + L-alanyl-L-anticapsin + H+ 6.3.2.49 L-alanine---L-anticapsin ligase
–
3-deacetyl-3-vinylbacteriochlorophyllide_a + ADP + phosphate + oxidized_ferredoxin <=> chlorophyllide_a + ATP + H2O + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.15 chlorophyllide a reductase
–
15,9''-di-cis-phytofluene + plastoquinone <=> 9,15,9''-tri-cis-zeta-carotene + plastoquinol 1.3.5.5 15-cis-phytoene desaturase
–
Rabelomycin <=> 11-Deoxylandomycinone not assigned
 –
UDP-glucose + 2''-deamino-2''-hydroxyneamine <=> Kanamycin_D + UDP + H+ 2.4.1.301 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
–
(22S)-22-hydroxycampesterol <=> (22S)-22-hydroxycampest-4-en-3-one not assigned
 –
dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose 5.3.2.3 TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)
–
dichloroarcyriaflavin_A + D-glucose <=> 4''-O-demethylrebeccamycin + H2O 4.3.3.5 4'-demethylrebeccamycin synthase
–
amygdalin + H2O <=> prunasin + D-glucose 3.2.1.117 amygdalin beta-glucosidase
3.2.1.21 beta-glucosidase
–
–
9,14-Decaketide_intermediate_1 <=> tetracenomycin_F2 + [acyl-carrier_protein] not assigned
 –
Trachelanthamidine <=> retronecine not assigned
 –
3-devinyl-3-(1-hydroxyethyl)chlorophyllide_a + NAD+ <=> bacteriochlorophyllide_a + NADH + H+ 1.1.1.396 bacteriochlorophyllide a dehydrogenase
–
a_very-long-chain_(3R)-3-hydroxyacyl-CoA <=> very-long-chain_(2E)-2-enoyl-CoA + H2O 4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
–
Neoabietinol <=> Neoabietal 1.14.13
–
H+ + L-ornithine <=> CO2 + putrescine 4.1.1.17 ornithine decarboxylase
4.1.1.18 lysine decarboxylase
4.1.1.19 arginine decarboxylase
4.1.1.86 diaminobutyrate decarboxylase
4.1.1.B12
–
–
–
–
–
alpha-D-glucose_6-phosphate <=> beta-D-glucose_6-phosphate 5.1.3.15 glucose-6-phosphate 1-epimerase
5.1.3.3 aldose 1-epimerase
5.3.1.9 glucose-6-phosphate isomerase
–
–
–
gamma-carotene <=> beta-carotene 5.5.1.19 lycopene beta-cyclase
–
dTDP-4-hydroxyamino-4,6-dideoxy-alpha-D-glucose + Calicheamicinone <=> dTDP + Calicheamicin_T0 2.4.1
–
dTDP-6-deoxy-beta-L-talose <=> dTDP-L-rhamnose 5.1.3.25 dTDP-L-rhamnose 4-epimerase
–
L-serine + acetyl-CoA <=> O-acetyl-L-serine + CoA 2.3.1.30 serine O-acetyltransferase
–
S-adenosyl-L-methionine + Orsellinate-[acp] <=> S-adenosyl-L-homocysteine + 2-Methoxyorsellinate-[acp] 2.1.1
–
(S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate + O2 <=> 4-hydroxyphenylglyoxylate + H2O2 1.1.3.46 4-hydroxymandelate oxidase
–
p-coumaryl_alcohol + NADP+ <=> 4-coumaraldehyde + NADPH + H+ 1.1.1.195 cinnamyl-alcohol dehydrogenase
–
NDP-2-amino-2,6-dideoxy-D-galactose <=> NDP-2-methylamino-2,6-dideoxy-D-galactose 2.1.1
–
Tropine + (R)-phenyllactyl-CoA <=> Littorine + CoA 2.3.1
2.3.1.185 tropine acyltransferase
–
–
(1''S)-averantin + NADP+ <=> norsolorinic_acid + NADPH + H+ 1.1.1.349 norsolorinic acid ketoreductase
1.1.1.B25
–
–
TDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + L-oleandrosyl-oleandolide <=> oleandomycin + dTDP + H+ 2.4.1
–
UDP-glucose + beta-D-glucosyl_crocetin <=> H+ + beta-D-gentiobiosyl_crocetin + UDP 2.4.1.330 beta-D-glucosyl crocetin beta-1,6-glucosyltransferase
–
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 <=> amidinoproclavaminate + succinate + CO2 1.14.11.21 clavaminate synthase
–
aclacinomycin_S <=> aclacinomycin_N not assigned
 –
Chlorobiocic_acid + dTDP-beta-L-noviose <=> novclobiocin_105 + dTDP not assigned
 –
(S)-cis-N-Methylstylopine + reduced_flavodoxin + O2 <=> protopine + flavin + H2O 1.14.14.97 methyltetrahydroprotoberberine 14-monooxygenase
–
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine <=> phosphatidylcholine + S-adenosyl-L-homocysteine + H+ 2.1.1.16 methylene-fatty-acyl-phospholipid synthase
2.1.1.17 phosphatidylethanolamine N-methyltransferase
2.1.1.71 phosphatidyl-N-methylethanolamine N-methyltransferase
–
–
–
H+ + 4-coumaroyl-CoA + malonyl-CoA + NADPH <=> isoliquiritigenin + CoA + CO2 + NADP+ + H2O 2.3.1.170 6'-deoxychalcone synthase
–
5-diphosphomevalonate + ATP <=> isopentenyl_diphosphate + CO2 + ADP + phosphate 4.1.1.33 diphosphomevalonate decarboxylase
–
Leucocyanidin + 2-oxoglutarate + O2 + H+ <=> cyanidin + succinate + CO2 + 2 H2O 1.14.20.4 anthocyanidin synthase
–
cannabigerolate + O2 <=> cannabidiolate + H2O2 1.21.3.3 reticuline oxidase
1.21.3.8 cannabidiolic acid synthase
–
–
S-(Indolylmethylthiohydroximoyl)-L-cysteine + H2O <=> 2-(3-indolyl)acetothiohydroximate + pyruvate + NH3 4.4.1
–
peptidyl-4-carboxyglutamate + 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + H+ + H2O <=> CO2 + peptidyl-glutamate + vitamin_KH2 + O2 4.1.1.90 peptidyl-glutamate 4-carboxylase
–
L-histidine <=> pilocarpine not assigned
 –
7-hydroxychlorophyllide_a <=> chlorophyllide_a not assigned
 –
H+ + Clavulanate-9-aldehyde + NADPH <=> clavulanic_acid + NADP+ not assigned
 –
FMN + O2 <=> 8-demethyl-8-formylriboflavin_5''-phosphate + H2O 2.6.1.114 8-demethyl-8-aminoriboflavin-5'-phosphate synthase
–
L-homoserine + succinyl-CoA <=> O-succinyl-L-homoserine + CoA 2.3.1.46 homoserine O-succinyltransferase
–
a_3-vinyl_bacteriochlorophyllide_d + (2E,6E)-farnesyl_diphosphate <=> Bacteriochlorophyll_d + diphosphate 2.5.1
–
24-ethylidenelophenol + ferricytochrome_b5 + O2 + H+ <=> 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + ferricytochrome_b5 + H2O 1.14.18.11 plant 4alpha-monomethylsterol monooxygenase
–
tetracenomycin_B2 + O2 + NADPH + H+ <=> 8-demethyltetracenomycin_C + H2O + NADP+ 1.14.13.200 tetracenomycin A2 monooxygenase-dioxygenase
–
GTP + valienol_1-phosphate + H+ <=> GDP-valienol + diphosphate 2.7.7.91 valienol-1-phosphate guanylyltransferase
–
lanosterol + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized_ferredoxin + H2O 1.14.15.36 sterol 14alpha-demethylase (ferredoxin)
–
2-phospho-D-glycerate <=> 3-phospho-D-glycerate 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
5.4.2.12 phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
–
–
thebaine + 2-oxoglutarate + O2 <=> oripavine + formaldehyde + succinate + CO2 1.14.11.32 codeine 3-O-demethylase
–
Leucocyanidin + NADP+ <=> taxifolin + NADPH + H+ 1.1.1.219 dihydroflavonol 4-reductase
–
3-dehydroshikimate <=> 3,4-dihydroxybenzoate + H2O 4.2.1.118 3-dehydroshikimate dehydratase
–
(9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate <=> 9-Oxononanoate + 3,6-Nonadienal not assigned
 –
UDP-glucose + bis(beta-D-glucosyl)_crocetin <=> H+ + beta-D-gentiobiosyl_beta-D-glucosyl_crocetin + UDP 2.4.1.330 beta-D-glucosyl crocetin beta-1,6-glucosyltransferase
–
4''-O-Desmethylpapaveroxine <=> narcotoline_hemiacetal not assigned
 –
(-)-vetispiradiene + reduced_flavodoxin + O2 <=> solavetivol + flavin + H2O 1.14.14.151 premnaspirodiene oxygenase
–
S-adenosyl-L-methionine + Glandicoline_B <=> Meleagrin + S-adenosyl-L-homocysteine + H+ 2.1.1
–
ent-7alpha-hydroxykaur-16-en-19-oate + reduced_flavodoxin + O2 <=> 6beta,7beta-Dihydroxykaurenoic_acid + flavin + H2O 1.14.14.107 ent-kaurenoic acid monooxygenase
–
glycolate + O2 <=> glyoxylate + H2O2 1.1.3.13 alcohol oxidase
1.1.3.15 (S)-2-hydroxy-acid oxidase
–
–
dTDP-3-O-methyl-4-oxo-2,6-dideoxy-L-mannose <=> dTDP-L-oleandrose not assigned
 –
L-alpha-glycerophosphate + NADP+ <=> dihydroxyacetone_phosphate + NADPH + H+ 1.1.1.156 glycerol 2-dehydrogenase (NADP+)
1.1.1.191 indole-3-acetaldehyde reductase (NADPH)
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldose reductase
1.1.1.261 sn-glycerol-1-phosphate dehydrogenase
1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)
1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)
1.1.1.94 glycerol-3-phosphate dehydrogenase [NAD(P)+]
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
–
–
–
–
–
–
–
–
–
(6E)-8-hydroxygeraniol + NADP+ <=> (6E)-8-oxogeranial + NADPH + H+ 1.1.1.324 8-hydroxygeraniol dehydrogenase
–
squalene + H2O <=> hopan-22-ol 4.2.1.129 squalene---hopanol cyclase
5.4.99.17 squalene---hopene cyclase
–
–
Stemmadenine <=> Catharanthine not assigned
 –
tryptamine <=> eserine not assigned
 –
gardneral + acetyl-CoA <=> vinorine + CoA 2.3.1.160 vinorine synthase
–
O2 + (S)-reticuline <=> H+ + H2O2 + (S)-scoulerine 1.21.3.3 reticuline oxidase
–
4-hydroxy-6-methylpretetramide + NADPH + O2 + H+ <=> 4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O 1.14.13.233 4-hydroxy-6-methylpretetramide 12a-monooxygenase
–
alpha-D-glucose + ADP <=> alpha-D-glucose_6-phosphate + AMP 2.7.1.147 ADP-specific glucose/glucosamine kinase
–
L-proline + a_quinone <=> L-pyrroline-5-carboxylate + a_quinol 1.5.5.2 proline dehydrogenase
1.5.99.B2
–
–
S-adenosyl-L-methionine + magnesium_protoporphyrin_monomethyl_ester + H2O <=> 131-hydroxy-magnesium-protoporphyrin_IX_13-monomethyl_ester + 5''-deoxyadenosine + L-methionine + H+ 1.21.98.3 anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase
–
(2E,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> all-trans-heptaprenyl_diphosphate + diphosphate 2.5.1.30 heptaprenyl diphosphate synthase
2.5.1.B41
–
–
germacrene_A + O2 + reduced_flavodoxin <=> germacra-1(10),4,11(13)-trien-12-ol + flavin + H2O 1.14.14.95 germacrene A hydroxylase
–
glycine + tetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH 1.4.1.f
1.4.4.2 glycine dehydrogenase (aminomethyl-transferring)
1.8.1.4 dihydrolipoyl dehydrogenase
2.1.2.10 aminomethyltransferase
–
–
–
–
(2S,5S)-5-carboxymethylproline + ATP <=> H+ + (3S,5S)-carbapenam_3-carboxylate + AMP + diphosphate 6.3.3.6 carbapenam-3-carboxylate synthase
–
coniferyl_alcohol + NADP+ <=> coniferyl_aldehyde + NADPH + H+ 1.1.1.194 coniferyl-alcohol dehydrogenase
1.1.1.195 cinnamyl-alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.90 aryl-alcohol dehydrogenase
1.1.1.91 aryl-alcohol dehydrogenase (NADP+)
–
–
–
–
–
validamycin_A + 2-oxoglutarate + O2 <=> validamycin_B + succinate + CO2 1.14.11.52 validamycin A dioxygenase
–
cathenamine + NADPH + H+ <=> Tetrahydroalstonine + NADP+ not assigned
 –
protodeoxyviolaceinate + O2 + NADPH + H+ <=> protoviolaceinate + NADP+ + H2O 1.14.13.217 protodeoxyviolaceinate monooxygenase
1.14.13.224 violacein synthase
–
–
resveratrol <=> piceatannol 1.14
–
L-valine + reduced_flavodoxin + O2 <=> N-hydroxy-L-valine + flavin + H2O 1.14.14.38 valine N-monooxygenase
1.14.14.39 isoleucine N-monooxygenase
–
–
H+ + versicolorone + NADPH + O2 <=> versiconol_acetate + NADP+ + H2O not assigned
 –
Avermectin_A1b_aglycone + dTDP-L-oleandrose <=> Avermectin_A1b_monosaccharide + dTDP 2.4.1
–
Gibberellin_A24 + 2-oxoglutarate + O2 <=> Gibberellin_A36 + succinate + CO2 1.14.11
–
nicotinate + 3,6-Dihydropyridine <=> Anatabine + CO2 not assigned
 –
5''''''-epi-Lividomycin_B <=> Lividomycin_B 5.1.3
–
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin_C + S-adenosyl-L-homocysteine + H+ 2.1.1.307 8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
–
5-Oxoavermectin_''''1b''''_aglycone + NADPH + H+ <=> Avermectin_B1b_aglycone + NADP+ not assigned
 –
dTDP-glucose + 2 NAD+ + H2O <=> dTDP-D-glucuronate + 2 NADH + 2 H+ 1.1.1
–
(9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate <=> 9,10-EOT + H2O 4.2.1.92 hydroperoxide dehydratase
–
dimethylallyl_diphosphate + adenine_in_tRNA <=> diphosphate + tRNA_containing_6-isopentenyladenosine 2.5.1.75 tRNA dimethylallyltransferase
–
(2E,6E)-farnesyl_diphosphate <=> (E)-alpha-bisabolene + diphosphate 4.2.3.38 alpha-bisabolene synthase
–
obtusifoliol + reduced_flavodoxin + O2 <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + flavin + H2O 1.14.14.154 sterol 14alpha-demethylase
–
2-hydroxyethylphosphonate + NAD+ <=> phosphonoacetaldehyde + NADH + H+ 1.1.1.309 phosphonoacetaldehyde reductase (NADH)
–
L-2-aminoadipate + L-cysteine + L-valine + ATP + H2O <=> H+ + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + AMP + diphosphate 6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
–
2''-deamino-2''-hydroxyparomamine + O2 <=> 2''-deamino-2''-hydroxy-6''-dehydroparomamine + H2O2 1.1.3
–
6''''''-hydroxyparomomycin + O2 <=> 6''''''-oxoparomomycin + H2O2 1.1.3
–
dTDP-L-olivose + NADP+ <=> dTDP-4-oxo-2,6-dideoxy-L-mannose + NADPH + H+ 1.1.1
–
(3Z)-hex-3-en-ol + NAD+ <=> cis-3-hexenal + NADH + H+ 1.1.1.1 alcohol dehydrogenase
–
(S)-scoulerine + reduced_flavodoxin + O2 <=> (S)-cheilanthifoline + flavin + 2 H2O 1.14.19.65 (S)-cheilanthifoline synthase
–
Lolitriol + dimethylallyl_diphosphate <=> Lolitrem_E + diphosphate 2.5.1
–
N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate <=> anthranilate + 5-phospho-alpha-D-ribose_1-diphosphate 2.4.2.18 anthranilate phosphoribosyltransferase
–
Emindole_SB + O2 + NADPH + H+ <=> 14,15-Epoxyemindole_SB + NADP+ + H2O 1.14.13
–
(-)-trans-isopiperitenol + NAD+ <=> (-)-isopiperitenone + NADH + H+ 1.1.1.223 isopiperitenol dehydrogenase
–
beta-tocopherol <=> alpha-tocopherol not assigned
 –
chlortetracycline + NADPH + H+ + O2 <=> 11a-Hydroxy-7-chlortetracycline + NADP+ + H2O 1.14.13.231 tetracycline 11a-monooxygenase
–
tabersonine <=> Lochnerinine not assigned
 –
pentalenene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> pentalen-13-al + H2O + oxidized_ferredoxin 1.14.15.32 pentalenene oxygenase
–
dTDP-acarviose-7-phosphate <=> acarbose_7'''-phosphate not assigned
 –
1-(2-aminophenyl)decane-1,3-dione <=> 2-heptyl-4(1H)-quinolone + H2O 2.3.1.230 2-heptyl-4(1H)-quinolone synthase
–
a_very-long-chain_(3R)-3-hydroxyacyl-CoA + NADP+ <=> a_very-long-chain_3-oxoacyl-CoA + NADPH + H+ 1.1.1.330 very-long-chain 3-oxoacyl-CoA reductase
–
4-Chloro-L-lysine + reduced_acceptor + O2 <=> 2-Amino-4-chloro-4-pentenoic_acid + acceptor + formaldehyde + NH3 + H2O 1.14.99
–
N-Acetyl-N6,O-didemethylpuromycin-5''-phosphate + S-adenosyl-L-methionine <=> N-Acetyl-O-demethylpuromycin-5''-phosphate + S-adenosyl-L-homocysteine 2
–
paraxanthine <=> 5-Acetylamino-6-formylamino-3-methyluracil 2.3.1.5 arylamine N-acetyltransferase
–
gibberellin_a9 + 2-oxoglutarate + O2 <=> gibberellin_A51 + succinate + CO2 1.14.11
1.14.11.13 gibberellin 2beta-dioxygenase
–
–
4''-Oxonebramine + NADPH + H+ <=> nebramine + NADP+ 1.1.1
–
2-methylacetoacetyl-CoA + CoA <=> propionyl-CoA + acetyl-CoA 2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase
–
–
NADP+ + (-)-menthol <=> H+ + (-)-menthone + NADPH 1.1.1.207 (-)-menthol dehydrogenase
–
H+ + glycine + succinyl-CoA <=> CO2 + CoA + 5-aminolevulinate 2.3.1.37 5-aminolevulinate synthase
–
1-carboxyvinyl_carboxyphosphonate + H+ <=> CO2 + (hydroxyphosphinyl)pyruvate 2.7.8.23 carboxyvinyl-carboxyphosphonate phosphorylmutase
–
(1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate <=> (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate 4.2.99.20 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
–
tRNAMet + L-glutamate + ATP <=> Glu-tRNAGln + diphosphate + AMP 6.1.1.17 glutamate---tRNA ligase
6.1.1.24 glutamate---tRNAGln ligase
–
–
gamma-tocotrienol <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol 5.5.1.24 tocopherol cyclase
–
S-adenosyl-L-methionine + caffeic_acid <=> H+ + ferulic_acid + S-adenosyl-L-homocysteine 2.1.1.104 caffeoyl-CoA O-methyltransferase
2.1.1.68 caffeate O-methyltransferase
–
–
5-hydroxyconiferaldehyde + NADPH <=> 5-hydroxyconiferyl_alcohol + NADP+ 1.1.1.195 cinnamyl-alcohol dehydrogenase
–
H2O + isochorismate <=> pyruvate + (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate 3.3.2.1 isochorismatase
–
S-adenosyl-L-methionine + Pretetramid <=> S-adenosyl-L-homocysteine + 6-methylpretetramide + H+ 2.1.1
2.1.1.M31
–
–
dodecanoyl-[acyl-carrier_protein] + H2O <=> [acyl-carrier_protein] + laurate + H+ 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase
3.1.2.21 dodecanoyl-[acyl-carrier-protein] hydrolase
–
–
ATP + formylglycinamide_ribonucleotide + L-glutamine + H2O <=> H+ + L-glutamate + ADP + phosphate + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine 6.3.5.3 phosphoribosylformylglycinamidine synthase
–
(2E,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> di-trans-poly-cis-decaprenyl_diphosphate + diphosphate 2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]
2.5.1.91 all-trans-decaprenyl-diphosphate synthase
–
–
L-serine + indole <=> L-tryptophan + H2O 4.1.99.1 tryptophanase
4.2.1.122 tryptophan synthase (indole-salvaging)
4.2.1.20 tryptophan synthase
–
–
–
acetyl-CoA + malonyl-CoA + NADPH + H+ <=> 2-hydroxy-5-methyl-1-naphthoate + CoA + CO2 + H2O + NADP+ 2.3.1.237 neocarzinostatin naphthoate synthase
–
S-adenosyl-L-methionine + 2-methoxy-6-polyprenyl-1,4-benzoquinol <=> 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-homocysteine + H+ 2.1.1.201 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
–
3''-phosphoadenylyl-sulfate + desulfoglucotropaeolin <=> adenosine_3,5''-bisphosphate + benzylglucosinolate + H+ 2.8.2.24 aromatic desulfoglucosinolate sulfotransferase
2.8.2.38 aliphatic desulfoglucosinolate sulfotransferase
–
–
5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + H2O <=> 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + phosphate 3.1.3.104 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
–
an_alcohol + NAD+ <=> an_aldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.103 L-threonine 3-dehydrogenase
1.1.1.11 D-arabinitol 4-dehydrogenase
1.1.1.14 L-iditol 2-dehydrogenase
1.1.1.17 mannitol-1-phosphate 5-dehydrogenase
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.192 long-chain-alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.202 1,3-propanediol dehydrogenase
1.1.1.21 aldose reductase
1.1.1.244 methanol dehydrogenase
1.1.1.245 cyclohexanol dehydrogenase
1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase
1.1.1.306 S-(hydroxymethyl)mycothiol dehydrogenase
1.1.1.307 D-xylose reductase
1.1.1.6 glycerol dehydrogenase
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.73 octanol dehydrogenase
1.1.1.77 lactaldehyde reductase
1.1.1.78 methylglyoxal reductase (NADH)
1.1.1.80 isopropanol dehydrogenase (NADP+)
1.1.1.B4
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
novclobiocin_104 + (1H-pyrrole-2-carbonyl)-[peptidyl-carrier_protein] <=> Clorobiocin not assigned
 –
(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2 1.10.3.16 dihydrophenazinedicarboxylate synthase
–
festuclavine + NAD+ <=> 6,8-dimethyl-6,7-didehydroergoline + NADH + H+ 1.5.1.44 festuclavine dehydrogenase
–
stemod-13(17)-ene + 3 O2 + 3 reduced_flavodoxin <=> syn-stemoden-19-oate + 3 flavin + 4 H2O 1.14.14.111 9beta-pimara-7,15-diene oxidase
–
3-geranyl-4-hydroxybenzoate + H+ <=> 2-polyprenylphenol + CO2 4.1.1.98 4-hydroxy-3-polyprenylbenzoate decarboxylase
–
S-adenosyl-L-methionine + (S)-tetrahydrocolumbamine <=> H+ + S-adenosyl-L-homocysteine + (-)-tetrahydropalmatine 2.1.1.117 (S)-scoulerine 9-O-methyltransferase
2.1.1.89 tetrahydrocolumbamine 2-O-methyltransferase
–
–
N6-(2-isopentenyl)adenine + reduced_flavodoxin + O2 <=> trans-zeatin + flavin + H2O not assigned
 –
NADP+ + bilirubin <=> Biliverdin + NADPH + H+ 1.3.1.24 biliverdin reductase
–
2-aminobenzoyl-CoA + malonyl-CoA + H+ <=> 4-hydroxy-2-methylquinoline + CoA + CO2 2.3.1
–
ent-kaur-16-en-19-al + reduced_flavodoxin + O2 <=> ent-kaur-16-en-19-oate + flavin + H2O 1.14.14.86 ent-kaurene monooxygenase
–
copalyl_diphosphate + H2O <=> phyllocladan-16alpha-ol + diphosphate 4.2.3.45 phyllocladan-16alpha-ol synthase
–
acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H+ 2.3.1.197 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase
–
L-tyrosine + O2 <=> L-Dopa 1.10.3.1 catechol oxidase
1.14.18.1 tyrosinase
–
–
alpha-D-glucose_1-phosphate + UTP + H+ <=> UDP-glucose + diphosphate 2.7.7.23 UDP-N-acetylglucosamine diphosphorylase
2.7.7.24 glucose-1-phosphate thymidylyltransferase
2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
2.7.7.33 glucose-1-phosphate cytidylyltransferase
2.7.7.64 UTP-monosaccharide-1-phosphate uridylyltransferase
2.7.7.9 UTP---glucose-1-phosphate uridylyltransferase
–
–
–
–
–
–
phosphoribulosylformimino-AICAR-phosphate + L-glutamine <=> H+ + L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol_3-phosphate + 5-aminoimidazole-4-carboxamide_ribonucleotide 2.4.2
4.3.1.B2
4.3.2.10 imidazole glycerol-phosphate synthase
–
–
–
citral + NAD+ + H2O <=> trans-geranic_acid + NADH + H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.36 retinal dehydrogenase
1.2.1.86 geranial dehydrogenase
1.2.1.94 farnesal dehydrogenase
–
–
–
–
3-[(2S,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate + L-phenylalanine <=> L-dihydroanticapsin + phenylpyruvate 2.6.1
–
tetracenomycin_A2 + O2 + NADPH + H+ <=> tetracenomycin_C + H2O + NADP+ 1.14.13.200 tetracenomycin A2 monooxygenase-dioxygenase
–
S-adenosyl-L-methionine + demethyldecarbamoylnovobiocin <=> S-adenosyl-L-homocysteine + decarbamoylnovobiocin + H+ 2.1.1.285 demethyldecarbamoylnovobiocin O-methyltransferase
–
kanamycin_B + 2-oxoglutarate + O2 <=> 2''-dehydrokanamycin_A + succinate + NH3 + CO2 1.14.11.37 kanamycin B dioxygenase
–
O-phospho-L-serine + H2O <=> L-serine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.15 histidinol-phosphatase
3.1.3.16 protein-serine/threonine phosphatase
3.1.3.2 acid phosphatase
3.1.3.20 phosphoglycerate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.3 phosphoserine phosphatase
3.1.3.48 protein-tyrosine-phosphatase
3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
3.1.3.8 3-phytase
–
–
–
–
–
–
–
–
–
–
–
3-Amino-4-hydroxybenzoic_acid + N-acetyl-L-cysteine + O2 + H+ <=> grixazone_B + H2O + CO2 1.10.3.15 grixazone synthase
–
NADP+ + dihydrozeatin <=> H+ + trans-zeatin + NADPH 1.3.1.69 zeatin reductase
–
beta-cryptoxanthin + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> zeaxanthin + H2O + oxidized_ferredoxin 1.14
1.14.13
1.14.15.24 beta-carotene 3-hydroxylase
–
–
–
geraniol + NAD+ <=> citral + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.183 geraniol dehydrogenase (NADP+)
1.1.1.198 (+)-borneol dehydrogenase
1.1.1.347 geraniol dehydrogenase (NAD+)
1.1.1.90 aryl-alcohol dehydrogenase
–
–
–
–
–
Pantetheine_4''-phosphate + H2O <=> pantetheine + phosphate 3.1.3
–
S-adenosyl-L-methionine + phenazine-1-carboxylic_acid <=> 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine 2.1.1.327 phenazine-1-carboxylate N-methyltransferase
–
6-Oxocampestanol + O2 + NADPH <=> Cathasterone + NADP+ + H2O 1.14.13
–
3''''-Oxogentamicin_A2 + L-glutamate <=> 3''''-Amino-3''''-deoxygentamicin_A2 + 2-oxoglutarate 2.6.1
–
Terpendole_I + dimethylallyl_diphosphate <=> Terpendole_J + diphosphate 2.5.1
–
gibberellin_a9 <=> 2,3-Dehydro-gibberellin_A9 1.14.11
–
dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-4-dehydro-beta-L-rhamnose 5.1.3.13 dTDP-4-dehydrorhamnose 3,5-epimerase
–
afzelechin + NADP+ + H2O <=> cis-3,4-leucopelargonidin + NADPH + H+ 1.17.1.3 leucoanthocyanidin reductase
–
DELTA5,7-avenasterol <=> isofucosterol 1.3.1.21 7-dehydrocholesterol reductase
–
theophylline + NADPH + O2 + H+ <=> 1-Methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.179 methylxanthine N3-demethylase
–
3-devinyl-3-(1-hydroxyethyl)chlorophyllide_a + ADP + oxidized_ferredoxin + phosphate <=> 3-devinyl-3-(1-hydroxyethyl)chlorophyllide_a + ATP + reduced_ferredoxin_[iron-sulfur]_cluster + H2O + H+ 1.3.7.15 chlorophyllide a reductase
–
2-deoxy-scyllo-inosamine + NADP+ <=> 3-amino-2,3-dideoxy-scyllo-inosose + NADPH + H+ 1.1.1.329 2-deoxy-scyllo-inosamine dehydrogenase
–
O-phospho-L-serine + 2-oxoglutarate <=> L-glutamate + 3-phosphohydroxypyruvate 2.6.1.52 phosphoserine transaminase
–
dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-gulose 5.1.3.27 dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase
–
echinenone + 2 reduced_ferredoxin_[iron-sulfur]_cluster + H+ + O2 <=> 3''-hydroxyechinenone + 2 oxidized_ferredoxin + H2O 1.14.13
1.14.15.24 beta-carotene 3-hydroxylase
–
–
oxalosuccinate + H+ <=> 2-oxoglutarate + CO2 1.1.1.42 isocitrate dehydrogenase (NADP+)
–
100-2 + dTDP-L-rhodinose <=> aggreticin + dTDP not assigned
 –
geranylgeranyl_diphosphate <=> diphosphate + casbene 4.2.3.8 casbene synthase
–
D-mannose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.8 mannose-6-phosphate isomerase
5.3.1.9 glucose-6-phosphate isomerase
–
–
(2E,6E)-farnesyl_diphosphate <=> pentalenene + diphosphate 4.2.3.7 pentalenene synthase
–
L-2-aminoadipate_adenylate + Holo-Lys2 <=> alpha-Aminoadipoyl-S-acyl_enzyme + AMP 1.2.1.95 L-2-aminoadipate reductase
–
(2E,6E)-farnesyl_diphosphate <=> (-)-vetispiradiene + diphosphate 4.2.3.21 vetispiradiene synthase
–
dTDP-4-ethylamino-3-O-methyl-2,4-dideoxy-L-threo-pentopyranose + Calicheamicin_PsAg <=> dTDP + Calicheamicin_alpha1(I) 2.4.2
–
7,9,12-Decaketide_intermediate_2 <=> 7,9,12-Decaketide_intermediate_3 + 2 H2O 4.2.1
–
alpha-D-glucose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.9 glucose-6-phosphate isomerase
–
dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O 4.2.1.159 dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
–
dimethylallyl_diphosphate + 5,10-dihydrophenazine_1-carboxylate <=> diphosphate + 5,10-dihydro-9-dimethylallylphenazine_1-carboxylate 2.5.1.121 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
–
S-adenosyl-L-methionine + protein_C-terminal_S-farnesyl-L-cysteine <=> S-adenosyl-L-homocysteine + protein_C-terminal_S-farnesyl-L-cysteine_methyl_ester 2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase
–
tetracycline + O2 + Cl- + FADH2 <=> 7-chlorotetracycline + H2O + FAD + H+ 1.14.19.49 tetracycline 7-halogenase
–
S-adenosyl-L-methionine + (S)-corytuberine <=> S-adenosyl-L-homocysteine + (S)-magnoflorine + H+ 2.1.1.337 reticuline N-methyltransferase
–
glycine + acceptor <=> cyanide + CO2 + reduced_acceptor 1.4.99.5 glycine dehydrogenase (cyanide-forming)
–
7,9,12-Decaketide_intermediate_1 + NADPH + H+ <=> 7,9,12-Decaketide_intermediate_2 + NADP+ 1.1.1
–
tryprostatin_A + reduced_flavodoxin + O2 <=> fumitremorgin_C + flavin + 2 H2O 1.14.19.71 fumitremorgin C synthase
–
(+)-trans-carveol + NAD+ <=> (S)-carvone + NADH + H+ 1.1.1.275 (+)-trans-carveol dehydrogenase
–
S-adenosyl-L-methionine + a_3-vinyl_bacteriochlorophyllide_d <=> S-adenosyl-L-homocysteine + a_bacteriochlorophyllide_c 2.1.1.333 bacteriochlorophyllide d C-20 methyltransferase
–
7-chloro-L-tryptophan + O2 <=> 2-imino-3-(7-chloroindol-3-yl)propanoate + H2O2 + H+ 1.4.3.23 7-chloro-L-tryptophan oxidase
–
tabersonine <=> 19-Hydroxytabersonine not assigned
 –
Caffeine + NADPH + O2 + H+ <=> paraxanthine + NADP+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
1.14.14.1 unspecific monooxygenase
–
–
–
S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin_C <=> 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin_C + S-adenosyl-L-homocysteine + H+ 2.1.1.306 8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase
–
3,5-diphosphomevalonate + H+ <=> isopentenyl_phosphate + CO2 + phosphate 4.1.1.110 bisphosphomevalonate decarboxylase
–
L-arogenate + NAD+ <=> L-tyrosine + CO2 + NADH 1.3.1.12 prephenate dehydrogenase
1.3.1.43 arogenate dehydrogenase
1.3.1.78 arogenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]
–
–
–
–
2'',7-Dihydroxy-4'',5''-methylenedioxyisoflavone + NADPH + H+ <=> (+)-Sophorol + NADP+ 1.3.1.45 2'-hydroxyisoflavone reductase
–
paromomycin <=> paromomycin 5.1.3
–
futalosine + H2O <=> dehypoxanthine_futalosine + hypoxanthine 3.2.2.26 futalosine hydrolase
–
N-acetylphosphinothricin + H2O <=> Phosphinothricin + acetate not assigned
 –
L-tyrosine + O2 + reduced_flavodoxin <=> N-hydroxy-L-tyrosine + flavin + H2O 1.14.14.36 tyrosine N-monooxygenase
–
6-phospho-D-glucono-1,5-lactone + H2O <=> H+ + 6-phosphogluconate 3.1.1.31 6-phosphogluconolactonase
–
ferruginol + reduced_flavodoxin + O2 <=> salviol + flavin + H2O 1.14.14.62 salviol synthase
–
Hygrine <=> tropinone not assigned
 –
(4R)-ipsdienol + NADP+ <=> ipsdienone + NADPH + H+ 1.1.1.386 ipsdienol dehydrogenase
–
O-acetyl-L-serine + Hydroxyurea <=> O-ureido-L-serine + acetate + H+ 2.5.1.51 beta-pyrazolylalanine synthase
2.6.99.3 O-ureido-L-serine synthase
–
–
9beta-pimara-7,15-diene + reduced_flavodoxin + O2 <=> 9beta-pimara-7,15-diene-3beta-ol + flavin + H2O 1.14.14.68 syn-pimaradiene 3-monooxygenase
–
5''''-phosphoribostamycin + H2O <=> ribostamycin + phosphate 3.1.3.88 5''-phosphoribostamycin phosphatase
–
O-phospho-L-serine + L-glutamate <=> N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate 2.5.1.140 N-(2-amino-2-carboxyethyl)-L-glutamate synthase
–
S-adenosyl-L-methionine + sterigmatocystin <=> 8-O-methylsterigmatocystin + S-adenosyl-L-homocysteine + H+ 2.1.1.110 sterigmatocystin 8-O-methyltransferase
–
fumigaclavine_A + dimethylallyl_diphosphate <=> fumigaclavine_C + diphosphate 2.5.1.100 fumigaclavine A dimethylallyltransferase
–
methyl_ecgonine + benzoyl-CoA <=> cocaine + CoA 2.3.1
–
S-adenosyl-L-methionine + erythromycin_D <=> S-adenosyl-L-homocysteine + erythromycin_B + H+ 2.1.1.254 erythromycin 3''-O-methyltransferase
–
formononetin + reduced_flavodoxin + O2 <=> 2''-hydroxyformononetin + flavin + H2O 1.14.14.89 4'-methoxyisoflavone 2'-hydroxylase
1.14.14.90 isoflavone 2'-hydroxylase
–
–
acetyl-CoA + (3Z)-hex-3-en-ol <=> cis-3-hexen-1-yl_acetate + CoA 2.3.1.195 (Z)-3-hexen-1-ol acetyltransferase
2.3.1.224 acetyl-CoA-benzylalcohol acetyltransferase
2.3.1.84 alcohol O-acetyltransferase
–
–
–
Polyphosphate + alpha-D-glucose <=> Polyphosphate + alpha-D-glucose_6-phosphate 2.7.1.63 polyphosphate---glucose phosphotransferase
–
5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NADP+ <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H+ 1.1.1.193 5-amino-6-(5-phosphoribosylamino)uracil reductase
–
S-adenosyl-L-methionine + Zymosterol <=> H+ + S-adenosyl-L-homocysteine + fecosterol 2.1.1.142 cycloartenol 24-C-methyltransferase
2.1.1.143 24-methylenesterol C-methyltransferase
2.1.1.41 sterol 24-C-methyltransferase
–
–
–
S-adenosyl-L-methionine + Fe-coproporphyrin_III <=> heme + CO2 + 5''-deoxyadenosine + L-methionine 1.3.98.6 AdoMet-dependent heme synthase
–
atropine + H2O <=> H+ + tropate + Tropine 3.1.1.10 tropinesterase
–
bisdemethoxycurcumin <=> demethoxycurcumin not assigned
 –
geranyl_diphosphate + 1,4-dihydroxy-2-naphthoate <=> a_demethylmenaquinol + diphosphate + CO2 2.5.1.74 1,4-dihydroxy-2-naphthoate polyprenyltransferase
–
D-glyceraldehyde_3-phosphate + L-arginine <=> N2-(2-carboxyethyl)-L-arginine + phosphate + H+ 2.5.1.66 N2-(2-carboxyethyl)arginine synthase
–
eriodictyol + reduced_flavodoxin + O2 <=> luteolin + flavin + H2O 1.14.14.162 flavanone 2-hydroxylase
1.14.19.76 flavone synthase II
–
–
palustradiene <=> Palustradienol 1.14.13
–
S-adenosyl-L-methionine + 3-Hydroxy-5-iodo-2-methoxyorsellinate-[acp] <=> S-adenosyl-L-homocysteine + 5-Iodo-2,3-dimethoxyorsellinate-[acp] 2.1.1
–
protoviolaceinate + O2 + NADH + H+ <=> violaceinate + NAD+ + H2O 1.14.13.224 violacein synthase
–
copalyl_diphosphate <=> pimara-8(14),15-diene + diphosphate 4.2.3.147 pimaradiene synthase
–
15-cis-phytoene + plastoquinone <=> 15,9''-di-cis-phytofluene + plastoquinol 1.3.5.5 15-cis-phytoene desaturase
–
2,3-Dehydro-UWM6 + L-isoleucine <=> Jadomycin_A + CO2 + H2O not assigned
 –
chlorophyll_a + H+ <=> pheophytin_a + Mg2+ 4.99.1.10 magnesium dechelatase
–
L-gamma-Glutamyl-(3R)-L-beta-ethynylserine + H2O <=> L-beta-Ethynylserine + L-glutamate not assigned
 –
NDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose <=> NDP-2-amino-4-oxo-2,6-dideoxy-D-galactose not assigned
 –
N6-(delta2-Isopentenyl)-adenosine_5''-monophosphate + H2O <=> N6-isopentenyladenosine + phosphate not assigned
 –
DELTA1-piperideine + Pelletierine <=> L-(+)-Anaferine not assigned
 –
gardneral <=> gardneral not assigned
 –
tRNA_containing_6-isopentenyladenosine <=> cis-Prenyl-tRNA not assigned
 –
S-Anthraniloyl-L-cysteinyl-protein + malonyl-CoA <=> 2-aminobenzoylacetyl-CoA + CO2 + S-Anthraniloyl-L-cysteinyl-protein 2.3.1.262 anthraniloyl-CoA anthraniloyltransferase
–
narbomycin + 4 reduced_ferredoxin_[iron-sulfur]_cluster + 4 H+ + 2 O2 <=> novapikromyin + 4 oxidized_ferredoxin + 2 H2O 1.14.15.33 pikromycin synthase
–
L-tyrosine + pC3'p + ATP <=> L-Tyrosyl-[pcp] + AMP + diphosphate not assigned
 –
baccatin_III + (3R)-3-amino-3-phenylpropanoyl-CoA <=> 3''-N-Debenzoyl-2''-deoxytaxol + CoA 2.3.2
–
17-O-acetylnorajmaline + H2O <=> norajmaline + acetate + H+ 3.1.1.80 acetylajmaline esterase
–
3''-N-Debenzoyl-2''-deoxytaxol + reduced_acceptor + O2 <=> 3''-N-Debenzoyltaxol + acceptor + H2O 1.14
–
divinyl_protochlorophyllide_a + NADPH <=> divinyl_chlorophyllide_a + NADP+ 1.3.1.33 protochlorophyllide reductase
–
(S)-beta-Tyrosyl-[pcp] <=> 3-(4-Hydroxyphenyl)-3-oxopropanoyl-[pcp] not assigned
 –
dTDP-4-oxo-5-C-methyl-L-rhamnose <=> dTDP-4-amino-4,6-dideoxy-5-C-methyl-D-allose not assigned
 –
naringenin + reduced_flavodoxin + O2 <=> eriodictyol + flavin + H2O 1.14.14.81 flavanoid 3',5'-hydroxylase
1.14.14.82 flavonoid 3'-monooxygenase
–
–
2,3-Epoxymenaquinone + peptidyl-4-carboxyglutamate + H2O <=> menaquinol + peptidyl-glutamate + CO2 + O2 4.1.1.90 peptidyl-glutamate 4-carboxylase
–
succinate + ITP + CoA <=> succinyl-CoA + IDP + phosphate 6.2.1.4 succinate---CoA ligase (GDP-forming)
–
5-enolpyruvylshikimate_3-phosphate <=> phosphate + chorismate 4.2.3.5 chorismate synthase
–
(3R,4R)-7,2''-dihydroxy-4''-methoxyisoflavanol + NADP+ <=> vestitone + NADPH + H+ 1.1.1.348 (3R)-2'-hydroxyisoflavanone reductase
–
7-methyl-3-oxooct-6-enoyl-CoA + CoA <=> 5-methylhex-4-enoyl-CoA + acetyl-CoA 2.3.1
2.3.1.16 acetyl-CoA C-acyltransferase
–
–
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> cucurbitadienol 5.4.99.33 cucurbitadienol synthase
–
(6E)-8-methylnon-6-enoyl-CoA + vanillylamine <=> capsaicin + CoA + H+ 2.3.2.35 capsaicin synthase
–
(E)-4-hydroxy-3-methylbut-2-en-1-yl_diphosphate + oxidized_ferredoxin + H2O <=> 2-C-methyl-D-erythritol_2,4-cyclodiphosphate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.17.7.1 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)
–
(2E,6E)-farnesyl_diphosphate <=> amorpha-4,11-diene + diphosphate 4.2.3.24 amorpha-4,11-diene synthase
–
Ansamitocinoside_P-3 + Carbamoyl_phosphate <=> 4''''-O-Carbamoyl_ansamitocinoside_P-3 + phosphate 2.1.3
–
pantothenate + H2O <=> beta-Alanine + (R)-pantoate 3.5.1.22 pantothenase
–
3-amino-4,7-dihydroxycoumarin <=> 3-Amino-4,7-dihydroxy-8-chlorocoumarin not assigned
 –
(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate <=> 12-oxododecenoic_acid + cis-3-hexenal 4.2.1.M17
4.2.1.M19
–
–
6alpha-Hydroxycampestanol <=> 6-Oxocampestanol not assigned
 –
Penicillin_N + 2-oxoglutarate + O2 <=> deacetoxycephalosporin_C + succinate + CO2 + H2O 1.14.20.1 deacetoxycephalosporin-C synthase
–
gentamicin_X2 + methylcobalamin + S-adenosyl-L-methionine + H+ + e- <=> geneticin + Cobalamin + 5''-Deoxyadenosine + L-methionine 2.1.1
–
S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine <=> S-adenosyl-L-homocysteine + deacetoxyvindoline + H+ 2.1.1.99 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
–
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 1.10.3.16 dihydrophenazinedicarboxylate synthase
–
O-acetyl-L-serine + Sulfide <=> L-cysteine + acetate + H+ 2.5.1.47 cysteine synthase
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
2.5.1.65 O-phosphoserine sulfhydrylase
4.2.1.22 cystathionine beta-synthase
4.2.1.50 pyrazolylalanine synthase
4.4.1.9 L-3-cyanoalanine synthase
–
–
–
–
–
–
myrcene + reduced_flavodoxin + O2 <=> (4R)-ipsdienol + flavin + H2O 1.14.14.31 ipsdienol synthase
–
Cinnamic_acid + NAD+ + H2O <=> benzoate + acetate + NADH + H+ not assigned
 –
2-Methyl-3-n-amyl-dihydropyrrole + FAD <=> 2-Methyl-3-n-amyl-pyrrole + FADH2 not assigned
 –
alpha-3,4''-anhydrovinblastine + H2O <=> vinblastine not assigned
 –
2-oxoglutarate + CoA + NAD+ <=> succinyl-CoA + CO2 + NADH 1.2.1.ak
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
1.8.1.4 dihydrolipoyl dehydrogenase
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
–
–
–
–
–
L-tyrosine + H2O2 <=> L-Dopa + H2O 1.11.2.6 L-tyrosine peroxygenase
1.14.18.1 tyrosinase
–
–
homoisocitrate + NAD+ <=> 2-oxoadipate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.42 isocitrate dehydrogenase (NADP+)
1.1.1.87 homoisocitrate dehydrogenase
–
–
–
(+)-cis-isopulegone <=> (R)-pulegone 5.3.3
–
Tetrahydroalstonine + reduced_flavodoxin + O2 <=> Alstonine + flavin + 2 H2O + 2 H+ 1.14.14
–
Jadomycin_A <=> Jadomycin_B 2.4.1
–
(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + reduced_flavodoxin + O2 <=> 3-dehydro-6-deoxoteasterone + flavin + H2O 1.14.14.147 3-epi-6-deoxocathasterone 23-monooxygenase
–
Zymosterol + NADP+ <=> H+ + zymosterone + NADPH 1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62 17beta-estradiol 17-dehydrogenase
–
–
–
(2E,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> all-trans-hexaprenyl_diphosphate + diphosphate 2.5.1.82 hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
2.5.1.83 hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
–
–
butyryl-CoA + NAD+ <=> crotonyl-CoA + NADH + H+ 1.3.1.44 trans-2-enoyl-CoA reductase (NAD+)
1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
–
–
4-coumaroyl-CoA + malonyl-CoA + H2O + H+ <=> CoA + bisdemethoxycurcumin + CO2 2.3.1.211 bisdemethoxycurcumin synthase
–
dihydrochanoclavine-I_aldehyde + NADP+ <=> chanoclavine-I_aldehyde + NADPH + H+ 1.3.1.100 chanoclavine-I aldehyde reductase
–
D-glucose_6-phosphate <=> 2-deoxy-scyllo-inosose + phosphate 4.2.3.124 2-deoxy-scyllo-inosose synthase
–
4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O <=> 2-[(2''-methylsulfanyl)ethyl]malate + CoA + H+ 2.3.3.17 methylthioalkylmalate synthase
–
1-Methylpyrrolinium <=> methyl_ecgonine not assigned
 –
Deacetylcolchicine + acetyl-CoA <=> H+ + Colchicine + CoA 2.3.1
–
S-adenosyl-L-methionine + delta-tocopherol <=> S-adenosyl-L-homocysteine + beta-tocopherol + H+ 2.1.1.95 tocopherol C-methyltransferase
–
(S)-2-amino-6-oxohexanoate + NADP+ + H2O <=> L-2-aminoadipate + NADPH + H+ 1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase
–
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> thalianol 5.4.99.31 thalianol synthase
–
N3-fumaroyl-L-2,3-diaminopropanoic_acid + L-glutamine + ATP + H2O <=> N3-fumarylcarboxyamido-L-2,3-diaminopropionic_acid + L-glutamate + ADP + phosphate 6.3.5
–
sinapyl_alcohol + NADP+ <=> sinapaldehyde + NADPH + H+ 1.1.1.195 cinnamyl-alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
–
–
trans-zeatin + UDP-D-xylose <=> H+ + O-beta-D-xylosylzeatin + UDP 2.4.1.203 trans-zeatin O-beta-D-glucosyltransferase
2.4.2.40 zeatin O-beta-D-xylosyltransferase
–
–
H+ + 4-coumaroyl-CoA + malonyl-CoA <=> naringenin_chalcone + CO2 + CoA 2.3.1.159 acridone synthase
2.3.1.74 chalcone synthase
–
–
Pelletierine <=> N-Methylpelletierine not assigned
 –
daunorubicin + NADPH + H+ + O2 <=> doxorubicin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase
–
vinblastine <=> vincristine not assigned
 –
chorismate + L-glutamine <=> (2S)-2-amino-4-deoxy-chorismate + L-glutamate 2.6.1.85 aminodeoxychorismate synthase
2.6.1.86 2-amino-4-deoxychorismate synthase
–
–
13-dihydrodaunorubicin + NADPH + H+ + O2 <=> daunorubicin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase
–
NAD+ + bilirubin <=> Biliverdin + NADH + H+ 1.3.1.24 biliverdin reductase
–
(S)-N-methylcoclaurine + reduced_flavodoxin + O2 <=> (S)-3''-hydroxy-N-methylcoclaurine + flavin + H2O 1.14.14.102 N-methylcoclaurine 3'-monooxygenase
–
2,3-Dehydro-gibberellin_A9 <=> gibberellin_GA7 1.14.11
–
L-tryptophan + O2 <=> H+ + 2-imino-3-(indol-3-yl)propanoate + H2O2 1.4.3
1.4.3.23 7-chloro-L-tryptophan oxidase
–
–
deoxyshikonin <=> shikonin not assigned
 –
primary_fluorescent_chlorophyll_catabolite + oxidized_ferredoxin <=> red_chlorophyll_catabolite + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.12 red chlorophyll catabolite reductase
–
geranyl_diphosphate <=> citral not assigned
 –
19-Chloroproansamitocin <=> 20-O-Methyl-19-chloroproansamitocin not assigned
 –
acyl-CoA + 2-acyl-sn-glycerol_3-phosphate <=> phosphatidic_acid + CoA 2.3.1.52 2-acylglycerol-3-phosphate O-acyltransferase
–
1alpha(S)-6-O-methyl-N-deacetylisoipecoside_aglycone <=> Protoemetine not assigned
 –
UDP-glucose + betanidin <=> H+ + betanin + UDP 2.4.1
–
6''-Oxogentamicin_X2 + L-glutamate <=> JI-20A + 2-oxoglutarate 2.6.1
–
(+)-bornyl-diphosphate + H2O <=> (+)-borneol + diphosphate 3.1.3
3.1.7.3 monoterpenyl-diphosphatase
–
–
(+)-epi-isozizaene + O2 + NADPH + H+ <=> (5S)-albaflavenol + H2O + NADP+ 1.14.13.106 epi-isozizaene 5-monooxygenase
–
acetyl-CoA + serotonin <=> H+ + CoA + N-acetylserotonin 2.3.1.5 arylamine N-acetyltransferase
2.3.1.87 aralkylamine N-acetyltransferase
–
–
S-adenosyl-L-methionine + 5-hydroxyferuloyl-CoA <=> H+ + S-adenosyl-L-homocysteine + sinapoyl-CoA 2.1.1.104 caffeoyl-CoA O-methyltransferase
–
S-adenosyl-L-methionine + 6-geranylgeranyl-2-methylbenzene-1,4-diol <=> S-adenosyl-L-homocysteine + 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H+ 2.1.1.295 2-methyl-6-phytyl-1,4-hydroquinone methyltransferase
–
(S)-2-hydroxy-2-ethyl-3-oxobutanoate <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate 1.1.1.86 ketol-acid reductoisomerase (NADP+)
5.4.99.3 2-acetolactate mutase
–
–
(S)-2-amino-6-oxohexanoate + NAD+ + H2O <=> L-2-aminoadipate + NADH + H+ 1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase
–
20-oxo-5-O-beta-mycaminosyltylactone + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 5-O-beta-mycaminosyltylonolide + H2O + oxidized_ferredoxin 1.14.15.34 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
–
S-adenosyl-L-methionine + Coproporphyrinogen-III <=> protoporphyrinogen-IX + CO2 + L-methionine + 5''-deoxyadenosine 1.3.98.3 coproporphyrinogen dehydrogenase
–
9beta-pimara-7,15-dien-19-oate <=> 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide not assigned
 –
chanoclavine-I_aldehyde <=> 6,8-dimethyl-6,7,8,9-tetradehydroergoline + H2O not assigned
 –
Isobutyronitrile + reduced_flavodoxin + O2 <=> acetone_cyanohydrin + flavin + H2O 1.14.14.41 (E)-2-methylbutanal oxime monooxygenase
–
(-)-alpha-terpineol <=> 1,8-cineole 4.2.3.108 1,8-cineole synthase
–
Coproporphyrinogen-III + O2 <=> coproporphyrin_III + H2O2 1.3.3.15 coproporphyrinogen III oxidase (coproporphyrin-forming)
1.3.3.4 protoporphyrinogen oxidase
–
–
(R)-reticuline + NADP+ <=> 1,2-dehydroreticuline + NADPH + H+ 1.5.1.27 1,2-dehydroreticulinium reductase (NADPH)
–
(S)-malate <=> fumarate + H2O 4.2.1.2 fumarate hydratase
4.2.1.34 (S)-2-methylmalate dehydratase
–
–
(-)-bursehernin + reduced_flavodoxin + O2 <=> (-)-5''-demethylyatein + flavin + H2O 1.14.14.131 bursehernin 5'-monooxygenase
–
Zymosterol + NADPH <=> 5alpha-cholesta-8-en-3beta-ol + NADP+ 1.3.1.72 Delta24-sterol reductase
–
S-adenosyl-L-methionine + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + TDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + H+ 2.1.1.234 dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase
2.1.1.235 dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase
–
–
2-Undecylpyrrole + NAD+ + H2O <=> 4-Keto-2-undecylpyrroline + NADH + H+ 1.17.1
–
theophylline + NADPH + O2 + H+ <=> 3-Methylxanthine + NADP+ + formaldehyde + H2O 1.14.13.178 methylxanthine N1-demethylase
–
octanoyl-CoA + L-Cysteinyl-protein <=> S-Octanoyl-L-cysteinyl-protein + CoA 2.3.1.230 2-heptyl-4(1H)-quinolone synthase
–
D-ribulose_5-phosphate <=> D-xylulose_5-phosphate 5.1.3.1 ribulose-phosphate 3-epimerase
5.3.1.34 D-erythrulose 4-phosphate isomerase
–
–
acyl_phosphate + sn-glycerol_3-phosphate <=> lysophosphatidic_acid + phosphate 2.3.1.275 acyl phosphate:glycerol-3-phosphate acyltransferase
–
24(28)-methylene_lophenol + O2 + ferricytochrome_b5 + H+ <=> 3beta-hydroxyergosta-7,24(241)-dien-4alpha-carboxylate + ferricytochrome_b5 + H2O 1.14.18.11 plant 4alpha-monomethylsterol monooxygenase
–
2-oxoadipate + NAD+ + CoA <=> CO2 + NADH + glutaryl-CoA 1.2.1.ak
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
1.8.1.4 dihydrolipoyl dehydrogenase
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
–
–
–
–
O2 + linolenic_acid <=> (9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate 1.13.11.12 linoleate 13S-lipoxygenase
1.13.11.45 linoleate 11-lipoxygenase
–
–
NDP-1-epi-valienol + 2-Amino-1,5-anhydro-2-deoxyglucitol <=> Salbostatin_6''-phosphate + NDP 2.5.1.135 validamine 7-phosphate valienyltransferase
–
(2E,6E)-farnesyl_diphosphate + n isopentenyl_diphosphate <=> n diphosphate + di-trans,poly-cis-polyprenyl_diphosphate 2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]
2.5.1.88 trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
–
–
UDP-glucose + beta-D-glucosyl_crocetin <=> bis(beta-D-glucosyl)_crocetin + UDP 2.4.1.271 crocetin glucosyltransferase
–
prephenate + NADP+ <=> 4-hydroxyphenylpyruvate + CO2 + NADPH 1.3.1.12 prephenate dehydrogenase
1.3.1.13 prephenate dehydrogenase (NADP+)
1.3.1.78 arogenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]
–
–
–
–
1-deoxy-11-oxopentalenate + O2 + NADPH + H+ <=> pentalenolactone_D + H2O + NADP+ 1.14.13.170 pentalenolactone D synthase
–
UDP-glucose + 2-(3-indolyl)acetothiohydroximate <=> desulfo-indol-3-yl-methyl_glucosinolate + UDP 2.4.1.195 N-hydroxythioamide S-beta-glucosyltransferase
–
zeinoxanthin + reduced_flavodoxin + O2 <=> lutein + flavin + H2O 1.14.14.158 carotenoid epsilon hydroxylase
–
C20911 <=> C20912 not assigned
 –
menaquinone + NADH + H+ <=> menaquinol + NAD+ 1.6.5
1.6.5.2 NAD(P)H dehydrogenase (quinone)
1.6.5.9 NADH:quinone reductase (non-electrogenic)
7.1.1.2 NADH:ubiquinone reductase (H+-translocating)
7.2.1.1 NADH:ubiquinone reductase (Na+-transporting)
–
–
–
–
–
(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate <=> (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate not assigned
 –
dTDP-6-deoxy-alpha-D-allose + Mycinamicin_VII <=> mycinamicin_VI + dTDP + H+ 2.4.1
–
(+)-cis-isopulegone + NADP+ <=> (-)-isopiperitenone + NADPH + H+ 1.3.1.82 (-)-isopiperitenone reductase
–
5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + HCO3- <=> H+ + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + phosphate 6.3.4.18 5-(carboxyamino)imidazole ribonucleotide synthase
–
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA <=> tigloyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
–
dTDP-6-deoxy-alpha-D-allose + NADP+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-gulose + NADPH + H+ 1.1.1.364 dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase
–
Roquefortine_F + reduced_flavodoxin + O2 <=> Neoxaline + flavin + H2O 1.14.14
–
5alpha-Cholest-7-en-3beta-ol + ferricytochrome_b5 + O2 + H+ <=> 7-dehydrocholesterol + ferricytochrome_b5 + H2O 1.14.19.20 Delta7-sterol 5(6)-desaturase
–
Fumiquinazoline_C <=> Fumiquinazoline_D not assigned
 –
N-Acetyl-N6,N6,O-tridemethylpuromycin-5''-phosphate + S-adenosyl-L-methionine <=> N-Acetyl-N6,O-didemethylpuromycin-5''-phosphate + S-adenosyl-L-homocysteine 2
–
copalyl_diphosphate + H2O <=> aphidicolan-16beta-ol + diphosphate 4.2.3.42 aphidicolan-16beta-ol synthase
–
demethyllactenocin + dTDP-beta-L-mycarose <=> Demethylmacrocin + dTDP + H+ 2.4.1.318 demethyllactenocin mycarosyltransferase
–
Ajmalicine + reduced_flavodoxin + O2 <=> serpentine + flavin + 2 H2O + 2 H+ 1.14.14
–
dimethylallyl_diphosphate + Paspalinine <=> Aflatrem + diphosphate 2.5.1
–
ergosterol + light <=> vitamin_D2 not assigned
 –
(S)-2-methylbutanoyl-CoA + acceptor <=> tigloyl-CoA + reduced_acceptor 1.3.8.1 short-chain acyl-CoA dehydrogenase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.99.12 2-methylacyl-CoA dehydrogenase
–
–
–
geranyl_diphosphate + isopentenyl_diphosphate <=> diphosphate + (2Z,6E)-farnesyl_diphosphate 2.5.1.68 (2Z,6E)-farnesyl diphosphate synthase
–
Palustradienol <=> Palustradienal 1.14.13
–
ferruginol + 2 reduced_flavodoxin + 2 O2 <=> sugiol + 2 flavin + 3 H2O 1.14.14.65 sugiol synthase
–
N3-fumarylcarboxyamido-L-2,3-diaminopropionic_acid + L-isoleucine + ATP <=> 3-{[(2E)-4-amino-4-oxobut-2-enoyl]amino}-L-alanyl-L-isoleucine + ADP + phosphate + H+ 6.3.2.47 dapdiamide synthase
–
acetyl-CoA + (13S,14R)-1,13-dihydroxy-N-methylcanadine <=> (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA 2.3.1.285 (13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase
–
phosphate + trehalose <=> beta-D-glucose_1-phosphate + D-glucose 2.4.1.64 alpha,alpha-trehalose phosphorylase
–
13-deoxydaunorubicin + NADPH + H+ + O2 <=> 13-dihydrodaunorubicin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase
–
fumitremorgin_B + 2-oxoglutarate + 2 O2 + reduced_acceptor <=> verruculogen + succinate + CO2 + H2O + acceptor 1.14.11.38 verruculogen synthase
–
cis-geranyl-CoA + HCO3- + ATP <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + phosphate + ADP + H+ 6.4.1.5 geranoyl-CoA carboxylase
–
2-exo-hydroxy-1,8-cineole + NAD+ <=> 6-Oxocineole + NADH + H+ 1.1.1.241 6-endo-hydroxycineole dehydrogenase
–
8-O-methyldihydrosterigmatocystin + 2 reduced_flavodoxin + 2 O2 <=> Aflatoxin_B2 + 2 flavin + H2O + methanol + CO2 1.14.14.117 aflatoxin B synthase
–
4-methylthiobutanaldoxime + L-cysteine + reduced_flavodoxin + O2 <=> S-(4-Methylthiobutylthiohydroximoyl)-L-cysteine + flavin + 2 H2O 1.14.14.43 (methylsulfanyl)alkanaldoxime N-monooxygenase
–
S-adenosyl-L-methionine + dTDP-4-amino-2,4-dideoxy-beta-L-xylose <=> S-adenosyl-L-homocysteine + dTDP-4-methylamino-2,4-dideoxy-beta-L-xylose 2.1.1
–
kanamycin_X + O2 <=> 6''-Oxokanamycin_X + H2O2 1.1.3
–
protoporphyrinogen-IX + 3 1,4-benzoquinone <=> protoporphyrin_IX + 3 hydroquinone 1.3.5.3 protoporphyrinogen IX dehydrogenase (quinone)
–
gibberellin_A12 <=> Gibberellin_A14 not assigned
 –
valienone_7-phosphate <=> 1-epi-valienol_7-phosphate not assigned
 –
Dihydrokalafungin_dihydroquinone_form + O2 + FMNH2 <=> 1,3,6,8-Tetrahydroxynaphthalene + H2O + FMN + H+ 1.14.14
–
2,3-Epoxymenaquinone + dithiothreitol <=> menaquinone + oxidized_dithiothreitol + H2O 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive)
–
campesterol + NADPH + H+ + O2 <=> 6-deoxocathasterone + NADP+ + H2O 1.14.13
1.14.99.B1
–
–
S-adenosyl-L-methionine + erythromycin_C <=> S-adenosyl-L-homocysteine + erythromycin + H+ 2.1.1.254 erythromycin 3''-O-methyltransferase
–
geranyl_diphosphate + isopentenyl_diphosphate <=> (2E,6E)-farnesyl_diphosphate + diphosphate 2.5.1.1 dimethylallyltranstransferase
2.5.1.10 (2E,6E)-farnesyl diphosphate synthase
2.5.1.29 geranylgeranyl diphosphate synthase
–
–
–
Mycinamicin_V + O2 + NADPH + H+ <=> mycinamicin_II + H2O + NADP+ 1.14.13
–
theophylline + NADH + O2 + H+ <=> 3-Methylxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
–
–
9,15,9''-tri-cis-zeta-carotene <=> 9,9''-di-cis-zeta-carotene 5.2.1.12 zeta-carotene isomerase
–
GDP-valienol + validamine_7-phosphate <=> validoxylamine_A_7''-phosphate + GDP + H+ 2.5.1.135 validamine 7-phosphate valienyltransferase
–
ATP + 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate <=> AMP + diphosphate + 5-[(2-{[(3S)-5-{[(2S)-2-amino-2-carboxyethyl]amino}-3-carboxy-3-hydroxy-5-oxopentanoyl]amino}ethyl)amino]-2,5-dioxopentanoate + H+ 6.3.2.55 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase
6.3.2.56 staphyloferrin B synthase
–
–
geranylgeranyl_diphosphate + homogentisate + H+ <=> diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 2.5.1.115 homogentisate phytyltransferase
2.5.1.116 homogentisate geranylgeranyltransferase
–
–
protopine + reduced_flavodoxin + O2 <=> 6-hydroxyprotopine + flavin + H2O 1.14.14.98 protopine 6-monooxygenase
–
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + reduced_ferredoxin + O2 <=> dTDP-4-hydroxyamino-4,6-dideoxy-alpha-D-glucose + oxidized_ferredoxin + H2O 1.14.15
–
1-deoxy-D-threo-hexo-2,5-diulose_6-phosphate + L-aspartate_4-semialdehyde <=> 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + 2,3-dioxopropyl_phosphate 2.2.1.10 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
–
NDP-4-oxo-6-deoxy-D-mannose <=> NDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose not assigned
 –
versicolorone + NADP+ <=> 1'-hydroxyversicolorone + NADPH 1.1.1.353 versiconal hemiacetal acetate reductase
–
19-Hydroxytabersonine <=> Horhammericine not assigned
 –
7,12-Decaketide_intermediate_1 <=> Decaketide_tricyclic_intermediate not assigned
 –
(5R)-albaflavenol + O2 + NADPH + H+ <=> albaflavenone + H2O + NADP+ 1.14.13.106 epi-isozizaene 5-monooxygenase
–
(S)-4-Amino-5-oxopentanoate + NADP+ + tRNAMet <=> Glu-tRNAGln + NADPH + H+ 1.2.1.70 glutamyl-tRNA reductase
–
2-[(2''-methylsulfanyl)ethyl]malate <=> 3-[(2''-methylsulfanyl)ethyl]malate 4.2.1.170 2-(omega-methylthio)alkylmalate dehydratase
–
N1,N5,N10-Tricoumaroyl_spermidine <=> N1,N5,N10-Tricaffeoyl_spermidine 1.14.13
–
kanosamine_6-phosphate + 2-oxoglutarate <=> 3-dehydro-D-glucose_6-phosphate + L-glutamate 2.6.1.104 3-dehydro-glucose-6-phosphate---glutamate transaminase
–
putrescine <=> Homospermidine + NH3 2.5.1.44 homospermidine synthase
–
(R)-3-(4-hydroxyphenyl)lactate + NADP+ <=> 4-hydroxyphenylpyruvate + NADPH + H+ 1.1.1.110 aromatic 2-oxoacid reductase
1.1.1.237 hydroxyphenylpyruvate reductase
–
–
acarbose_7'''-phosphate <=> acarbose not assigned
 –
(1''S)-averantin + reduced_flavodoxin + O2 <=> (1''S,5''S)-5''-hydroxyaverantin + flavin + H2O 1.14.14.116 averantin hydroxylase
–
Avermectin_A1a_aglycone + dTDP-L-oleandrose <=> Avermectin_A1a_monosaccharide + dTDP 2.4.1
–
NADP+ + 3-oxo-2((2Z)-pentenyl)-cyclopentane-1-octanoic_acid <=> H+ + NADPH + 12-oxo-phytodienoic_acid 1.3.1.42 12-oxophytodienoate reductase
–
15,16-dihydrobiliverdin + oxidized_ferredoxin <=> Biliverdin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.2 15,16-dihydrobiliverdin:ferredoxin oxidoreductase
1.3.7.6 phycoerythrobilin synthase
–
–
S-adenosyl-L-methionine + (S)-scoulerine <=> H+ + S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine 2.1.1.117 (S)-scoulerine 9-O-methyltransferase
–
(E)-phenylacetaldoxime <=> (Z)-phenylacetaldoxime 1.14.14.44 phenylacetaldehyde oxime monooxygenase
–
paromamine + UDP-alpha-D-kanosamine <=> kanamycin_C + UDP + H+ 2.4.1.301 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase
–
24-methylene_cholesterol + NADPH + H+ <=> ergosta-5-enol + NADP+ 1.3.1
–
laurate + malonyl-CoA + glycine <=> 4-Keto-2-undecylpyrroline + 2 H2O + 2 CO2 + CoA not assigned
 –
H+ + L-aspartate <=> beta-Alanine + CO2 4.1.1.11 aspartate 1-decarboxylase
4.1.1.15 glutamate decarboxylase
4.1.1.25 tyrosine decarboxylase
4.1.1.29 sulfinoalanine decarboxylase
–
–
–
–
3-dehydroquinate <=> H2O + 3-dehydroshikimate 4.2.1.10 3-dehydroquinate dehydratase
–
4-coumaroyl-CoA <=> caffeoyl-CoA 1.14.13
–
isocitrate <=> glyoxylate + succinate 4.1.3.1 isocitrate lyase
–
3-oxo-2((2Z)-pentenyl)-cyclopentane-1-octanoic_acid + CoA + ATP <=> 3-oxo-2-(cis-2''-pentenyl)-cyclopentane-1-octanoyl-CoA + AMP + diphosphate 6.2.1
–
3-(hydroxyphosphonoylmethyl)malate <=> Deamino-alpha-keto-demethylphosphinothricin not assigned
 –
H2O + N-acetyl-L,L-2,6-diaminopimelate <=> LL-2,6-Diaminoheptanedioate + acetate 3.5.1.47 N-acetyldiaminopimelate deacetylase
–
Dihydrokalafungin + NADH + H+ <=> Dihydrokalafungin_dihydroquinone_form + NAD+ not assigned
 –
ascorbate + 1-aminocyclopropane-1-carboxylate + O2 <=> H2O + ethylene + dehydroascorbate + cyanide + CO2 1.14.17.4 aminocyclopropanecarboxylate oxidase
–
malonyl-CoA + (S)-methylmalonyl-CoA + NADPH + H+ <=> 10-deoxymethynolide + CoA + CO2 + H2O + NADP+ 2.3.1.239 10-deoxymethynolide synthase
–
isochorismate <=> salicylate + pyruvate 3.3.2.1 isochorismatase
4.2.99.21 isochorismate lyase
–
–
trehalose + H2O <=> D-glucose + D-glucose 3.2.1.10 oligo-1,6-glucosidase
3.2.1.20 alpha-glucosidase
3.2.1.28 alpha,alpha-trehalase
3.2.1.3 glucan 1,4-alpha-glucosidase
–
–
–
–
(10bS,4aR)-noroxomaritidine <=> (4aR,10bS)-Normaritidine not assigned
 –
4-hydroxy-2,2''-bipyrrole-5-methanol + NADP+ <=> 4-hydroxy-2,2''-bipyrrole-5-carbaldehyde + NADPH + H+ 1.1.1
–
ATP + fumarate + L-2,3-diaminopropionic_acid <=> AMP + diphosphate + N3-fumaroyl-L-2,3-diaminopropanoic_acid + H+ 6.3.2.46 fumarate---(S)-2,3-diaminopropanoate ligase
–
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine <=> H+ + ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole 6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
–
Avermectin_B1b_monosaccharide + dTDP-L-oleandrose <=> avermectin_B1b + dTDP 2.4.1
–
starch <=> Dextrin + maltose 3.2.1.1 alpha-amylase
3.2.1.133 glucan 1,4-alpha-maltohydrolase
3.2.1.2 beta-amylase
–
–
–
1,6,6-Trimethyl-2,7-dioxa(3,2,2)bicyclononan-3-one <=> 4,5-Dihydro-5,5-dimethyl-4-(3-oxobutyl)furan-2(3H)-one not assigned
 –
UDP-glucose + 2-Methyl-2-hydroxybutyronitrile <=> lotaustralin + UDP + H+ 2.4.1.63 linamarin synthase
–
Chromopyrrolate + O2 + NADH + H+ <=> staurosporine_aglycone + CO2 + H2O + NAD+ 1.13.12
–
4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ <=> zymosterone + NADPH + CO2 1.1.1.170 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
–
10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl_acetate <=> 10-deacetyl-2-debenzoylbaccatin_III not assigned
 –
norsolorinic_acid_anthrone + O2 <=> norsolorinic_acid + H2O 1.13.12.20 noranthrone monooxygenase
–
UDP-glucose + abscisic_acid <=> beta-D-glucopyranosyl_abscisate + UDP 2.4.1.263 abscisate beta-glucosyltransferase
–
9''-cis-neoxanthin + O2 <=> 2-cis,4-trans-xanthoxin + (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12''-apo-beta-caroten-12''-al 1.13.11.51 9-cis-epoxycarotenoid dioxygenase
–
ATP + 4-methoxy-2,2''-bipyrrole-5-carbaldehyde + 2-Undecylpyrrole <=> ADP + phosphate + Undecylprodigiosin + H+ 6.4.1
–
dopamine + secologanin <=> H2O + N-deacetylisoipecoside 4.3.3.3 deacetylisoipecoside synthase
–
AminoDAHP <=> AminoDHQ + phosphate 4.2.1.M26
–
CTP + (2E,6E)-farnesol <=> CDP + farnesyl_phosphate + H+ 2.7.1.216 farnesol kinase
–
(13E)-8alpha-hydroxylabd-13-en-15-yl_diphosphate <=> geranylgeranyl_diphosphate + H2O 4.2.1.133 copal-8-ol diphosphate hydratase
4.2.3.133 alpha-copaene synthase
–
–
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ <=> 3-dehydro-4-methylzymosterol + NADPH + CO2 1.1.1.170 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
–
ATP + malonyl-[acyl-carrier_protein] + L-glutamine + H2O <=> AMP + diphosphate + Malonamoyl-[acyl-carrier_protein] + L-glutamate 6.3.5
–
deacetylvindoline + acetyl-CoA <=> vindoline + CoA 2.3.1.107 deacetylvindoline O-acetyltransferase
–
2-Undecylpyrrole + NADP+ + H2O <=> 4-Keto-2-undecylpyrroline + NADPH + H+ 1.17.1
–
festuclavine <=> fumigaclavine_B not assigned
 –
4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H2O <=> bisdemethoxycurcumin + CoA + CO2 2.3.1.219 demethoxycurcumin synthase
–
(R)-pulegone + reduced_flavodoxin + O2 <=> (+)-menthofuran + flavin + H2O 1.14.14.143 (+)-menthofuran synthase
–
nicotinate <=> 3,6-Dihydronicotinic_acid not assigned
 –
1-Dehydro-[6]-gingerdione <=> [6]-gingerol not assigned
 –
kanamycin_A + 2-oxoglutarate <=> 6''-Oxokanamycin_X + L-glutamate 2.6.1.94 2'-deamino-2'-hydroxyneamine transaminase
–
3-hydroxyechinenone + O2 + reduced_acceptor <=> adonirubin + H2O + acceptor 1.14.99.63 beta-carotene 4-ketolase
1.14.99.64 zeaxanthin 4-ketolase
–
–
4-hydroxy-2,2''-bipyrrole-5-methanol + NAD+ <=> 4-hydroxy-2,2''-bipyrrole-5-carbaldehyde + NADH + H+ 1.1.1
–
1-deoxy-11-oxopentalenate + O2 + NADPH + H+ <=> neopentalenolactone_D + H2O + NADP+ 1.14.13.171 neopentalenolactone D synthase
–
3,4-Dihydro-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylate <=> 3,4-Dihydro-7-hydroxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylate 1.14
–
Palustradienal <=> Palustric_acid not assigned
 –
L-tyrosine + H2O + O2 <=> 4-hydroxyphenylpyruvate + NH3 + H2O2 1.4.3.11 L-glutamate oxidase
1.4.3.14 L-lysine oxidase
1.4.3.2 L-amino-acid oxidase
–
–
–
S-adenosyl-L-methionine + caffeoyl_alcohol <=> S-adenosyl-L-homocysteine + coniferyl_alcohol 2.1.1.104 caffeoyl-CoA O-methyltransferase
2.1.1.68 caffeate O-methyltransferase
–
–
dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-L-allose <=> dTDP-L-megosamine not assigned
 –
H+ + L-tryptophan <=> CO2 + tryptamine 4.1.1.105 L-tryptophan decarboxylase
4.1.1.28 aromatic-L-amino-acid decarboxylase
4.1.1.53 phenylalanine decarboxylase
–
–
–
Megalomicin_A <=> Megalomicin_C2 not assigned
 –
Aurachin_B_epoxide <=> aurachin_A not assigned
 –
Nogalavinone <=> 1-OH-Nogalamycinone not assigned
 –
geranylgeranyl_diphosphate <=> ent-copalyl_diphosphate 5.5.1.12 copalyl diphosphate synthase
5.5.1.13 ent-copalyl diphosphate synthase
5.5.1.14 syn-copalyl-diphosphate synthase
–
–
–
typhasterol + NADPH + H+ + O2 <=> 24-epicastasterone + NADP+ + H2O 1.14
–
4-(2-amino-3-chlorophenyl)pyrrole + Cl- + O2 + FADH2 <=> aminopyrrolnitrin + H2O + FAD 1.14.19
–
N6-(4-hydroxy-3-methyl-2-(E)-butenyl)ATP + H2O <=> N6-(4-hydroxy-3-methyl-2-(E)-butenyl)ADP + phosphate + H+ not assigned
 –
2-carboxy-1,4-naphthoquinone + phytyl_diphosphate + H+ <=> demethylphylloquinone + diphosphate + CO2 2.5.1.130 2-carboxy-1,4-naphthoquinone phytyltransferase
–
citrate <=> cis-aconitate + H2O 4.2.1.117 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
4.2.1.3 aconitate hydratase
–
–
S-adenosyl-L-methionine + dTDP-4-dehydro-6-deoxy-alpha-D-gulose <=> S-adenosyl-L-homocysteine + dTDP-4-oxo-5-C-methyl-L-rhamnose 2.1.1
–
S-adenosyl-L-methionine + norajmaline <=> ajmaline + S-adenosyl-L-homocysteine + H+ 2.1.1.M48
–
norbelladine + NADP+ <=> Norcraugsodine + NADPH + H+ 1.4.1
–
8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide_d + H2O <=> 3-(1-hydroxyethyl)-pyrochlorophyllide_a 4.2.1.169 3-vinyl bacteriochlorophyllide d 31-hydratase
–
dTDP-4-dehydro-6-deoxy-D-glucose + NADPH + H+ <=> dTDP-L-rhamnose + NADP+ 1.1.1
1.1.1.133 dTDP-4-dehydrorhamnose reductase
–
–
S-adenosyl-L-methionine + Isoandrocymbine <=> H+ + O-Methylandrocymbine + S-adenosyl-L-homocysteine 2.1.1
–
glutaryl-CoA + flavin <=> crotonyl-CoA + CO2 + reduced_flavodoxin 1.3.8.6 glutaryl-CoA dehydrogenase (ETF)
–
4-hydroxyphenylpyruvate + O2 <=> (S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate + CO2 1.13.11.46 4-hydroxymandelate synthase
–
NADH + vitamin_K + H+ <=> NAD+ + vitamin_KH2 1.6.5.2 NAD(P)H dehydrogenase (quinone)
7.1.1.2 NADH:ubiquinone reductase (H+-translocating)
–
–
UDP-glucose + N-Demethylansamitocin_P-3 <=> UDP + Ansamitocinoside_P-3 2.4.1
–
taxa-4(20),11-dien-5alpha,13alpha-diol <=> 10-deacetyl-2-debenzoylbaccatin_III not assigned
 –
C-9_Reduced_nonaketamide <=> Nonaketamide_monocyclic_intermediate + 2 H2O 4.2.1
–
9,10-EOT <=> 10-OPDA not assigned
 –
(2E,6E)-farnesyl_diphosphate <=> beta-selinene + diphosphate 4.2.3.66 beta-selinene cyclase
–
taxa-4(20),11-dien-5alpha-yl_acetate + reduced_flavodoxin + O2 <=> 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl_acetate + flavin + H2O 1.14.14.105 taxane 10beta-hydroxylase
–
Salbostatin_6''-phosphate + H2O <=> Salbostatin + phosphate 3.1.3
–
ATP + acetyl-CoA + HCO3- <=> ADP + phosphate + malonyl-CoA + H+ 6.4.1.2 acetyl-CoA carboxylase
6.4.1.3 propionyl-CoA carboxylase
6.4.1.4 methylcrotonoyl-CoA carboxylase
–
–
–
N6-acetyl-N6-hydroxy-L-lysine + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + ATP <=> aerobactin + AMP + diphosphate + H+ 6.3.2.39 aerobactin synthase
–
6-phosphogluconate + NADP+ <=> D-ribulose_5-phosphate + CO2 + NADPH 1.1.1.351 phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
–
–
S-adenosyl-L-methionine + 131-hydroxy-magnesium-protoporphyrin_IX_13-monomethyl_ester <=> 131-oxo-magnesium-protoporphyrin_IX_13-monomethyl_ester + 5''-deoxyadenosine + L-methionine + H+ 1.21.98.3 anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase
–
aklavinone + NADP+ <=> aklaviketone + NADPH + H+ 1.1.1.362 aklaviketone reductase
–
aurachin_C + O2 + NADH + H+ <=> 4-hydroxy-2-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]quinolin-3(4H)-one_1-oxide + NAD+ + H2O 1.14.13.222 aurachin C monooxygenase/isomerase
–
S-adenosyl-L-methionine + (S)-3''-hydroxy-N-methylcoclaurine <=> H+ + S-adenosyl-L-homocysteine + (S)-reticuline 2.1.1.116 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
2.1.1.128 (RS)-norcoclaurine 6-O-methyltransferase
–
–
tabersonine + reduced_flavodoxin + O2 <=> 16-hydroxytabersonine + flavin + H2O 1.14.14.103 tabersonine 16-hydroxylase
–
gibberellin_a9 <=> gibberellin_a20 not assigned
 –
Deamino-alpha-keto-demethylphosphinothricin <=> L-glutamyl_gamma-phosphinic_acid not assigned
 –
1-Methylxanthine + NADH + O2 + H+ <=> xanthine + NAD+ + formaldehyde + H2O 1.14.13.178 methylxanthine N1-demethylase
–
5a,11a-dehydrotetracycline + reduced_coenzyme_F420 <=> tetracycline + coenzyme_F420 1.3.98.4 5a,11a-dehydrotetracycline reductase
–
ribostamycin + NAD+ <=> 3''''-Oxoribostamycin + NADH + H+ 1.1.1
–
7,9,12-Decaketide_intermediate_3 <=> [4,5-dihydroxy-10-oxo-3-(3-oxobutanoyl)-9,10-dihydroanthracen-2-yl]acetate not assigned
 –
S-adenosyl-L-methionine + Cycloartenol <=> H+ + S-adenosyl-L-homocysteine + 24(28)-methylene_cycloartanol 2.1.1.142 cycloartenol 24-C-methyltransferase
2.1.1.41 sterol 24-C-methyltransferase
–
–
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H+ <=> 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 4.1.1.117 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
–
beta-Keto-L-tyrosyl-[pcp] <=> 2-Hydroxy-beta-keto-L-tyrosyl-[pcp] not assigned
 –
5-aminolevulinate <=> H+ + H2O + porphobilinogen 4.2.1.24 porphobilinogen synthase
–
FMNH2 + NAD+ <=> FMN + NADH + H+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.18.1.4 rubredoxin---NAD(P)+ reductase
1.5.1
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.37 FAD reductase (NADH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.39 FMN reductase [NAD(P)H]
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.42 FMN reductase (NADH)
–
–
–
–
–
–
–
–
–
–
dTDP-3-N,N-dimethylamino-2,3,6-trideoxy-4-keto-D-glucose <=> dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-L-allose 5.1.3
–
1-(3,4-Dihydroxyphenyl)-1-decene-3,5-dione + S-adenosyl-L-methionine <=> 1-Dehydro-[6]-gingerdione + S-adenosyl-L-homocysteine 2.1.1
–
L-phenylalanine + 2 reduced_flavodoxin + 2 O2 <=> (E)-phenylacetaldoxime + 2 flavin + CO2 + 3 H2O 1.14.14.40 phenylalanine N-monooxygenase
–
cathenamine + NADPH + H+ <=> Ajmalicine + NADP+ not assigned
 –
H+ + 1'-hydroxyversicolorone + NADPH + O2 <=> versiconal_hemiacetal_acetate + NADP+ + H2O not assigned
 –
L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O 2.1.2.1 glycine hydroxymethyltransferase
–
(+/-)-1-deoxypentalenic_acid + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> pentalenate + oxidized_ferredoxin + H2O 1.14.15.11 pentalenic acid synthase
–
L-ornithine + Carbamoyl_phosphate <=> H+ + L-citrulline + phosphate 2.1.3.3 ornithine carbamoyltransferase
2.1.3.6 putrescine carbamoyltransferase
3.5.3.12 agmatine deiminase
–
–
–
D-Urobilinogen + O2 <=> D-Urobilin + H2O not assigned
 –
paraxanthine + NADPH + H+ + O2 <=> 1-Methylxanthine + NADP+ + formaldehyde + H2O 1.13.12
–
100-1 + dTDP-D-boivinose <=> Urdamycin_B + dTDP 2.4.1
–
acyl-CoA + sn-glycerol_3-phosphate <=> CoA + 2-acyl-sn-glycerol_3-phosphate 2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase
2.3.1.198 glycerol-3-phosphate 2-O-acyltransferase
–
–
7,9,12-Octaketide_intermediate_1 + NADPH + H+ <=> 7,9,12-Octaketide_intermediate_2 + NADP+ 1.1.1
–
acetyl-CoA <=> acetoacetyl-CoA + CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase
–
–
–
–
–
O-Methylandrocymbine <=> N-Formyldemecolcine not assigned
 –
streptomycin + ATP <=> H+ + streptomycin_6-phosphate + ADP 2.7.1.72 streptomycin 6-kinase
–
ATP + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + L-2,3-diaminopropionic_acid <=> AMP + diphosphate + 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + H+ 6.3.2.55 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase
–
Lochnericine <=> Horhammericine not assigned
 –
S-adenosyl-L-methionine + mycinamicin_III <=> S-adenosyl-L-homocysteine + mycinamicin_IV + H+ 2.1.1.237 mycinamicin III 3''-O-methyltransferase
–
protodeoxyviolaceinate + O2 + NADH + H+ <=> protoviolaceinate + NAD+ + H2O 1.14.13.217 protodeoxyviolaceinate monooxygenase
1.14.13.224 violacein synthase
–
–
dTDP-beta-L-mycarose + erythronolide_B <=> 3-alpha-mycarosylerythronolide_B + dTDP + H+ 2.4.1.328 erythronolide mycarosyltransferase
–
acetaldehyde + H2O + NAD+ <=> acetate + NADH + H+ 1.17.1.4 xanthine dehydrogenase
1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.18 malonate-semialdehyde dehydrogenase (acetylating)
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.21 glycolaldehyde dehydrogenase
1.2.1.22 lactaldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase
1.2.1.32 aminomuconate-semialdehyde dehydrogenase
1.2.1.36 retinal dehydrogenase
1.2.1.39 phenylacetaldehyde dehydrogenase
1.2.1.41 glutamate-5-semialdehyde dehydrogenase
1.2.1.46 formaldehyde dehydrogenase
1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase
1.2.1.48 long-chain-aldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.69 fluoroacetaldehyde dehydrogenase
1.2.1.8 betaine-aldehyde dehydrogenase
1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
1.2.1.99 4-(gamma-glutamylamino)butanal dehydrogenase
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
L-alanine + Vanillin <=> pyruvate + vanillylamine 2.6.1.119 vanillin aminotransferase
–
2'-hydroxydihydrodaidzein <=> daidzein + H2O 4.2.1.105 2-hydroxyisoflavanone dehydratase
–
S-adenosyl-L-methionine + 2,7-dihydroxy-5-methyl-1-naphthoate <=> S-adenosyl-L-homocysteine + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H+ 2.1.1.303 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
–
3-Dimethylallyl-4-hydroxybenzaldehyde <=> 3-dimethylallyl-4-hydroxybenzoate not assigned
 –
S-adenosyl-L-methionine + dTDP-4-oxo-2,6-dideoxy-D-allose <=> S-adenosyl-L-homocysteine + dTDP-3-methyl-4-oxo-2,6-dideoxy-D-glucose + H+ 2.1.1
–
Dopaxanthin_quinone + H+ <=> betanidin not assigned
 –
Mycinamicin_VIII + O2 + NADPH + H+ <=> Mycinamicin_VII + H2O + NADP+ 1.14.13
–
L-isoleucine + H2O + NAD+ <=> NH3 + (S)-3-methyl-2-oxopentanoate + NADH + H+ 1.4.1.1 alanine dehydrogenase
1.4.1.2 glutamate dehydrogenase
1.4.1.20 phenylalanine dehydrogenase
1.4.1.23 valine dehydrogenase (NAD+)
1.4.1.5 L-amino-acid dehydrogenase
1.4.1.8 valine dehydrogenase (NADP+)
1.4.1.9 leucine dehydrogenase
–
–
–
–
–
–
–
(2S)-dihydrotricetin + 2-oxoglutarate + O2 <=> dihydromyricetin + succinate + CO2 1.14.11.9 flavanone 3-dioxygenase
–
TDP-3-dimethylamino-4,6-dideoxy-alpha-D-glucopyranose + Protomycinolide_IV <=> Mycinamicin_VIII + dTDP + H+ 2.4.1
–
ATP + (R)-2-Aza-beta-tyrosine + pC3'p <=> AMP + diphosphate + (R)-2-Aza-beta-tyrosyl-[pcp] 6.2.1
–
geranylhydroquinone + reduced_flavodoxin + O2 <=> 3''''-hydroxygeranylhydroquinone + flavin + H2O 1.14.14.174 geranylhydroquinone 3''-hydroxylase
–
epsilon-Rhodomycin_T + H2O <=> 15-Demethoxy-epsilon-rhodomycin + methanol 3.1.1.95 aclacinomycin methylesterase
–
(S)-3-Chloro-beta-tyrosyl-[pcp] + FADH2 + O2 <=> (S)-3-Chloro-4,5-dihydroxy-beta-phenylalanyl-[pcp] + FAD + H2O 1.14.14.15 (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase
–
6alpha-Hydroxy-castasterone + O2 + reduced_flavodoxin <=> 24-epicastasterone + 2 H2O + flavin 1.14
–
2''-Hydroxydihydrodaidzein + NADPH + H+ <=> demethylmedicarpin + NADP+ + H2O not assigned
 –
geranylgeranyl_diphosphate <=> ent-copalyl_diphosphate 5.5.1.12 copalyl diphosphate synthase
5.5.1.13 ent-copalyl diphosphate synthase
5.5.1.14 syn-copalyl-diphosphate synthase
–
–
–
oripavine + 2-oxoglutarate + O2 <=> morphinone + formaldehyde + succinate + CO2 1.14.11.31 thebaine 6-O-demethylase
–
demethylmedicarpin + reduced_flavodoxin + O2 <=> (6aS,11aS)-3,6a,9-trihydroxypterocarpan + flavin + H2O 1.14.14.93 3,9-dihydroxypterocarpan 6a-monooxygenase
–
H+ + prephenate <=> 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 4.1.1.100 prephenate decarboxylase
–
ATP + 2-epi-5-epi-valiolone <=> ADP + 2-epi-5-epi-valiolone_7-phosphate + H+ 2.7.1.188 2-epi-5-epi-valiolone 7-kinase
–
saccharopine + H2O + NAD+ <=> L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+ 1.5.1.9 saccharopine dehydrogenase (NAD+, L-glutamate-forming)
–
(2E,6E)-farnesyl_diphosphate <=> aristolochene + diphosphate 4.2.3.9 aristolochene synthase
–
H+ + 2-C-methyl-D-erythritol_4-phosphate + CTP <=> 4-(cytidine_5''-diphospho)-2-C-methyl-D-erythritol + diphosphate 2.7.7.60 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
–
oxaloacetate + GTP <=> CO2 + phosphoenolpyruvate + GDP 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)
–
–
Cinnamic_acid + CoA + ATP <=> cinnamoyl-CoA + AMP + diphosphate 6.2.1
6.2.1.12 4-coumarate---CoA ligase
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.30 phenylacetate---CoA ligase
–
–
–
–
mycinamicin_IV + O2 + NADPH + H+ <=> Mycinamicin_V + H2O + NADP+ 1.14.13
–
levopimaradienol <=> levopimaradienal 1.14.13
–
antheraxanthin + ascorbate <=> zeaxanthin + dehydroascorbate + H2O 1.23.5.1 violaxanthin de-epoxidase
–
bacteriochlorophyllide_a + geranylgeranyl_diphosphate + H+ <=> geranylgeranyl-bacteriochlorophyllide_a + diphosphate 2.5.1.133 bacteriochlorophyll a synthase
–
H+ + Cinnamic_acid + O2 + NADPH <=> H2O + NADP+ + coumaric_acid 1.14.13.14 trans-cinnamate 2-monooxygenase
1.14.14.91 trans-cinnamate 4-monooxygenase
–
–
dTDP-4-amino-4,6-dideoxy-5-C-methyl-D-allose <=> dTDP-4-dimethylamino-4,6-dideoxy-5-C-methyl-D-allose 2.1.1
–
3''-Phosphoadenylyl_sulfate + OA-6129_B1 <=> Adenosine_3'',5''-bisphosphate + OA-6129_C 2.8.2
–
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate <=> dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + L-glutamate 2.6.1.106 dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
–
(E)-2-methylpropanal-oxime <=> Isobutyraldoxime 1.14.14.41 (E)-2-methylbutanal oxime monooxygenase
–
H+ + feruloyl-CoA + NADPH <=> coniferyl_aldehyde + NADP+ + CoA 1.2.1.44 cinnamoyl-CoA reductase
1.2.1.68 coniferyl-aldehyde dehydrogenase
–
–
ferruginol + reduced_flavodoxin + O2 <=> 11-hydroxyferruginol + flavin + H2O 1.14.14.60 ferruginol monooxygenase
–
saccharopine + H2O + NAD+ <=> 2-oxoglutarate + L-lysine + NADH + H+ 1.5.1.7 saccharopine dehydrogenase (NAD+, L-lysine-forming)
1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming)
–
–
3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD+ <=> momilactone_A + NADH + H+ 1.1.1.295 momilactone-A synthase
–
quercetin + reduced_flavodoxin + O2 <=> myricetin + flavin + H2O 1.14.14.81 flavanoid 3',5'-hydroxylase
–
(2S)-2-amino-4-deoxy-chorismate + FMN <=> 2-amino-2-deoxychorismate + FMNH2 1.3.8.t
1.3.99.24 2-amino-4-deoxychorismate dehydrogenase
–
–
L-homocysteine + 5-methyltetrahydrofolate <=> L-methionine + tetrahydrofolate 2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
–
–
nonaprenyl_diphosphate + 4-hydroxybenzoate <=> 4-hydroxy-3-nonaprenylbenzoate + diphosphate 2.5.1.39 4-hydroxybenzoate polyprenyltransferase
–
isobutyryl-CoA + 5 methylmalonyl-CoA + 7 malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin_''''1b''''_aglycone + 12 CO2 + 13 CoA + 6 H2O + 9 NADP+ not assigned
 –
maltooligosyltrehalose + H2O <=> amylose + trehalose 3.2.1.141 4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase
–
D-glucose_6-phosphate + H2O <=> D-glucose + phosphate 3.1.3
3.1.3.1 alkaline phosphatase
3.1.3.10 glucose-1-phosphatase
3.1.3.104 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
3.1.3.2 acid phosphatase
3.1.3.20 phosphoglycerate phosphatase
3.1.3.23 sugar-phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.38 3-phosphoglycerate phosphatase
3.1.3.4 phosphatidate phosphatase
3.1.3.58 sugar-terminal-phosphatase
3.1.3.68 2-deoxyglucose-6-phosphatase
3.1.3.8 3-phytase
3.1.3.9 glucose-6-phosphatase
3.1.7.1 prenyl-diphosphatase
3.6.1.1 inorganic diphosphatase
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
strictosidine_aglycone <=> Dialdehyde not assigned
 –
S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose + H+ 2.1.1.236 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase
–
18-Carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[acp] + NADPH + H+ <=> C-9_Reduced_nonaketamide + NADP+ 1.1.1
–
L-homoserine + NADP+ <=> L-aspartate_4-semialdehyde + NADPH + H+ 1.1.1.3 homoserine dehydrogenase
–
S-adenosyl-L-methionine + (S)-Coclaurine <=> H+ + (S)-N-methylcoclaurine + S-adenosyl-L-homocysteine 2.1.1.115 (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
2.1.1.140 (S)-coclaurine-N-methyltransferase
–
–
3,5,7-trioxododecanoyl-CoA <=> CoA + 2,4-dihydroxy-6-pentylbenzoate + H+ 4.4.1.26 olivetolic acid cyclase
–
phytyl_diphosphate + NADP+ <=> geranylgeranyl_diphosphate + NADPH + H+ 1.3.1.83 geranylgeranyl diphosphate reductase
–
Leucocyanidin + 2-oxoglutarate + O2 <=> taxifolin + succinate + CO2 + H2O 1.14.20.4 anthocyanidin synthase
–
heme + 3 reduced_flavodoxin + 3 O2 <=> Biliverdin + Fe2+ + CO + 3 flavin + 3 H2O 1.14.14.18 heme oxygenase (biliverdin-producing)
1.14.99.58 heme oxygenase (biliverdin-IX-beta and delta-forming)
–
–
dTDP-3-amino-4-oxo-2,3,6-trideoxy-L-allose <=> dTDP-L-ristosamine not assigned
 –
Oleandolide + dTDP-L-olivose <=> L-olivosyl-oleandolide + dTDP + H+ 2.4.1
–
ent-isokaurene + O2 + reduced_flavodoxin <=> ent-isokauren-2beta-ol + flavin + H2O 1.14.14.76 ent-isokaurene C2/C3-hydroxylase
–
cytidine_5''-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + H2O <=> (S)-2-hydroxypropylphosphonate + CMP + H+ 3.6.1
–
chorismate <=> 3-[(1-carboxyvinyl)oxy]benzoate + H2O 4.2.1.151 chorismate dehydratase
–
geranylgeranyl_diphosphate <=> Cembrene not assigned
 –
canthaxanthin + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> adonirubin + oxidized_ferredoxin + H2O 1.14.15.24 beta-carotene 3-hydroxylase
–
pyruvate + CoA + oxidized_ferredoxin <=> acetyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.1 pyruvate synthase
1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)
1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
–
–
–
gibberellin_a37 <=> Gibberellin_A36 not assigned
 –
(R)-3-(4-hydroxyphenyl)lactate + NAD+ <=> 4-hydroxyphenylpyruvate + NADH + H+ 1.1.1.110 aromatic 2-oxoacid reductase
1.1.1.222 (R)-4-hydroxyphenyllactate dehydrogenase
1.1.1.237 hydroxyphenylpyruvate reductase
1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.96 diiodophenylpyruvate reductase
–
–
–
–
–
–
1-hydroxyneurosporene <=> demethylspheroidene 1.3.99.27 1-hydroxycarotenoid 3,4-desaturase
–
H2O + L-arginine <=> Urea + L-ornithine 3.5.3.1 arginase
3.5.3.7 guanidinobutyrase
–
–
Campest-4-en-3beta-ol + NAD+ <=> (24R)-ergost-4-en-3-one + NADH + H+ 1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase
–
succinyl-CoA + acetate <=> succinate + acetyl-CoA 2.8.3.1 propionate CoA-transferase
2.8.3.18 succinyl-CoA:acetate CoA-transferase
2.8.3.8 acetate CoA-transferase
–
–
–
Geissoschizine + NADP+ <=> 4,21-Dehydrogeissoschizine + NADPH 1.3.1.36 geissoschizine dehydrogenase
–
cyclic_dehypoxanthinyl_futalosine <=> 1,4-dihydroxy-6-naphthoate 1.14
–
S-adenosyl-L-methionine + (S)-canadine <=> (S)-N-methylcanadine + S-adenosyl-L-homocysteine 2.1.1.122 (S)-tetrahydroprotoberberine N-methyltransferase
–
S-adenosyl-L-methionine + N-Demethylansamitocin_P-3 <=> S-adenosyl-L-homocysteine + Ansamitocin_P-3 2.1.1
–
3,6,7,8-Tetrahydroxy-2-naphthoate <=> 3-Hydroxy-6,7,8-trimethoxy-2-naphthoate 2.1.1
–
UWM6 <=> 2,3-Dehydro-UWM6 + H2O 4.2.1
–
7-deoxyloganate + reduced_flavodoxin + O2 <=> loganic_acid + flavin + H2O 1.14.14.85 7-deoxyloganate 7-hydroxylase
–
UDP-N-acetyl-D-glucosamine + 2-deoxystreptamine <=> H+ + 2''-N-acetylparomamine + UDP 2.4.1.283 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase
–
(S)-4-Amino-5-oxopentanoate <=> 5-aminolevulinate 5.4.3.8 glutamate-1-semialdehyde 2,1-aminomutase
–
dTDP-glucose <=> H2O + dTDP-4-dehydro-6-deoxy-D-glucose 4.2.1.46 dTDP-glucose 4,6-dehydratase
4.2.1.76 UDP-glucose 4,6-dehydratase
–
–
pyruvate + CoA + NAD+ <=> acetyl-CoA + CO2 + NADH 1.2.1.aj
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
1.8.1.4 dihydrolipoyl dehydrogenase
2.3.1.12 dihydrolipoyllysine-residue acetyltransferase
–
–
–
–
–
–
H2O + cephalosporin_C <=> H+ + acetate + deacetylcephalosporin_C 3.1.1.41 cephalosporin-C deacetylase
3.5.2.6 beta-lactamase
–
–
(+)-borneol + NAD+ <=> (+)-Camphor + NADH + H+ 1.1.1.198 (+)-borneol dehydrogenase
–
12-Demethyl-11,12-dehydropaspaline + O2 + NADPH + H+ <=> beta-PC-M6 + NADP+ + H2O 1.14.13
–
9-cis-10''-apo-beta-carotenal + O2 <=> carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal 1.13.11.69 carlactone synthase
–
monacolin_L_acid + O2 + reduced_flavodoxin <=> monacolin_J_acid + flavin + H2O 1.14.14.125 monacolin L hydroxylase
–
(-)-deoxypodophyllotoxin <=> podophyllotoxin not assigned
 –
acetone <=> diketone not assigned
 –
shikimate + NAD+ <=> 3-dehydroshikimate + NADH + H+ 1.1.1.166 hydroxycyclohexanecarboxylate dehydrogenase
1.1.1.24 quinate dehydrogenase
1.1.1.25 shikimate dehydrogenase
1.1.1.282 quinate/shikimate dehydrogenase
–
–
–
–
N2-Acetyl-L-ornithine + H2O <=> L-ornithine + acetate 2.3.1.35 glutamate N-acetyltransferase
3.5.1.14 N-acyl-aliphatic-L-amino acid amidohydrolase
3.5.1.16 acetylornithine deacetylase
3.5.1.17 acyl-lysine deacylase
3.5.1.B4
–
–
–
–
–
Littorine <=> L-hyoscyamine not assigned
 –
3-hydroxy-5-methylhex-4-enoyl-CoA + NAD+ <=> 5-methyl-3-oxo-4-hexenoyl-CoA + NADH + H+ 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
–
indole + reduced_flavodoxin + O2 <=> indolin-2-one + flavin + H2O 1.14.14.153 indole-2-monooxygenase
–
L-valine + 2-oxoglutarate <=> L-glutamate + 2-oxoisovalerate 2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.66 valine---pyruvate transaminase
–
–
–
–
cadaverine <=> sparteine not assigned
 –
theophylline + NADH + O2 + H+ <=> 1-Methylxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.179 methylxanthine N3-demethylase
–
–
2-hydroxyethylphosphonate + O2 <=> H+ + hydroxymethylphosphonate + formate 1.13.11.72 2-hydroxyethylphosphonate dioxygenase
–
L-homoserine + NAD+ <=> L-aspartate_4-semialdehyde + NADH + H+ 1.1.1.3 homoserine dehydrogenase
–
(-)-menthone + NADPH + H+ + O2 <=> (4R,7S)-7-isopropyl-4-methyloxepan-2-one + NADP+ + H2O 1.14.13.105 monocyclic monoterpene ketone monooxygenase
–
Caffeine + NADH + O2 + H+ <=> Theobromine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
–
–
dopamine + Protoemetine <=> 7''-O-demethylcephaeline + H2O not assigned
 –
L-phenylalanine + reduced_flavodoxin + O2 <=> N-hydroxy-L-phenylalanine + flavin + H2O 1.14.14.40 phenylalanine N-monooxygenase
–
Avermectin_B1a_monosaccharide + dTDP-L-oleandrose <=> avermectin_B1a + dTDP 2.4.1
–
cis-aconitate + H2O <=> isocitrate 4.2.1.3 aconitate hydratase
–
UDP-glucose + pelargonidin <=> UDP + pelargonidin_3-O-beta-D-glucoside + H+ 2.4.1.115 anthocyanidin 3-O-glucosyltransferase
2.4.1.91 flavonol 3-O-glucosyltransferase
–
–
a_demethylmenaquinol + S-adenosyl-L-methionine <=> menaquinol + S-adenosyl-L-homocysteine 2.1.1.163 demethylmenaquinone methyltransferase
–
1-(5-phosphoribosyl)-AMP + H2O <=> N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide_ribonucleotide 3.5.4.19 phosphoribosyl-AMP cyclohydrolase
–
2 delta-cadinene <=> gossypol not assigned
 –
dihydrochanoclavine-I_aldehyde <=> 6,8-dimethyl-6,7-didehydroergoline + H2O not assigned
 –
phosphatidylserine + H+ <=> phosphatidylethanolamine + CO2 4.1.1.65 phosphatidylserine decarboxylase
–
11-hydroxyferruginol + 3 reduced_flavodoxin + 3 O2 <=> carnosic_acid + 3 flavin + 4 H2O 1.14.14.61 carnosic acid synthase
–
chlorophyllide_a + oxidized_ferredoxin + ADP + phosphate <=> protochlorophyllide + reduced_ferredoxin_[iron-sulfur]_cluster + ATP + H2O 1.3.7.15 chlorophyllide a reductase
1.3.7.7 ferredoxin:protochlorophyllide reductase (ATP-dependent)
–
–
cycloeucalenol + NADP+ <=> cycloeucalenone + NADPH + H+ 1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase
–
2-cis,4-trans-xanthoxin + NAD+ <=> abscisic_aldehyde + NADH + H+ 1.1.1.288 xanthoxin dehydrogenase
–
a_bacteriochlorophyllide_c + (2E,6E)-farnesyl_diphosphate + H+ <=> bacteriochlorophyll_c + diphosphate 2.5.1
2.5.1.bl
–
–
dTDP-4-oxo-2,6-dideoxy-D-allose <=> dTDP-4-deoxy-4-thio-alpha-D-digitoxose not assigned
 –
glyoxylate + L-serine <=> Hydroxypyruvate + glycine 2.6.1.15 glutamine---pyruvate transaminase
2.6.1.35 glycine---oxaloacetate transaminase
2.6.1.4 glycine transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.45 serine---glyoxylate transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase
–
–
–
–
–
–
–
7-deoxyloganin + reduced_flavodoxin + O2 <=> loganin + flavin + H2O 1.14.14.85 7-deoxyloganate 7-hydroxylase
–
10-deacetylbaccatin_III + acetyl-CoA <=> baccatin_III + CoA 2.3.1.167 10-deacetylbaccatin III 10-O-acetyltransferase
–
S-adenosyl-L-methionine + 7''-O-demethylcephaeline <=> cephaeline + S-adenosyl-L-homocysteine + H+ 2.1.1
2.1.1.B83
2.1.1.B85
–
–
–
Premithramycin_A2' + dTDP-D-mycarose <=> Premithramycin_A3 + dTDP + H+ 2.4.1
–
hydroxymethylphosphonate <=> Formylphosphonate not assigned
 –
N6-(4-hydroxy-3-methyl-2-(E)-butenyl)ADP + H2O <=> H+ + N6-(4-hydroxy-3-methyl-2-(E)-butyl)adenosine_5'-phosphate + phosphate not assigned
 –
(S)-3-hydroxybutyryl-CoA + NAD+ <=> acetoacetyl-CoA + NADH + H+ 1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
1.1.1.36 acetoacetyl-CoA reductase
–
–
–
N-Demethyl-desepoxyansamitocin_P-3 <=> N-Demethylansamitocin_P-3 not assigned
 –
aurachin_D + O2 + NADPH + H+ <=> aurachin_C + H2O + NADP+ 1.14.13
–
nonaprenyl_diphosphate + homogentisate + H+ <=> 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate 2.5.1.117 homogentisate solanesyltransferase
–
(2E,6E)-farnesyl_diphosphate + H2O <=> (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate 4.2.3.22 germacradienol synthase
–
Holyrine_A <=> O-Demethyl-N-demethyl-staurosporine not assigned
 –
2''''''-acetyl-6''''''-deamino-6''''''-hydroxyneomycin_C + H2O <=> 6''''''-deamino-6''''''-hydroxyneomycin_C + acetate 3.5.1.113 2'''-acetyl-6'''-hydroxyneomycin C deacetylase
–
L-phenylalanine <=> L-homophenylalanine not assigned
 –
5alpha-campestan-3-one + NADP+ <=> H+ + (24R)-ergost-4-en-3-one + NADPH 1.3.1
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
–
–
N1,N5,N10-Triferuloyl_spermidine <=> N1,N5,N10-Tri(hydroxyferuloyl)_spermidine 1.14.13
–
3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp] <=> 7,9,12-Decaketide_intermediate_1 not assigned
 –
malonyl-CoA + (S)-methylmalonyl-CoA + NADPH + H+ <=> narbonolide + CoA + CO2 + H2O + NADP+ 2.3.1.240 narbonolide synthase
–
dTDP-3-methyl-4-oxo-alpha-D-ribopyranose <=> dTDP-madurosamine not assigned
 –
Hydroxymethylbilane <=> uroporphyrinogen_III + H2O 4.2.1.75 uroporphyrinogen-III synthase
–
ATP + L-methionine + H2O <=> S-adenosyl-L-methionine + phosphate + diphosphate 2.5.1.6 methionine adenosyltransferase
–
6,7,4''-Trihydroxyflavanone + O2 + reduced_flavodoxin <=> 2,6,7,4''-Tetrahydroxyisoflavanone + H2O + flavin 1.14.14.87 2-hydroxyisoflavanone synthase
–
hexanoyl-[acyl-carrier_protein] + malonyl-CoA + H+ <=> norsolorinic_acid_anthrone + [acyl-carrier_protein] + CoA + CO2 + H2O 2.3.1.221 noranthrone synthase
–
L-isoleucine + 2-oxoglutarate <=> L-glutamate + (S)-3-methyl-2-oxopentanoate 2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.67 2-aminohexanoate transaminase
–
–
S-adenosyl-L-methionine + loganic_acid <=> S-adenosyl-L-homocysteine + loganin 2.1.1.50 loganate O-methyltransferase
–
L-tyrosine + H2O + NAD+ <=> 4-hydroxyphenylpyruvate + NH3 + NADH 1.4.1.20 phenylalanine dehydrogenase
1.4.1.5 L-amino-acid dehydrogenase
–
–
ATP + beta-D-glucose <=> ADP + beta-D-glucose_6-phosphate 2.7.1.1 hexokinase
2.7.1.2 glucokinase
–
–
ent-kaur-16-ene + reduced_flavodoxin + O2 <=> ent-kaur-16-en-19-ol + flavin + H2O 1.14.14.86 ent-kaurene monooxygenase
–
dimethylallyl_diphosphate + brevianamide_F <=> diphosphate + tryprostatin_B 2.5.1.106 tryprostatin B synthase
–
Stemmadenine <=> tabersonine not assigned
 –
8-amino-8-demethylriboflavin_5''-phosphate + H2O <=> 8-amino-8-demethyl-D-riboflavin + phosphate 3.1.3
–
chlorophyllide_a + NADP+ <=> divinyl_chlorophyllide_a + NADPH + H+ 1.3.1.75 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)
–
Avermectin_A1b_monosaccharide + dTDP-L-oleandrose <=> Avermectin_A1b + dTDP 2.4.1
–
(2E,6E)-farnesyl_diphosphate <=> (+)-epi-isozizaene + diphosphate 4.2.3.37 epi-isozizaene synthase
–
S-adenosyl-L-methionine + N1-Hydroxy-roquefortine_C <=> Roquefortine_F + S-adenosyl-L-homocysteine + H+ 2.1.1
–
3''-Amino-3''-deoxy-AMP + L-tyrosine <=> N6,N6,O-Tridemethylpuromycin-5''-phosphate not assigned
 –
5-Deoxystrigol <=> Strigol 1.14.13
–
copalyl_diphosphate <=> abieta-8(14),12-diene + diphosphate 4.2.3.32 levopimaradiene synthase
–
Homospermidine <=> Trachelanthamidine not assigned
 –
geranyl_diphosphate <=> myrcene + diphosphate 4.2.3.15 myrcene synthase
4.2.3.20 (R)-limonene synthase
–
–
L-lysine + 2-oxoglutarate + O2 + Cl- + H+ <=> 4-Chloro-L-lysine + succinate + CO2 + H2O 1.14.20
–
narbomycin + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> neopikromycin + oxidized_ferredoxin + H2O 1.14.15.33 pikromycin synthase
–
(S)-tetrahydropapaverine + 2 O2 <=> papaverine + 2 H2O2 1.3.3.8 tetrahydroberberine oxidase
–
4''-Oxolividamine + NADPH + H+ <=> Lividamine + NADP+ 1.1.1
–
coniferyl_aldehyde + NADPH + H+ + O2 <=> 5-hydroxyconiferaldehyde + NADP+ + H2O 1.14.13
–
(+)-7-Isojasmonate_CoA + H2O <=> H+ + (+)-7-Isojasmonate + CoA 3.1.2.20 acyl-CoA hydrolase
3.2.1
–
–
Episterone + NADPH + H+ <=> episterol + NADP+ 1.1.1
1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase
–
–
validone_7-phosphate <=> validamine_7-phosphate not assigned
 –
4-coumaroyl-CoA + 2-oxoglutarate + O2 <=> 2,4-dihydroxycinnamoyl-CoA + succinate + CO2 1.14.11.62 trans-4-coumaroyl-CoA 2-hydroxylase
–
N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD+ + H2O <=> 2-oxoglutarate + L-2,3-diaminopropionic_acid + NADH + H+ 1.5.1.51 N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase
–
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + L-3,4-dihydroxybutan-2-one_4-phosphate <=> H+ + 6,7-dimethyl-8-(1'-D-ribityl)lumazine + phosphate + H2O 2.5.1.78 6,7-dimethyl-8-ribityllumazine synthase
2.5.1.9 riboflavin synthase
–
–
L-asparagine <=> H+ + H2O + Beta-cyanoalanine 3.5.5.4 cyanoalanine nitrilase
4.2.1.65 3-cyanoalanine hydratase
–
–
C20916 <=> Tabtoxin not assigned
 –
tetrahymanol <=> squalene + H2O 4.2.1.123 tetrahymanol synthase
–
C20914 + L-threonine <=> C20915 not assigned
 –
tetracenomycin_B3 <=> Tetracenomycin_E not assigned
 –
cis-beta-D-Glucosyl-2-hydroxycinnamate + H2O <=> cis-2-hydroxycinnamate + D-glucose 3.2.1.21 beta-glucosidase
–
versiconol + NADP+ <=> versiconal + NADPH 1.1.1.353 versiconal hemiacetal acetate reductase
–
cis-Zeatin_riboside + H2O <=> D-ribose + cis-zeatin not assigned
 –
ATP + 4-hydroxytryptamine <=> ADP + 4-hydroxytryptamine_4-phosphate + H+ 2.7.1.222 4-hydroxytryptamine kinase
–
acyl-CoA + lysophosphatidic_acid <=> phosphatidic_acid + CoA 2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase
–
dimethylallyl_diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin_C <=> diphosphate + fumitremorgin_B 2.5.1.110 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
–
H+ + N,N-dihydroxy-L-isoleucine <=> (1E,2S)-2-methylbutanal_oxime + CO2 + H2O 1.14.14.38 valine N-monooxygenase
1.14.14.39 isoleucine N-monooxygenase
–
–
7-chloro-L-tryptophan + O2 <=> 4-(2-amino-3-chlorophenyl)pyrrole + CO2 + 2 H2O not assigned
 –
H+ + sinapoyl-CoA + NADPH <=> sinapaldehyde + NADP+ + CoA 1.2.1.44 cinnamoyl-CoA reductase
–
4-coumaroyl-CoA + malonyl-CoA + hexanoyl-CoA + H2O <=> (1E,4Z)-5-hydroxy-1-(4-hydroxyphenyl)deca-1,4-dien-3-one + 3 CoA + 2 CO2 not assigned
 –
6-phosphogluconate + NAD+ <=> D-ribulose_5-phosphate + CO2 + NADH 1.1.1.343 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)
1.1.1.351 phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
–
–
–
N-hydroxy-L-tyrosine + O2 + reduced_flavodoxin <=> N,N-dihydroxy-L-tyrosine + flavin + H2O 1.14.14.36 tyrosine N-monooxygenase
–
cis-Prenyl-tRNA <=> cis-Zeatin_riboside_monophosphate not assigned
 –
tetracenomycin_A2 <=> Tetracenomycin_X not assigned
 –
sedoheptulose_7-phosphate + D-glyceraldehyde_3-phosphate <=> D-ribose_5-phosphate + D-xylulose_5-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase
–
–
NTP + AMP <=> NDP + ADP 2.7.4.10 nucleoside-triphosphate---adenylate kinase
–
UDP-glucose + trans-zeatin <=> H+ + O-beta-D-glucosyl-trans-zeatin + UDP 2.4.1.203 trans-zeatin O-beta-D-glucosyltransferase
–
H+ + H2O + 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH3 3.5.4.26 diaminohydroxyphosphoribosylaminopyrimidine deaminase
–
(2E,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> undecaprenyl_diphosphate + diphosphate 2.5.1.31 ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
2.5.1.M1
–
–
(-)-epiafzelechin + NADP+ <=> H+ + pelargonidin + NADPH 1.3.1.112 anthocyanidin reductase [(2S)-flavan-3-ol-forming]
1.3.1.77 anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]
–
–
(S)-8-oxocitronellyl_enol <=> cis-trans-nepetalactol 5.5.1.34 (+)-cis,trans-nepetalactol synthase
–
(S)-reticuline + reduced_flavodoxin + O2 <=> 1,2-dehydroreticuline + flavin + 2 H2O 1.14.19.54 1,2-dehydroreticuline synthase
–
isopentenyl_phosphate + ATP <=> isopentenyl_diphosphate + ADP 2.7.4.26 isopentenyl phosphate kinase
–
1-epi-valienol_7-phosphate <=> 1,7-Diphospho-1-epi-valienol not assigned
 –
L-cystathionine + H2O <=> L-cysteine + 2-oxobutyrate + NH3 2.5.1.48 cystathionine gamma-synthase
4.4.1.1 cystathionine gamma-lyase
–
–
NDP-D-mannose <=> NDP-4-oxo-6-deoxy-D-mannose not assigned
 –
8 malonyl-CoA + 7 NADPH + 7 H+ + [acyl-carrier_protein] <=> 3-Hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-[acp] + 8 CoA + 8 CO2 + 6 H2O + 7 NADP+ not assigned
 –
D-glucono-1,5-lactone + H2O <=> H+ + D-gluconate 3.1.1.17 gluconolactonase
3.1.1.35 dihydrocoumarin hydrolase
–
–
1,4-dihydroxy-6-naphthoate <=> menaquinone not assigned
 –
1-deoxy-11beta-hydroxypentalenic_acid + NAD+ <=> 1-deoxy-11-oxopentalenate + NADH + H+ 1.1.1.340 1-deoxy-11beta-hydroxypentalenate dehydrogenase
–
S-adenosyl-L-methionine + anthranilate <=> H+ + S-adenosyl-L-homocysteine + N-Methylanthranilate 2.1.1.111 anthranilate N-methyltransferase
–
ent-kaurene <=> stevioside not assigned
 –
S-adenosyl-L-methionine + 5-hydroxyconiferaldehyde <=> H+ + S-adenosyl-L-homocysteine + sinapaldehyde 2.1.1.104 caffeoyl-CoA O-methyltransferase
2.1.1.68 caffeate O-methyltransferase
–
–
6,8a-Seco-6,8a-deoxy-5-oxoavermectin_''''1b''''_aglycone + NADPH + O2 <=> 5-Oxoavermectin_''''1b''''_aglycone + NADP+ + H2O 1.14
–
ATP + 15,173-seco-F430-173-acid <=> ADP + phosphate + coenzyme_F430 6.4.1.9 coenzyme F430 synthetase
–
copalyl_diphosphate <=> isopimara-7,15-diene + diphosphate 4.2.3.44 isopimara-7,15-diene synthase
–
beta-amyrin + reduced_flavodoxin + O2 <=> 24-hydroxy-beta-amyrin + flavin + H2O 1.14.14.134 beta-amyrin 24-hydroxylase
–
ent-cassa-12,15-diene + O2 + reduced_flavodoxin <=> ent-11beta-hydroxycassa-12,15-diene + flavin + H2O 1.14.14.112 ent-cassa-12,15-diene 11-hydroxylase
–
2 N-Methyl-cyclo(L-Trp-L-Phe) <=> (-)-Ditryptophenaline 1
–
L-2-aminoadipate + 2-oxoglutarate <=> L-glutamate + 2-oxoadipate 2.6.1.39 2-aminoadipate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
–
–
dTDP-L-4-oxovancosamine <=> dTDP-beta-L-vancosamine not assigned
 –
dihydrochelirubine + reduced_flavodoxin + O2 <=> 12-hydroxydihydrochelirubine + flavin + H2O 1.14.14.101 dihydrochelirubine 12-monooxygenase
–
LL-2,6-Diaminoheptanedioate + 2-oxoglutarate <=> (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O + H+ 2.6.1.83 LL-diaminopimelate aminotransferase
–
daidzein + reduced_flavodoxin + O2 <=> 2''-hydroxydaidzein + flavin + H2O 1.14.14.89 4'-methoxyisoflavone 2'-hydroxylase
1.14.14.90 isoflavone 2'-hydroxylase
–
–
S-adenosyl-L-methionine + 6-Methylsalicylyl-CoA <=> S-adenosyl-L-homocysteine + 3,6-Dimethylsalicylyl-CoA 2.1.1
–
zeatin_riboside + H2O <=> D-ribose + trans-zeatin not assigned
 –
2''''''-acetyl-6''''''-hydroxyparomomycin + H2O <=> 6''''''-hydroxyparomomycin + acetate 3.5.1
–
copalyl_diphosphate <=> miltiradiene + diphosphate 4.2.3.131 miltiradiene synthase
–
(3Z)-phycocyanobilin + oxidized_ferredoxin <=> Biliverdin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.3.7.5 phycocyanobilin:ferredoxin oxidoreductase
–
15-Demethoxy-epsilon-rhodomycin + O2 + 2 glutathione <=> beta-Rhodomycin + CO2 + H2O + GSSG not assigned
 –
13-dihydrocarminomycin + NADPH + H+ + O2 <=> carminomycin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase
–
131-oxo-magnesium-protoporphyrin_IX_13-monomethyl_ester + O2 + NADPH <=> divinyl_protochlorophyllide_a + NADP+ + H2O 1.14.13.81 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
–
(-)-matairesinol + reduced_flavodoxin + O2 <=> (-)-pluviatolide + flavin + 2 H2O 1.14.19.72 (-)-pluviatolide synthase
–
phosphatidic_acid + H2O <=> diacylglycerol + phosphate 3.1.3.4 phosphatidate phosphatase
3.1.3.81 diacylglycerol diphosphate phosphatase
3.1.4.3 phospholipase C
–
–
–
2-deoxy-scyllo-inosamine + NAD+ <=> 3-amino-2,3-dideoxy-scyllo-inosose + NADH + H+ 1.1.1.329 2-deoxy-scyllo-inosamine dehydrogenase
–
narcotoline_hemiacetal + NAD+ <=> Narcotoline + NADH + H+ 1.1.1.415 noscapine synthase
–
epicatechin + NADP+ <=> cyanidin + NADPH + H+ 1.17.1.3 leucoanthocyanidin reductase
1.3.1.112 anthocyanidin reductase [(2S)-flavan-3-ol-forming]
1.3.1.77 anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]
–
–
–
5,10-dihydrophenazine_1-carboxylate + O2 <=> phenazine-1-carboxylic_acid + H2O2 not assigned
 –
4-coumaroyl-CoA + quinate <=> 5-O-p-coumaroylquinic_acid + CoA 2.3.1.133 shikimate O-hydroxycinnamoyltransferase
2.3.1.99 quinate O-hydroxycinnamoyltransferase
–
–
L-glutamine + 2-deoxy-scyllo-inosose <=> 2-Oxoglutaramate + 2-deoxy-scyllo-inosamine 2.6.1.100 L-glutamine:2-deoxy-scyllo-inosose aminotransferase
2.6.1.50 glutamine---scyllo-inositol transaminase
–
–
L-N-acetyl-2-amino-6-oxopimelate <=> C20911 not assigned
 –
10-deoxysarpagine + reduced_flavodoxin + O2 <=> sarpagine + flavin + H2O 1.14.14.136 deoxysarpagine hydroxylase
–
geraniol + reduced_flavodoxin + O2 <=> (6E)-8-hydroxygeraniol + flavin + H2O 1.14.14.1 unspecific monooxygenase
1.14.14.83 geraniol 8-hydroxylase
–
–
N6,N6,O-Tridemethylpuromycin-5''-phosphate + acetyl-CoA <=> N-Acetyl-N6,N6,O-tridemethylpuromycin-5''-phosphate + CoA 2.3
–
tylactone + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-glucopyranose <=> 5-O-beta-D-mycaminosyltylactone + dTDP + H+ 2.4.1.316 tylactone mycaminosyltransferase
–
gamma-L-Glutamyl-[acp] <=> 4-Aminobutyryl-[acp] + CO2 4.1.1.95 L-glutamyl-[BtrI acyl-carrier protein] decarboxylase
–
6-Deoxydihydrokalafungin + O2 <=> Dihydrokalafungin + H2O not assigned
 –
acetyl-CoA + Deacetylepithienamycin_F <=> CoA + Epithienamycin_F 2.3.1
–
7,9,12-Decaketide_intermediate_3 <=> UWM6 not assigned
 –
prunasin + H2O <=> (R)-mandelonitrile + D-glucose 3.2.1.118 prunasin beta-glucosidase
3.2.1.119 vicianin beta-glucosidase
3.2.1.21 beta-glucosidase
3.2.1.74 glucan 1,4-beta-glucosidase
–
–
–
–
(S)-canadine + O2 + H+ <=> Berberine + H2O2 1.3.3.8 tetrahydroberberine oxidase
–
S-adenosyl-L-methionine + 131-oxo-magnesium-protoporphyrin_IX_13-monomethyl_ester <=> divinyl_protochlorophyllide_a + 5''-deoxyadenosine + L-methionine + H+ 1.21.98.3 anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase
–
(2E,6E)-farnesyl_diphosphate <=> germacrene_A + diphosphate 4.2.3.23 germacrene-A synthase
4.2.3.9 aristolochene synthase
–
–
S-adenosyl-L-methionine + (S)-Norlaudanosoline <=> S-adenosyl-L-homocysteine + (S)-6-O-methylnorlaudanosoline + H+ 2.1.1.128 (RS)-norcoclaurine 6-O-methyltransferase
–
Octaketide_bicyclic_intermediate + NADPH + H+ <=> (R)-Chiral_alcohol + NADP+ 1.1.1
–
O-ureido-L-serine <=> O-ureido-D-serine 5.1.1.19 O-ureido-serine racemase
–
coniferyl_alcohol + NADPH + H+ + O2 <=> 5-hydroxyconiferyl_alcohol + NADP+ + H2O 1.14.13
–
10-deoxymethymycin + 4 reduced_ferredoxin_[iron-sulfur]_cluster + 4 H+ + 2 O2 <=> novamethymycin + 4 oxidized_ferredoxin + 2 H2O 1.14.15.33 pikromycin synthase
–
20,21-Diprenylterpendole_I + 3 O2 + 3 NADPH + 3 H+ <=> Lolitriol + 3 NADP+ + 4 H2O 1.14.13
–
L-tryptophan + L-phenylalanine <=> cyclo-L-Trp-L-Phe 6.3.2
–
4''-O-Methylnorbelladine + reduced_flavodoxin + O2 <=> N-Demethylnarwedine + flavin + 2 H2O 1.14.19
–
S-adenosyl-L-methionine + macrocin <=> tylosin + S-adenosyl-L-homocysteine + H+ 2.1.1.101 macrocin O-methyltransferase
–
2''-deamino-2''-hydroxy-6''-dehydroparomamine + L-glutamate <=> 2''-deamino-2''-hydroxyneamine + 2-oxoglutarate 2.6.1.94 2'-deamino-2'-hydroxyneamine transaminase
–
trans-cinnamate <=> cocaine not assigned
 –
alkane <=> R-CHOH-R' not assigned
 –
deacetylcephalosporin_C + Carbamoyl_phosphate <=> 7beta-(5-D-Aminoadipamido)-3-carbamoyloxymethylceph-3-em-4-carboxylic_acid + phosphate 2.1.3.7 3-hydroxymethylcephem carbamoyltransferase
–
S-adenosyl-L-methionine + (S)-6-O-methylnorlaudanosoline <=> S-adenosyl-L-homocysteine + 3''-Hydroxy-N-methyl-(S)-coclaurine 2.1.1.115 (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
–
4-Deoxy-4-thio-alpha-D-digitoxosyl-calicheamicin_T0 + 5-Iodo-2,3-dimethoxyorsellinate-[acp] <=> Calicheamicin_PsAg + [acyl-carrier_protein] not assigned
 –
3-hydroxyindolin-2-one + reduced_flavodoxin + O2 <=> 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + flavin + H2O 1.14.14.109 3-hydroxyindolin-2-one monooxygenase
–
Fe-coproporphyrin_III + H2O2 + H+ <=> heme + CO2 + H2O 1.3.98.5 hydrogen peroxide-dependent heme synthase
–
N-Methylanthranilate + ATP + CoA <=> N-methylanthraniloyl-CoA + AMP + diphosphate 6.2.1
6.2.1.32 anthranilate---CoA ligase
–
–
erythromycin + O2 <=> Erythromycin_E + H2O not assigned
 –
Landomycin_D <=> Landomycin_E not assigned
 –
N-Demethyl-desepoxymaytansinol + isobutyryl-CoA <=> N-Demethyl-desepoxyansamitocin_P-3 + CoA not assigned
 –
versiconol_acetate + H2O <=> versiconol + acetate 3.1.1.94 versiconal hemiacetal acetate esterase
–
(2E,6E)-farnesyl_diphosphate + 4-hydroxy-2-methylquinoline <=> aurachin_D + diphosphate 2.5.1
–
lycopene <=> gamma-carotene 5.5.1.19 lycopene beta-cyclase
–
methylglyoxal + D-fructose_1,6-bisphosphate <=> D-glyceraldehyde_3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose_6-phosphate 2.2.1.11 6-deoxy-5-ketofructose 1-phosphate synthase
–
S-adenosyl-L-methionine + dehypoxanthine_futalosine <=> cyclic_dehypoxanthinyl_futalosine + L-methionine + 5''-deoxyadenosine + H+ 1.21.98.1 cyclic dehypoxanthinyl futalosine synthase
–
1-guanidino-1-deoxy-scyllo-inositol <=> 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol not assigned
 –
Dopaxanthin + O2 <=> Dopaxanthin_quinone + H2O 1.10.3
1.14.18.1 tyrosinase
–
–
riboflavin + ATP <=> FMN + ADP + H+ 2.7.1.161 CTP-dependent riboflavin kinase
2.7.1.26 riboflavin kinase
–
–
thebaine + 2-oxoglutarate + O2 <=> neopinone + formaldehyde + succinate + CO2 1.14.11.31 thebaine 6-O-demethylase
–
L-glutamine + 3-amino-2,3-dideoxy-scyllo-inosose <=> 2-Oxoglutaramate + 2-deoxystreptamine 2.6.1.101 L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
2.6.1.50 glutamine---scyllo-inositol transaminase
–
–
neomycin_C <=> neomycin 5.1.3
–
Terpendole_J + dimethylallyl_diphosphate <=> 20,21-Diprenylterpendole_J + diphosphate 2.5.1
–
abietadienol + reduced_flavodoxin + O2 <=> abietadienal + flavin + H2O 1.14.14.145 abieta-7,13-dien-18-ol hydroxylase
–
S-adenosyl-L-methionine + magnesium_protoporphyrin_IX <=> S-adenosyl-L-homocysteine + magnesium_protoporphyrin_monomethyl_ester 2.1.1.11 magnesium protoporphyrin IX methyltransferase
–
3-(2''-Methylthio)ethylmalic_acid + NAD+ <=> 2-Oxo-5-methylthiopentanoic_acid + CO2 + NADH + H+ 1.1.1
–
4''-O-methylnorbelladine + reduced_flavodoxin + O2 <=> (10bS,4aR)-noroxomaritidine + flavin + 2 H2O 1.14.19.50 noroxomaritidine synthase
–
UWM6 + dTDP-D-boivinose <=> C1''-C9-Glycosylated_UWM6 + dTDP 2.4.1
–
aclacinomycin_T + H2O <=> 15-demethylaclacinomycin_T + methanol + H+ 3.1.1.95 aclacinomycin methylesterase
–
Phosphinothricin + acetyl-CoA <=> H+ + CoA + N-acetylphosphinothricin 2.3.1.183 phosphinothricin acetyltransferase
–
5''''-phosphoribosylparomamine + H2O <=> 5-Ribosylparomamine + phosphate 3.1.3
–
gamma-L-glutamyl-butirosin_B <=> butirosin_B + 5-oxoproline 4.3.2.6 gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase
–
(3R)-2''-hydroxydihydrodaidzein + NADP+ <=> 2''-hydroxydaidzein + NADPH + H+ 1.3.1.51 2'-hydroxydaidzein reductase
–
geranylgeranyl_diphosphate <=> ent-copalyl_diphosphate 5.5.1.12 copalyl diphosphate synthase
5.5.1.13 ent-copalyl diphosphate synthase
5.5.1.14 syn-copalyl-diphosphate synthase
–
–
–
N3-fumarylcarboxyamido-L-2,3-diaminopropionic_acid + L-leucine + ATP <=> 3-{[(2E)-4-amino-4-oxobut-2-enoyl]amino}-L-alanyl-L-leucine + ADP + phosphate + H+ 6.3.2.47 dapdiamide synthase
–
(R)-2,3-dihydroxy-3-methylbutanoate <=> 2-oxoisovalerate + H2O 4.2.1.9 dihydroxy-acid dehydratase
–
Landomycin_H <=> 8-D-Olivosyl-landomycin not assigned
 –
N-acetylpuromycin + H2O <=> puromycin + acetate not assigned
 –
chlorophyllide_a + H+ <=> pheophorbide_a + Mg2+ 4.99.1.10 magnesium dechelatase
–
S-adenosyl-L-methionine + cytidine_5''-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + reduced_acceptor <=> 5''-deoxyadenosine + L-methionine + S-adenosyl-L-homocysteine + cytidine_5''-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + acceptor + H+ 2.1.1.308 cytidylyl-2-hydroxyethylphosphonate methyltransferase
–
7,9,12-Octaketide_intermediate_3 <=> Octaketide_bicyclic_intermediate + H2O 4
–
6-methylpretetramide + NADPH + O2 + H+ <=> 4-hydroxy-6-methylpretetramide + NADP+ + H2O 1.14.13.232 6-methylpretetramide 4-monooxygenase
–
miltiradiene <=> abieta-8,11,13-triene not assigned
 –
N1,N5,N10-Tricaffeoyl_spermidine <=> N1,N5,N10-Triferuloyl_spermidine 2.1.1
–
gibberellin_A12 + O2 + 2-oxoglutarate <=> gibberellin_a15 + CO2 + succinate 1.14.11
1.14.11.12 gibberellin-44 dioxygenase
–
–
paraxanthine + O2 + H2O <=> 1,7-dimethyluric_acid + H2O2 1.17.3.2 xanthine oxidase
–
Antibiotic_JI-20B <=> gentamicin_C2 not assigned
 –
eriodictyol + reduced_flavodoxin + O2 <=> pentahydroxyflavanone + flavin + H2O 1.14.14.81 flavanoid 3',5'-hydroxylase
–
trans-geranic_acid + CoA <=> trans-Geranyl-CoA + H2O 2.8.3
–
beta-carotene <=> echinenone not assigned
 –
34a-Deoxy-rifamycin_W <=> Rifamycin_W not assigned
 –
4-coumaroyl-CoA + spermidine <=> N1,N5,N10-Tricoumaroyl_spermidine + CoA + H+ 2.3.1.M34
–
O2 + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine <=> H2O + isopenicillin_N 1.21.3.1 isopenicillin-N synthase
–
UDP-glucose + (S)-4-hydroxymandelonitrile <=> H+ + UDP + Dhurrin 2.4.1.85 cyanohydrin beta-glucosyltransferase
–
L-glutamate_5-semialdehyde + phosphate + NADP+ <=> L-5-glutamyl_phosphate + NADPH + H+ 1.2.1.41 glutamate-5-semialdehyde dehydrogenase
–
(2E,6E)-farnesol + NADP+ <=> (2E,6E)-farnesal + NADPH + H+ 1.1.1.21 aldose reductase
1.1.1.216 farnesol dehydrogenase (NADP+)
–
–
(S)-3-acetyloctanal + amino_acid <=> 2-Methyl-3-n-amyl-dihydropyrrole + a_2-oxo_carboxylate 2.6.1
–
feruloyl-CoA + H2O <=> 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA 4.1.2.61 feruloyl-CoA hydratase/lyase
4.2.1.101 trans-feruloyl-CoA hydratase
–
–
S-adenosyl-L-methionine + phosphatidylethanolamine <=> phosphatidyl-N-methylethanolamine + S-adenosyl-L-homocysteine + H+ 2.1.1.17 phosphatidylethanolamine N-methyltransferase
–
delta-carotene <=> epsilon-carotene 5.5.1.18 lycopene epsilon-cyclase
–
3,4-Dihydro-7-methoxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylic_acid <=> 3,4-Dihydro-7-methoxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carbonyl-CoA not assigned
 –
S-(4-Methylthiobutylthiohydroximoyl)-L-cysteine + H2O <=> an_(E)-omega-(methylthio)alkyl-thiohydroximate + pyruvate + NH3 4.4.1
4.4.1.13 cysteine-S-conjugate beta-lyase
–
–
H+ + 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate <=> indole-3-glycerol_phosphate + CO2 + H2O 4.1.1.48 indole-3-glycerol-phosphate synthase
–
L-threonine <=> 2-oxobutyrate + NH3 4.2.3.1 threonine synthase
4.3.1.17 L-serine ammonia-lyase
4.3.1.19 threonine ammonia-lyase
–
–
–
ent-copalyl_diphosphate <=> ent-sandaracopimara-8(14),15-diene + diphosphate 4.2.3.19 ent-kaurene synthase
4.2.3.29 ent-sandaracopimaradiene synthase
–
–
S-adenosyl-L-methionine + palmatine + NADPH <=> S-adenosyl-L-homocysteine + corydaline + NADP+ 2.1.1.147 corydaline synthase
–
(1''S)-averantin + reduced_flavodoxin + O2 <=> (1''S,5''R)-5''-hydroxyaverantin + flavin + H2O 1.14.14.116 averantin hydroxylase
–
S-adenosyl-L-methionine + dihydrodemethylsterigmatocystin <=> H+ + dihydrosterigmatocystin + S-adenosyl-L-homocysteine 2.1.1.109 demethylsterigmatocystin 6-O-methyltransferase
–
1,3-dihydroxy-N-methylacridone <=> Melicopicine not assigned
 –
protein_C-terminal_S-farnesyl-L-cysteine_methyl_ester <=> S-(2E,6E)-farnesyl-L-cysteine not assigned
 –
(6E)-8-hydroxylinalool + reduced_flavodoxin + O2 <=> (6E)-8-oxolinalool + flavin + 2 H2O 1.14.14.84 linalool 8-monooxygenase
–
trans-Geranyl-CoA <=> geranoyl-CoA 5.2.1
–
(R)-5-phosphomevalonate + ATP <=> 5-diphosphomevalonate + ADP 2.7.4.2 phosphomevalonate kinase
–
Roquefortine_C + reduced_flavodoxin + O2 <=> N1-Hydroxy-roquefortine_C + flavin + H2O 1.14.14
–
L-tyrosine + 2-oxoglutarate <=> 4-hydroxyphenylpyruvate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.24 diiodotyrosine transaminase
2.6.1.27 tryptophan transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.49 dihydroxyphenylalanine transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
2.6.1.79 glutamate---prephenate aminotransferase
2.6.1.9 histidinol-phosphate transaminase
–
–
–
–
–
–
–
–
–
–
–
–
L-proline + NAD+ <=> L-pyrroline-5-carboxylate + NADH + H+ 1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
1.5.1.2 pyrroline-5-carboxylate reductase
1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]
1.5.5.2 proline dehydrogenase
–
–
–
–
levopimaradienal <=> Levopimaric_acid not assigned
 –
UDP-glucose + dihydrozeatin <=> H+ + Dihydrozeatin-O-glucoside + UDP 2.4.1
–
(1S,2R,3S,4S,5R,6S)-4-amino-2-carbamimidamido-3,5,6-trihydroxycyclohexyl_phosphate + L-arginine <=> streptidine_6-phosphate + L-ornithine not assigned
 –
Coproporphyrinogen-III + O2 + H+ <=> protoporphyrinogen-IX + CO2 + H2O 1.3.3.3 coproporphyrinogen oxidase
–
secologanin <=> gentiopicroside not assigned
 –
L-glutamate + acetyl-CoA <=> H+ + N-acetyl-L-glutamate + CoA 2.3.1.1 amino-acid N-acetyltransferase
2.3.1.17 aspartate N-acetyltransferase
2.3.1.183 phosphinothricin acetyltransferase
2.7.2.8 acetylglutamate kinase
6.3.4.16 carbamoyl-phosphate synthase (ammonia)
–
–
–
–
–
3''''-hydroxy-geranylhydroquinone <=> deoxyshikonin not assigned
 –
(3E)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate <=> 3-[(2E,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-ylidene]-2-oxopropanoate not assigned
 –
avenasterol + NADP+ <=> avenastenone + NADPH + H+ 1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase
–
H+ + isochorismate + 2-oxoglutarate <=> (1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate + CO2 2.2.1.9 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase
–
(E)-phenylacetaldoxime + L-cysteine + NADPH + O2 + H+ <=> S-(Phenylacetothiohydroximoyl)-L-cysteine + NADP+ + 2 H2O 1.14.14.45 aromatic aldoxime N-monooxygenase
–
(-)-menthone + NADP+ <=> (R)-pulegone + NADPH + H+ 1.3.1.81 (+)-pulegone reductase
–
Premithramycinone + dTDP-D-boivinose <=> Premithramycin_A1 + dTDP + H+ 2.4.1
–
L-cysteine + H2O <=> L-serine + Sulfide 2.5.1.47 cysteine synthase
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
4.2.1.22 cystathionine beta-synthase
–
–
–
Gibberellin_19 + O2 + 2-oxoglutarate <=> H+ + gibberellin_a20 + CO2 + succinate 1.14.11
1.14.11.12 gibberellin-44 dioxygenase
–
–
aurachin_C + O2 + NADPH + H+ <=> 4-hydroxy-2-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]quinolin-3(4H)-one_1-oxide + NADP+ + H2O 1.14.13.222 aurachin C monooxygenase/isomerase
–
L-histidinal + NAD+ + H2O <=> H+ + L-histidine + NADH 1.1.1.23 histidinol dehydrogenase
–
geranyl_diphosphate + 4-hydroxybenzoate <=> 3-geranyl-4-hydroxybenzoate + diphosphate 2.5.1.39 4-hydroxybenzoate polyprenyltransferase
2.5.1.93 4-hydroxybenzoate geranyltransferase
–
–
pyruvate + L-aspartate_4-semialdehyde <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+ 4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase
–
phosphatidylcholine + H2O <=> diacylglycerol + phosphocholine + H+ 3.1.1.4 phospholipase A2
3.1.4.12 sphingomyelin phosphodiesterase
3.1.4.3 phospholipase C
–
–
–
Nicotine + CO2 + H+ <=> 1-Methylpyrrolinium + nicotinate not assigned
 –
L-cysteine + cyanide <=> H+ + Sulfide + Beta-cyanoalanine 2.5.1.47 cysteine synthase
2.8.1.1 thiosulfate sulfurtransferase
4.4.1.9 L-3-cyanoalanine synthase
–
–
–
clavaminate <=> Clavulanate-9-aldehyde not assigned
 –
N6-acetyl-N6-hydroxy-L-lysine + citrate + ATP <=> N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + AMP + diphosphate + H+ 6.3.2.38 N2-citryl-N6-acetyl-N6-hydroxylysine synthase
–
2-epi-5-epi-valiolone_7-phosphate <=> 5-epi-valiolone_7-phosphate 5.1.3.35 2-epi-5-epi-valiolone 7-phosphate 2-epimerase
–
4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA <=> acetyl-CoA + Vanillin 4.1.2.41 vanillin synthase
4.1.2.61 feruloyl-CoA hydratase/lyase
–
–
enzyme_N6-(dihydrolipoyl)lysine + NAD+ <=> [dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine + NADH + H+ 1.8.1.4 dihydrolipoyl dehydrogenase
–
N6-isopentenyladenosine + reduced_flavodoxin + O2 <=> zeatin_riboside + flavin + H2O not assigned
 –
taxa-4(20),11-dien-5alpha-ol + acetyl-CoA <=> taxa-4(20),11-dien-5alpha-yl_acetate + CoA 2.3.1.162 taxadien-5alpha-ol O-acetyltransferase
–
C20821 + pantetheine <=> OA-6129_A not assigned
 –
(R)-3-phosphomevalonate + ATP <=> 3,5-diphosphomevalonate + ADP + H+ 2.7.1.186 mevalonate-3-phosphate 5-kinase
–
abietadienal + reduced_flavodoxin + O2 <=> abietic_acid + flavin + H2O 1.14.14.145 abieta-7,13-dien-18-ol hydroxylase
–
amylose <=> maltooligosyltrehalose 5.4.99.15 (1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase
–
3-Geranylgeranylindole + O2 + NADPH + H+ <=> 10,11-Epoxy-3-geranylgeranylindole + NADP+ + H2O 1.14.13
–
neamine + 5-phospho-alpha-D-ribose_1-diphosphate <=> 5''''-phosphoribostamycin + diphosphate 2.4.2.49 neamine phosphoribosyltransferase
–
epigallocatechin + NADP+ <=> delphinidin + NADPH + H+ 1.3.1.112 anthocyanidin reductase [(2S)-flavan-3-ol-forming]
1.3.1.77 anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]
–
–
beta-carotene + reduced_acceptor + O2 <=> echinenone + acceptor + H2O 1.14.99.63 beta-carotene 4-ketolase
–
L-tyrosine + O2 + H2O <=> 4-hydroxyphenylacetaldehyde + CO2 + NH3 + H2O2 4.1.1.108 4-hydroxyphenylacetaldehyde synthase
–
8-O-methylsterigmatocystin <=> aflatoxin_G1 not assigned
 –
ATP + diacylglycerol <=> H+ + phosphatidic_acid + ADP 2.7.1.107 diacylglycerol kinase (ATP)
2.7.1.138 ceramide kinase
2.7.1.94 acylglycerol kinase
–
–
–
C20913 <=> C20914 + CO2 4.1.1
–
L-valine + 2 reduced_flavodoxin + 2 O2 <=> (E/Z)-isobutyraldoxime + 2 flavin + CO2 + 3 H2O 1.14.14.38 valine N-monooxygenase
–
acetone_cyanohydrin <=> cyanide + acetone 4.1.2.37 hydroxynitrilase
4.1.2.46 aliphatic (R)-hydroxynitrile lyase
4.1.2.47 (S)-hydroxynitrile lyase
–
–
–
H+ + 4-coumaroyl-CoA + malonyl-CoA <=> (4-coumaroyl)acetyl-CoA + CoA + CO2 2.3.1.218 phenylpropanoylacetyl-CoA synthase
–
Dihydrosanguinarine + reduced_flavodoxin + O2 <=> 10-Hydroxydihydrosanguinarine + flavin + H2O 1.14.14.100 dihydrosanguinarine 10-monooxygenase
–
feruloyl-CoA <=> 5-hydroxyferuloyl-CoA not assigned
 –
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine <=> phosphatidyl-N,N-dimethylethanolamine + H+ + S-adenosyl-L-homocysteine 2.1.1.103 phosphoethanolamine N-methyltransferase
2.1.1.16 methylene-fatty-acyl-phospholipid synthase
2.1.1.17 phosphatidylethanolamine N-methyltransferase
2.1.1.71 phosphatidyl-N-methylethanolamine N-methyltransferase
–
–
–
–
S-adenosyl-L-methionine + tetracenomycin_B3 <=> tetracenomycin_B2 + S-adenosyl-L-homocysteine 2.1.1
–
5-O-beta-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose <=> demethyllactenocin + dTDP + H+ 2.4.1.317 O-mycaminosyltylonolide 6-deoxyallosyltransferase
–
3-dimethylallyl-4-hydroxymandelate + O2 <=> 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O 1.13.12.23 4-hydroxy-3-prenylbenzoate synthase
–
neopinone <=> codeinone not assigned
 –
(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate <=> (1R,5aS,6R)-4a-Hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate + H2O + H+ not assigned
 –
isocitrate + NADP+ <=> oxalosuccinate + NADPH + H+ 1.1.1.42 isocitrate dehydrogenase (NADP+)
–
N-debenzoyl-(3''-RS)-taxol + benzoyl-CoA <=> H+ + paclitaxel + CoA 2.3.1
–
OPC4-CoA + FAD <=> trans-2-Enoyl-OPC4-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
–
vitamin_D3 + O2 + reduced_flavodoxin <=> 25-hydroxyvitamin_D3 + flavin + H2O 1.14.14.24 vitamin D 25-hydroxylase
–
(S)-4-hydroxymandelonitrile <=> 4-hydroxybenzaldehyde + cyanide 4.1.2.11 hydroxymandelonitrile lyase
4.1.2.47 (S)-hydroxynitrile lyase
–
–
echinenone <=> canthaxanthin not assigned
 –
ADP-glucose + H2O <=> AMP + alpha-D-glucose_1-phosphate + H+ 3.6.1.13 ADP-ribose diphosphatase
3.6.1.21 ADP-sugar diphosphatase
3.6.1.45 UDP-sugar diphosphatase
3.6.1.9 nucleotide diphosphatase
–
–
–
–
S-adenosyl-L-methionine + a_bacteriochlorophyllide_c + H2O <=> bacteriochlorophyllide_e + 5''-deoxyadenosine + L-methionine + H+ 1.17.98.2 bacteriochlorophyllide c C-71-hydroxylase
–
3-Dehydroteasterone <=> typhasterol not assigned
 –
sparteine <=> Cytisine not assigned
 –
N,N'-bis(7-[[(2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)-3-methyl-1H-pyrrole-2,4-dicarboxamide + 2 (1H-pyrrole-2-carbonyl)-[peptidyl-carrier_protein] <=> coumermycin not assigned
 –
ent-isokauren-2beta-ol + O2 + reduced_flavodoxin <=> ent-isokaurene-2beta,3beta-diol + flavin + H2O 1.14.14.76 ent-isokaurene C2/C3-hydroxylase
–
S-adenosyl-L-methionine + gamma-tocopherol <=> S-adenosyl-L-homocysteine + alpha-tocopherol + H+ 2.1.1.95 tocopherol C-methyltransferase
–
(13E)-8alpha-hydroxylabd-13-en-15-yl_diphosphate <=> cis-abienol + diphosphate 4.2.3.140 cis-abienol synthase
–
1,2-dihydrovomilenine + NADP+ <=> Vomilenine + NADPH + H+ 1.5.1.32 vomilenine reductase
–
apigenin + reduced_flavodoxin + O2 <=> luteolin + flavin + H2O 1.14.14.81 flavanoid 3',5'-hydroxylase
1.14.14.82 flavonoid 3'-monooxygenase
–
–
dTDP-6-deoxy-alpha-D-allose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-gulose + NADH + H+ 1.1.1.364 dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase
–
tetracenomycin_D3 <=> tetracenomycin_B3 not assigned
 –
3-Hydroxy-OPC4-CoA <=> trans-2-Enoyl-OPC4-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase
–
–
S-adenosyl-L-methionine + 7-methylxanthine <=> H+ + Theobromine + S-adenosyl-L-homocysteine 2.1.1.159 theobromine synthase
2.1.1.160 caffeine synthase
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–
indole-3-glycerol_phosphate <=> indole + D-glyceraldehyde_3-phosphate 4.1.2.8 indole-3-glycerol-phosphate lyase
4.2.1.20 tryptophan synthase
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dimethylallyl_diphosphate <=> isoprene + diphosphate 4.2.3.27 isoprene synthase
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kanosamine_6-phosphate + H2O <=> kanosamine + phosphate 3.1.3.92 kanosamine-6-phosphate phosphatase
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2-amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate <=> H+ + 3-Amino-4-hydroxybenzoic_acid + phosphate + H2O 4.1.99.20 3-amino-4-hydroxybenzoate synthase
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3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp] <=> 9,14-Decaketide_intermediate_1 + 2 H2O 2.3.1.235 tetracenomycin F2 synthase
4.2.1
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(S)-4-(3''-acetyl-5''-hydroxy-4''-oxo-1,4''-dihydronapthalen-2''-yl)-3-hydroxybutanoate <=> 2-((1R,3S),-1,9''-dihydroxy-1''-methyl-10''-oxo-3,4,5,10''-tetrahydro-1H-benzo[g]isochromen-3''-yl)acetate 5.5.1
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dTDP-6-deoxy-beta-L-talose + NAD+ <=> dTDP-4-dehydro-beta-L-rhamnose + NADH + H+ 1.1.1.339 dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
1.1.1.344 dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]
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(2E,6E)-farnesyl_diphosphate <=> (E)-beta-caryophyllene + diphosphate 4.2.3.57 (-)-beta-caryophyllene synthase
4.2.3.89 (+)-beta-caryophyllene synthase
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H+ + cannabidiolate <=> cannabidiol + CO2 not assigned
 –
isopimara-7,15-diene <=> isopimara-7,15-dienol 1.14.13
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naringenin + 2-oxoglutarate + O2 <=> apigenin + succinate + CO2 + H2O + H+ 1.14.20.4 anthocyanidin synthase
1.14.20.5 flavone synthase I
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hexadecanal <=> alkane + CO 4.1.99.5 aldehyde oxygenase (deformylating)
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paraxanthine + NADH + O2 + H+ <=> 7-methylxanthine + NAD+ + formaldehyde + H2O 1.14.13.128 7-methylxanthine demethylase
1.14.13.178 methylxanthine N1-demethylase
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7-hydroxy-2,4,5''-trimethoxyisoflavone <=> 9-Demethylmunduserone not assigned
 –
H+ + H2O + L-pyrroline-5-carboxylate <=> L-glutamate_5-semialdehyde 0.0.0.0
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1,3-dihydroxy-N-methylacridone <=> Rutacridone not assigned
 –
paromamine + UDP-D-xylose <=> gentamicin_A2 + UDP + H+ 2.4.2
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L-serine + L-homocysteine <=> L-cystathionine + H2O 2.5.1.47 cysteine synthase
4.2.1.22 cystathionine beta-synthase
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geranyl_diphosphate <=> (+)-limonene + diphosphate 4.2.3.20 (R)-limonene synthase
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5-phosphoribosylamine + ATP + glycine <=> H+ + ADP + phosphate + beta-glycinamide_ribonucleotide 6.3.4.13 phosphoribosylamine---glycine ligase
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2,5,7,4'-tetrahydroxyisoflavanone <=> genistein + H2O + H+ 4.2.1.105 2-hydroxyisoflavanone dehydratase
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myo-inositol + NAD+ <=> scyllo-inosose + NADH + H+ 1.1.1.114 apiose 1-reductase
1.1.1.18 inositol 2-dehydrogenase
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fumigaclavine_B + acetyl-CoA <=> fumigaclavine_A + CoA 2.3.1.205 fumigaclavine B O-acetyltransferase
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valienone + ATP <=> H+ + valienone_7-phosphate + ADP 2.7.1.214 C7-cyclitol 7-kinase
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dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate 2.6.1.89 dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase
–
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ 1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase
–
7,9,12-Decaketide_intermediate_5 <=> 7,9,12-Decaketide_intermediate_6 + 2 H2O 4.2.1
–
(2S)-2-amino-4-deoxy-chorismate + H2O <=> (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylic_acid + pyruvate 3.3.2.15 trans-2,3-dihydro-3-hydroxyanthranilic acid synthase
3.3.2.B1
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(-)-trans-carveol + NADP+ <=> (-)-Carvone + NADPH + H+ 1.1.1.243 carveol dehydrogenase
1.3.1.102 2-alkenal reductase (NADP+)
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Megalomicin_A <=> Megalomicin_C1 not assigned
 –
phosphatidylcholine + H2O <=> 2-acylglycerophosphocholine