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Benzoate degradation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
benzoate + NADPH + H+ + O2 <=> (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NADP+ 1.14.12.10 benzoate 1,2-dioxygenase
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pimeloyl-CoA + NAD+ <=> H+ + NADH + 6-carboxyhex-2-enoyl-CoA 1.3.1.62 pimeloyl-CoA dehydrogenase
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cis-3,4-dehydroadipyl-CoA_semialdehyde + NADP+ + H2O <=> cis-3,4-dehydroadipyl-CoA + NADPH + H+ 1.2.1.77 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)
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benzoyl-CoA + reduced_acceptor <=> cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor 1.3
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2-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> H+ + 3-carboxy-cis,cis-muconate 5.5.1.2 3-carboxy-cis,cis-muconate cycloisomerase
5.5.1.5 carboxy-cis,cis-muconate cyclase
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H+ + 3,4-dihydroxybenzoate <=> CO2 + catechol 4.1.1.59 gallate decarboxylase
4.1.1.61 4-hydroxybenzoate decarboxylase
4.1.1.63 protocatechuate decarboxylase
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catechol + O2 <=> H+ + cis,cis-muconate 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.3 protocatechuate 3,4-dioxygenase
1.13.11.37 hydroxyquinol 1,2-dioxygenase
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NADPH + O2 + 4-hydroxybenzoate + H+ <=> NADP+ + CO2 + H2O + hydroquinone 1.14.13.64 4-hydroxybenzoate 1-hydroxylase
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2-Pyrone-4,6-dicarboxylate + H2O <=> 4-oxalomesaconate + H+ 3.1.1.57 2-pyrone-4,6-dicarboxylate lactonase
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H+ + 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> CO2 + 2-(5-oxo-4,5-dihydrofuran-2-yl)acetic_acid 4.1.1.44 4-carboxymuconolactone decarboxylase
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glutaconyl-CoA + H+ <=> CO2 + crotonyl-CoA 1.3.8.6 glutaryl-CoA dehydrogenase (ETF)
6.4.1.4 methylcrotonoyl-CoA carboxylase
7.2.4.5 glutaconyl-CoA decarboxylase
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–
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6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+ <=> H+ + 6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH 1.1.1.368 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
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2-hydroxymuconate-6-semialdehyde + H2O + NAD+ <=> 2-hydroxy-2,4-hexadienedioate + NADH + H+ 1.2.1.32 aminomuconate-semialdehyde dehydrogenase
1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase
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benzoate + CoA + ATP <=> benzoyl-CoA + diphosphate + AMP 6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.25 benzoate---CoA ligase
6.2.1.32 anthranilate---CoA ligase
6.2.1.33 4-chlorobenzoate---CoA ligase
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3-oxopimeloyl-CoA + CoA <=> glutaryl-CoA + acetyl-CoA 2.3.1
2.3.1.16 acetyl-CoA C-acyltransferase
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H2O + 2-(5-oxo-4,5-dihydrofuran-2-yl)acetic_acid <=> H+ + 3-oxoadipate 3.1.1.24 3-oxoadipate enol-lactonase
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3-oxoadipate + NADP+ <=> maleylacetate + NADPH + H+ 1.3.1.32 maleylacetate reductase
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(4S)-(+)-muconolactone <=> H+ + cis,cis-muconate 5.5.1.1 muconate cycloisomerase
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O2 + 3,4-dihydroxybenzoate <=> H+ + 3-carboxy-cis,cis-muconate 1.13.11.3 protocatechuate 3,4-dioxygenase
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3-hydroxypimeloyl-CoA + NAD+ <=> H+ + NADH + 3-oxopimeloyl-CoA 1.1.1.259 3-hydroxypimeloyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
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2-ketocyclohexane-1-carboxyl-CoA + H2O <=> H+ + pimeloyl-CoA 3.1.2
3.7.1
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2-hydro-1,2-dihydroxybenzoate + NAD+ <=> catechol + CO2 + NADH 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
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benzoate <=> 3-hydroxybenzoate not assigned
 –
4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde + NADP+ <=> 2-Pyrone-4,6-dicarboxylate + NADPH + H+ 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
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glutaryl-CoA + flavin <=> crotonyl-CoA + CO2 + reduced_flavodoxin 1.3.8.6 glutaryl-CoA dehydrogenase (ETF)
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cyclohex-1-ene-1-carbonyl-CoA + H2O <=> 2-hydroxycyclohexane-1-carbonyl-CoA 4.2.1
4.2.1.100 cyclohexa-1,5-dienecarbonyl-CoA hydratase
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3-carboxy-2-hydroxymuconate_semialdehyde + H+ <=> 2-hydroxymuconate-6-semialdehyde + CO2 4.1.1
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3,4-dihydroxybenzoate + NADH + O2 <=> Hydroxyquinol + NAD+ + CO2 1.13.11
1.14.13.64 4-hydroxybenzoate 1-hydroxylase
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4-hydroxy-2-oxopentanoate <=> pyruvate + acetaldehyde 4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
4.1.3.39 4-hydroxy-2-oxovalerate aldolase
4.1.3.43 4-hydroxy-2-oxohexanoate aldolase
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phenol + O2 + NADH + H+ <=> catechol + H2O + NAD+ 1.14.13.244 phenol 2-monooxygenase (NADH)
1.14.13.7 phenol 2-monooxygenase (NADPH)
1.14.14.20 phenol 2-monooxygenase (FADH2)
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3-hydroxybenzoate + O2 + NADPH + H+ <=> 3,4-dihydroxybenzoate + H2O + NADP+ 1.14.13.2 4-hydroxybenzoate 3-monooxygenase
1.14.13.23 3-hydroxybenzoate 4-monooxygenase
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4-Methylene-2-oxoglutarate + H2O <=> 4-hydroxy-4-methyl-2-oxoglutarate 4.2.1
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cis-benzene_dihydrodiol + NAD+ <=> catechol + NADH + H+ 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.3.1.119 chlorobenzene dihydrodiol dehydrogenase
1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
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(S)-3-hydroxybutyryl-CoA + NADP+ <=> acetoacetyl-CoA + NADPH + H+ 1.1.1.157 3-hydroxybutyryl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
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3-hydroxybenzoate + O2 + NADH + H+ <=> 2,5-Dihydroxybenzoate + H2O + NAD+ 1.14.13.24 3-hydroxybenzoate 6-monooxygenase
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3-sulfocatechol + O2 + H2O <=> 2-hydroxy-2,4-hexadienedioate + sulfite + H+ 1.13.11.2 catechol 2,3-dioxygenase
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resorcinol + NADPH + O2 + H+ <=> Hydroxyquinol + NADP+ + H2O 1.14.13.219 resorcinol 4-hydroxylase (NADPH)
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succinyl-CoA + 3-oxoadipate <=> succinate + 3-oxoadipyl-CoA 2.8.3.6 3-oxoadipate CoA-transferase
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4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde <=> 4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde not assigned
 –
2-hydroxy-2,4-hexadienedioate <=> 4-oxalocrotonate 5.3.2.6 2-hydroxymuconate tautomerase
5.3.2.M1
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cyclohexanecarboxyl-CoA + acceptor <=> cyclohex-1-ene-1-carbonyl-CoA + reduced_acceptor 1.3
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4-hydroxybenzoyl-CoA + H2O <=> H+ + 4-hydroxybenzoate + CoA 3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.23 4-hydroxybenzoyl-CoA thioesterase
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resorcinol + NADH + O2 + H+ <=> Hydroxyquinol + NAD+ + H2O 1.14.13.220 resorcinol 4-hydroxylase (NADH)
1.14.13.6 orcinol 2-monooxygenase
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2,6-dihydroxybenzoate + H+ <=> resorcinol + CO2 4.1.1.103 gamma-resorcylate decarboxylase
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benzoate + NADH + H+ + O2 <=> 2-hydro-1,2-dihydroxybenzoate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase
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O2 + 3,4-dihydroxybenzoate <=> H+ + 4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde 1.13.11.8 protocatechuate 4,5-dioxygenase
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catechol + O2 <=> 2-hydroxymuconate-6-semialdehyde + H+ 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
1.13.11.2 catechol 2,3-dioxygenase
1.13.11.36 chloridazon-catechol dioxygenase
1.13.11.37 hydroxyquinol 1,2-dioxygenase
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
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cyclohexa-1,5-diene-1-carbonyl-CoA <=> cyclohexa-2,5-diene-1-carbonyl-CoA not assigned
 –
2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O <=> cis-3,4-dehydroadipyl-CoA_semialdehyde + formate + H+ 4.1.2.44 2,3-epoxybenzoyl-CoA dihydrolase
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resorcinol + FADH2 + O2 <=> Hydroxyquinol + FAD + H2O + H+ 1.14.14.27 resorcinol 4-hydroxylase (FADH2)
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4-oxalocrotonate <=> 2-oxopent-4-enoate + CO2 4.1.1.77 2-oxo-3-hexenedioate decarboxylase
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ATP + cyclohexanecarboxylate + CoA <=> AMP + diphosphate + cyclohexanecarboxyl-CoA 6.2.1
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.25 benzoate---CoA ligase
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benzoate + reduced_flavodoxin + O2 <=> 4-hydroxybenzoate + flavin + H2O 1.14.14.1 unspecific monooxygenase
1.14.14.92 benzoate 4-monooxygenase
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6-hydroxycyclohex-1-ene-1-carbonyl-CoA <=> cyclohexa-1,5-diene-1-carbonyl-CoA + H2O 4.2.1.100 cyclohexa-1,5-dienecarbonyl-CoA hydratase
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cyclohex-1-ene-1-carbonyl-CoA + flavin <=> cyclohexa-1,5-diene-1-carbonyl-CoA + reduced_flavodoxin 1.3.8.10 cyclohex-1-ene-1-carbonyl-CoA dehydrogenase
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succinyl-CoA + acetyl-CoA <=> 3-oxoadipyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.174 3-oxoadipyl-CoA thiolase
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benzoyl-CoA + oxidized_ferredoxin + H2O <=> 4-hydroxybenzoyl-CoA + reduced_ferredoxin 1.1.7.1 4-hydroxybenzoyl-CoA reductase
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O2 + 2,3-Dihydroxybenzoate <=> H+ + 3-carboxy-2-hydroxymuconate_semialdehyde 1.13.11.14 2,3-dihydroxybenzoate 3,4-dioxygenase
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Benzene + NADH + O2 <=> phenol + NAD+ + H2O 1.14.13.236 toluene 4-monooxygenase
1.14.13.244 phenol 2-monooxygenase (NADH)
1.14.13.25 methane monooxygenase (soluble)
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6-carboxyhex-2-enoyl-CoA + H2O <=> 3-hydroxypimeloyl-CoA 4.2.1
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NADH + O2 + 4-hydroxybenzoate + H+ <=> NAD+ + CO2 + H2O + hydroquinone 1.14.13.114 6-hydroxynicotinate 3-monooxygenase
1.14.13.64 4-hydroxybenzoate 1-hydroxylase
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6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O <=> H+ + 3-hydroxypimeloyl-CoA 3.7.1.21 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase
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4-hydroxybenzoate + NADH + O2 + H+ <=> 3,4-dihydroxybenzoate + NAD+ + H2O 1.14.13.2 4-hydroxybenzoate 3-monooxygenase
1.14.13.33 4-hydroxybenzoate 3-monooxygenase [NAD(P)H]
1.14.99.15 4-methoxybenzoate monooxygenase (O-demethylating)
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cyclohexa-1,5-diene-1-carbonyl-CoA <=> cyclohex-1,4-diene-1-carboxyl-CoA not assigned
 –
4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde + H2O <=> 4-Methylene-2-oxoglutarate + formate 3.7.1
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O2 + reduced_acceptor + 4-Methoxybenzoate <=> H2O + acceptor + 4-hydroxybenzoate + formaldehyde 1.14.99.15 4-methoxybenzoate monooxygenase (O-demethylating)
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acetyl-CoA <=> acetoacetyl-CoA + CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase
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2-Aminobenzenesulfonate + NADH + O2 + H+ <=> 3-sulfocatechol + NH3 + NAD+ 1.14.12.14 2-aminobenzenesulfonate 2,3-dioxygenase
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cis-3,4-dehydroadipyl-CoA <=> 2,3-dehydroadipyl-CoA 5.3.3
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3,4-dihydroxybenzoate + NADPH + O2 <=> Hydroxyquinol + NADP+ + CO2 1.13.11
1.14.13.64 4-hydroxybenzoate 1-hydroxylase
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2-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> H+ + 3-carboxy-cis,cis-muconate 5.5.1.2 3-carboxy-cis,cis-muconate cycloisomerase
5.5.1.5 carboxy-cis,cis-muconate cyclase
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4-oxalocrotonate + H2O <=> 4-hydroxy-2-oxopentanoate + CO2 4.1.1
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(S)-3-hydroxybutyryl-CoA <=> H2O + crotonyl-CoA 1.3.8.7 medium-chain acyl-CoA dehydrogenase
4.2.1.116 3-hydroxypropionyl-CoA dehydratase
4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase
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3-oxoadipate + NAD+ <=> maleylacetate + NADH + H+ 1.3.1.32 maleylacetate reductase
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4-hydroxybenzoate + NADPH + O2 + H+ <=> 3,4-dihydroxybenzoate + NADP+ + H2O 1.14.13.2 4-hydroxybenzoate 3-monooxygenase
1.14.13.33 4-hydroxybenzoate 3-monooxygenase [NAD(P)H]
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acetaldehyde + CoA + NAD+ <=> acetyl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.42 hexadecanal dehydrogenase (acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)
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4-carboxy-4-hydroxy-2-oxoadipate <=> 4-oxalomesaconate + H2O 4.2.1.83 4-oxalomesaconate hydratase
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4-oxalomesaconate <=> 4-carboxy-2-hydroxy-cis,cis-muconate 5.3.2.8 4-oxalomesaconate tautomerase
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H+ + 2,3-Dihydroxybenzoate <=> CO2 + catechol 4.1.1.103 gamma-resorcylate decarboxylase
4.1.1.46 o-pyrocatechuate decarboxylase
4.1.1.91 salicylate decarboxylase
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O2 + reduced_acceptor + 3-hydroxybenzoate <=> H2O + acceptor + 2,3-Dihydroxybenzoate 1.14.99.23 3-hydroxybenzoate 2-monooxygenase
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2-Hydroxy-2-hydropyrone-4,6-dicarboxylate + NAD+ <=> 2-Pyrone-4,6-dicarboxylate + NADH + H+ 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
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CoA + 4-hydroxybenzoate + ATP <=> 4-hydroxybenzoyl-CoA + diphosphate + AMP 6.2.1.27 4-hydroxybenzoate---CoA ligase
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benzoyl-CoA + NADPH + H+ + O2 <=> 2,3-epoxy-2,3-dihydrobenzoyl-CoA + NADP+ + H2O 1.14.13.208 benzoyl-CoA 2,3-epoxidase
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glutaryl-CoA + acceptor <=> glutaconyl-CoA + reduced_acceptor 1.3.99.32 glutaryl-CoA dehydrogenase (acceptor)
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3-hydroxy-cis,cis-muconate <=> maleylacetate 0.0.0.0
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(4S)-(+)-muconolactone <=> 2-(5-oxo-4,5-dihydrofuran-2-yl)acetic_acid 5.3.3.4 muconolactone Delta-isomerase
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4-hydroxy-4-methyl-2-oxoglutarate <=> pyruvate 4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
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cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized_ferredoxin + ADP + phosphate <=> benzoyl-CoA + reduced_ferredoxin_[iron-sulfur]_cluster + ATP + H2O 1.3.7.8 benzoyl-CoA reductase
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H+ + O2 + NADH + Benzene <=> NAD+ + cis-benzene_dihydrodiol 1.14.12.11 toluene dioxygenase
1.14.12.3 benzene 1,2-dioxygenase
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Hydroxyquinol + O2 <=> 3-hydroxy-cis,cis-muconate + H+ 1.13.11.37 hydroxyquinol 1,2-dioxygenase
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4-carboxy-4-hydroxy-2-oxoadipate <=> pyruvate + oxaloacetate 4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
4.1.3.B3
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2-hydroxymuconate-6-semialdehyde + H2O <=> formate + 2-oxopent-4-enoate 3.7.1.9 2-hydroxymuconate-6-semialdehyde hydrolase
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2-hydroxycyclohexane-1-carbonyl-CoA + NAD+ <=> H+ + 2-ketocyclohexane-1-carboxyl-CoA + NADH 1.1.1
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4-hydroxy-2-oxopentanoate <=> 2-oxopent-4-enoate + H2O 4.2.1.80 2-oxopent-4-enoate hydratase
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cyclohexanecarboxyl-CoA + flavin <=> cyclohex-1-ene-1-carbonyl-CoA + reduced_flavodoxin 1.3.8.11 cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein)
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