|
|
N2-Acetyl-L-ornithine + 2-oxoglutarate <=> L-glutamate + N-acetyl-L-glutamate_5-semialdehyde
|
2.6.1.11
acetylornithine transaminase
2.6.1.13
ornithine aminotransferase
|
–
–
|
|
BRENDA:
BR48055
KEGG:
R02283
MetaCyc:
ACETYLORNTRANSAM-RXN
SABIO-RK:
2248
|
|
|
|
L-aspartate + 2-oxoglutarate <=> oxaloacetate + L-glutamate
|
2.6.1.1
aspartate transaminase
2.6.1.19
4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2
alanine transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.5
tyrosine transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.75
cysteine-conjugate transaminase
2.6.1.78
aspartate---prephenate aminotransferase
2.6.1.79
glutamate---prephenate aminotransferase
|
–
–
–
–
–
–
–
–
–
–
|
|
BRENDA:
BR47671;
BS377429
KEGG:
R00355
MetaCyc:
ASPAMINOTRANS-RXN;
RXN-13697
SABIO-RK:
825
|
|
|
|
L-aspartate + L-citrulline + ATP <=> H+ + argininosuccinate + diphosphate + AMP
|
6.3.4.5
argininosuccinate synthase
|
–
|
|
BRENDA:
BR142;
BS408483
KEGG:
R01954
MetaCyc:
ARGSUCCINSYN-RXN
SABIO-RK:
572
|
|
|
|
NADP+ + H2O + L-glutamate <=> NADPH + 2-oxoglutarate + NH3 + H+
|
1.4.1.13
glutamate synthase (NADPH)
1.4.1.2
glutamate dehydrogenase
1.4.1.3
glutamate dehydrogenase [NAD(P)+]
1.4.1.4
glutamate dehydrogenase (NADP+)
|
–
–
–
–
|
|
BRENDA:
BR36869;
BS397591-a
KEGG:
R00248
MetaCyc:
GLUTAMATE-DEHYDROGENASE-NADP+-RXN;
GLUTDEHYD-RXN;
RXN-20084
SABIO-RK:
757
|
|
|
|
L-arginine + NADPH + H+ + O2 <=> L-citrulline + NO + NADP+ + H2O
|
1.14.13.39
nitric-oxide synthase (NADPH)
1.14.14.47
nitric-oxide synthase (flavodoxin)
|
–
–
|
|
BRENDA:
BR52111;
BS394886
KEGG:
R00557
MetaCyc:
NITRIC-OXIDE-SYNTHASE-RXN
SABIO-RK:
969
|
|
|
|
2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate
|
2.6.1.1
aspartate transaminase
2.6.1.12
alanine---oxo-acid transaminase
2.6.1.2
alanine transaminase
2.6.1.37
2-aminoethylphosphonate---pyruvate transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.4
glycine transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.5
tyrosine transaminase
2.6.1.79
glutamate---prephenate aminotransferase
|
–
–
–
–
–
–
–
–
–
|
|
BRENDA:
BR47397
KEGG:
R00258
MetaCyc:
ALANINE-AMINOTRANSFERASE-RXN;
RXN-13698
SABIO-RK:
763
|
|
|
|
NH3 + L-glutamate + ATP <=> H+ + L-glutamine + ADP + phosphate
|
6.3.1.2
glutamine synthetase
|
–
|
|
BRENDA:
BR6443
KEGG:
R00253
MetaCyc:
GLUTAMINESYN-RXN
SABIO-RK:
760
|
|
|
|
H2O + L-arginine <=> NH3 + L-citrulline
|
3.5.3.15
protein-arginine deiminase
3.5.3.6
arginine deiminase
|
–
–
|
|
BRENDA:
BR22730;
BS369889
KEGG:
R00552
MetaCyc:
ARGININE-DEIMINASE-RXN
SABIO-RK:
97
|
|
|
|
L-glutamine + H2O <=> L-glutamate + NH3
|
1.4.1.13
glutamate synthase (NADPH)
1.4.1.14
glutamate synthase (NADH)
1.4.7.1
glutamate synthase (ferredoxin)
2.3.2.2
gamma-glutamyltransferase
2.4.2
2.4.2.14
amidophosphoribosyltransferase
3.4.11.17
tryptophanyl aminopeptidase
3.5.1.1
asparaginase
3.5.1.2
glutaminase
3.5.1.38
glutamin-(asparagin-)ase
3.5.1.43
peptidyl-glutaminase
3.5.1.44
protein-glutamine glutaminase
4.3.1.B2
4.3.2.10
imidazole glycerol-phosphate synthase
4.3.3.6
pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
6.3.4.2
CTP synthase (glutamine hydrolysing)
6.3.5.13
lipid II isoglutaminyl synthase (glutamine-hydrolysing)
6.3.5.2
GMP synthase (glutamine-hydrolysing)
6.3.5.4
asparagine synthase (glutamine-hydrolysing)
6.3.5.5
carbamoyl-phosphate synthase (glutamine-hydrolysing)
6.3.5.6
asparaginyl-tRNA synthase (glutamine-hydrolysing)
6.3.5.7
glutaminyl-tRNA synthase (glutamine-hydrolysing)
|
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
–
|
|
BRENDA:
BR22683
KEGG:
R00256
MetaCyc:
GLUTAMIN-RXN
SABIO-RK:
762
|
|
|
|
[amino_group_carrier_protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + 2-oxoglutarate <=> L-glutamate + LysW-L-glutamate_5-semialdehyde
|
2.6.1
2.6.1.11
acetylornithine transaminase
|
–
–
|
|
KEGG:
R10932
MetaCyc:
RXN-15007
|
|
|
|
N-acetyl-L-glutamate_5-semialdehyde + NADP+ + phosphate <=> H+ + N-acetyl-L-glutamyl_5-phosphate + NADPH
|
1.2.1.38
N-acetyl-gamma-glutamyl-phosphate reductase
|
–
|
|
BRENDA:
BR36780
KEGG:
R03443
MetaCyc:
N-ACETYLGLUTPREDUCT-RXN
|
|
|
|
N2-Acetyl-L-ornithine + H2O <=> L-ornithine + acetate
|
2.3.1.35
glutamate N-acetyltransferase
3.5.1.14
N-acyl-aliphatic-L-amino acid amidohydrolase
3.5.1.16
acetylornithine deacetylase
3.5.1.17
acyl-lysine deacylase
3.5.1.B4
|
–
–
–
–
–
|
|
BRENDA:
BR19236
KEGG:
R00669
MetaCyc:
ACETYLORNDEACET-RXN
SABIO-RK:
1049
|
|
|
|
N-acetyl-L-citrulline + H2O <=> L-citrulline + acetate
|
3.5.1.16
acetylornithine deacetylase
3.5.1.B4
|
–
–
|
|
BRENDA:
BR48939;
BS394032
KEGG:
R09107
MetaCyc:
RXN-7933
|
|
|
|
argininosuccinate <=> L-arginine + fumarate
|
4.3.2.1
argininosuccinate lyase
4.3.2.2
adenylosuccinate lyase
|
–
–
|
|
BRENDA:
BR3431
KEGG:
R01086
MetaCyc:
ARGSUCCINLYA-RXN
SABIO-RK:
573
|
|
|
|
N2-Acetyl-L-ornithine + Carbamoyl_phosphate <=> H+ + N-acetyl-L-citrulline + phosphate
|
2.1.3.11
N-succinylornithine carbamoyltransferase
2.1.3.9
N-acetylornithine carbamoyltransferase
|
–
–
|
|
BRENDA:
BR48711
KEGG:
R07245
MetaCyc:
2.1.3.9-RXN
|
|
|
|
NAD+ + H2O + L-glutamate <=> NADH + 2-oxoglutarate + NH3 + H+
|
1.4.1.14
glutamate synthase (NADH)
1.4.1.2
glutamate dehydrogenase
1.4.1.3
glutamate dehydrogenase [NAD(P)+]
1.4.1.4
glutamate dehydrogenase (NADP+)
1.4.1.5
L-amino-acid dehydrogenase
|
–
–
–
–
–
|
|
BRENDA:
BR36868
KEGG:
R00243
MetaCyc:
GLUTAMATE-DEHYDROGENASE-NADP+-RXN_WOP;
GLUTAMATE-DEHYDROGENASE-RXN
SABIO-RK:
755
|
|
|
|
[amino_group_carrier_protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O <=> L-ornithine + [LysW]-C-terminal-L-glutamate
|
3.5.1.132
[amino group carrier protein]-ornithine hydrolase
|
–
|
|
KEGG:
R10933
|
|
|
|
LysW-L-glutamate + ATP <=> LysW-L-glutamyl_5-phosphate + ADP
|
2.7.2
|
–
|
|
KEGG:
R10930
|
|
|
|
L-ornithine + Carbamoyl_phosphate <=> H+ + L-citrulline + phosphate
|
2.1.3.3
ornithine carbamoyltransferase
2.1.3.6
putrescine carbamoyltransferase
3.5.3.12
agmatine deiminase
|
–
–
–
|
|
BRENDA:
BR43950;
BS140887
KEGG:
R01398
MetaCyc:
ORNCARBAMTRANSFER-RXN;
RXN-13482
SABIO-RK:
98
|
|
|
|
L-glutamate + acetyl-CoA <=> H+ + N-acetyl-L-glutamate + CoA
|
2.3.1.1
amino-acid N-acetyltransferase
2.3.1.17
aspartate N-acetyltransferase
2.3.1.183
phosphinothricin acetyltransferase
2.7.2.8
acetylglutamate kinase
6.3.4.16
carbamoyl-phosphate synthase (ammonia)
|
–
–
–
–
–
|
|
BRENDA:
BR43962
KEGG:
R00259
MetaCyc:
N-ACETYLTRANSFER-RXN
SABIO-RK:
764
|
|
|
|
ATP + Urea + HCO3- + H+ <=> ADP + phosphate + allophanate
|
6.3.4.6
urea carboxylase
|
–
|
|
BRENDA:
BR143
KEGG:
R00774
SABIO-RK:
1126
|
|
|
|
H+ + Urea + H2O <=> NH3 + CO2
|
3.5.1.5
urease
|
–
|
|
BRENDA:
BR22694
KEGG:
R00131
MetaCyc:
UREASE-RXN
SABIO-RK:
289
|
|
|
|
allophanate + H2O + H+ <=> NH3 + CO2
|
3.5.1.54
allophanate hydrolase
|
–
|
|
BRENDA:
BR22698
KEGG:
R00005
MetaCyc:
ALLOPHANATE-HYDROLASE-RXN
|
|
|
|
NH3 + HCO3- + ATP <=> Carbamoyl_phosphate + ADP + H2O + H+
|
2.7.2.2
carbamate kinase
|
–
|
|
BRENDA:
BR47825
KEGG:
R00150
MetaCyc:
CARBAMATE-KINASE-RXN
|
|
|
|
L-arginine + reduced_flavodoxin + O2 <=> L-citrulline + NO + flavin + H2O + H+
|
1.14.14.47
nitric-oxide synthase (flavodoxin)
|
–
|
|
BRENDA:
BR40515
KEGG:
R11711
MetaCyc:
RXN-13568
|
|
|
|
H2O + L-arginine <=> Urea + L-ornithine
|
3.5.3.1
arginase
3.5.3.7
guanidinobutyrase
|
–
–
|
|
BRENDA:
BR19260;
BS140960
KEGG:
R00551
MetaCyc:
ARGINASE-RXN
SABIO-RK:
574
|
|
|
|
N-acetyl-L-glutamate + ATP <=> N-acetyl-L-glutamyl_5-phosphate + ADP
|
2.7.2.8
acetylglutamate kinase
|
–
|
|
BRENDA:
BR47830
KEGG:
R02649
MetaCyc:
ACETYLGLUTKIN-RXN
SABIO-RK:
2545
|
|
|
|
ATP + NH3 + CO2 + H2O <=> ADP + phosphate + Carbamoyl_phosphate
|
6.3.4.16
carbamoyl-phosphate synthase (ammonia)
6.3.5.5
carbamoyl-phosphate synthase (glutamine-hydrolysing)
|
–
–
|
|
BRENDA:
BS369145
KEGG:
R00149
SABIO-RK:
715
|
|
|
|
L-glutamate + [LysW]-C-terminal-L-glutamate + ATP <=> LysW-L-glutamate + ADP + phosphate
|
6.3.2
|
–
|
|
KEGG:
R10929
|
|
|
|
L-glutamate + N2-Acetyl-L-ornithine <=> N-acetyl-L-glutamate + L-ornithine
|
2.3.1.35
glutamate N-acetyltransferase
|
–
|
|
BRENDA:
BR44035
KEGG:
R02282
MetaCyc:
GLUTAMATE-N-ACETYLTRANSFERASE-RXN
SABIO-RK:
2247
|
|
|
|
LysW-L-glutamyl_5-phosphate + NADPH + H+ <=> LysW-L-glutamate_5-semialdehyde + NADP+ + phosphate
|
1.2.1
|
–
|
|
KEGG:
R10931
|
|