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Alanine, aspartate and glutamate metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
ATP + L-glutamine + HCO3- + H2O <=> L-glutamate + Carbamoyl_phosphate + ADP + phosphate + H+ 6.3.4.16 carbamoyl-phosphate synthase (ammonia)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
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L-aspartate + H+ <=> L-alanine + CO2 4.1.1.12 aspartate 4-decarboxylase
4.4.1.1 cystathionine gamma-lyase
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1-pyrroline-5-carboxylate + NADP+ + H2O <=> L-glutamate + NADPH 1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
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L-aspartate + 2-oxoglutarate <=> oxaloacetate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.75 cysteine-conjugate transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase
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succinate_semialdehyde + NADP+ + H2O <=> NADPH + succinate + H+ 1.1.1.21 aldose reductase
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)
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NADP+ + H2O + L-glutamate <=> NADPH + 2-oxoglutarate + NH3 + H+ 1.4.1.13 glutamate synthase (NADPH)
1.4.1.2 glutamate dehydrogenase
1.4.1.3 glutamate dehydrogenase [NAD(P)+]
1.4.1.4 glutamate dehydrogenase (NADP+)
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ATP + L-aspartate + NH3 <=> diphosphate + AMP + L-asparagine + H+ 6.3.1.1 aspartate---ammonia ligase
6.3.5.4 asparagine synthase (glutamine-hydrolysing)
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L-aspartate + L-citrulline + ATP <=> H+ + argininosuccinate + diphosphate + AMP 6.3.4.5 argininosuccinate synthase
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L-glutamate + NADP+ <=> H+ + L-glutamine + 2-oxoglutarate + NADPH 1.4.1.13 glutamate synthase (NADPH)
1.4.1.B5
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ATP + citrate + L-glutamate <=> ADP + phosphate + beta-Citryl-L-glutamate + H+ 6.3.1.17 beta-citrylglutamate synthase
6.3.2.B11
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2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate 2.6.1.1 aspartate transaminase
2.6.1.12 alanine---oxo-acid transaminase
2.6.1.2 alanine transaminase
2.6.1.37 2-aminoethylphosphonate---pyruvate transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.4 glycine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.79 glutamate---prephenate aminotransferase
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L-aspartate + IMP + GTP <=> H+ + adenylosuccinate + phosphate + GDP 6.3.4.4 adenylosuccinate synthase
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N-Acetyl-L-Asp-L-Glu + H2O <=> N-acetyl-L-aspartate + L-glutamate 3.4.17.21 glutamate carboxypeptidase II
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glyoxylate + L-alanine <=> glycine + pyruvate 2.6.1.15 glutamine---pyruvate transaminase
2.6.1.18 beta-alanine---pyruvate transaminase
2.6.1.2 alanine transaminase
2.6.1.4 glycine transaminase
2.6.1.40 (R)-3-amino-2-methylpropionate---pyruvate transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.45 serine---glyoxylate transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
2.6.1.B16
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NH3 + L-glutamate + ATP <=> H+ + L-glutamine + ADP + phosphate 6.3.1.2 glutamine synthetase
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L-glutamine + H2O <=> L-glutamate + NH3 1.4.1.13 glutamate synthase (NADPH)
1.4.1.14 glutamate synthase (NADH)
1.4.7.1 glutamate synthase (ferredoxin)
2.3.2.2 gamma-glutamyltransferase
2.4.2
2.4.2.14 amidophosphoribosyltransferase
3.4.11.17 tryptophanyl aminopeptidase
3.5.1.1 asparaginase
3.5.1.2 glutaminase
3.5.1.38 glutamin-(asparagin-)ase
3.5.1.43 peptidyl-glutaminase
3.5.1.44 protein-glutamine glutaminase
4.3.1.B2
4.3.2.10 imidazole glycerol-phosphate synthase
4.3.3.6 pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
6.3.4.2 CTP synthase (glutamine hydrolysing)
6.3.5.13 lipid II isoglutaminyl synthase (glutamine-hydrolysing)
6.3.5.2 GMP synthase (glutamine-hydrolysing)
6.3.5.4 asparagine synthase (glutamine-hydrolysing)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
6.3.5.6 asparaginyl-tRNA synthase (glutamine-hydrolysing)
6.3.5.7 glutaminyl-tRNA synthase (glutamine-hydrolysing)
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ATP + N-Acetyl-L-Asp-L-Glu + L-glutamate <=> ADP + phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate 6.3.2.42 N-acetylaspartylglutamylglutamate synthase
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L-aspartate <=> D-Aspartate 5.1.1.10 amino-acid racemase
5.1.1.13 aspartate racemase
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argininosuccinate <=> L-arginine + fumarate 4.3.2.1 argininosuccinate lyase
4.3.2.2 adenylosuccinate lyase
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H+ + L-glutamate <=> CO2 + 4-aminobutanoate 4.1.1.15 glutamate decarboxylase
4.1.1.25 tyrosine decarboxylase
4.1.1.29 sulfinoalanine decarboxylase
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NAD+ + H2O + L-glutamate <=> NADH + 2-oxoglutarate + NH3 + H+ 1.4.1.14 glutamate synthase (NADH)
1.4.1.2 glutamate dehydrogenase
1.4.1.3 glutamate dehydrogenase [NAD(P)+]
1.4.1.4 glutamate dehydrogenase (NADP+)
1.4.1.5 L-amino-acid dehydrogenase
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L-glutamate + NAD+ <=> L-glutamine + 2-oxoglutarate + NADH + H+ 1.4.1.13 glutamate synthase (NADPH)
1.4.1.14 glutamate synthase (NADH)
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L-aspartate + acetyl-CoA <=> N-acetyl-L-aspartate + CoA + H+ 2.3.1.17 aspartate N-acetyltransferase
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L-aspartate <=> NH3 + fumarate 4.3.1.1 aspartate ammonia-lyase
4.3.1.2 methylaspartate ammonia-lyase
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L-asparagine + a_2-oxo_carboxylate <=> 2-oxosuccinamic_acid + an_L-amino_acid 2.6.1.14 asparagine---oxo-acid transaminase
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L-pyrroline-5-carboxylate + NAD+ + H2O <=> H+ + L-glutamate + NADH 1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
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L-aspartate + H2O + O2 <=> oxaloacetate + NH3 + H2O2 1.4.3.1 D-aspartate oxidase
1.4.3.16 L-aspartate oxidase
1.4.3.2 L-amino-acid oxidase
1.4.3.3 D-amino-acid oxidase
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2-Oxoglutaramate + H2O <=> 2-oxoglutarate + NH3 3.5.1.111 2-oxoglutaramate amidase
3.5.1.3 omega-amidase
3.5.1.36 N-methyl-2-oxoglutaramate hydrolase
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ATP + L-aspartate + L-glutamine + H2O <=> AMP + diphosphate + L-asparagine + L-glutamate + H+ 6.3.5.4 asparagine synthase (glutamine-hydrolysing)
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N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + H2O <=> N-Acetyl-L-Asp-L-Glu + L-glutamate 3.4.17.21 glutamate carboxypeptidase II
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beta-D-fructose_6-phosphate + L-glutamine <=> D-glucose_6-phosphate + L-glutamate 2.6.1.16 glutamine---fructose-6-phosphate transaminase (isomerizing)
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N-acetyl-L-aspartate + H2O <=> L-aspartate + acetate 3.4.17.1 carboxypeptidase A
3.5.1.134 (indol-3-yl)acetyl-L-aspartate hydrolase
3.5.1.14 N-acyl-aliphatic-L-amino acid amidohydrolase
3.5.1.15 aspartoacylase
3.5.1.68 N-formylglutamate deformylase
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N-acetyl-L-aspartate + L-glutamate + ATP <=> N-Acetyl-L-Asp-L-Glu + ADP + phosphate + H+ 6.3.2.41 N-acetylaspartylglutamate synthase
6.3.2.42 N-acetylaspartylglutamylglutamate synthase
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L-aspartate + Carbamoyl_phosphate <=> H+ + L-carbamoyl-L-aspartate + phosphate 2.1.3.2 aspartate carbamoyltransferase
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succinate_semialdehyde + NAD+ + H2O <=> NADH + succinate + H+ 1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.21 glycolaldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
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5-phosphoribosylamine + diphosphate + L-glutamate <=> 5-phospho-alpha-D-ribose_1-diphosphate + L-glutamine + H2O 2.4.2.14 amidophosphoribosyltransferase
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pyruvate + L-aspartate <=> L-alanine + oxaloacetate 2.6.1.1 aspartate transaminase
2.6.1.12 alanine---oxo-acid transaminase
2.6.1.64 glutamine---phenylpyruvate transaminase
2.6.1.78 aspartate---prephenate aminotransferase
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O2 + H2O + D-Aspartate <=> NH3 + H2O2 + oxaloacetate 1.4.3.1 D-aspartate oxidase
1.4.3.15 D-glutamate(D-aspartate) oxidase
1.4.3.3 D-amino-acid oxidase
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2-oxosuccinamic_acid + H2O <=> oxaloacetate + NH3 3.5.1.3 omega-amidase
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L-glutamine + pyruvate <=> 2-Oxoglutaramate + L-alanine 2.6.1.15 glutamine---pyruvate transaminase
2.6.1.51 serine---pyruvate transaminase
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H+ + L-carbamoyl-L-aspartate + H2O <=> NH3 + CO2 + L-aspartate 3.5.1.7 ureidosuccinase
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L-alanine + H2O + NAD+ <=> pyruvate + NH3 + NADH + H+ 1.4.1.1 alanine dehydrogenase
1.4.1.23 valine dehydrogenase (NAD+)
1.4.1.3 glutamate dehydrogenase [NAD(P)+]
1.4.1.8 valine dehydrogenase (NADP+)
1.4.1.9 leucine dehydrogenase
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adenylosuccinate <=> fumarate + AMP 4.3.2.2 adenylosuccinate lyase
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4-aminobutanoate + pyruvate <=> succinate_semialdehyde + L-alanine 2.6.1.116 6-aminohexanoate aminotransferase
2.6.1.18 beta-alanine---pyruvate transaminase
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.40 (R)-3-amino-2-methylpropionate---pyruvate transaminase
2.6.1.96 4-aminobutyrate---pyruvate transaminase
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ATP + NH3 + CO2 + H2O <=> ADP + phosphate + Carbamoyl_phosphate 6.3.4.16 carbamoyl-phosphate synthase (ammonia)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
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L-asparagine + H2O <=> L-aspartate + NH3 3.4.11.17 tryptophanyl aminopeptidase
3.4.19.5 beta-aspartyl-peptidase
3.5.1.1 asparaginase
3.5.1.13 aryl-acylamidase
3.5.1.2 glutaminase
3.5.1.26 N4-(beta-N-acetylglucosaminyl)-L-asparaginase
3.5.1.3 omega-amidase
3.5.1.38 glutamin-(asparagin-)ase
3.5.5.4 cyanoalanine nitrilase
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4-aminobutanoate + 2-oxoglutarate <=> succinate_semialdehyde + L-glutamate 2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.22 (S)-3-amino-2-methylpropionate transaminase
2.6.1.29 diamine transaminase
2.6.1.48 5-aminovalerate transaminase
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Visualization of the pathway