|
|
H+ + pyruvate <=> (S)-2-Hydroxy-2-methyl-3-oxobutanoate + CO2
|
2.2.1.6
acetolactate synthase
4.1.1.1
pyruvate decarboxylase
|
–
–
|
|
BRENDA:
BR37100;
BS386675
KEGG:
R00006;
R00226
MetaCyc:
ACETOLACTSYN-RXN
SABIO-RK:
6473;
749
|
|
|
|
N2-Acetyl-L-ornithine + 2-oxoglutarate <=> L-glutamate + N-acetyl-L-glutamate_5-semialdehyde
|
2.6.1.11
acetylornithine transaminase
2.6.1.13
ornithine aminotransferase
|
–
–
|
|
BRENDA:
BR48055
KEGG:
R02283
MetaCyc:
ACETYLORNTRANSAM-RXN
SABIO-RK:
2248
|
|
|
|
2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate
|
4.2.1.33
3-isopropylmalate dehydratase
|
–
|
|
BRENDA:
BR413;
BR49521;
BS1964
KEGG:
R03968;
R04001
MetaCyc:
3-ISOPROPYLMALISOM-RXN;
RXN-8991
SABIO-RK:
3704;
3736
|
|
|
|
p-hydroxyphenylacetaldoxime + L-cysteine + NADPH + O2 + H+ <=> S-(Hydroxyphenylacetothiohydroximoyl)-L-cysteine + NADP+ + 2 H2O
|
1.14.14.45
aromatic aldoxime N-monooxygenase
|
–
|
|
KEGG:
R10672
|
|
|
|
(S)-2-hydroxy-2-ethyl-3-oxobutanoate <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate
|
1.1.1.86
ketol-acid reductoisomerase (NADP+)
5.4.99.3
2-acetolactate mutase
|
–
–
|
|
KEGG:
R05069
MetaCyc:
RXN-14106
|
|
|
|
7-methylthio-2-oxoheptanoate + acetyl-CoA + H2O <=> H+ + 2-[(5''-methylsulfanyl)pentyl]malate + CoA
|
2.3.3.17
methylthioalkylmalate synthase
|
–
|
|
BRENDA:
BS438972
KEGG:
R08631
MetaCyc:
RXNQT-4169
|
|
|
|
2R,3R-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O
|
4.2.1.9
dihydroxy-acid dehydratase
|
–
|
|
BRENDA:
BS453486
KEGG:
R05070
MetaCyc:
DIHYDROXYMETVALDEHYDRAT-RXN
|
|
|
|
L-2-aminoadipate + 2-oxoglutarate <=> L-glutamate + 2-oxoadipate
|
2.6.1.39
2-aminoadipate transaminase
2.6.1.7
kynurenine---oxoglutarate transaminase
|
–
–
|
|
BRENDA:
BR47689
KEGG:
R01939
MetaCyc:
2-AMINOADIPATE-AMINOTRANSFERASE-RXN
SABIO-RK:
1992
|
|
|
|
L-tetrahomomethionine + 2 O2 + 2 reduced_flavodoxin <=> 4-methylthioheptanaldoxime + CO2 + 3 H2O + 2 flavin
|
1.14.14.42
homomethionine N-monooxygenase
|
–
|
|
BRENDA:
BS438386
KEGG:
R08673
|
|
|
|
S-(Indolylmethylthiohydroximoyl)-L-cysteine + H2O <=> 2-(3-indolyl)acetothiohydroximate + pyruvate + NH3
|
4.4.1
|
–
|
|
KEGG:
R08170
|
|
|
|
2-Oxo-5-methylthiopentanoic_acid + an_L-amino_acid <=> L-homomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
|
KEGG:
R08622
|
|
|
|
(R)-citramalate <=> citraconate + H2O
|
4.2.1.31
maleate hydratase
4.2.1.35
(R)-2-methylmalate dehydratase
|
–
–
|
|
BRENDA:
BR415
KEGG:
R03896
MetaCyc:
R-2-METHYLMALATE-DEHYDRATASE-RXN
SABIO-RK:
3641
|
|
|
|
2-[(4''-methylsulfanyl)butyl]malate <=> 3-[(4''-methylsulfanyl)butyl]malate
|
4.2.1.170
2-(omega-methylthio)alkylmalate dehydratase
|
–
|
|
KEGG:
R08628
MetaCyc:
RXNQT-4167
|
|
|
|
L-homomethionine + 2 reduced_flavodoxin + 2 O2 <=> an_omega-(methylthio)-(E)-alkanal_oxime + 2 flavin + CO2 + 3 H2O
|
1.14.14.42
homomethionine N-monooxygenase
|
–
|
|
BRENDA:
BR52625;
BS438376
KEGG:
R08665;
R11646
|
|
|
|
H+ + (2S)-2-isopropyl-3-oxosuccinate <=> 4-methyl-2-oxopentanoate + CO2
|
0.0.0.0
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
|
BRENDA:
BR52894
KEGG:
R01652
MetaCyc:
RXN-7800
|
|
|
|
L-phenylalanine + 2-oxoglutarate <=> phenylpyruvate + L-glutamate
|
2.6.1.1
aspartate transaminase
2.6.1.24
diiodotyrosine transaminase
2.6.1.27
tryptophan transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.5
tyrosine transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.60
aromatic-amino-acid---glyoxylate transaminase
2.6.1.64
glutamine---phenylpyruvate transaminase
2.6.1.7
kynurenine---oxoglutarate transaminase
2.6.1.70
aspartate---phenylpyruvate transaminase
2.6.1.79
glutamate---prephenate aminotransferase
2.6.1.9
histidinol-phosphate transaminase
|
–
–
–
–
–
–
–
–
–
–
–
–
–
|
|
BRENDA:
BS353519
KEGG:
R00694
MetaCyc:
RXN-10814
SABIO-RK:
1074
|
|
|
|
(R)-2-hydroxybutane-1,2,4-tricarboxylate <=> homoisocitrate
|
4.2.1.114
methanogen homoaconitase
|
–
|
|
BRENDA:
BR49013
KEGG:
R09720
MetaCyc:
RXN-13722
|
|
|
|
2-oxoisovalerate + acetyl-CoA + H2O <=> H+ + (2S)-2-isopropylmalate + CoA
|
2.3.3.13
2-isopropylmalate synthase
2.3.3.17
methylthioalkylmalate synthase
|
–
–
|
|
BRENDA:
BR47381;
BS353415;
BS375022;
BS438748
KEGG:
R01213
MetaCyc:
2-ISOPROPYLMALATESYN-RXN
SABIO-RK:
545
|
|
|
|
(-)-threo-iso(homo)2citrate + NAD+ <=> 2-oxopimelic_acid + CO2 + NADH
|
1.1.1
|
–
|
|
KEGG:
R08214
MetaCyc:
R214-RXN
|
|
|
|
L-valine + 2 reduced_flavodoxin + 2 O2 <=> (E/Z)-isobutyraldoxime + 2 flavin + CO2 + 3 H2O
|
1.14.14.38
valine N-monooxygenase
|
–
|
|
BRENDA:
BR49380
KEGG:
R08663
|
|
|
|
(Z)-hex-1-ene-1,2,6-tricarboxylate + H2O <=> (-)-threo-iso(homo)3citrate
|
4.2.1.114
methanogen homoaconitase
|
–
|
|
BRENDA:
BS421928
KEGG:
R10396
MetaCyc:
R217-RXN
|
|
|
|
LysW-L-glutamyl_5-phosphate + NADPH + H+ <=> LysW-L-glutamate_5-semialdehyde + NADP+ + phosphate
|
1.2.1
|
–
|
|
KEGG:
R10931
|
|
|
|
[amino_group_carrier_protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O <=> L-ornithine + [LysW]-C-terminal-L-glutamate
|
3.5.1.132
[amino group carrier protein]-ornithine hydrolase
|
–
|
|
KEGG:
R10933
|
|
|
|
isocitrate + NAD+ <=> 2-oxoglutarate + CO2 + NADH
|
1.1.1.286
isocitrate---homoisocitrate dehydrogenase
1.1.1.41
isocitrate dehydrogenase (NAD+)
1.1.1.42
isocitrate dehydrogenase (NADP+)
1.1.1.87
homoisocitrate dehydrogenase
|
–
–
–
–
|
|
BRENDA:
BR29304;
BS371189
KEGG:
R00709
MetaCyc:
ISOCITRATE-DEHYDROGENASE-NAD+-RXN
SABIO-RK:
15068;
270
|
|
|
|
L-phenylalanine + a_2-oxo_carboxylate <=> phenylpyruvate + an_L-amino_acid
|
2.6.1
|
–
|
|
KEGG:
R10499
|
|
|
|
citrate <=> isocitrate
|
4.2.1.3
aconitate hydratase
|
–
|
|
BRENDA:
BS18704
KEGG:
R01324
MetaCyc:
RXN-14047
SABIO-RK:
272
|
|
|
|
dihomocitrate + CoA + H+ <=> 2-oxoadipate + acetyl-CoA + H2O
|
2.3.3
4.1.3
|
–
–
|
|
KEGG:
R08331
MetaCyc:
R211-RXN
|
|
|
|
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ <=> 3-hydroxy-3-methyl-2-oxobutanoic_acid + NADPH + H+
|
1.1.1.86
ketol-acid reductoisomerase (NADP+)
|
–
|
|
KEGG:
R04440
SABIO-RK:
8850
|
|
|
|
citrate <=> cis-aconitate + H2O
|
4.2.1.117
2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
4.2.1.3
aconitate hydratase
|
–
–
|
|
BRENDA:
BR419
KEGG:
R01325
MetaCyc:
ACONITATEDEHYDR-RXN
SABIO-RK:
268
|
|
|
|
Oxaloglutarate <=> 2-oxoadipate + CO2
|
1.1.1.286
isocitrate---homoisocitrate dehydrogenase
1.1.1.87
homoisocitrate dehydrogenase
|
–
–
|
|
KEGG:
R01936
|
|
|
|
L-isoleucine + 2 reduced_flavodoxin + 2 O2 <=> (1E,2S)-2-methylbutanal_oxime + 2 flavin + CO2 + 3 H2O
|
1.14.14.39
isoleucine N-monooxygenase
|
–
|
|
BRENDA:
BR49376
KEGG:
R09403
|
|
|
|
isocitrate + NADP+ <=> oxalosuccinate + NADPH + H+
|
1.1.1.42
isocitrate dehydrogenase (NADP+)
|
–
|
|
BRENDA:
BS438365
KEGG:
R01899
MetaCyc:
RXN-9951
SABIO-RK:
242
|
|
|
|
(S)-2-Hydroxy-2-methyl-3-oxobutanoate <=> 3-hydroxy-3-methyl-2-oxobutanoic_acid
|
1.1.1.86
ketol-acid reductoisomerase (NADP+)
5.4.99.3
2-acetolactate mutase
|
–
–
|
|
BRENDA:
BR250
KEGG:
R03052;
R05071
MetaCyc:
2-ACETOLACTATE-MUTASE-RXN
SABIO-RK:
2898
|
|
|
|
UDP-glucose + 2-(3-indolyl)acetothiohydroximate <=> desulfo-indol-3-yl-methyl_glucosinolate + UDP
|
2.4.1.195
N-hydroxythioamide S-beta-glucosyltransferase
|
–
|
|
BRENDA:
BR52366
KEGG:
R08164
MetaCyc:
RXN-1442
|
|
|
|
homoisocitrate + NAD+ <=> Oxaloglutarate + NADH + H+
|
1.1.1.286
isocitrate---homoisocitrate dehydrogenase
1.1.1.87
homoisocitrate dehydrogenase
|
–
–
|
|
KEGG:
R04862
|
|
|
|
acetyl-CoA + pyruvate + H2O <=> H+ + (R)-citramalate + CoA
|
2.3.1.182
(R)-citramalate synthase
2.3.3.13
2-isopropylmalate synthase
|
–
–
|
|
BRENDA:
BR48833
KEGG:
R07399
MetaCyc:
RXN-7743
SABIO-RK:
9043
|
|
|
|
2-[(6''-methylsulfanyl)hexyl]malate <=> 3-[(6''-methylsulfanyl)hexyl]malate
|
4.2.1.170
2-(omega-methylthio)alkylmalate dehydratase
|
–
|
|
KEGG:
R08641
MetaCyc:
RXNQT-4173
|
|
|
|
6-methylthio-2-oxohexanoate + acetyl-CoA + H2O <=> H+ + 2-[(4''-methylsulfanyl)butyl]malate + CoA
|
2.3.3.17
methylthioalkylmalate synthase
|
–
|
|
BRENDA:
BS438966
KEGG:
R08627
MetaCyc:
RXNQT-4166
|
|
|
|
8-methylthio-2-oxooctanoate + acetyl-CoA + H2O <=> H+ + 2-[(6''-methylsulfanyl)hexyl]malate + CoA
|
2.3.3.17
methylthioalkylmalate synthase
|
–
|
|
BRENDA:
BS438979
KEGG:
R08640
MetaCyc:
RXNQT-4172
|
|
|
|
L-hexahomomethionine + 2 O2 + 2 reduced_flavodoxin <=> 4-methylthiononanaldoxime + CO2 + 3 H2O + 2 flavin
|
1.14.14.42
homomethionine N-monooxygenase
|
–
|
|
BRENDA:
BS438375
KEGG:
R08675
|
|
|
|
H+ + pyruvate + 2-oxobutyrate <=> (S)-2-hydroxy-2-ethyl-3-oxobutanoate + CO2
|
2.2.1.6
acetolactate synthase
|
–
|
|
BRENDA:
BS386670;
BS454179
KEGG:
R08648
MetaCyc:
ACETOOHBUTSYN-RXN
SABIO-RK:
6688
|
|
|
|
N2-Acetyl-L-ornithine + H2O <=> L-ornithine + acetate
|
2.3.1.35
glutamate N-acetyltransferase
3.5.1.14
N-acyl-aliphatic-L-amino acid amidohydrolase
3.5.1.16
acetylornithine deacetylase
3.5.1.17
acyl-lysine deacylase
3.5.1.B4
|
–
–
–
–
–
|
|
BRENDA:
BR19236
KEGG:
R00669
MetaCyc:
ACETYLORNDEACET-RXN
SABIO-RK:
1049
|
|
|
|
5-methylthio-2-oxopentanoate + acetyl-CoA + H2O <=> H+ + 2-[(3''-methylsulfanyl)propyl]malate + CoA
|
2.3.3.17
methylthioalkylmalate synthase
|
–
|
|
BRENDA:
BS438895
KEGG:
R08623
MetaCyc:
RXNQT-4163
|
|
|
|
3''-phosphoadenylyl-sulfate + desulfo-p-hydroxy-benzylglucosinolate <=> adenosine_3,5''-bisphosphate + p-hydroxybenzylglucosinolate + H+
|
2.8.2
2.8.2.24
aromatic desulfoglucosinolate sulfotransferase
|
–
–
|
|
BRENDA:
BS358759
KEGG:
R08662
MetaCyc:
RXN-18762
|
|
|
|
S-(Hydroxyphenylacetothiohydroximoyl)-L-cysteine + H2O <=> p-Hydroxyphenylacetothiohydroximate + pyruvate + NH3 + H+
|
4.4.1
4.4.1.13
cysteine-S-conjugate beta-lyase
|
–
–
|
|
KEGG:
R08660
MetaCyc:
RXN-19596
|
|
|
|
L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate
|
2.6.1.1
aspartate transaminase
2.6.1.2
alanine transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.6
leucine transaminase
2.6.1.67
2-aminohexanoate transaminase
2.6.1.9
histidinol-phosphate transaminase
|
–
–
–
–
–
–
–
–
|
|
BRENDA:
BR47691
KEGG:
R01090
MetaCyc:
BRANCHED-CHAINAMINOTRANSFERLEU-RXN
SABIO-RK:
1352
|
|
|
|
L-valine + 2-oxoglutarate <=> L-glutamate + 2-oxoisovalerate
|
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.6
leucine transaminase
2.6.1.66
valine---pyruvate transaminase
|
–
–
–
–
|
|
BRENDA:
BS356553
KEGG:
R01214
MetaCyc:
BRANCHED-CHAINAMINOTRANSFERVAL-RXN
SABIO-RK:
1446
|
|
|
|
2R,3R-2,3-dihydroxy-3-methylpentanoate + NADP+ <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate + NADPH + H+
|
1.1.1.86
ketol-acid reductoisomerase (NADP+)
|
–
|
|
KEGG:
R05068
|
|
|
|
2-[(3''-methylsulfanyl)propyl]malate <=> 3-[(3''-methylsulfanyl)propyl]malate
|
4.2.1.170
2-(omega-methylthio)alkylmalate dehydratase
|
–
|
|
KEGG:
R08624
MetaCyc:
RXNQT-4164
|
|
|
|
isocitrate + NADP+ <=> 2-oxoglutarate + CO2 + NADPH
|
1.1.1.286
isocitrate---homoisocitrate dehydrogenase
1.1.1.41
isocitrate dehydrogenase (NAD+)
1.1.1.42
isocitrate dehydrogenase (NADP+)
|
–
–
–
|
|
BRENDA:
BR29305;
BS370920
KEGG:
R00267
MetaCyc:
ISOCITDEH-RXN
SABIO-RK:
14842;
15247;
269
|
|
|
|
cis-aconitate + H2O <=> isocitrate
|
4.2.1.3
aconitate hydratase
|
–
|
|
BRENDA:
BS18708
KEGG:
R01900
MetaCyc:
ACONITATEHYDR-RXN
SABIO-RK:
273
|
|
|
|
homoisocitrate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
|
4.2.1.114
methanogen homoaconitase
4.2.1.36
homoaconitate hydratase
|
–
–
|
|
BRENDA:
BR416
KEGG:
R04371
MetaCyc:
HOMOACONITATE-HYDRATASE-RXN
SABIO-RK:
4067
|
|
|
|
trihomocitrate <=> (Z)-hex-1-ene-1,2,6-tricarboxylate + H2O
|
4.2.1.114
methanogen homoaconitase
|
–
|
|
BRENDA:
BS424131
KEGG:
R10395
MetaCyc:
R216-RXN
|
|
|
|
2-Oxo-7-methylthioheptanoic_acid + an_L-amino_acid <=> L-trihomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
|
KEGG:
R08630
|
|
|
|
(Z)-pent-1-ene-1,2,5-tricarboxylate + H2O <=> (-)-threo-iso(homo)2citrate
|
4.2.1.114
methanogen homoaconitase
|
–
|
|
BRENDA:
BS421927
KEGG:
R10393
MetaCyc:
R213-RXN
|
|
|
|
(E,Z)-indolyl-3-acetaldoxime + L-cysteine + NADPH + O2 + H+ <=> S-(Indolylmethylthiohydroximoyl)-L-cysteine + NADP+ + 2 H2O
|
1.14.14.43
(methylsulfanyl)alkanaldoxime N-monooxygenase
1.14.14.45
aromatic aldoxime N-monooxygenase
|
–
–
|
|
KEGG:
R08168
SABIO-RK:
14613
|
|
|
|
2-oxo-4-phenylbutanoic_acid + an_L-amino_acid <=> L-homophenylalanine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
|
KEGG:
R10503
|
|
|
|
2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate
|
4.2.1.33
3-isopropylmalate dehydratase
|
–
|
|
BRENDA:
BR413;
BR49521;
BS1964
KEGG:
R03968;
R04001
MetaCyc:
3-ISOPROPYLMALISOM-RXN;
RXN-8991
SABIO-RK:
3704;
3736
|
|
|
|
L-glutamate + N2-Acetyl-L-ornithine <=> N-acetyl-L-glutamate + L-ornithine
|
2.3.1.35
glutamate N-acetyltransferase
|
–
|
|
BRENDA:
BR44035
KEGG:
R02282
MetaCyc:
GLUTAMATE-N-ACETYLTRANSFERASE-RXN
SABIO-RK:
2247
|
|
|
|
4-methylthiobutanaldoxime + L-cysteine + reduced_flavodoxin + O2 <=> S-(4-Methylthiobutylthiohydroximoyl)-L-cysteine + flavin + 2 H2O
|
1.14.14.43
(methylsulfanyl)alkanaldoxime N-monooxygenase
|
–
|
|
KEGG:
R08666
|
|
|
|
3''-phosphoadenylyl-sulfate + desulfo-indol-3-yl-methyl_glucosinolate <=> adenosine_3,5''-bisphosphate + glucobrassicin + H+
|
2.8.2.24
aromatic desulfoglucosinolate sulfotransferase
2.8.2.38
aliphatic desulfoglucosinolate sulfotransferase
|
–
–
|
|
BRENDA:
BR52177;
BS407937
KEGG:
R08167
MetaCyc:
RXN-1443
|
|
|
|
(2R,3S)-3-isopropylmalate + NAD+ <=> 4-methyl-2-oxopentanoate + CO2 + NADH
|
1.1.1.286
isocitrate---homoisocitrate dehydrogenase
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
|
BRENDA:
BS355845;
BS383027
KEGG:
R10052
MetaCyc:
RXN-13158
SABIO-RK:
12393
|
|
|
|
L-aspartate + 2-oxoglutarate <=> oxaloacetate + L-glutamate
|
2.6.1.1
aspartate transaminase
2.6.1.19
4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2
alanine transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.5
tyrosine transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.75
cysteine-conjugate transaminase
2.6.1.78
aspartate---prephenate aminotransferase
2.6.1.79
glutamate---prephenate aminotransferase
|
–
–
–
–
–
–
–
–
–
–
|
|
BRENDA:
BR47671;
BS377429
KEGG:
R00355
MetaCyc:
ASPAMINOTRANS-RXN;
RXN-13697
SABIO-RK:
825
|
|
|
|
H+ + trihomocitrate + CoA <=> 2-oxopimelic_acid + acetyl-CoA + H2O
|
2.3.3
4.1.3
|
–
–
|
|
KEGG:
R08332
MetaCyc:
R215-RXN
|
|
|
|
L-dihomomethionine + 2 O2 + 2 reduced_flavodoxin <=> omega-(methylthio)-(E)-alkanal_oxime + CO2 + 3 H2O + 2 flavin
|
1.14.14.42
homomethionine N-monooxygenase
|
–
|
|
BRENDA:
BS438372
KEGG:
R08670
|
|
|
|
2-Oxo-9-methylthiononanoic_acid + an_L-amino_acid <=> L-pentahomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
|
KEGG:
R08643
|
|
|
|
L-tyrosine + 2 O2 + 2 reduced_flavodoxin <=> p-hydroxyphenylacetaldoxime + 2 flavin + CO2 + 3 H2O
|
1.14.14.36
tyrosine N-monooxygenase
1.14.14.40
phenylalanine N-monooxygenase
|
–
–
|
|
BRENDA:
BR51798
KEGG:
R10671
|
|
|
|
2-Oxo-10-methylthiodecanoic_acid + an_L-amino_acid <=> L-hexahomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
|
KEGG:
R08647
|
|
|
|
dihomocitrate <=> (Z)-pent-1-ene-1,2,5-tricarboxylate + H2O
|
4.2.1.114
methanogen homoaconitase
|
–
|
|
BRENDA:
BS423311
KEGG:
R10392
MetaCyc:
R212-RXN
|
|
|
|
3-(2''-Methylthio)ethylmalic_acid + NAD+ <=> 2-Oxo-5-methylthiopentanoic_acid + CO2 + NADH + H+
|
1.1.1
|
–
|
|
KEGG:
R08621
|
|
|
|
[amino_group_carrier_protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + 2-oxoglutarate <=> L-glutamate + LysW-L-glutamate_5-semialdehyde
|
2.6.1
2.6.1.11
acetylornithine transaminase
|
–
–
|
|
KEGG:
R10932
MetaCyc:
RXN-15007
|
|
|
|
N-acetyl-L-glutamate_5-semialdehyde + NADP+ + phosphate <=> H+ + N-acetyl-L-glutamyl_5-phosphate + NADPH
|
1.2.1.38
N-acetyl-gamma-glutamyl-phosphate reductase
|
–
|
|
BRENDA:
BR36780
KEGG:
R03443
MetaCyc:
N-ACETYLGLUTPREDUCT-RXN
|
|
|
|
L-tryptophan + 2 reduced_flavodoxin + 2 O2 <=> (E,Z)-indolyl-3-acetaldoxime + 2 flavin + CO2 + 3 H2O
|
1.14.14.156
tryptophan N-monooxygenase
|
–
|
|
BRENDA:
BR49593
KEGG:
R08160
|
|
|
|
L-phenylalanine + 2 reduced_flavodoxin + 2 O2 <=> (E)-phenylacetaldoxime + 2 flavin + CO2 + 3 H2O
|
1.14.14.40
phenylalanine N-monooxygenase
|
–
|
|
BRENDA:
BR49589
KEGG:
R09578
|
|
|
|
L-isoleucine + 2-oxoglutarate <=> L-glutamate + (S)-3-methyl-2-oxopentanoate
|
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.67
2-aminohexanoate transaminase
|
–
–
|
|
BRENDA:
BS356522;
BS452227
KEGG:
R02199
MetaCyc:
BRANCHED-CHAINAMINOTRANSFERILEU-RXN
SABIO-RK:
2171;
9086
|
|
|
|
LysW-gamma-L-alpha-aminoadipate_6-semialdehyde + L-glutamate <=> LysW-gamma-L-lysine + 2-oxoglutarate
|
2.6.1.118
[amino-group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase
|
–
|
|
KEGG:
R09778
|
|
|
|
(R)-2,3-dihydroxy-3-methylbutanoate <=> 2-oxoisovalerate + H2O
|
4.2.1.9
dihydroxy-acid dehydratase
|
–
|
|
KEGG:
R04441
MetaCyc:
DIHYDROXYISOVALDEHYDRAT-RXN
|
|
|
|
LysW-gamma-L-lysine + H2O <=> L-lysine + [LysW]-C-terminal-L-glutamate
|
3.5.1.130
[amino group carrier protein]-lysine hydrolase
|
–
|
|
KEGG:
R09779
|
|
|
|
L-trihomomethionine + 2 reduced_flavodoxin + 2 O2 <=> 6-Methylthiohexanaldoxime + 2 flavin + CO2 + 3 H2O
|
1.14.14.42
homomethionine N-monooxygenase
|
–
|
|
KEGG:
R08672
|
|
|
|
LysW-L-glutamate + ATP <=> LysW-L-glutamyl_5-phosphate + ADP
|
2.7.2
|
–
|
|
KEGG:
R10930
|
|
|
|
dihomocitrate <=> (-)-threo-iso(homo)2citrate
|
4.2.1.114
methanogen homoaconitase
|
–
|
|
KEGG:
R10391
|
|
|
|
3-[(4''-methylsulfanyl)butyl]malate + NAD+ <=> 7-methylthio-2-oxoheptanoate + CO2 + NADH
|
1.1.1
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
|
KEGG:
R08629
MetaCyc:
RXNQT-4168
|
|
|
|
LysW-gamma-L-alpha-aminoadipyl_6-phosphate + NADPH + H+ <=> LysW-gamma-L-alpha-aminoadipate_6-semialdehyde + NADP+ + phosphate
|
1.2.1.103
[amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase
|
–
|
|
KEGG:
R09777
|
|
|
|
acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H+
|
2.3.3.1
citrate (Si)-synthase
2.3.3.14
homocitrate synthase
2.3.3.16
citrate synthase (unknown stereospecificity)
2.3.3.3
citrate (Re)-synthase
|
–
–
–
–
|
|
BRENDA:
BR44118
KEGG:
R00351
MetaCyc:
CITSYN-RXN;
RXN-14905
SABIO-RK:
267
|
|
|
|
homoisocitrate + NAD+ <=> 2-oxoadipate + CO2 + NADH
|
1.1.1.286
isocitrate---homoisocitrate dehydrogenase
1.1.1.42
isocitrate dehydrogenase (NADP+)
1.1.1.87
homoisocitrate dehydrogenase
|
–
–
–
|
|
BRENDA:
BR48021
KEGG:
R01934
MetaCyc:
RXN-7970
SABIO-RK:
1988
|
|
|
|
2-[(7''-methylsulfanyl)heptyl]malate <=> 3-[(7''-methylsulfanyl)heptyl]malate
|
4.2.1.170
2-(omega-methylthio)alkylmalate dehydratase
|
–
|
|
KEGG:
R08645
MetaCyc:
RXNQT-4176
|
|
|
|
L-homophenylalanine + 2 O2 + 2 NADPH + 2 H+ <=> 3-Phenylpropionaldoxim + 2 NADP+ + CO2 + 3 H2O
|
1.14.13
|
–
|
|
KEGG:
R08655
|
|
|
|
2-[(2''-methylsulfanyl)ethyl]malate <=> 3-[(2''-methylsulfanyl)ethyl]malate
|
4.2.1.170
2-(omega-methylthio)alkylmalate dehydratase
|
–
|
|
KEGG:
R08620
MetaCyc:
RXN-2203
|
|
|
|
L-aspartate + ATP <=> L-4-aspartyl_phosphate + ADP
|
2.7.2.4
aspartate kinase
|
–
|
|
BRENDA:
BR47827
KEGG:
R00480
MetaCyc:
ASPARTATEKIN-RXN
SABIO-RK:
912
|
|
|
|
UDP-glucose + an_(E)-omega-(methylthio)alkyl-thiohydroximate <=> H+ + an_aliphatic_desulfoglucosinolate + UDP
|
2.4.1.195
N-hydroxythioamide S-beta-glucosyltransferase
|
–
|
|
BRENDA:
BR52365
KEGG:
R08668;
R12045
MetaCyc:
RXN-2208
|
|
|
|
3''-phosphoadenylyl-sulfate + desulfoglucotropaeolin <=> adenosine_3,5''-bisphosphate + benzylglucosinolate + H+
|
2.8.2.24
aromatic desulfoglucosinolate sulfotransferase
2.8.2.38
aliphatic desulfoglucosinolate sulfotransferase
|
–
–
|
|
BRENDA:
BR47919;
BS358758
KEGG:
R03214
MetaCyc:
RXN-4606
|
|
|
|
N-acetyl-L-glutamate + ATP <=> N-acetyl-L-glutamyl_5-phosphate + ADP
|
2.7.2.8
acetylglutamate kinase
|
–
|
|
BRENDA:
BR47830
KEGG:
R02649
MetaCyc:
ACETYLGLUTKIN-RXN
SABIO-RK:
2545
|
|
|
|
L-glutamate + [LysW]-C-terminal-L-glutamate + ATP <=> LysW-L-glutamate + ADP + phosphate
|
6.3.2
|
–
|
|
KEGG:
R10929
|
|
|
|
(2R,3S)-3-isopropylmalate + NAD+ <=> (2S)-2-isopropyl-3-oxosuccinate + NADH + H+
|
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
|
|
BRENDA:
BR47597;
BS373119
KEGG:
R04426
MetaCyc:
3-ISOPROPYLMALDEHYDROG-RXN
|
|
|
|
9-methylthio-2-oxononanoate + acetyl-CoA + H2O <=> H+ + 2-[(7''-methylsulfanyl)heptyl]malate + CoA
|
2.3.3.17
methylthioalkylmalate synthase
|
–
|
|
BRENDA:
BS438985
KEGG:
R08644
MetaCyc:
RXNQT-4175
|
|
|
|
L-pentahomomethionine + 2 O2 + 2 reduced_flavodoxin <=> 4-methylthiooctanaldoxime + CO2 + 3 H2O + 2 flavin
|
1.14.14.42
homomethionine N-monooxygenase
|
–
|
|
BRENDA:
BS438382
KEGG:
R08674
|
|
|
|
2-Benzylmalate <=> 3-Benzylmalate
|
4.2.1
|
–
|
|
KEGG:
R10501
MetaCyc:
RXN-14463
|
|
|
|
phenylpyruvate + acetyl-CoA + H2O <=> 2-Benzylmalate + CoA + H+
|
2.3.3
|
–
|
|
KEGG:
R10500
MetaCyc:
RXN-14462
|
|
|
|
UDP-glucose + phenylacetothiohydroximate <=> desulfoglucotropaeolin + UDP
|
2.4.1.195
N-hydroxythioamide S-beta-glucosyltransferase
|
–
|
|
BRENDA:
BR48049
KEGG:
R03213
MetaCyc:
2.4.1.195-RXN
SABIO-RK:
3040
|
|
|
|
2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate
|
2.6.1.1
aspartate transaminase
2.6.1.12
alanine---oxo-acid transaminase
2.6.1.2
alanine transaminase
2.6.1.37
2-aminoethylphosphonate---pyruvate transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.4
glycine transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.5
tyrosine transaminase
2.6.1.79
glutamate---prephenate aminotransferase
|
–
–
–
–
–
–
–
–
–
|
|
BRENDA:
BR47397
KEGG:
R00258
MetaCyc:
ALANINE-AMINOTRANSFERASE-RXN;
RXN-13698
SABIO-RK:
763
|
|
|
|
4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O <=> 2-[(2''-methylsulfanyl)ethyl]malate + CoA + H+
|
2.3.3.17
methylthioalkylmalate synthase
|
–
|
|
BRENDA:
BS438092
KEGG:
R08619
MetaCyc:
RXN-2202
|
|
|
|
S-(4-Methylthiobutylthiohydroximoyl)-L-cysteine + H2O <=> an_(E)-omega-(methylthio)alkyl-thiohydroximate + pyruvate + NH3
|
4.4.1
4.4.1.13
cysteine-S-conjugate beta-lyase
|
–
–
|
|
KEGG:
R08667
MetaCyc:
RXN-8052
|
|
|
|
(2R,3S)-3-isopropylmalate <=> (2S)-2-isopropylmalate
|
4.2.1.33
3-isopropylmalate dehydratase
|
–
|
|
BRENDA:
BR50204
KEGG:
R10170
MetaCyc:
RXN-13163
|
|
|
|
3-[(6''-methylsulfanyl)hexyl]malate + NAD+ <=> 9-methylthio-2-oxononanoate + CO2 + NADH
|
1.1.1
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
|
KEGG:
R08642
MetaCyc:
RXNQT-4174
|
|
|
|
L-leucine + 2 O2 + 2 NADPH + 2 H+ <=> (E/Z)-isovaleraldoxime + 3 H2O + 2 NADP+ + CO2
|
1.14.13
|
–
|
|
KEGG:
R08664
|
|
|
|
2-[(5''-methylsulfanyl)pentyl]malate <=> 3-[(5''-methylsulfanyl)pentyl]malate
|
4.2.1.170
2-(omega-methylthio)alkylmalate dehydratase
|
–
|
|
KEGG:
R08634
MetaCyc:
RXNQT-4170
|
|
|
|
2-Oxo-8-methylthiooctanoic_acid + an_L-amino_acid <=> L-tetrahomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
|
KEGG:
R08638
|
|
|
|
3-Benzylmalate + NAD+ <=> 2-oxo-4-phenylbutanoic_acid + CO2 + NADH
|
1.1.1
|
–
|
|
KEGG:
R10502
MetaCyc:
RXN-14466
|
|
|
|
ATP + [LysW]-C-terminal-L-glutamate + L-2-aminoadipate <=> ADP + phosphate + [LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate
|
6.3.2.43
[amino-group carrier protein]---L-2-aminoadipate ligase
|
–
|
|
BRENDA:
BS424678
KEGG:
R09775
|
|
|
|
UDP-glucose + p-Hydroxyphenylacetothiohydroximate <=> desulfo-p-hydroxy-benzylglucosinolate + UDP
|
2.4.1.195
N-hydroxythioamide S-beta-glucosyltransferase
|
–
|
|
KEGG:
R08661
MetaCyc:
RXN-18761
|
|
|
|
(R)-2-hydroxybutane-1,2,4-tricarboxylate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
|
4.2.1
4.2.1.114
methanogen homoaconitase
4.2.1.36
homoaconitate hydratase
|
–
–
–
|
|
BRENDA:
BR49014;
BS1972
KEGG:
R03444
MetaCyc:
RXN3O-1983
SABIO-RK:
3238
|
|
|
|
S-(Phenylacetothiohydroximoyl)-L-cysteine + H2O <=> phenylacetothiohydroximate + pyruvate + NH3 + H+
|
4.4.1
4.4.1.13
cysteine-S-conjugate beta-lyase
|
–
–
|
|
KEGG:
R08654
MetaCyc:
RXN-8054
|
|
|
|
L-tyrosine + 2-oxoglutarate <=> 4-hydroxyphenylpyruvate + L-glutamate
|
2.6.1.1
aspartate transaminase
2.6.1.2
alanine transaminase
2.6.1.24
diiodotyrosine transaminase
2.6.1.27
tryptophan transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.49
dihydroxyphenylalanine transaminase
2.6.1.5
tyrosine transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.7
kynurenine---oxoglutarate transaminase
2.6.1.79
glutamate---prephenate aminotransferase
2.6.1.9
histidinol-phosphate transaminase
|
–
–
–
–
–
–
–
–
–
–
–
–
|
|
BRENDA:
BR47696
KEGG:
R00734
MetaCyc:
TYROSINE-AMINOTRANSFERASE-RXN
SABIO-RK:
1097
|
|
|
|
[LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate + ATP <=> LysW-gamma-L-alpha-aminoadipyl_6-phosphate + ADP
|
2.7.2.17
[amino-group carrier protein]-L-2-aminoadipate 6-kinase
|
–
|
|
KEGG:
R09776
|
|
|
|
D-erythro-3-Methylmalate + NAD+ <=> 2-oxobutyrate + CO2 + NADH
|
1.1.1
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
|
KEGG:
R00994
MetaCyc:
RXN-7745
|
|
|
|
L-methionine + a_2-oxo_carboxylate <=> 4-methylsulfanyl-2-oxobutanoate + an_aliphatic_L-amino_acid
|
2.6.1.88
methionine transaminase
|
–
|
|
BRENDA:
BR49829
KEGG:
R08618
|
|
|
|
3-[(5''-methylsulfanyl)pentyl]malate + NAD+ <=> 8-methylthio-2-oxooctanoate + CO2 + NADH
|
1.1.1
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
|
KEGG:
R08636
MetaCyc:
RXNQT-4171
|
|
|
|
L-glutamate + acetyl-CoA <=> H+ + N-acetyl-L-glutamate + CoA
|
2.3.1.1
amino-acid N-acetyltransferase
2.3.1.17
aspartate N-acetyltransferase
2.3.1.183
phosphinothricin acetyltransferase
2.7.2.8
acetylglutamate kinase
6.3.4.16
carbamoyl-phosphate synthase (ammonia)
|
–
–
–
–
–
|
|
BRENDA:
BR43962
KEGG:
R00259
MetaCyc:
N-ACETYLTRANSFER-RXN
SABIO-RK:
764
|
|
|
|
(-)-threo-iso(homo)3citrate + NAD+ <=> 2-Oxosuberate + CO2 + NADH
|
1.1.1
|
–
|
|
KEGG:
R08215
MetaCyc:
R218-RXN
|
|
|
|
(E)-phenylacetaldoxime + L-cysteine + NADPH + O2 + H+ <=> S-(Phenylacetothiohydroximoyl)-L-cysteine + NADP+ + 2 H2O
|
1.14.14.45
aromatic aldoxime N-monooxygenase
|
–
|
|
KEGG:
R10670
|
|
|
|
3''-phosphoadenylyl-sulfate + desulfo-4-methylthiobutylglucosinolate <=> adenosine_3,5''-bisphosphate + H+ + glucoerucin
|
2.8.2
2.8.2.38
aliphatic desulfoglucosinolate sulfotransferase
|
–
–
|
|
BRENDA:
BS407934
KEGG:
R08671
MetaCyc:
RXNQT-4329
|
|
|
|
3-[(3''-methylsulfanyl)propyl]malate + NAD+ <=> 6-methylthio-2-oxohexanoate + CO2 + NADH
|
1.1.1
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
|
KEGG:
R08625
MetaCyc:
RXNQT-4165
|
|
|
|
2-oxoglutarate + H2O + acetyl-CoA <=> H+ + (R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
|
2.3.3.14
homocitrate synthase
|
–
|
|
BRENDA:
BR44122;
BS321812
KEGG:
R00271
MetaCyc:
HOMOCITRATE-SYNTHASE-RXN
SABIO-RK:
532
|
|
|
|
trihomocitrate <=> (-)-threo-iso(homo)3citrate
|
4.2.1.114
methanogen homoaconitase
|
–
|
|
KEGG:
R10394
|
|
|
|
oxalosuccinate + H+ <=> 2-oxoglutarate + CO2
|
1.1.1.42
isocitrate dehydrogenase (NADP+)
|
–
|
|
BRENDA:
BR48779
KEGG:
R00268
MetaCyc:
RXN-8642
SABIO-RK:
241
|
|
|
|
citraconate + H2O <=> D-erythro-3-Methylmalate
|
4.2.1.35
(R)-2-methylmalate dehydratase
|
–
|
|
KEGG:
R03898
MetaCyc:
RXN-7744
|
|
|
|
L-aspartate_4-semialdehyde + phosphate + NADP+ <=> L-4-aspartyl_phosphate + NADPH + H+
|
1.2.1.11
aspartate-semialdehyde dehydrogenase
|
–
|
|
BRENDA:
BR36772
KEGG:
R02291
MetaCyc:
ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
SABIO-RK:
2255
|
|
|
|
3''-phosphoadenylyl-sulfate + an_aliphatic_desulfoglucosinolate <=> adenosine_3,5''-bisphosphate + H+ + glucoiberverin
|
2.8.2
2.8.2.38
aliphatic desulfoglucosinolate sulfotransferase
|
–
–
|
|
KEGG:
R08669
MetaCyc:
RXN-2209
|
|
|
|
2-Oxo-6-methylthiohexanoic_acid + an_L-amino_acid <=> L-dihomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
|
KEGG:
R08626
|
|
|
|
3-[(7''-methylsulfanyl)heptyl]malate + NAD+ <=> 2-Oxo-10-methylthiodecanoate + CO2 + NADH
|
1.1.1
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
|
KEGG:
R08646
MetaCyc:
RXNQT-4178
|
|
|
|
L-2,4-diaminobutanoate + 2-oxoglutarate <=> L-aspartate_4-semialdehyde + L-glutamate
|
2.6.1.46
diaminobutyrate---pyruvate transaminase
2.6.1.76
diaminobutyrate---2-oxoglutarate transaminase
4.1.1.86
diaminobutyrate decarboxylase
|
–
–
–
|
|
BRENDA:
BR29484
KEGG:
R06977
MetaCyc:
R101-RXN
SABIO-RK:
7483
|
|