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leucine metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
isovaleryl-CoA + FAD <=> 3-methylcrotonoyl-CoA + FADH2 1.3.8.4 isovaleryl-CoA dehydrogenase
1.3.8.7 medium-chain acyl-CoA dehydrogenase


4-methyl-2-oxopentanoate + H+ <=> Isovaleraldehyde + CO2 4.1.1.1 pyruvate decarboxylase
4.1.1.7 benzoylformate decarboxylase
4.1.1.72 branched-chain-2-oxoacid decarboxylase



ATP + L-leucine + tRNALeu <=> AMP + diphosphate + L-leucyl-tRNALeu 6.1.1.4 leucine---tRNA ligase

L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.67 2-aminohexanoate transaminase
2.6.1.9 histidinol-phosphate transaminase








(2R,3S)-3-isopropylmalate + NAD+ <=> (2S)-2-isopropyl-3-oxosuccinate + NADH + H+ 1.1.1.85 3-isopropylmalate dehydrogenase

2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate 4.2.1.33 3-isopropylmalate dehydratase

(S)-3-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA 4.1.3.4 hydroxymethylglutaryl-CoA lyase

(S)-3-hydroxy-3-methylglutaryl-CoA <=> H2O + trans-3-methylglutaconyl-CoA 4.2.1.18 methylglutaconyl-CoA hydratase

L-leucine + NAD+ + H2O <=> H+ + NH3 + NADH + 4-methyl-2-oxopentanoate 1.4.1.1 alanine dehydrogenase
1.4.1.20 phenylalanine dehydrogenase
1.4.1.23 valine dehydrogenase (NAD+)
1.4.1.8 valine dehydrogenase (NADP+)
1.4.1.9 leucine dehydrogenase





L-leucine <=> (3R)-beta-leucine 5.4.3.7 leucine 2,3-aminomutase

3-methyl-1-butanol + NAD+ <=> Isovaleraldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.265 3-methylbutanal reductase



3-methylcrotonoyl-CoA + HCO3- + ATP <=> trans-3-methylglutaconyl-CoA + ADP + phosphate + H+ 6.4.1.4 methylcrotonoyl-CoA carboxylase
6.4.1.5 geranoyl-CoA carboxylase


H+ + (2S)-2-isopropyl-3-oxosuccinate <=> 4-methyl-2-oxopentanoate + CO2 0.0.0.0
1.1.1.85 3-isopropylmalate dehydrogenase


(3R)-beta-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-3-oxopentanoate not assigned

4-methyl-3-oxopentanoate + H2O <=> H+ + Isobutyrate + acetate not assigned

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