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Lysine biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
L-lysine + (3R)-3-methyl-D-ornithine + ATP <=> (2R,3R)-3-Methylornithinyl-N6-lysine + products_of_ATP_breakdown 6.3.2

H+ + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O <=> L-2-amino-6-oxopimelate 0.0.0.0
3.5.99


H2O + N-acetyl-L,L-2,6-diaminopimelate <=> LL-2,6-Diaminoheptanedioate + acetate 3.5.1.47 N-acetyldiaminopimelate deacetylase

L-lysine <=> (3R)-3-methyl-D-ornithine 5.4.99.58 methylornithine synthase

LysW-gamma-L-lysine + H2O <=> L-lysine + [LysW]-C-terminal-L-glutamate 3.5.1.130 [amino group carrier protein]-lysine hydrolase

LysW-gamma-L-alpha-aminoadipate_6-semialdehyde + L-glutamate <=> LysW-gamma-L-lysine + 2-oxoglutarate 2.6.1.118

homoisocitrate + NAD+ <=> 2-oxoadipate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.42 isocitrate dehydrogenase (NADP+)
1.1.1.87 homoisocitrate dehydrogenase



L-aspartate_4-semialdehyde + phosphate + NADP+ <=> L-4-aspartyl_phosphate + NADPH + H+ 1.2.1.11 aspartate-semialdehyde dehydrogenase

L-2-aminoadipate_adenylate + Holo-Lys2 <=> alpha-Aminoadipoyl-S-acyl_enzyme + AMP 1.2.1.95 L-2-aminoadipate reductase

alpha-Aminoadipoyl-S-acyl_enzyme + NADPH + H+ <=> (S)-2-amino-6-oxohexanoate + Holo-Lys2 + NADP+ 1.2.1.95 L-2-aminoadipate reductase

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ 1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase

homoisocitrate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O 4.2.1.114 methanogen homoaconitase
4.2.1.36 homoaconitate hydratase


(2R,3R)-3-Methylornithinyl-N6-lysine + NAD+ + H2O <=> (2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine + NH3 + NADH + H+ 1.4.1

[LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate54 + ATP <=> LysW-gamma-L-alpha-aminoadipyl_6-phosphate + ADP 2.7.2.17

H2O + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + succinyl-CoA <=> N-succinyl-L-2-amino-6-oxoheptanedioate + CoA 2.3.1.117 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

L-aspartate + ATP <=> L-4-aspartyl_phosphate + ADP 2.7.2.4 aspartate kinase

meso-2,6-diaminoheptanedioate + NADP+ + H2O <=> L-2-amino-6-oxopimelate + NH3 + NADPH + H+ 1.4.1.16 diaminopimelate dehydrogenase

(2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine <=> H+ + pyrrolysine + H2O not assigned

LL-2,6-Diaminoheptanedioate + 2-oxoglutarate <=> (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O + H+ 2.6.1.83 LL-diaminopimelate aminotransferase

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ 1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase

saccharopine + H2O + NAD+ <=> 2-oxoglutarate + L-lysine + NADH + H+ 1.5.1.7 saccharopine dehydrogenase (NAD+, L-lysine-forming)
1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming)


2-oxoglutarate + H2O + acetyl-CoA <=> H+ + homocitrate + CoA 2.3.3.14 homocitrate synthase

2-oxoglutarate + N-succinyl-LL-2,6-diaminoheptanedioate <=> L-glutamate + N-succinyl-L-2-amino-6-oxoheptanedioate 2.6.1.17 succinyldiaminopimelate transaminase

pyruvate + L-aspartate_4-semialdehyde <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+ 4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase

LysW-gamma-L-alpha-aminoadipyl_6-phosphate + NADPH + H+ <=> LysW-gamma-L-alpha-aminoadipate_6-semialdehyde + NADP+ + phosphate 1.2.1.103

saccharopine + NADP+ + H2O <=> H+ + L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH 1.5.1.10 saccharopine dehydrogenase (NADP+, L-glutamate-forming)

acetyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O <=> CoA + L-N-acetyl-2-amino-6-oxopimelate 2.3.1
2.3.1.89 tetrahydrodipicolinate N-acetyltransferase


UDP-MurNAc-L-Ala-D-Glu + meso-2,6-diaminoheptanedioate + ATP <=> H+ + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate + phosphate + ADP 6.3.2.13 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase

UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate + D-Ala-D-Ala + ATP <=> H+ + UDP-N-acetylmuramoyl-pentapeptide + phosphate + ADP 6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase

L-N-acetyl-2-amino-6-oxopimelate + L-glutamate <=> N-acetyl-L,L-2,6-diaminopimelate + 2-oxoglutarate 2.6.1

meso-2,6-diaminoheptanedioate + H+ <=> L-lysine + CO2 4.1.1.20 diaminopimelate decarboxylase

L-2-aminoadipate + 2-oxoglutarate <=> L-glutamate + 2-oxoadipate 2.6.1.39 2-aminoadipate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase


homocitrate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O 4.2.1
4.2.1.114 methanogen homoaconitase
4.2.1.36 homoaconitate hydratase



ATP + [LysW]-C-terminal-L-glutamate + L-2-aminoadipate <=> ADP + phosphate + [LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate54 6.3.2.43 [lysine-biosynthesis-protein LysW]---L-2-aminoadipate ligase

L-homoserine + NADP+ <=> L-aspartate_4-semialdehyde + NADPH + H+ 1.1.1.3 homoserine dehydrogenase

L-homoserine + NAD+ <=> L-aspartate_4-semialdehyde + NADH + H+ 1.1.1.3 homoserine dehydrogenase

L-2-aminoadipate + ATP <=> L-2-aminoadipate_adenylate + diphosphate 1.2.1.95 L-2-aminoadipate reductase

LL-2,6-Diaminoheptanedioate <=> meso-2,6-diaminoheptanedioate 5.1.1.10 amino-acid racemase
5.1.1.7 diaminopimelate epimerase


H2O + N-succinyl-LL-2,6-diaminoheptanedioate <=> LL-2,6-Diaminoheptanedioate + succinate 3.5.1.18 succinyl-diaminopimelate desuccinylase

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