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L-leucine biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(2R,3S)-3-isopropylmalate + NAD+ <=> (2S)-2-isopropyl-3-oxosuccinate + NADH + H+ 1.1.1.85 3-isopropylmalate dehydrogenase

2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate 4.2.1.33 3-isopropylmalate dehydratase

2-oxoisovalerate + acetyl-CoA + H2O <=> H+ + (2S)-2-isopropylmalate + CoA 2.3.3.13 2-isopropylmalate synthase
2.3.3.17 methylthioalkylmalate synthase


H+ + (2S)-2-isopropyl-3-oxosuccinate <=> 4-methyl-2-oxopentanoate + CO2 0.0.0.0
1.1.1.85 3-isopropylmalate dehydrogenase


2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate 4.2.1.33 3-isopropylmalate dehydratase

L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.67 2-aminohexanoate transaminase
2.6.1.9 histidinol-phosphate transaminase








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