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Biosynthesis of secondary metabolites

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
indole-3-glycerol_phosphate + L-serine <=> L-tryptophan + H2O + D-glyceraldehyde_3-phosphate 4.2.1.20 tryptophan synthase

S-adenosyl-L-methionine + Theobromine <=> H+ + Caffeine + S-adenosyl-L-homocysteine 2.1.1.160 caffeine synthase

Avermectin_A1b_aglycone + dTDP-L-oleandrose <=> Avermectin_A1b_monosaccharide + dTDP 2.4.1

Formylphosphonate <=> Phosphonoformate not assigned

S-adenosyl-L-methionine + 8-ethyl-12-methyl-3-vinyl-bacteriochlorophyllide_d <=> S-adenosyl-L-homocysteine + 8,12-diethyl-3-vinyl-bacteriochlorophyllide_d + H+ 2.1.1.331 bacteriochlorophyllide d C-121-methyltransferase

(1H-pyrrole-2-carbonyl)-[peptidyl-carrier_protein] + pC3'p <=> (1H-pyrrole-2-carbonyl)-[peptidyl-carrier_protein] + pC3'p not assigned

ATP + (R)-2-Aza-beta-tyrosine + pC3'p <=> AMP + diphosphate + (R)-2-Aza-beta-tyrosyl-[pcp] 6.2.1

chlortetracycline + NADPH + H+ + O2 <=> 11a-Hydroxy-7-chlortetracycline + NADP+ + H2O 1.14.13.231 tetracycline 11a-monooxygenase

(S)-4-(3''-acetyl-5''-hydroxy-4''-oxo-1,4''-dihydronapthalen-2''-yl)-3-hydroxybutanoate <=> 2-((1R,3S),-1,9''-dihydroxy-1''-methyl-10''-oxo-3,4,5,10''-tetrahydro-1H-benzo[g]isochromen-3''-yl)acetate 5.5.1

7-hydroxychlorophyllide_a + O2 + NADPH + H+ <=> chlorophyllide_b + 2 H2O + NADP+ 1.14.13.122 chlorophyllide-a oxygenase

FMNH2 + NAD+ <=> FMN + NADH + H+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.18.1.4 rubredoxin---NAD(P)+ reductase
1.5.1
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.37 FAD reductase (NADH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.39 FMN reductase [NAD(P)H]
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.42 FMN reductase (NADH)










tabersonine <=> Lochnerinine not assigned

1-(2-aminophenyl)decane-1,3-dione <=> 2-heptyl-4(1H)-quinolone + H2O 2.3.1.230 2-heptyl-4(1H)-quinolone synthase

NDP-1-epi-valienol + 2-Amino-1,5-anhydro-2-deoxyglucitol <=> Salbostatin_6''-phosphate + NDP 2.5.1.135 validamine 7-phosphate valienyltransferase

Coumermic_acid + 2 dTDP-beta-L-noviose + 2 S-adenosyl-L-methionine <=> N,N'-bis(7-[[(2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)-3-methyl-1H-pyrrole-2,4-dicarboxamide + 2 dTDP + 2 S-adenosyl-L-homocysteine not assigned

aurachin_C + O2 + NADH + H+ <=> 4-hydroxy-2-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]quinolin-3(4H)-one_1-oxide + NAD+ + H2O 1.14.13.222 aurachin C monooxygenase/isomerase

Leucocyanidin + NADP+ <=> taxifolin + NADPH + H+ 1.1.1.219 dihydroflavonol 4-reductase

12-Demethyl-11,12-dehydropaspaline + O2 + NADPH + H+ <=> beta-PC-M6 + NADP+ + H2O 1.14.13

chlorophyllide_a + H+ <=> pheophorbide_a + Mg2+ 4.99.1.10 magnesium dechelatase

2-(hydroxyphosphonoylmethyl)malate <=> 3-(hydroxyphosphonoylmethyl)malate 4.2.1.166 phosphinomethylmalate isomerase

vitamin_D3 + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> 25-hydroxyvitamin_D3 + oxidized_ferredoxin + H2O 1.14.15.22 vitamin D 1,25-hydroxylase

XMP + H2O <=> Xanthosine + phosphate 3.1.3.5 5'-nucleotidase

ATP + protoporphyrin_IX + Mg2+ + H2O <=> H+ + magnesium_protoporphyrin_IX + phosphate + ADP 6.6.1.1 magnesium chelatase

3,5,7,9,11,13,15-Heptaoxo-hexadecanoyl-[acp] <=> 7,9,12-Octaketide_intermediate_1 not assigned

N6-(delta2-Isopentenyl)-adenosine_5''-monophosphate + H2O <=> N6-isopentenyladenosine + phosphate not assigned

UDP-glucose + validoxylamine_A <=> validamycin_A + UDP + H+ 2.4.1.338 validoxylamine A glucosyltransferase

L-homoserine + succinyl-CoA <=> O-succinyl-L-homoserine + CoA 2.3.1.46 homoserine O-succinyltransferase

UDP-glucose + NAD+ <=> H+ + UDP-3-ketoglucose + NADH 1.1.1
1.1.1.M53


3-Hydroxy-OPC6-CoA + NAD+ <=> 3-Oxo-OPC6-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


5-epi-Valiolol_7-phosphate <=> 1-epi-valienol_7-phosphate not assigned

malonyl-CoA + cinnamoyl-CoA + H+ <=> CoA + pinosylvin + CO2 2.3.1.146 pinosylvin synthase
2.3.1.95 trihydroxystilbene synthase


(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 + H+ <=> 5,10-Dihydrophenazine + H2O2 + CO2 not assigned

dTDP-alpha-D-fucopyranose + NADP+ <=> dTDP-4-dehydro-6-deoxy-D-glucose + NADPH + H+ 1.1.1.266 dTDP-4-dehydro-6-deoxyglucose reductase
1.1.1.B28


vitamin_D3 + O2 + flavin_hydroquinone <=> 25-hydroxyvitamin_D3 + [oxidized_NADPH-hemoprotein_reductase] + H2O 1.14.14.24 vitamin D 25-hydroxylase

delta-carotene <=> alpha-carotene 5.5.1.19 lycopene beta-cyclase

S-adenosyl-L-methionine + Pretetramid <=> S-adenosyl-L-homocysteine + 6-methylpretetramide + H+ 2.1.1
2.1.1.M31


S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O <=> 6-amino-6-deoxyfutalosine + L-methionine + HCO3- + H+ 2.5.1.120 aminodeoxyfutalosine synthase

ATP + AMP <=> ADP 1.13.12.7 firefly luciferase
2.7.1.20 adenosine kinase
2.7.4.10 nucleoside-triphosphate---adenylate kinase
2.7.4.11 (deoxy)adenylate kinase
2.7.4.14 UMP/CMP kinase
2.7.4.3 adenylate kinase
2.7.4.31 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase
2.7.4.8 guanylate kinase
2.7.4.9 dTMP kinase









myrcene + flavin_hydroquinone + O2 <=> (4R)-ipsdienol + [oxidized_NADPH-hemoprotein_reductase] + H2O 1.14.14.31 ipsdienol synthase

CTP + phosphatidic_acid + H+ <=> CDP-diacylglycerol + diphosphate 2.7.7.41 phosphatidate cytidylyltransferase

Neoabietinol <=> Neoabietal 1.14.13

(1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate <=> (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate 4.2.99.20 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

feruloyl-CoA + 2-oxoglutarate + O2 <=> trans-6-hydroxyferuloyl-CoA + succinate + CO2 1.14.11.61 feruloyl-CoA 6-hydroxylase

7-deoxyloganin + flavin_hydroquinone + O2 <=> loganin + [oxidized_NADPH-hemoprotein_reductase] + H2O 1.14.14.85 7-deoxyloganate 7-hydroxylase

Dopaxanthin + O2 <=> Dopaxanthin_quinone + H2O 1.10.3
1.14.18.1 tyrosinase


monacolin_J_acid + (S)-2-Methylbutanoyl-[acp] <=> lovastatin_acid + [acyl-carrier_protein] 2.3.1.238 monacolin J acid methylbutanoate transferase

(4aR,10bS)-Normaritidine <=> crinine not assigned

(3R,4R)-7,2''-dihydroxy-4''-methoxyisoflavanol + NADP+ <=> vestitone + NADPH + H+ 1.1.1.348 (3R)-2'-hydroxyisoflavanone reductase

p-coumaryl_alcohol <=> caffeoyl_alcohol not assigned

copalyl_diphosphate <=> abieta-8(14),12-diene + diphosphate 4.2.3.32 levopimaradiene synthase

3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp] <=> 9,14-Decaketide_intermediate_1 + 2 H2O 2.3.1.235 tetracenomycin F2 synthase
4.2.1


2-polyprenyl-6-methoxyphenol + O2 <=> 2-Polyprenyl-6-methoxy-1,4-benzoquinone + H2O 1.14.13

amylose <=> glycogen 2.4.1.18 1,4-alpha-glucan branching enzyme
2.4.1.25 4-alpha-glucanotransferase
3.2.1.1 alpha-amylase
3.2.1.116 glucan 1,4-alpha-maltotriohydrolase
3.2.1.133 glucan 1,4-alpha-maltohydrolase
3.2.1.135 neopullulanase
3.2.1.41 pullulanase
3.2.1.54 cyclomaltodextrinase
3.2.1.68 isoamylase









(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 <=> (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2 1.10.3.16 dihydrophenazinedicarboxylate synthase

Zymosterol + NADP+ <=> H+ + zymosterone + NADPH 1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62 17beta-estradiol 17-dehydrogenase



UWM6 <=> Rabelomycin not assigned

indole + flavin_hydroquinone + O2 <=> indolin-2-one + [oxidized_NADPH-hemoprotein_reductase] + H2O 1.14.14.153 indole-2-monooxygenase

geranylgeranyl_diphosphate + homogentisate + H+ <=> diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 2.5.1.115 homogentisate phytyltransferase
2.5.1.116 homogentisate geranylgeranyltransferase


Gibberellin_A24 <=> gibberellin_a9 + CO2 1.14.11.12 gibberellin-44 dioxygenase

(1''S,5''S)-hydroxyaverantin + NAD+ <=> H+ + 5''-oxoaverantin + NADH 1.1.1.352 5'-hydroxyaverantin dehydrogenase

Avermectin_B1b_monosaccharide + dTDP-L-oleandrose <=> avermectin_B1b + dTDP 2.4.1

Hydroxyspheroidene + 2 O2 + 4 reduced_ferredoxin + 4 H+ <=> Hydroxyspheroidenone + 3 H2O + 4 oxidized_ferredoxin 1.14.15.9 spheroidene monooxygenase

alpha-D-mannose_1-phosphate <=> D-mannose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.8 phosphomannomutase



1-carboxyvinyl_carboxyphosphonate + H+ <=> CO2 + (hydroxyphosphinyl)pyruvate 2.7.8.23 carboxyvinyl-carboxyphosphonate phosphorylmutase

2''-deamino-2''-hydroxyparomamine + UDP-alpha-D-kanosamine <=> kanamycin_X + UDP + H+ 2.4.1.301 2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase

L-homoserine + NADP+ <=> L-aspartate_4-semialdehyde + NADPH + H+ 1.1.1.3 homoserine dehydrogenase

GDP-mannose <=> GDP-beta-L-galactose 5.1.3.18 GDP-mannose 3,5-epimerase

3,4-Dihydro-7-hydroxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylate <=> 3,4-Dihydro-7-methoxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylic_acid 2.1.1

acyl-CoA + 2-acyl-sn-glycerol_3-phosphate <=> phosphatidic_acid + CoA 2.3.1.52 2-acylglycerol-3-phosphate O-acyltransferase

2-octaprenylphenol + O2 + NADPH + H+ <=> 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP+ 1.14.13.240 2-polyprenylphenol 6-hydroxylase

131-oxo-magnesium-protoporphyrin_IX_13-monomethyl_ester + O2 + NADPH <=> divinyl_protochlorophyllide_a + NADP+ + H2O 1.14.13.81 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase

H+ + 2-C-methyl-D-erythritol_4-phosphate + CTP <=> 4-(cytidine_5''-diphospho)-2-C-methyl-D-erythritol + diphosphate 2.7.7.60 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

NDP-1-epi-valienol_7-phosphate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose <=> dTDP-acarviose-7-phosphate 2.4

ribostamycin + NAD+ <=> 3''''-Oxoribostamycin + NADH + H+ 1.1.1

6-phosphogluconate + NAD+ <=> D-ribulose_5-phosphate + CO2 + NADH 1.1.1.343 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)
1.1.1.351 phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)



validone_7-phosphate <=> validamine_7-phosphate not assigned

alpha-D-sedoheptulopyranose_7-phosphate <=> 2-epi-5-epi-valiolone + phosphate 4.2.3.152 2-epi-5-epi-valiolone synthase

Premithramycin_A2' + dTDP-D-mycarose <=> Premithramycin_A3 + dTDP + H+ 2.4.1

beta-D-glucose_6-phosphate + NAD+ <=> 6-phospho-D-glucono-1,5-lactone + NADH + H+ 1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]
1.1.1.388 glucose-6-phosphate dehydrogenase (NAD+)


S-adenosyl-L-methionine + dTDP-4-oxo-2,6-dideoxy-D-allose <=> S-adenosyl-L-homocysteine + dTDP-3-methyl-4-oxo-2,6-dideoxy-D-glucose + H+ 2.1.1

6-Deoxocastasterone + O2 + reduced_flavodoxin <=> 6alpha-Hydroxy-castasterone + H2O + flavin 1.14

(+)-cis-isopulegone <=> (R)-pulegone 5.3.3

UDP-glucose + abscisic_acid <=> beta-D-glucopyranosyl_abscisate + UDP 2.4.1.263 abscisate beta-glucosyltransferase

(3S)-2,3-epoxy-2,3-dihydrosqualene <=> marneral 5.4.99.53 marneral synthase

L-phenylalanine + 2 flavin_hydroquinone + 2 O2 <=> (E)-phenylacetaldoxime + 2 [oxidized_NADPH-hemoprotein_reductase] + CO2 + 3 H2O 1.14.14.40 phenylalanine N-monooxygenase

3-Hydroxy-OPC6-CoA <=> trans-2-Enoyl-OPC6-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase


feruloylacetyl-CoA + feruloyl-CoA + H2O <=> curcumin + CoA + CO2 2.3.1.217 curcumin synthase

NDP-2-amino-2,6-dideoxy-D-galactose <=> NDP-2-methylamino-2,6-dideoxy-D-galactose 2.1.1

N1,N5,N10-Tricaffeoyl_spermidine <=> N1,N5,N10-Triferuloyl_spermidine 2.1.1

Cathasterone + O2 + reduced_acceptor <=> Teasterone + H2O + acceptor 1.14

C20818 <=> C20819 2.1.1

N-Acetyl-N6,O-didemethylpuromycin-5''-phosphate + S-adenosyl-L-methionine <=> N-Acetyl-O-demethylpuromycin-5''-phosphate + S-adenosyl-L-homocysteine 2

pentalenene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> pentalen-13-al + H2O + oxidized_ferredoxin 1.14.15.32 pentalenene oxygenase

ADP-glucose + H2O <=> AMP + alpha-D-glucose_1-phosphate + H+ 3.6.1.13 ADP-ribose diphosphatase
3.6.1.21 ADP-sugar diphosphatase
3.6.1.45 UDP-sugar diphosphatase
3.6.1.9 nucleotide diphosphatase




(hydroxyphosphinyl)pyruvate + acetyl-CoA + H2O <=> H+ + 2-(hydroxyphosphonoylmethyl)malate + CoA 2.3.3.18 2-phosphinomethylmalate synthase

ent-copalyl_diphosphate <=> ent-cassa-12,15-diene + diphosphate 4.2.3.28 ent-cassa-12,15-diene synthase

dTDP-4-dehydro-6-deoxy-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose 5.3.2.3 TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)

(1''S)-averantin + flavin_hydroquinone + O2 <=> (1''S,5''S)-5''-hydroxyaverantin + [oxidized_NADPH-hemoprotein_reductase] + H2O 1.14.14.116 averantin hydroxylase

violaxanthin <=> 9-cis-violaxanthin not assigned

quercetin_3-O-glucoside + UDP-L-rhamnose <=> rutin + UDP 2.4.1.159 flavonol-3-O-glucoside L-rhamnosyltransferase
2.4.1.B53


13-Desoxypaxilline + NADPH + O2 + H+ <=> Paspalicine + NADP+ + 2 H2O not assigned

5 ATP + 3 L-4-hydroxyphenylglycine + L-arginine + L-serine + H2O <=> 5 AMP + 5 diphosphate + nocardicin_G + L-4-Hydroxyphenylglycyl-L-arginine not assigned

O-acetyl-L-serine + Sulfide <=> L-cysteine + acetate + H+ 2.5.1.47 cysteine synthase
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
2.5.1.65 O-phosphoserine sulfhydrylase
4.2.1.22 cystathionine beta-synthase
4.2.1.50 pyrazolylalanine synthase
4.4.1.9 L-3-cyanoalanine synthase






(9Z,11E,13S,15Z)-13-hydroperoxy-9,11,15-octadecatrienoate <=> H2O + (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate 4.2.1.92 hydroperoxide dehydratase

proclavaminate + 2-oxoglutarate + O2 <=> dihydroclavaminate + CO2 + H2O + succinate 1.14.11.21 clavaminate synthase

(S)-2-methylbutanoyl-CoA + enzyme_N6-(dihydrolipoyl)lysine <=> CoA + [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(2-methylbutanoyl)dihydrolipoyllysine 2.3.1.168 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase

2-(or_4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + flavin_hydroquinone + O2 <=> glyceollin + [oxidized_NADPH-hemoprotein_reductase] + 2 H2O 1.14.14.135 glyceollin synthase

L-arginine + NADPH + H+ + O2 <=> L-citrulline + NO + NADP+ + H2O 1.14.13.39 nitric-oxide synthase (NADPH)
1.14.14.47 nitric-oxide synthase (flavodoxin)


(S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate + O2 <=> 4-hydroxyphenylglyoxylate + H2O2 1.1.3.46 4-hydroxymandelate oxidase

Dialdehyde + H+ <=> 4,21-Dehydrocorynantheine_aldehyde + H2O not assigned

3,4-Dihydroxybenzaldehyde + tyramine <=> Norcraugsodine + H2O + H+ 4.3.3

2-Amino-4-chloro-4-pentenoic_acid <=> DL-propargylglycine + Cl- + H+ 4.5.1

6''''''-hydroxyparomomycin + O2 <=> 6''''''-oxoparomomycin + H2O2 1.1.3

Rifamycin_W <=> Rifamycin_W-hemiacetal not assigned

L-glutamine + 2-deoxy-scyllo-inosose <=> 2-Oxoglutaramate + 2-deoxy-scyllo-inosamine 2.6.1.100 L-glutamine:2-deoxy-scyllo-inosose aminotransferase
2.6.1.50 glutamine---scyllo-inositol transaminase


trans-5-O-caffeoylshikimate + CoA <=> caffeoyl-CoA + shikimate 2.3.1
2.3.1.133 shikimate O-hydroxycinnamoyltransferase
2.3.1.99 quinate O-hydroxycinnamoyltransferase



gibberellin_a15 <=> gibberellin_a37 not assigned

UDP-glucose + coumaric_acid <=> H+ + 2-O-(beta-D-glucosyl)-2-hydroxycinnamate + UDP 2.4.1.114 2-coumarate O-beta-glucosyltransferase
2.4.1.35 phenol beta-glucosyltransferase


9,14-Decaketide_intermediate_1 <=> tetracenomycin_F2 + [acyl-carrier_protein] not assigned

S-adenosyl-L-methionine + 2-deoxy-scyllo-inosamine <=> 3-amino-2,3-dideoxy-scyllo-inosose + 5''-deoxyadenosine + L-methionine + H+ 1.1.99.38 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)

(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2 1.10.3.16 dihydrophenazinedicarboxylate synthase

(S)-1-hydroxy-N-methylcanadine + flavin_hydroquinone + O2 <=> (13S,14R)-1,13-dihydroxy-N-methylcanadine + [oxidized_NADPH-hemoprotein_reductase] + H2O 1.14.14.163 (S)-1-hydroxy-N-methylcanadine 13-hydroxylase

3-(2''-Methylthio)ethylmalic_acid + NAD+ <=> 2-Oxo-5-methylthiopentanoic_acid + CO2 + NADH + H+ 1.1.1

2-Polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine <=> 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine 2.1.1.201 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase

H+ + (E)-4-coumaroyl-CoA + malonyl-CoA <=> resveratrol + CoA + CO2 2.3.1.146 pinosylvin synthase
2.3.1.95 trihydroxystilbene synthase


oxaloacetate + GTP <=> CO2 + phosphoenolpyruvate + GDP 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)


S-farnesyl_protein + H2O <=> protein_C-terminal_S-farnesyl-L-cysteine + peptide 3.4.22
3.4.24.84 Ste24 endopeptidase


(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA <=> tigloyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase

phytyl_diphosphate + homogentisate + H+ <=> 2-methyl-6-phytylbenzene-1,4-diol + CO2 + diphosphate 2.5.1.115 homogentisate phytyltransferase

dimethylallyl_diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin_C <=> diphosphate + fumitremorgin_B 2.5.1.110 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase

(2S)-dihydrotricetin + 2-oxoglutarate + O2 <=> dihydromyricetin + succinate + CO2 1.14.11.9 flavanone 3-dioxygenase

2''-deamino-2''-hydroxy-6''-dehydroparomamine + L-glutamate <=> 2''-deamino-2''-hydroxyneamine + 2-oxoglutarate 2.6.1.94 2'-deamino-2'-hydroxyneamine transaminase

(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol 5.4.99.17 squalene---hopene cyclase
5.4.99.7 lanosterol synthase


taxa-4(20),11-dien-5alpha-ol + reduced_flavodoxin + O2 <=> taxa-4(20),11-dien-5alpha,13alpha-diol + flavin + H2O 1.14.14.106 taxane 13alpha-hydroxylase

taxifolin + 2-oxoglutarate + O2 <=> quercetin + succinate + CO2 + H2O 1.14.20.4 anthocyanidin synthase
1.14.20.6 flavonol synthase


S-adenosyl-L-methionine + secologanate <=> S-adenosyl-L-homocysteine + secologanin 2.1.1.50 loganate O-methyltransferase

S-adenosyl-L-methionine + a_demethylmenaquinol <=> menaquinol + S-adenosyl-L-homocysteine + H+ 2.1.1.163 demethylmenaquinone methyltransferase

(+)-piperitol + flavin_hydroquinone + O2 <=> sesamin + [oxidized_NADPH-hemoprotein_reductase] + 2 H2O 1.14.19.74 (+)-piperitol/(+)-sesamin synthase

(S)-8-oxocitronellyl_enol + NAD+ <=> (6E)-8-oxogeranial + NADH + H+ 1.3.1.122
1.3.1.99 iridoid synthase


clavaminate <=> Clavulanate-9-aldehyde not assigned

shikimate + pyrroloquinoline_quinone <=> 3-dehydroshikimate + reduced_pyrroloquinoline_quinone 1.1.5.8 quinate dehydrogenase (quinone)

10-deoxymethymycin + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> neomethymycin + oxidized_ferredoxin + H2O 1.14.15.33 pikromycin synthase

ergosterol + light <=> vitamin_D2 not assigned

L-valine + 2-oxoglutarate <=> L-glutamate + 2-oxoisovalerate 2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.66 valine---pyruvate transaminase




meso-2,6-diaminoheptanedioate + NADP+ + H2O <=> L-2-amino-6-oxopimelate + NH3 + NADPH + H+ 1.4.1.16 diaminopimelate dehydrogenase

1,4-dihydroxy-2-naphthoate <=> 2-carboxy-1,4-naphthoquinone not assigned

phosphatidylethanolamine + L-serine <=> phosphatidylserine + ethanolamine 2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase

geranylgeranyl_diphosphate <=> Cembrene not assigned

H+ + Phosphonopyruvate <=> phosphonoacetaldehyde + CO2 4.1.1.82 phosphonopyruvate decarboxylase

tabersonine <=> Horhammericine not assigned

UDP-glucose + beta-D-fructose_6-phosphate <=> sucrose_6F-phosphate + UDP + H+ 2.4.1.13 sucrose synthase
2.4.1.14 sucrose-phosphate synthase


DELTA1-piperideine + acetoacetyl-CoA + H2O <=> Pelletierine + CoA + CO2 not assigned

(4-coumaroyl)acetyl-CoA + (E)-4-coumaroyl-CoA + H2O <=> bisdemethoxycurcumin + CoA + CO2 2.3.1.219 demethoxycurcumin synthase

S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine <=> H+ + S-adenosyl-L-homocysteine + Dihydromacarpine 2.1.1.120 12-hydroxydihydrochelirubine 12-O-methyltransferase

(1E,2S)-2-methylbutanal_oxime <=> (Z)-2-methylbutanal_oxime 1.14.14.41 (E)-2-methylbutanal oxime monooxygenase

amidinoproclavaminate + H2O <=> proclavaminate + Urea 3.5.3.22 proclavaminate amidinohydrolase

dihydrochanoclavine-I_aldehyde + NADP+ <=> chanoclavine-I_aldehyde + NADPH + H+ 1.3.1.100 chanoclavine-I aldehyde reductase

N-acetyldemethyl_phosphinothricin_tripeptide + methylcobalamin + S-adenosyl-L-methionine + H+ + e- <=> L-N-acetylphosphinothricin_bialophos + cob(II)alamin + 5''-Deoxyadenosine + L-methionine 2.1.1.326 N-acetyldemethylphosphinothricin P-methyltransferase

kaempferol + flavin_hydroquinone + O2 <=> quercetin + [oxidized_NADPH-hemoprotein_reductase] + H2O 1.14.14.81 flavanoid 3',5'-hydroxylase
1.14.14.82 flavonoid 3'-monooxygenase


delta-tocotrienol <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol 5.5.1.24 tocopherol cyclase

Caffeine + O2 + NADPH + H+ <=> theophylline + formaldehyde + NADP+ + H2O 1.13.12
1.14.13.128 7-methylxanthine demethylase


gibberellin_A51 <=> Gibberellin_A51-catabolite 1.14.11.13 gibberellin 2beta-dioxygenase

phenylacetonitrile + flavin_hydroquinone + O2 <=> (R)-mandelonitrile + [oxidized_NADPH-hemoprotein_reductase] + H2O 1.14.14.44 phenylacetaldehyde oxime monooxygenase
1.14.14.77 phenylacetonitrile alpha-monooxygenase


enzyme_N6-(dihydrolipoyl)lysine + NAD+ <=> [2-oxoglutarate_dehydrogenase_E2_protein]_N6-lipoyl-L-lysine + NADH + H+ 1.8.1.4 dihydrolipoyl dehydrogenase

(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O <=> 7-aminocephalosporanic_acid + Glutarate 3.5.1.11 penicillin amidase
3.5.1.93 glutaryl-7-aminocephalosporanic-acid acylase


alpha-Aminoadipoyl-S-acyl_enzyme + NADPH + H+ <=> (S)-2-amino-6-oxohexanoate + Holo-Lys2 + NADP+ 1.2.1.95 L-2-aminoadipate reductase

zeaxanthin + reduced_ferredoxin_[iron-sulfur]_cluster + H+ + O2 <=> antheraxanthin + oxidized_ferredoxin + H2O 1.14.15.21 zeaxanthin epoxidase

7,9,12-Decaketide_intermediate_6 <=> 12-Deoxyaklanonic_acid not assigned

H+ + DELTA9-tetrahydrocannabinolate <=> DELTA9-tetrahydrocannabinol + CO2 not assigned

L-ornithine + Carbamoyl_phosphate <=> H+ + L-citrulline + phosphate 2.1.3.3 ornithine carbamoyltransferase
2.1.3.6 putrescine carbamoyltransferase
3.5.3.12 agmatine deiminase



cytidine_5''-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + H2O <=> (S)-2-hydroxypropylphosphonate + CMP + H+ 3.6.1

gardneral + acetyl-CoA <=> vinorine + CoA 2.3.1.160 vinorine synthase

squalene + flavin_hydroquinone + O2 <=> (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized_NADPH-hemoprotein_reductase] + H2O 1.14.14.17 squalene monooxygenase

L-isoleucine + 2-oxoglutarate <=> L-glutamate + (S)-3-methyl-2-oxopentanoate 2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.67 2-aminohexanoate transaminase


(2E)-5-methylhexa-2,4-dienoyl-CoA + H2O <=> 3-hydroxy-5-methylhex-4-enoyl-CoA 4.2.1
4.2.1.17 enoyl-CoA hydratase


(-)-deoxypodophyllotoxin <=> podophyllotoxin not assigned

6''''''-deamino-6''''''-hydroxyneomycin_C + O2 <=> 6''''''-deamino-6''''''-oxoneomycin_C + H2O2 1.1.3.44 6'''-hydroxyneomycin C oxidase

(+)-7-Isojasmonate_CoA + acetyl-CoA <=> 3-oxo-2-(cis-2''-pentenyl)-cyclopentane-1-(3-oxobutanoyl)-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase

12-Demethyl-11,12-dehydropaspaline + 3 O2 + 3 NADPH + 3 H+ <=> Terpendole_I + 3 NADP+ + 3 H2O 1.14.13

pheophorbide_a + H2O + H+ <=> pyropheophorbide_a + methanol + CO2 3.1.1.82 pheophorbidase

cadaverine <=> sparteine not assigned

S-adenosyl-L-methionine + (S)-corytuberine <=> S-adenosyl-L-homocysteine + (S)-magnoflorine + H+ 2.1.1.337 reticuline N-methyltransferase

(4R)-ipsdienol + NADP+ <=> ipsdienone + NADPH + H+ 1.1.1.386 ipsdienol dehydrogenase

L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + 4a-hydroxytetrahydrobiopterin 1.14.16.2 tyrosine 3-monooxygenase

novclobiocin_104 + (1H-pyrrole-2-carbonyl)-[peptidyl-carrier_protein] <=> Clorobiocin not assigned