Copied!

Pathway Search

Please choose a pathway from the list:


Arginine biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
NAD+ + H2O + L-glutamate <=> NADH + 2-oxoglutarate + NH3 + H+ 1.4.1.14 glutamate synthase (NADH)
1.4.1.2 glutamate dehydrogenase
1.4.1.3 glutamate dehydrogenase [NAD(P)+]
1.4.1.4 glutamate dehydrogenase (NADP+)
1.4.1.5 L-amino-acid dehydrogenase





argininosuccinate <=> L-arginine + fumarate 4.3.2.1 argininosuccinate lyase
4.3.2.2 adenylosuccinate lyase


L-glutamate + N2-Acetyl-L-ornithine <=> N-acetyl-L-glutamate + L-ornithine 2.3.1.35 glutamate N-acetyltransferase

N-acetyl-L-glutamate + ATP <=> N-acetyl-L-glutamyl_5-phosphate + ADP 2.7.2.8 acetylglutamate kinase

NADP+ + H2O + L-glutamate <=> NADPH + 2-oxoglutarate + NH3 + H+ 1.4.1.13 glutamate synthase (NADPH)
1.4.1.2 glutamate dehydrogenase
1.4.1.3 glutamate dehydrogenase [NAD(P)+]
1.4.1.4 glutamate dehydrogenase (NADP+)




N2-Acetyl-L-ornithine + 2-oxoglutarate <=> L-glutamate + N-acetyl-L-glutamate_5-semialdehyde 2.6.1.11 acetylornithine transaminase
2.6.1.13 ornithine aminotransferase


[amino_group_carrier_protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O <=> L-ornithine + [LysW]-C-terminal-L-glutamate 3.5.1.132 [amino group carrier protein]-ornithine hydrolase

allophanate + H2O + H+ <=> NH3 + CO2 3.5.1.54 allophanate hydrolase

L-glutamine + H2O <=> L-glutamate + NH3 1.4.1.13 glutamate synthase (NADPH)
1.4.1.14 glutamate synthase (NADH)
1.4.7.1 glutamate synthase (ferredoxin)
2.3.2.2 gamma-glutamyltransferase
2.4.2.14 amidophosphoribosyltransferase
3.4.11.17 tryptophanyl aminopeptidase
3.5.1.1 asparaginase
3.5.1.2 glutaminase
3.5.1.38 glutamin-(asparagin-)ase
3.5.1.43 peptidyl-glutaminase
3.5.1.44 protein-glutamine glutaminase
4.3.1.B2
4.3.2.10 imidazole glycerol-phosphate synthase
4.3.3.6 pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
6.3.4.2 CTP synthase (glutamine hydrolysing)
6.3.5.13 lipid II isoglutaminyl synthase (glutamine-hydrolysing)
6.3.5.2 GMP synthase (glutamine-hydrolysing)
6.3.5.4 asparagine synthase (glutamine-hydrolysing)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
6.3.5.6 asparaginyl-tRNA synthase (glutamine-hydrolysing)
6.3.5.7 glutaminyl-tRNA synthase (glutamine-hydrolysing)





















ATP + NH3 + CO2 + H2O <=> ADP + phosphate + Carbamoyl_phosphate 6.3.4.16 carbamoyl-phosphate synthase (ammonia)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)


[amino_group_carrier_protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + 2-oxoglutarate <=> L-glutamate + LysW-L-glutamate_5-semialdehyde 2.6.1
2.6.1.11 acetylornithine transaminase


L-arginine + reduced_flavodoxin + O2 <=> L-citrulline + NO + flavin + H2O + H+ 1.14.14.47 nitric-oxide synthase (flavodoxin)

NH3 + L-glutamate + ATP <=> H+ + L-glutamine + ADP + phosphate 6.3.1.2 glutamine synthetase

L-ornithine + Carbamoyl_phosphate <=> H+ + L-citrulline + phosphate 2.1.3.3 ornithine carbamoyltransferase
2.1.3.6 putrescine carbamoyltransferase
3.5.3.12 agmatine deiminase



LysW-L-glutamyl_5-phosphate + NADPH + H+ <=> LysW-L-glutamate_5-semialdehyde + NADP+ + phosphate 1.2.1

L-arginine + NADPH + H+ + O2 <=> L-citrulline + NO + NADP+ + H2O 1.14.13.39 nitric-oxide synthase (NADPH)
1.14.14.47 nitric-oxide synthase (flavodoxin)


NH3 + HCO3- + ATP <=> Carbamoyl_phosphate + ADP + H2O + H+ 2.7.2.2 carbamate kinase

N2-Acetyl-L-ornithine + Carbamoyl_phosphate <=> H+ + N-acetyl-L-citrulline + phosphate 2.1.3.11 N-succinylornithine carbamoyltransferase
2.1.3.9 N-acetylornithine carbamoyltransferase


N2-Acetyl-L-ornithine + H2O <=> L-ornithine + acetate 2.3.1.35 glutamate N-acetyltransferase
3.5.1.14 N-acyl-aliphatic-L-amino acid amidohydrolase
3.5.1.16 acetylornithine deacetylase
3.5.1.17 acyl-lysine deacylase
3.5.1.B4





H2O + L-arginine <=> Urea + L-ornithine 3.5.3.1 arginase
3.5.3.7 guanidinobutyrase


2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate 2.6.1.1 aspartate transaminase
2.6.1.12 alanine---oxo-acid transaminase
2.6.1.2 alanine transaminase
2.6.1.37 2-aminoethylphosphonate---pyruvate transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.4 glycine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.79 glutamate---prephenate aminotransferase









L-aspartate + 2-oxoglutarate <=> oxaloacetate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.75 cysteine-conjugate transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase










N-acetyl-L-citrulline + H2O <=> L-citrulline + acetate 3.5.1.16 acetylornithine deacetylase
3.5.1.B4


N-acetyl-L-glutamate_5-semialdehyde + NADP+ + phosphate <=> H+ + N-acetyl-L-glutamyl_5-phosphate + NADPH 1.2.1.38 N-acetyl-gamma-glutamyl-phosphate reductase

H+ + Urea + H2O <=> NH3 + CO2 3.5.1.5 urease

L-glutamate + [LysW]-C-terminal-L-glutamate + ATP <=> LysW-L-glutamate + ADP + phosphate 6.3.2

LysW-L-glutamate + ATP <=> LysW-L-glutamyl_5-phosphate + ADP 2.7.2

ATP + Urea + HCO3- + H+ <=> ADP + phosphate + allophanate 6.3.4.6 urea carboxylase

L-aspartate + L-citrulline + ATP <=> H+ + argininosuccinate + diphosphate + AMP 6.3.4.5 argininosuccinate synthase

L-glutamate + acetyl-CoA <=> H+ + N-acetyl-L-glutamate + CoA 2.3.1.1 amino-acid N-acetyltransferase
2.3.1.17 aspartate N-acetyltransferase
2.3.1.183 phosphinothricin acetyltransferase
2.7.2.8 acetylglutamate kinase
6.3.4.16 carbamoyl-phosphate synthase (ammonia)





H2O + L-arginine <=> NH3 + L-citrulline 3.5.3.15 protein-arginine deiminase
3.5.3.6 arginine deiminase


Visualization of the pathway