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3-methylbutanol biosynthesis (engineered)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(2R,3S)-3-isopropylmalate + NAD+ <=> (2S)-2-isopropyl-3-oxosuccinate + NADH + H+ 1.1.1.85 3-isopropylmalate dehydrogenase

3-methyl-1-butanol + NAD+ <=> Isovaleraldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.265 3-methylbutanal reductase



2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate 4.2.1.33 3-isopropylmalate dehydratase

4-methyl-2-oxopentanoate + H+ <=> Isovaleraldehyde + CO2 4.1.1.1 pyruvate decarboxylase
4.1.1.7 benzoylformate decarboxylase
4.1.1.72 branched-chain-2-oxoacid decarboxylase



2-oxoisovalerate + acetyl-CoA + H2O <=> H+ + (2S)-2-isopropylmalate + CoA 2.3.3.13 2-isopropylmalate synthase
2.3.3.17 methylthioalkylmalate synthase


H+ + (2S)-2-isopropyl-3-oxosuccinate <=> 4-methyl-2-oxopentanoate + CO2 0.0.0.0
1.1.1.85 3-isopropylmalate dehydrogenase


2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate 4.2.1.33 3-isopropylmalate dehydratase

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